NF-KappaB in Long-Term Memory and Structural Plasticity in the Adult Mammalian Brain

Kaltschmidt B, Kaltschmidt C (2015)
Frontiers in Molecular Neuroscience 8: 69.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
OA 1.88 MB
Abstract / Bemerkung
The transcription factor nuclear factor kappaB (NF-κB) is a well-known regulator of inflammation, stress, and immune responses as well as cell survival. In the nervous system, NF-κB is one of the crucial components in the molecular switch that converts short- to long-term memory—a process that requires de novo gene expression. Here, the researches published on NF-κB and downstream target genes in mammals will be reviewed, which are necessary for structural plasticity and long-term memory, both under normal and pathological conditions in the brain. Genetic evidence has revealed that NF-κB regulates neuroprotection, neuronal transmission, and long-term memory. In addition, after genetic ablation of all NF-κB subunits, a severe defect in hippocampal adult neurogenesis was observed during aging. Proliferation of neural precursors is increased; however, axon outgrowth, synaptogenesis, and tissue homeostasis of the dentate gyrus are hampered. In this process, the NF-κB target gene PKAcat and other downstream target genes such as Igf2 are critically involved. Therefore, NF-κB activity seems to be crucial in regulating structural plasticity and replenishment of granule cells within the hippocampus throughout the life. In addition to the function of NF-κB in neurons, we will discuss on a neuroinflammatory role of the transcription factor in glia. Finally, a model for NF-κB homeostasis on the molecular level is presented, in order to explain seemingly the contradictory, the friend or foe, role of NF-κB in the nervous system.
Frontiers in Molecular Neuroscience
Open-Access-Publikationskosten wurden durch die Deutsche Forschungsgemeinschaft und die Universität Bielefeld gefördert.
Page URI


Kaltschmidt B, Kaltschmidt C. NF-KappaB in Long-Term Memory and Structural Plasticity in the Adult Mammalian Brain. Frontiers in Molecular Neuroscience. 2015;8: 69.
Kaltschmidt, B., & Kaltschmidt, C. (2015). NF-KappaB in Long-Term Memory and Structural Plasticity in the Adult Mammalian Brain. Frontiers in Molecular Neuroscience, 8, 69. doi:10.3389/fnmol.2015.00069
Kaltschmidt, Barbara, and Kaltschmidt, Christian. 2015. “NF-KappaB in Long-Term Memory and Structural Plasticity in the Adult Mammalian Brain”. Frontiers in Molecular Neuroscience 8: 69.
Kaltschmidt, B., and Kaltschmidt, C. (2015). NF-KappaB in Long-Term Memory and Structural Plasticity in the Adult Mammalian Brain. Frontiers in Molecular Neuroscience 8:69.
Kaltschmidt, B., & Kaltschmidt, C., 2015. NF-KappaB in Long-Term Memory and Structural Plasticity in the Adult Mammalian Brain. Frontiers in Molecular Neuroscience, 8: 69.
B. Kaltschmidt and C. Kaltschmidt, “NF-KappaB in Long-Term Memory and Structural Plasticity in the Adult Mammalian Brain”, Frontiers in Molecular Neuroscience, vol. 8, 2015, : 69.
Kaltschmidt, B., Kaltschmidt, C.: NF-KappaB in Long-Term Memory and Structural Plasticity in the Adult Mammalian Brain. Frontiers in Molecular Neuroscience. 8, : 69 (2015).
Kaltschmidt, Barbara, and Kaltschmidt, Christian. “NF-KappaB in Long-Term Memory and Structural Plasticity in the Adult Mammalian Brain”. Frontiers in Molecular Neuroscience 8 (2015): 69.
Alle Dateien verfügbar unter der/den folgenden Lizenz(en):
Copyright Statement:
Dieses Objekt ist durch das Urheberrecht und/oder verwandte Schutzrechte geschützt. [...]
Access Level
OA Open Access
Zuletzt Hochgeladen
MD5 Prüfsumme

20 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Cellular Specificity of NF-κB Function in the Nervous System.
Dresselhaus EC, Meffert MK., Front Immunol 10(), 2019
PMID: 31143184
Innate Immune Signaling and Alcohol Use Disorders.
Coleman LG, Crews FT., Handb Exp Pharmacol 248(), 2018
PMID: 29500721
IKK2/NF-κB signaling protects neurons after traumatic brain injury.
