Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients

Obed A, Stern S, Jarrad A, Lorf T (2015)
World Journal of Gastroenterology 21(14): 4423-4426.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Obed, Aiman; Stern, SteffenUniBi; Jarrad, Anwar; Lorf, Thomas
Abstract / Bemerkung
Alcoholic liver disease (ALD) is the second most common diagnosis among patients undergoing liver transplantation (LT). The recovery results of patients transplanted for ALD are often at least as good as those of patients transplanted for other diagnoses and better than those suffering from hepatitis C virus, cryptogenic cirrhosis, or hepatocellular carcinoma. In the case of medically non-responding patients with severe acute alcoholic hepatitis or acute-on chronic liver failure, the refusal of LT is often based on the lack of the required alcohol abstinence period of six months. The obligatory abidance of a period of abstinence as a transplant eligibility requirement for medically non-responding patients seems unfair and inhumane, since the majority of these patients will not survive the six-month abstinence period. Data from various studies have challenged the 6-mo rule, while excellent survival results of LT have been observed in selected patients with severe alcoholic hepatitis not responding to medical therapy. Patients with severe advanced ALD should have legal access to LT. The mere lack of pre-LT abstinence should not be an obstacle for being listed.
Liver transplantation; Abstinence; Six month abstinence rule; Cirrhosis; Alcohol; Alcoholic hepatitis
World Journal of Gastroenterology
Page URI


Obed A, Stern S, Jarrad A, Lorf T. Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients. World Journal of Gastroenterology. 2015;21(14):4423-4426.
Obed, A., Stern, S., Jarrad, A., & Lorf, T. (2015). Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients. World Journal of Gastroenterology, 21(14), 4423-4426. doi:10.3748/wjg.v21.i14.4423
Obed, Aiman, Stern, Steffen, Jarrad, Anwar, and Lorf, Thomas. 2015. “Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients”. World Journal of Gastroenterology 21 (14): 4423-4426.
Obed, A., Stern, S., Jarrad, A., and Lorf, T. (2015). Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients. World Journal of Gastroenterology 21, 4423-4426.
Obed, A., et al., 2015. Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients. World Journal of Gastroenterology, 21(14), p 4423-4426.
A. Obed, et al., “Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients”, World Journal of Gastroenterology, vol. 21, 2015, pp. 4423-4426.
Obed, A., Stern, S., Jarrad, A., Lorf, T.: Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients. World Journal of Gastroenterology. 21, 4423-4426 (2015).
Obed, Aiman, Stern, Steffen, Jarrad, Anwar, and Lorf, Thomas. “Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients”. World Journal of Gastroenterology 21.14 (2015): 4423-4426.

7 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

The Patient Who Continues to Smoke On-Treatment: An Ethical Dilemma.
Patro A, Guerrini CJ, Huang AT, Sikora AG., Otolaryngol Head Neck Surg 158(3), 2018
PMID: 29337655
Extracorporeal cellular therapy (ELAD) in severe alcoholic hepatitis: A multinational, prospective, controlled, randomized trial.
Thompson J, Jones N, Al-Khafaji A, Malik S, Reich D, Munoz S, MacNicholas R, Hassanein T, Teperman L, Stein L, Duarte-Rojo A, Malik R, Adhami T, Asrani S, Shah N, Gaglio P, Duddempudi A, Borg B, Jalan R, Brown R, Patton H, Satoskar R, Rossi S, Parikh A, ElSharkawy A, Mantry P, Sher L, Wolf D, Hart M, Landis C, Wigg A, Habib S, McCaughan G, Colquhoun S, Henry A, Bedard P, Landeen L, Millis M, Ashley R, Frank W, Henry A, Stange J, Subramanian R, VTI-208 Study Group., Liver Transpl 24(3), 2018
PMID: 29171941
New Concepts on Reversibility and Targeting of Liver Fibrosis; A Review Article.
Ebrahimi H, Naderian M, Sohrabpour AA., Middle East J Dig Dis 10(3), 2018
PMID: 30186577
Liver transplantation and alcoholic liver disease: History, controversies, and considerations.
Marroni CA, Fleck AM, Fernandes SA, Galant LH, Mucenic M, de Mattos Meine MH, Mariante-Neto G, Brandão ABM., World J Gastroenterol 24(26), 2018
PMID: 30018475
Meta-analysis of patient survival and rate of alcohol relapse in liver-transplanted patients for acute alcoholic hepatitis.
Al-Saeedi M, Barout MH, Probst P, Khajeh E, Weiss KH, Diener MK, Mehrabi A., Langenbecks Arch Surg 403(7), 2018
PMID: 30349998
Severe acute alcoholic hepatitis and liver transplant: A never-ending mournful story.
Obed A, Bashir A, Stern S, Jarrad A., Clin Mol Hepatol 24(4), 2018
PMID: 30360030

