Carpal tunnel syndrome associated with oral bisphosphonates. a population-based cohort study

Carvajal A, Martin Arias LH, Sainz M, Escudero A, Fierro I, Sauzet O, Cornelius VR, Molokhia M (2016)
Plos One 11(1): e0146772.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Carvajal, Alfonso; Martin Arias, Luis H.; Sainz, Maria; Escudero, Antonio; Fierro, Inmaculada; Sauzet, OdileUniBi; Cornelius, Victoria R.; Molokhia, Mariam
Abstract / Bemerkung
Background Bisphosphonates are widely used to prevent osteoporotic fractures. Some severe musculoskeletal reactions have been described with this medication; among them, some cases of carpal tunnel syndrome. Thus, the aim of this study was to explore whether bisphosphonates may be associated with this syndrome. Methods A cohort study was conducted to compare exposed to unexposed women; the exposed group was that composed of women having received at least one prescription of an oral bisphosphonate. For the purpose, we used information from The Health Improvement Network (THIN) database. The outcome of interest was defined as those women diagnosed with carpal tunnel syndrome. A survival analysis was performed; the Cox proportional hazard model was used to calculate hazard ratios and 95% confidence intervals, and to adjust for identified confounding variables. Results Out of a sample of 59,475 women older than 51 years, 19,825 were treated with bisphosphonates during the period studied. No differences in age distribution or mean follow-up time were observed between the two groups in comparison. Overall, there were 572 women diagnosed with carpal tunnel syndrome, 242 (1.2%) in the group exposed to bisphosphonates, and 330 (0.8%) in the unexposed. An adjusted hazard ratio of developing carpal tunnel syndrome of 1.38 (95% CI, 1.15-1.64) was found for women exposed to bisphosphonates; no significant changes in the hazard ratios were found when considering different levels of bisphosphonate exposure. Conclusions An increased risk of carpal tunnel syndrome is associated with the use of bisphosphonates in postmenopausal women.
Erscheinungsjahr
2016
Zeitschriftentitel
Plos One
Band
11
Ausgabe
1
Art.-Nr.
e0146772
ISSN
1932-6203
Page URI
https://pub.uni-bielefeld.de/record/2901311

Zitieren

Carvajal A, Martin Arias LH, Sainz M, et al. Carpal tunnel syndrome associated with oral bisphosphonates. a population-based cohort study. Plos One. 2016;11(1): e0146772.
Carvajal, A., Martin Arias, L. H., Sainz, M., Escudero, A., Fierro, I., Sauzet, O., Cornelius, V. R., et al. (2016). Carpal tunnel syndrome associated with oral bisphosphonates. a population-based cohort study. Plos One, 11(1), e0146772. doi:10.1371/journal.pone.0146772
Carvajal, Alfonso, Martin Arias, Luis H., Sainz, Maria, Escudero, Antonio, Fierro, Inmaculada, Sauzet, Odile, Cornelius, Victoria R., and Molokhia, Mariam. 2016. “Carpal tunnel syndrome associated with oral bisphosphonates. a population-based cohort study”. Plos One 11 (1): e0146772.
Carvajal, A., Martin Arias, L. H., Sainz, M., Escudero, A., Fierro, I., Sauzet, O., Cornelius, V. R., and Molokhia, M. (2016). Carpal tunnel syndrome associated with oral bisphosphonates. a population-based cohort study. Plos One 11:e0146772.
Carvajal, A., et al., 2016. Carpal tunnel syndrome associated with oral bisphosphonates. a population-based cohort study. Plos One, 11(1): e0146772.
A. Carvajal, et al., “Carpal tunnel syndrome associated with oral bisphosphonates. a population-based cohort study”, Plos One, vol. 11, 2016, : e0146772.
Carvajal, A., Martin Arias, L.H., Sainz, M., Escudero, A., Fierro, I., Sauzet, O., Cornelius, V.R., Molokhia, M.: Carpal tunnel syndrome associated with oral bisphosphonates. a population-based cohort study. Plos One. 11, : e0146772 (2016).
Carvajal, Alfonso, Martin Arias, Luis H., Sainz, Maria, Escudero, Antonio, Fierro, Inmaculada, Sauzet, Odile, Cornelius, Victoria R., and Molokhia, Mariam. “Carpal tunnel syndrome associated with oral bisphosphonates. a population-based cohort study”. Plos One 11.1 (2016): e0146772.

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