Mettang M, Reichel SN, Lattke M, Palmer A, Abaei A, Rasche V, Huber-Lang M, Baumann B, Wirth T., FASEB J 32(4), 2018
PMID: 29187362
Single-cell transcriptomics of the developing lateral geniculate nucleus reveals insights into circuit assembly and refinement.
Kalish BT, Cheadle L, Hrvatin S, Nagy MA, Rivera S, Crow M, Gillis J, Kirchner R, Greenberg ME., Proc Natl Acad Sci U S A 115(5), 2018
PMID: 29343640
The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-in Mice.
Riedlinger T, Haas J, Busch J, van de Sluis B, Kracht M, Schmitz ML., Biomedicines 6(1), 2018
PMID: 29562713
Stability and Function of Hippocampal Mossy Fiber Synapses Depend on Bcl11b/Ctip2.
De Bruyckere E, Simon R, Nestel S, Heimrich B, Kätzel D, Egorov AV, Liu P, Jenkins NA, Copeland NG, Schwegler H, Draguhn A, Britsch S., Front Mol Neurosci 11(), 2018
PMID: 29674952
Subunit-Specific Role of NF-κB in Cancer.
Kaltschmidt B, Greiner JFW, Kadhim HM, Kaltschmidt C., Biomedicines 6(2), 2018
PMID: 29673141
Combined Rosiglitazone and Forskolin Have Neuroprotective Effects in SD Rats after Spinal Cord Injury.
Meng QQ, Meng QQ, Lei W, Chen H, Feng ZC, Hu LQ, Zhang XL, Li S., PPAR Res 2018(), 2018
PMID: 30034460
Hippocampal nuclear factor kappa B accounts for stress-induced anxiety behaviors via enhancing neuronal nitric oxide synthase (nNOS)-carboxy-terminal PDZ ligand of nNOS-Dexras1 coupling.
Zhu LJ, Ni HY, Chen R, Chang L, Shi HJ, Qiu D, Zhang Z, Wu DL, Jiang ZC, Xin HL, Zhou QG, Zhu DY., J Neurochem 146(5), 2018
PMID: 29858554
Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants.
Martín-Hernández D, Caso JR, Javier Meana J, Callado LF, Madrigal JLM, García-Bueno B, Leza JC., J Neuroinflammation 15(1), 2018
PMID: 30180869
Activity-dependent synapse to nucleus signaling.
Lim AF, Lim WL, Ch'ng TH., Neurobiol Learn Mem 138(), 2017
PMID: 27473670
The role of neuroimmune signaling in alcoholism.
Crews FT, Lawrimore CJ, Walter TJ, Coleman LG., Neuropharmacology 122(), 2017
PMID: 28159648
NF-κB regulates neuronal ankyrin-G via a negative feedback loop.
König HG, Schwamborn R, Andresen S, Kinsella S, Watters O, Fenner B, Prehn JH., Sci Rep 7(), 2017
PMID: 28181483
IGF-II promotes neuroprotection and neuroplasticity recovery in a long-lasting model of oxidative damage induced by glucocorticoids.
Martín-Montañez E, Millon C, Boraldi F, Garcia-Guirado F, Pedraza C, Lara E, Santin LJ, Pavia J, Garcia-Fernandez M., Redox Biol 13(), 2017
PMID: 28575743
l-Acetylcarnitine: A Mechanistically Distinctive and Potentially Rapid-Acting Antidepressant Drug.
Chiechio S, Canonico PL, Grilli M., Int J Mol Sci 19(1), 2017
PMID: 29267192
Motor phenotypes and molecular networks associated with germline deficiency of Ciz1.
Xiao J, Vemula SR, Xue Y, Khan MM, Kuruvilla KP, Marquez-Lona EM, Cobb MR, LeDoux MS., Exp Neurol 283(pt a), 2016
PMID: 27163549
Single-particle tracking uncovers dynamics of glutamate-induced retrograde transport of NF-κB p65 in living neurons.
Widera D, Klenke C, Nair D, Heidbreder M, Malkusch S, Sibarita JB, Choquet D, Kaltschmidt B, Heilemann M, Kaltschmidt C., Neurophotonics 3(4), 2016
PMID: 27226975

99 References

Daten bereitgestellt von Europe PubMed Central.

