Validation of diagnostic tests for depressive disorder in drug-resistant mesial temporal lobe epilepsy

Zingano B de L, Guarnieri R, Diaz AP, Schwarzbold ML, Horta Bicalho MA, Claudino LS, Markowitsch HJ, Wolf P, Lin K, Walz R (2015)
Epilepsy & Behavior 50: 61-66.

Zeitschriftenaufsatz | Veröffentlicht| Englisch
 
Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Autor/in
Zingano, Bianca de Lemos; Guarnieri, Ricardo; Diaz, Alexandre Paim; Schwarzbold, Marcelo Liborio; Horta Bicalho, Maria Alice; Claudino, Lucia Sukys; Markowitsch, Hans J.UniBi; Wolf, Peter; Lin, Katia; Walz, Roger
Abstract / Bemerkung
Purpose: This study aimed to evaluate the diagnostic accuracy of the Hamilton Rating Scale for Depression (HRSD), the Beck Depression Inventory (BDI), the Hospital Anxiety and Depression Scale (HADS), and the Hospital Anxiety and Depression Scale-Depression subscale (HADS-D) as diagnostic tests for depressive disorder in drug-resistant mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). Methods: One hundred three patients with drug-resistant MTLE-HS were enrolled. All patients underwent a neurological examination, interictal and ictal video-electroencephalogram (V-EEG) analyses, and magnetic resonance imaging (MRI). Psychiatric interviews were based on DSM-IV-TR criteria and ILAE Commission of Psychobiology classification as a gold standard; HRSD, BDI, HADS, and HADS-D were used as psychometric diagnostic tests, and receiver operating characteristic (ROC) curves were used to determine the optimal threshold scores. Results: For all the scales, the areas under the curve (AUCs) were approximately 0.8, and they were able to identify depression in this sample. A threshold of >= 9 on the HRSD and a threshold of >= 8 on the HADS-D showed a sensitivity of 70% and specificity of 80%. A threshold of >= 19 on the BDI and HADS-D total showed a sensitivity of 55% and a specificity of approximately 90%. The instruments showed a negative predictive value of approximately 87% and a positive predictive value of approximately 65% for the BDI and HADS total and approximately 60% for the HRSD and HADS-D. Conclusions: HRSD >= 9 and HADS-D >= 8 had the best balance between sensitivity (approximately 70%) and specificity (approximately 80%). However, with these thresholds, these diagnostic tests do not appear useful in identifying depressive disorder in this population with epilepsy, and their specificity (approximately 80%) and PPV (approximately 55%) were lower than those of the other scales. We believe that the BDI and HADS total are valid diagnostic tests for depressive disorder in patients with MTLE-HS, as both scales showed acceptable (though not high) specificity and PPV for this type of study. (C) 2015 Elsevier Inc. All rights reserved.
Stichworte
Diagnostic tests; Depressive disorder; Drug-resistant mesial temporal lobe epilepsy; Hippocampal sclerosis; Diagnostic accuracy
Erscheinungsjahr
2015
Zeitschriftentitel
Epilepsy & Behavior
Band
50
Seite(n)
61-66
ISSN
1525-5050
Page URI
https://pub.uni-bielefeld.de/record/2782685