39 References

Daten bereitgestellt von Europe PubMed Central.

Acute alcoholic hepatitis, end stage alcoholic liver disease and liver transplantation: an Italian position statement.
Testino G, Burra P, Bonino F, Piani F, Sumberaz A, Peressutti R, Giannelli Castiglione A, Patussi V, Fanucchi T, Ancarani O, De Cerce G, Iannini AT, Greco G, Mosti A, Durante M, Babocci P, Quartini M, Mioni D, Arico S, Baselice A, Leone S, Lozer F, Scafato E, Borro P; Group of Italian Regions., World J. Gastroenterol. 20(40), 2014
PMID: 25356027
[Benefits in reducing alcohol consumption: how nalmefene can help].
Bendimerad P, Blecha L., Encephale 40(6), 2014
PMID: 25454365
Understanding the tumor suppressor PTEN in chronic alcoholism and hepatocellular carcinoma.
Shearn CT, Petersen DR., Adv. Exp. Med. Biol. 815(), 2015
PMID: 25427907
Liver transplantation in alcoholic patients: impact of an alcohol addiction unit within a liver transplant center.
Addolorato G, Mirijello A, Leggio L, Ferrulli A, D'Angelo C, Vassallo G, Cossari A, Gasbarrini G, Landolfi R, Agnes S, Gasbarrini A; Gemelli OLT Group, Abbate V, Abenavoli L, Antonelli M, Annicchiarico E, Avolio AW, Biolato M, Campanale C, Capristo E, Caputo F, Cesario V, Castagneto M, de Matthaeis N, Favale C, Ferrarese D, Garcovich M, Frongillo F, Grieco A, Malandrino N, Miele L, Milani A, Nesci A, Nure E, Pelecca G, Pepe G, Pietrogiacomi P, Pizzolante F, Pompili M, Ponziani FR, Rapaccini G, Riccardi L, Rinninella E, Santoro MC, Sganga G, Siciliano M, Vero V, Vonghia L., Alcohol. Clin. Exp. Res. 37(9), 2013
PMID: 23578009
Reply to: "liver transplantation and severe acute alcoholic hepatitis: an ethical consideration".
Donckier V, Lucidi V, Gustot T, Moreno C., J. Hepatol. 61(3), 2014
PMID: 24882053
Early liver transplantation for severe alcoholic hepatitis.
Mathurin P, Moreno C, Samuel D, Dumortier J, Salleron J, Durand F, Castel H, Duhamel A, Pageaux GP, Leroy V, Dharancy S, Louvet A, Boleslawski E, Lucidi V, Gustot T, Francoz C, Letoublon C, Castaing D, Belghiti J, Donckier V, Pruvot FR, Duclos-Vallee JC., N. Engl. J. Med. 365(19), 2011
PMID: 22070476
Pharmacotherapy of acute alcoholic hepatitis in clinical practice.
Abenavoli L, Milic N, Rouabhia S, Addolorato G., World J. Gastroenterol. 20(9), 2014
PMID: 24605014
Increased delayed mortality in patients with acute-on-chronic liver failure who have prior decompensation.
Shi Y, Zheng MH, Yang Y, Wei W, Yang Q, Hu A, Hu Y, Wu Y, Yan H., J. Gastroenterol. Hepatol. 30(4), 2015
PMID: 25250673
Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis.