c-Rel, an NF-kappaB family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formation.
Ahn HJ, Hernandez CM, Levenson JM, Lubin FD, Liou HC, Sweatt JD., Learn. Mem. 15(7), 2008
PMID: 18626097
I kappa B: a specific inhibitor of the NF-kappa B transcription factor.
Baeuerle PA, Baltimore D., Science 242(4878), 1988
PMID: 3140380
Late-onset Parkinsonism in NFκB/c-Rel-deficient mice.
Baiguera C, Alghisi M, Pinna A, Bellucci A, De Luca MA, Frau L, Morelli M, Ingrassia R, Benarese M, Porrini V, Pellitteri M, Bertini G, Fabene PF, Sigala S, Spillantini MG, Liou HC, Spano PF, Pizzi M., Brain 135(Pt 9), 2012
PMID: 22915735
Prodynorphin gene expression relates to NF-kappa B factors.
Bakalkin G, Yakovleva T, Terenius L., Brain Res. Mol. Brain Res. 24(1-4), 1994
PMID: 7968369
Gene expression profiling of facilitated L-LTP in VP16-CREB mice reveals that BDNF is critical for the maintenance of LTP and its synaptic capture.
Barco A, Patterson SL, Patterson S, Alarcon JM, Gromova P, Mata-Roig M, Morozov A, Kandel ER., Neuron 48(1), 2005
PMID: 16202713
cAMP response element-binding protein is a primary hub of activity-driven neuronal gene expression.
Benito E, Valor LM, Jimenez-Minchan M, Huber W, Barco A., J. Neurosci. 31(50), 2011
PMID: 22171029
Loss of Nfkb1 leads to early onset aging.
Bernal GM, Wahlstrom JS, Crawley CD, Cahill KE, Pytel P, Liang H, Kang S, Weichselbaum RR, Yamini B., Aging (Albany NY) 6(11), 2014
PMID: 25553648
Constitutive nuclear factor-kappa B activity is required for central neuron survival.
Bhakar AL, Tannis LL, Zeindler C, Russo MP, Jobin C, Park DS, MacPherson S, Barker PA., J. Neurosci. 22(19), 2002
PMID: 12351721
A requirement for nuclear factor-kappaB in developmental and plasticity-associated synaptogenesis.
Boersma MC, Dresselhaus EC, De Biase LM, Mihalas AB, Bergles DE, Meffert MK., J. Neurosci. 31(14), 2011
PMID: 21471377
Astroglial nuclear factor-kappaB regulates learning and memory and synaptic plasticity in female mice.
Bracchi-Ricard V, Brambilla R, Levenson J, Hu WH, Bramwell A, Sweatt JD, Green EJ, Bethea JR., J. Neurochem. 104(3), 2007
PMID: 17953667
Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury.
Brambilla R, Bracchi-Ricard V, Hu WH, Frydel B, Bramwell A, Karmally S, Green EJ, Bethea JR., J. Exp. Med. 202(1), 2005
PMID: 15998793
A critical role for IGF-II in memory consolidation and enhancement.
Chen DY, Stern SA, Garcia-Osta A, Saunier-Rebori B, Pollonini G, Bambah-Mukku D, Blitzer RD, Alberini CM., Nature 469(7331), 2011
PMID: 21270887
Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death.
Cho IH, Hong J, Suh EC, Kim JH, Lee H, Lee JE, Lee S, Kim CH, Kim DW, Jo EK, Lee KE, Karin M, Lee SJ., Brain 131(Pt 11), 2008
PMID: 18819987
A functional role for adult hippocampal neurogenesis in spatial pattern separation.
Clelland CD, Choi M, Romberg C, Clemenson GD Jr, Fragniere A, Tyers P, Jessberger S, Saksida LM, Barker RA, Gage FH, Bussey TJ., Science 325(5937), 2009
PMID: 19590004
Intra-axonal translation and retrograde trafficking of CREB promotes neuronal survival.
Cox LJ, Hengst U, Gurskaya NG, Lukyanov KA, Jaffrey SR., Nat. Cell Biol. 10(2), 2008
PMID: 18193038
Impaired adult neurogenesis associated with short-term memory defects in NF-kappaB p50-deficient mice.