Zitieren

Zingano B de L, Guarnieri R, Diaz AP, et al. Validation of diagnostic tests for depressive disorder in drug-resistant mesial temporal lobe epilepsy. Epilepsy & Behavior. 2015;50:61-66.
Zingano, B. de L., Guarnieri, R., Diaz, A. P., Schwarzbold, M. L., Horta Bicalho, M. A., Claudino, L. S., Markowitsch, H. J., et al. (2015). Validation of diagnostic tests for depressive disorder in drug-resistant mesial temporal lobe epilepsy. Epilepsy & Behavior, 50, 61-66. doi:10.1016/j.yebeh.2015.06.004
Zingano, B. de L., Guarnieri, R., Diaz, A. P., Schwarzbold, M. L., Horta Bicalho, M. A., Claudino, L. S., Markowitsch, H. J., Wolf, P., Lin, K., and Walz, R. (2015). Validation of diagnostic tests for depressive disorder in drug-resistant mesial temporal lobe epilepsy. Epilepsy & Behavior 50, 61-66.
Zingano, B. de L., et al., 2015. Validation of diagnostic tests for depressive disorder in drug-resistant mesial temporal lobe epilepsy. Epilepsy & Behavior, 50, p 61-66.
B. de L. Zingano, et al., “Validation of diagnostic tests for depressive disorder in drug-resistant mesial temporal lobe epilepsy”, Epilepsy & Behavior, vol. 50, 2015, pp. 61-66.
Zingano, B. de L., Guarnieri, R., Diaz, A.P., Schwarzbold, M.L., Horta Bicalho, M.A., Claudino, L.S., Markowitsch, H.J., Wolf, P., Lin, K., Walz, R.: Validation of diagnostic tests for depressive disorder in drug-resistant mesial temporal lobe epilepsy. Epilepsy & Behavior. 50, 61-66 (2015).
Zingano, Bianca de Lemos, Guarnieri, Ricardo, Diaz, Alexandre Paim, Schwarzbold, Marcelo Liborio, Horta Bicalho, Maria Alice, Claudino, Lucia Sukys, Markowitsch, Hans J., Wolf, Peter, Lin, Katia, and Walz, Roger. “Validation of diagnostic tests for depressive disorder in drug-resistant mesial temporal lobe epilepsy”. Epilepsy & Behavior 50 (2015): 61-66.

7 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Amygdala levels of the GluA1 subunit of glutamate receptors and its phosphorylation state at serine 845 in the anterior hippocampus are biomarkers of ictal fear but not anxiety.
Leal RB, Lopes MW, Formolo DA, de Carvalho CR, Hoeller AA, Latini A, Sousa DS, Wolf P, Prediger RD, Bortolotto ZA, Linhares MN, Lin K, Walz R., Mol Psychiatry (), 2018
PMID: 29880883
Depression screening tools in persons with epilepsy: A systematic review of validated tools.
Gill SJ, Lukmanji S, Fiest KM, Patten SB, Wiebe S, Jetté N., Epilepsia 58(5), 2017
PMID: 28064446
The approach to patients with psychogenic nonepileptic seizures in epilepsy surgery centers regarding diagnosis, treatment, and education.
Valente KD, De Paola L, Palmini A, Faveret E, de Araujo-Filho GM, van der Linden H, Bianchin MM, Walz R, Alessi R, Velasco T, Teixeira WA, LaFrance WC., Epilepsy Behav 68(), 2017
PMID: 28131930
Predictors of meaningful improvement in quality of life after temporal lobe epilepsy surgery: A prospective study.
Pauli C, Schwarzbold ML, Diaz AP, de Oliveira Thais MER, Kondageski C, Linhares MN, Guarnieri R, de Lemos Zingano B, Ben J, Nunes JC, Markowitsch HJ, Wolf P, Wiebe S, Lin K, Walz R., Epilepsia 58(5), 2017
PMID: 28332703
Validation of the Polish Version of the Hamilton Rating Scale for Depression in patients with epilepsy.
Wiglusz MS, Landowski J, Michalak L, Cubała WJ., Epilepsy Behav 62(), 2016
PMID: 27450310
A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system.
Lopes MW, Leal RB, Guarnieri R, Schwarzbold ML, Hoeller A, Diaz AP, Boos GL, Lin K, Linhares MN, Nunes JC, Quevedo J, Bortolotto ZA, Markowitsch HJ, Lightman SL, Walz R., Transl Psychiatry 6(12), 2016
PMID: 27959333

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 26119622
PubMed | Europe PMC

Suchen in

Google Scholar