Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii

Fouotsa H, Lannang AM, Dzoyem JP, Tatsimo SJN, Neumann B, Mbazoa CD, Razakarivony AA, Nkengfack AE, Eloff JN, Sewald N (2015)
Planta Medica 81(7): 594-599.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Fouotsa, HuguesUniBi; Lannang, Alain MeliUniBi ; Dzoyem, Jean Paul; Tatsimo, Simplice J. N.; Neumann, Beate; Mbazoa, Celine Djama; Razakarivony, Andrianambinina A.UniBi; Nkengfack, Augustin Ephrem; Eloff, Jacobus N.; Sewald, NorbertUniBi
Abstract / Bemerkung
A new prenylated xanthone, 1,3,5,8-tetrahydroxy-2-(3-methybut-2-enyl)-4-(3,7-dimethylocta-2,6-dienyl) xanthone (1), and a new benzophenone (2), together with four known xanthone derivatives, cheffouxanthone (3), smeathxanthone A (4), smeathxanthone B (5), ananixanthone (6), and two pentacyclic triterpenes, epi-friedelinol (7) and friedelin (8), were isolated from the stem bark of Garcinia smeathmannii. The structures of the compounds were elucidated on the basis of 1D and 2DNMR experiments, and compound 2 was further characterized and confirmed by single X-ray analysis. Compounds 1, 2, and 3 exhibited the most prominent antibacterial activity against gram-positive Enterococcus faecalis with minimal inhibitory concentration values of 8, 8, and 2 mu g/mL, respectively, while compounds 1, 3, 4, and 6 showed the capacity to scavenge free radicals.
Stichworte
antioxidant; antibacterial; benzophenone; xanthone; Garcinia smeathmannii; Guttiferae
Erscheinungsjahr
2015
Zeitschriftentitel
Planta Medica
Band
81
Ausgabe
7
Seite(n)
594-599
ISSN
0032-0943
Page URI
https://pub.uni-bielefeld.de/record/2759917

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Fouotsa H, Lannang AM, Dzoyem JP, et al. Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii. Planta Medica. 2015;81(7):594-599.
Fouotsa, H., Lannang, A. M., Dzoyem, J. P., Tatsimo, S. J. N., Neumann, B., Mbazoa, C. D., Razakarivony, A. A., et al. (2015). Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii. Planta Medica, 81(7), 594-599. doi:10.1055/s-0035-1545841
Fouotsa, H., Lannang, A. M., Dzoyem, J. P., Tatsimo, S. J. N., Neumann, B., Mbazoa, C. D., Razakarivony, A. A., Nkengfack, A. E., Eloff, J. N., and Sewald, N. (2015). Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii. Planta Medica 81, 594-599.
Fouotsa, H., et al., 2015. Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii. Planta Medica, 81(7), p 594-599.
H. Fouotsa, et al., “Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii”, Planta Medica, vol. 81, 2015, pp. 594-599.
Fouotsa, H., Lannang, A.M., Dzoyem, J.P., Tatsimo, S.J.N., Neumann, B., Mbazoa, C.D., Razakarivony, A.A., Nkengfack, A.E., Eloff, J.N., Sewald, N.: Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii. Planta Medica. 81, 594-599 (2015).
Fouotsa, Hugues, Lannang, Alain Meli, Dzoyem, Jean Paul, Tatsimo, Simplice J. N., Neumann, Beate, Mbazoa, Celine Djama, Razakarivony, Andrianambinina A., Nkengfack, Augustin Ephrem, Eloff, Jacobus N., and Sewald, Norbert. “Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii”. Planta Medica 81.7 (2015): 594-599.

3 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Secondary metabolites from Aspergillus japonicus CAM231, an endophytic fungus associated with Garcinia preussii.
Jouda JB, Fopossi JD, Kengne FM, Djama Mbazoa C, Golz C, Strohmann C, Fogue SK, Wandji J., Nat Prod Res 31(8), 2017
PMID: 27806646
Chemical and Biological Research on Herbal Medicines Rich in Xanthones.
Ruan J, Zheng C, Liu Y, Qu L, Yu H, Han L, Zhang Y, Wang T., Molecules 22(10), 2017
PMID: 29019929

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