Denis-Donini S, Dellarole A, Crociara P, Francese MT, Bortolotto V, Quadrato G, Canonico PL, Orsetti M, Ghi P, Memo M, Bonini SA, Ferrari-Toninelli G, Grilli M., J. Neurosci. 28(15), 2008
PMID: 18400889
Calcium oscillations increase the efficiency and specificity of gene expression.
Dolmetsch RE, Xu K, Lewis RS., Nature 392(6679), 1998
PMID: 9582075
NF-kappaB protects neurons from ischemic injury after middle cerebral artery occlusion in mice.
Duckworth EA, Butler T, Collier L, Collier S, Pennypacker KR., Brain Res. 1088(1), 2006
PMID: 16630592
Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection.
Fridmacher V, Kaltschmidt B, Goudeau B, Ndiaye D, Rossi FM, Pfeiffer J, Kaltschmidt C, Israel A, Memet S., J. Neurosci. 23(28), 2003
PMID: 14561868
The MHC-specific enhanceosome and its role in MHC class I and beta(2)-microglobulin gene transactivation.
Gobin SJ, van Zutphen M, Westerheide SD, Boss JM, van den Elsen PJ., J. Immunol. 167(9), 2001
PMID: 11673530
Synaptic activation of NF-kappa B by glutamate in cerebellar granule neurons in vitro.
Guerrini L, Blasi F, Denis-Donini S., Proc. Natl. Acad. Sci. U.S.A. 92(20), 1995
PMID: 7568076
IKK mediates ischemia-induced neuronal death.
Herrmann O, Baumann B, de Lorenzi R, Muhammad S, Zhang W, Kleesiek J, Malfertheiner M, Kohrmann M, Potrovita I, Maegele I, Beyer C, Burke JR, Hasan MT, Bujard H, Wirth T, Pasparakis M, Schwaninger M., Nat. Med. 11(12), 2005
PMID: 16286924
It takes two to tango: IκBs, the multifunctional partners of NF-κB.
Hinz M, Arslan SC, Scheidereit C., Immunol. Rev. 246(1), 2012
PMID: 22435547
Functional requirement for class I MHC in CNS development and plasticity.
Huh GS, Boulanger LM, Du H, Riquelme PA, Brotz TM, Shatz CJ., Science 290(5499), 2000
PMID: 11118151
Regrowing the adult brain: NF-κB controls functional circuit formation and tissue homeostasis in the dentate gyrus.
Imielski Y, Schwamborn JC, Luningschror P, Heimann P, Holzberg M, Werner H, Leske O, Puschel AW, Memet S, Heumann R, Israel A, Kaltschmidt C, Kaltschmidt B., PLoS ONE 7(2), 2012
PMID: 22312433
The IKK complex, a central regulator of NF-kappaB activation.
Israel A., Cold Spring Harb Perspect Biol 2(3), 2010
PMID: 20300203
Increased hippocampal neurogenesis in Alzheimer's disease.
Jin K, Peel AL, Mao XO, Xie L, Cottrell BA, Henshall DC, Greenberg DA., Proc. Natl. Acad. Sci. U.S.A. 101(1), 2003
PMID: 14660786
Chronic inflammation induces telomere dysfunction and accelerates ageing in mice.
Jurk D, Wilson C, Passos JF, Oakley F, Correia-Melo C, Greaves L, Saretzki G, Fox C, Lawless C, Anderson R, Hewitt G, Pender SL, Fullard N, Nelson G, Mann J, van de Sluis B, Mann DA, von Zglinicki T., Nat Commun 2(), 2014
PMID: 24960204
Neuronal NF-kappaB influences thermoregulation and survival in a sepsis model.
Juttler E, Inta I, Eigler V, Herrmann O, Maegele I, Maser-Gluth C, Schwaninger M., J. Neuroimmunol. 189(1-2), 2007
PMID: 17655939
NF-kappaB-dependent regulation of brain-derived neurotrophic factor in hippocampal neurons by X-linked inhibitor of apoptosis protein.
Kairisalo M, Korhonen L, Sepp M, Pruunsild P, Kukkonen JP, Kivinen J, Timmusk T, Blomgren K, Lindholm D., Eur. J. Neurosci. 30(6), 2009
PMID: 19735291
Constitutive NF-kappa B activity is modulated via neuron-astroglia interaction.
Kaltschmidt B, Kaltschmidt C., Exp Brain Res 130(1), 2000
PMID: 10638446
NF-kappaB in the nervous system.
