Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii

Fouotsa, Hugues; Lannang, Alain Meli; Dzoyem, Jean Paul; Tatsimo, Simplice J. N.; Neumann, Beate; Mbazoa, Celine Djama; Razakarivony, Andrianambinina A.; Nkengfack, Augustin Ephrem; Eloff, Jacobus N.; Sewald, Norbert

Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii

Fouotsa H, Lannang AM, Dzoyem JP, Tatsimo SJN, Neumann B, Mbazoa CD, Razakarivony AA, Nkengfack AE, Eloff JN, Sewald N (2015)
Planta Medica 81(7): 594-599.

Zeitschriftenaufsatz | Veröffentlicht | Englisch

Download

Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!

DOI

https://doi.org/10.1055/s-0035-1545841

Autor*in

Fouotsa, Hugues^UniBi; Lannang, Alain Meli^UniBi ; Dzoyem, Jean Paul; Tatsimo, Simplice J. N.; Neumann, Beate; Mbazoa, Celine Djama; Razakarivony, Andrianambinina A.^UniBi; Nkengfack, Augustin Ephrem; Eloff, Jacobus N.; Sewald, Norbert^UniBi

Einrichtung

Fakultät für Chemie > Organische Chemie III

Abstract / Bemerkung

A new prenylated xanthone, 1,3,5,8-tetrahydroxy-2-(3-methybut-2-enyl)-4-(3,7-dimethylocta-2,6-dienyl) xanthone (1), and a new benzophenone (2), together with four known xanthone derivatives, cheffouxanthone (3), smeathxanthone A (4), smeathxanthone B (5), ananixanthone (6), and two pentacyclic triterpenes, epi-friedelinol (7) and friedelin (8), were isolated from the stem bark of Garcinia smeathmannii. The structures of the compounds were elucidated on the basis of 1D and 2DNMR experiments, and compound 2 was further characterized and confirmed by single X-ray analysis. Compounds 1, 2, and 3 exhibited the most prominent antibacterial activity against gram-positive Enterococcus faecalis with minimal inhibitory concentration values of 8, 8, and 2 mu g/mL, respectively, while compounds 1, 3, 4, and 6 showed the capacity to scavenge free radicals.

Stichworte

antioxidant; antibacterial; benzophenone; xanthone; Garcinia smeathmannii; Guttiferae

Erscheinungsjahr

2015

Zeitschriftentitel

Planta Medica

Band

Ausgabe

Seite(n)

594-599

ISSN

0032-0943

Page URI

https://pub.uni-bielefeld.de/record/2759917

Zitieren

Fouotsa H, Lannang AM, Dzoyem JP, et al. Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii. Planta Medica. 2015;81(7):594-599.

Fouotsa, H., Lannang, A. M., Dzoyem, J. P., Tatsimo, S. J. N., Neumann, B., Mbazoa, C. D., Razakarivony, A. A., et al. (2015). Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii. Planta Medica, 81(7), 594-599. doi:10.1055/s-0035-1545841

Fouotsa, Hugues, Lannang, Alain Meli, Dzoyem, Jean Paul, Tatsimo, Simplice J. N., Neumann, Beate, Mbazoa, Celine Djama, Razakarivony, Andrianambinina A., Nkengfack, Augustin Ephrem, Eloff, Jacobus N., and Sewald, Norbert. 2015. “Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii”. Planta Medica 81 (7): 594-599.

Fouotsa, H., Lannang, A. M., Dzoyem, J. P., Tatsimo, S. J. N., Neumann, B., Mbazoa, C. D., Razakarivony, A. A., Nkengfack, A. E., Eloff, J. N., and Sewald, N. (2015). Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii. Planta Medica 81, 594-599.

Fouotsa, H., et al., 2015. Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii. Planta Medica, 81(7), p 594-599.

H. Fouotsa, et al., “Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii”, Planta Medica, vol. 81, 2015, pp. 594-599.

Fouotsa, H., Lannang, A.M., Dzoyem, J.P., Tatsimo, S.J.N., Neumann, B., Mbazoa, C.D., Razakarivony, A.A., Nkengfack, A.E., Eloff, J.N., Sewald, N.: Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii. Planta Medica. 81, 594-599 (2015).

Fouotsa, Hugues, Lannang, Alain Meli, Dzoyem, Jean Paul, Tatsimo, Simplice J. N., Neumann, Beate, Mbazoa, Celine Djama, Razakarivony, Andrianambinina A., Nkengfack, Augustin Ephrem, Eloff, Jacobus N., and Sewald, Norbert. “Antibacterial and Antioxidant Xanthones and Benzophenone from Garcinia smeathmannii”. Planta Medica 81.7 (2015): 594-599.

Daten bereitgestellt von European Bioinformatics Institute (EBI)

3 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Secondary metabolites from Aspergillus japonicus CAM231, an endophytic fungus associated with Garcinia preussii.
Jouda JB, Fopossi JD, Kengne FM, Djama Mbazoa C, Golz C, Strohmann C, Fogue SK, Wandji J., Nat Prod Res 31(8), 2017
PMID: 27806646

Chemical and Biological Research on Herbal Medicines Rich in Xanthones.
Ruan J, Zheng C, Liu Y, Qu L, Yu H, Han L, Zhang Y, Wang T., Molecules 22(10), 2017
PMID: 29019929

Two New Diphenylketones and a New Xanthone from Talaromyces islandicus EN-501, an Endophytic Fungus Derived from the Marine Red Alga Laurencia okamurai.
Li HL, Li XM, Liu H, Meng LH, Wang BG., Mar Drugs 14(12), 2016
PMID: 27941601