Kaltschmidt B, Kaltschmidt C., Cold Spring Harb Perspect Biol 1(3), 2009
PMID: 20066105
Cyclooxygenase-2 is a neuronal target gene of NF-kappaB.
Kaltschmidt B, Linker RA, Deng J, Kaltschmidt C., BMC Mol. Biol. 3(), 2002
PMID: 12466023
NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling.
Kaltschmidt B, Ndiaye D, Korte M, Pothion S, Arbibe L, Prullage M, Pfeiffer J, Lindecke A, Staiger V, Israel A, Kaltschmidt C, Memet S., Mol. Cell. Biol. 26(8), 2006
PMID: 16581769
Inhibition of NF-kappaB potentiates amyloid beta-mediated neuronal apoptosis.
Kaltschmidt B, Uherek M, Wellmann H, Volk B, Kaltschmidt C., Proc. Natl. Acad. Sci. U.S.A. 96(16), 1999
PMID: 10430956
Signaling via NF-kappaB in the nervous system.
Kaltschmidt B, Widera D, Kaltschmidt C., Biochim. Biophys. Acta 1745(3), 2005
PMID: 15993497
Brain synapses contain inducible forms of the transcription factor NF-kappa B.
Kaltschmidt C, Kaltschmidt B, Baeuerle PA., Mech. Dev. 43(2-3), 1993
PMID: 8297787
Stimulation of ionotropic glutamate receptors activates transcription factor NF-kappa B in primary neurons.
Kaltschmidt C, Kaltschmidt B, Baeuerle PA., Proc. Natl. Acad. Sci. U.S.A. 92(21), 1995
PMID: 7568184
Constitutive NF-kappa B activity in neurons.
Kaltschmidt C, Kaltschmidt B, Neumann H, Wekerle H, Baeuerle PA., Mol. Cell. Biol. 14(6), 1994
PMID: 8196637
The molecular and systems biology of memory.
Kandel ER, Dudai Y, Mayford MR., Cell 157(1), 2014
PMID: 24679534
Lack of NF-kappaB p50 exacerbates degeneration of hippocampal neurons after chemical exposure and impairs learning.
Kassed CA, Willing AE, Garbuzova-Davis S, Sanberg PR, Pennypacker KR., Exp. Neurol. 176(2), 2002
PMID: 12359170
Hsc70 is a novel interactor of NF-kappaB p65 in living hippocampal neurons.
Klenke C, Widera D, Engelen T, Muller J, Noll T, Niehaus K, Schmitz ML, Kaltschmidt B, Kaltschmidt C., PLoS ONE 8(6), 2013
PMID: 23762333
Nuclear factor κB activation impairs ependymal ciliogenesis and links neuroinflammation to hydrocephalus formation.
Lattke M, Magnutzki A, Walther P, Wirth T, Baumann B., J. Neurosci. 32(34), 2012
PMID: 22915098
A bioinformatics analysis of memory consolidation reveals involvement of the transcription factor c-rel.
Levenson JM, Choi S, Lee SY, Cao YA, Ahn HJ, Worley KC, Pizzi M, Liou HC, Sweatt JD., J. Neurosci. 24(16), 2004
PMID: 15102909
From calcium to NF-kappa B signaling pathways in neurons.
Lilienbaum A, Israel A., Mol. Cell. Biol. 23(8), 2003
PMID: 12665571
γCaMKII shuttles Ca²⁺/CaM to the nucleus to trigger CREB phosphorylation and gene expression.
Ma H, Groth RD, Cohen SM, Emery JF, Li B, Hoedt E, Zhang G, Neubert TA, Tsien RW., Cell 159(2), 2014
PMID: 25303525
Disruption of CREB function in brain leads to neurodegeneration.
Mantamadiotis T, Lemberger T, Bleckmann SC, Kern H, Kretz O, Martin Villalba A, Tronche F, Kellendonk C, Gau D, Kapfhammer J, Otto C, Schmid W, Schutz G., Nat. Genet. 31(1), 2002
PMID: 11967539
Identification of novel small molecule activators of nuclear factor-κB with neuroprotective action via high-throughput screening.
Manuvakhova MS, Johnson GG, White MC, Ananthan S, Sosa M, Maddox C, McKellip S, Rasmussen L, Wennerberg K, Hobrath JV, White EL, Maddry JA, Grimaldi M., J. Neurosci. Res. 89(1), 2011
PMID: 21046675
Synapses and memory storage.
Mayford M, Siegelbaum SA, Kandel ER., Cold Spring Harb Perspect Biol 4(6), 2012
PMID: 22496389
Gene expression of the transcription factor NF-kappa B in hippocampus: regulation by synaptic activity.
Meberg PJ, Kinney WR, Valcourt EG, Routtenberg A., Brain Res. Mol. Brain Res. 38(2), 1996
PMID: 8793106
NF-kappa B functions in synaptic signaling and behavior.
Meffert MK, Chang JM, Wiltgen BJ, Fanselow MS, Baltimore D., Nat. Neurosci. 6(10), 2003
PMID: 12947408
Cytokine-induced nuclear factor kappa B activation promotes the survival of developing neurons.
Middleton G, Hamanoue M, Enokido Y, Wyatt S, Pennica D, Jaffray E, Hay RT, Davies AM., J. Cell Biol. 148(2), 2000
PMID: 10648565
Early growth response 2 (Egr-2) expression is triggered by NF-κB activation.
Nafez S, Oikawa K, Odero GL, Sproule M, Ge N, Schapansky J, Abrenica B, Hatherell A, Cadonic C, Zhang S, Song X, Kauppinen T, Glazner GW, Grilli M, Czubryt MP, Eisenstat DD, Albensi BC., Mol. Cell. Neurosci. 64(), 2014
PMID: 25553923
Activation of the transcription factor NF-kappaB in Schwann cells is required for peripheral myelin formation.
Nickols JC, Valentine W, Kanwal S, Carter BD., Nat. Neurosci. 6(2), 2003
PMID: 12514737
Impaired acute and inflammatory nociception in mice lacking the p50 subunit of NF-kappaB.
Niederberger E, Schmidtko A, Gao W, Kuhlein H, Ehnert C, Geisslinger G., Eur. J. Pharmacol. 559(1), 2006
PMID: 17217946
The transcriptional coactivators p300 and CBP are histone acetyltransferases.
Ogryzko VV, Schiltz RL, Russanova V, Howard BH, Nakatani Y., Cell 87(5), 1996
PMID: 8945521
NF-κB p50 subunit knockout impairs late LTP and alters long term memory in the mouse hippocampus.
Oikawa K, Odero GL, Platt E, Neuendorff M, Hatherell A, Bernstein MJ, Albensi BC., BMC Neurosci 13(), 2012
PMID: 22553912
NF-kappaB/Rel regulates inhibitory and excitatory neuronal function and synaptic plasticity.
O'Mahony A, Raber J, Montano M, Foehr E, Han V, Lu SM, Kwon H, LeFevour A, Chakraborty-Sett S, Greene WC., Mol. Cell. Biol. 26(19), 2006
PMID: 16980629
Regulation of nuclear factor kappaB in the hippocampus by group I metabotropic glutamate receptors.
O'Riordan KJ, Huang IC, Pizzi M, Spano P, Boroni F, Egli R, Desai P, Fitch O, Malone L, Ahn HJ, Liou HC, Sweatt JD, Levenson JM., J. Neurosci. 26(18), 2006
PMID: 16672661
Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice.
Pascual-Lucas M, Viana da Silva S, Di Scala M, Garcia-Barroso C, Gonzalez-Aseguinolaza G, Mulle C, Alberini CM, Cuadrado-Tejedor M, Garcia-Osta A., EMBO Mol Med 6(10), 2014
PMID: 25100745
Opposing roles for NF-kappa B/Rel factors p65 and c-Rel in the modulation of neuron survival elicited by glutamate and interleukin-1beta.
Pizzi M, Goffi F, Boroni F, Benarese M, Perkins SE, Liou HC, Spano P., J. Biol. Chem. 277(23), 2002
PMID: 11912207
Identification and optogenetic manipulation of memory engrams in the hippocampus.
Ramirez S, Tonegawa S, Liu X., Front Behav Neurosci 7(), 2013
PMID: 24478647
Making memories last: the synaptic tagging and capture hypothesis.
Redondo RL, Morris RG., Nat. Rev. Neurosci. 12(1), 2011
PMID: 21170072
Memory. Engram cells retain memory under retrograde amnesia.
Ryan TJ, Roy DS, Pignatelli M, Arons A, Tonegawa S., Science 348(6238), 2015
PMID: 26023136
IκB kinase/nuclear factor κB-dependent insulin-like growth factor 2 (Igf2) expression regulates synapse formation and spine maturation via Igf2 receptor signaling.
Schmeisser MJ, Baumann B, Johannsen S, Vindedal GF, Jensen V, Hvalby OC, Sprengel R, Seither J, Maqbool A, Magnutzki A, Lattke M, Oswald F, Boeckers TM, Wirth T., J. Neurosci. 32(16), 2012
PMID: 22514330
NF-kappaB activity in transgenic mice: developmental regulation and tissue specificity.
Schmidt-Ullrich R, Memet S, Lilienbaum A, Feuillard J, Raphael M, Israel A., Development 122(7), 1996
PMID: 8681793
In utero gene therapy: the case for.
Schneider H, Coutelle C., Nat. Med. 5(3), 1999
PMID: 10086371

Semon R.., 1920
CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases.
Sheng M, Thompson MA, Greenberg ME., Science 252(5011), 1991
PMID: 1646483
Stimulated nuclear translocation of NF-kappaB and shuttling differentially depend on dynein and the dynactin complex.
Shrum CK, Defrancisco D, Meffert MK., Proc. Natl. Acad. Sci. U.S.A. 106(8), 2009
PMID: 19196984
Protein degradation by ubiquitin-proteasome system in formation and labilization of contextual conditioning memory.
Sol Fustinana M, de la Fuente V, Federman N, Freudenthal R, Romano A., Learn. Mem. 21(9), 2014
PMID: 25135196
Inhibition of transcription factor NF-kappaB in the central nervous system ameliorates autoimmune encephalomyelitis in mice.
van Loo G, De Lorenzi R, Schmidt H, Huth M, Mildner A, Schmidt-Supprian M, Lassmann H, Prinz MR, Pasparakis M., Nat. Immunol. 7(9), 2006
PMID: 16892069
A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM., Nat. Rev. Genet. 10(4), 2009
PMID: 19274049
Retrograde transport of transcription factor NF-kappa B in living neurons.
Wellmann H, Kaltschmidt B, Kaltschmidt C., J. Biol. Chem. 276(15), 2000
PMID: 11096106
Regulation of transcription factors by neuronal activity.
West AE, Griffith EC, Greenberg ME., Nat. Rev. Neurosci. 3(12), 2002
PMID: 12461549
Methods for the modulation and analysis of NF-κB-dependent adult neurogenesis.
Widera D, Muller J, Imielski Y, Heimann P, Kaltschmidt C, Kaltschmidt B., J Vis Exp (84), 2014
PMID: 24561872
Myeloid IKKβ promotes antitumor immunity by modulating CCL11 and the innate immune response.
Yang J, Hawkins OE, Barham W, Gilchuk P, Boothby M, Ayers GD, Joyce S, Karin M, Yull FE, Richmond A., Cancer Res. 74(24), 2014
PMID: 25336190
Lack of the p50 subunit of nuclear factor-kappaB increases the vulnerability of hippocampal neurons to excitotoxic injury.
Yu Z, Zhou D, Bruce-Keller AJ, Kindy MS, Mattson MP., J. Neurosci. 19(20), 1999
PMID: 10516305
Neuroprotective role for the p50 subunit of NF-kappaB in an experimental model of Huntington's disease.
Yu Z, Zhou D, Cheng G, Mattson MP., J. Mol. Neurosci. 15(1), 2000
PMID: 11211235
Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH.
Zhang G, Li J, Purkayastha S, Tang Y, Zhang H, Yin Y, Li B, Liu G, Cai D., Nature 497(7448), 2013
PMID: 23636330
Nuclear factor kappa B signaling initiates early differentiation of neural stem cells.
Zhang Y, Liu J, Yao S, Li F, Xin L, Lai M, Bracchi-Ricard V, Xu H, Yen W, Meng W, Liu S, Yang L, Karmally S, Liu J, Zhu H, Gordon J, Khalili K, Srinivasan S, Bethea JR, Mo X, Hu W., Stem Cells 30(3), 2012
PMID: 22134901

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

PMID: 26635522
PubMed | Europe PMC

Suchen in

Google Scholar