Moreau R, Jalan R, Gines P, Pavesi M, Angeli P, Cordoba J, Durand F, Gustot T, Saliba F, Domenicali M, Gerbes A, Wendon J, Alessandria C, Laleman W, Zeuzem S, Trebicka J, Bernardi M, Arroyo V; CANONIC Study Investigators of the EASL–CLIF Consortium, Aguilar Melero P, Albillos A, Alessandria C, Angeli P, Arroyo V, Banares R, Benten D, Bernardi M, Bocci M, Caraceni P, Catalina MV, Chin JL, Coenraad MJ, Coilly A, Concepcion M, Cordoba J, de Gottardi A, de la Mata M, Deulofeu C, Domenicali M, Dorn L, Durand F, Elkrief L, Fernandez J, Garcia E, Gatta A, Gerber L, Gerbes A, Gines P, Groenbæk H, Guevara M, Gustot T, Hausen A, Hopf C, Jalan R, Karlsen S, Laleman W, Lohse AW, Maggioli C, Markwardt D, Martinez J, Marzano A, McCormick P, Mesonero F, Montero Alvarez JL, Mookerjee RP, Morando F, Moreau R, Moreno C, Morrell B, Mortensen C, Nevens F, Pavesi M, Peck-Radosavljevic M, Pereira G, Risso A, Rizzetto M, Rodriguez E, Romano A, Saliba F, Samuel D, Sauerbruch T, Simon-Talero M, Solis-Munoz P, Soriano G, Sperl J, Spindelboeck W, Stauber R, Steib C, Trebicka J, Valla D, Van Vlierberghe H, Verbeke L, Vogel W, Wege H, Welzel T, Wendon J, Willars C, Yago Baenas M, Zaccherini G, Zeuzem S., Gastroenterology 144(7), 2013
PMID: 23474284
Survival in infection-related acute-on-chronic liver failure is defined by extrahepatic organ failures.
Bajaj JS, O'Leary JG, Reddy KR, Wong F, Biggins SW, Patton H, Fallon MB, Garcia-Tsao G, Maliakkal B, Malik R, Subramanian RM, Thacker LR, Kamath PS; North American Consortium For The Study Of End-Stage Liver Disease (NACSELD)., Hepatology 60(1), 2014
PMID: 24677131
Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute-on-chronic liver failure: the RELIEF trial.
Banares R, Nevens F, Larsen FS, Jalan R, Albillos A, Dollinger M, Saliba F, Sauerbruch T, Klammt S, Ockenga J, Pares A, Wendon J, Brunnler T, Kramer L, Mathurin P, de la Mata M, Gasbarrini A, Mullhaupt B, Wilmer A, Laleman W, Eefsen M, Sen S, Zipprich A, Tenorio T, Pavesi M, Schmidt HH, Mitzner S, Williams R, Arroyo V; RELIEF study group, Catalina MV, Durango M, Gonzalez-Alonso R, Liano F, Martin C, Penas B, Leckie P, Mookerjee RP, Cheshire L, Glaser S, Appenrodt B, Rockmann F, Scholmerich J, Evenepoel P, Hermans G, Meersseman P, Wauters J, Ichai P, Samuel D, Belnard M, Pozo JC, Montero JL, Escorsell A, Mas A., Hepatology 57(3), 2013
PMID: 23213075
Artificial liver support systems in the management of complications of cirrhosis.
Stadlbauer V, Davies NA, Sen S, Jalan R., Semin. Liver Dis. 28(1), 2008
PMID: 18293280
Change in model for end-stage liver disease score at two weeks, as an indicator of mortality or liver transplantation at 60 days in acute-on-chronic liver failure
Kumar R, Krishnamoorthy TL, Tan HK, Lui HF, Chow WC., 2014
Orthotopic liver transplantation for alcoholic cirrhosis.
Starzl TE, Van Thiel D, Tzakis AG, Iwatsuki S, Todo S, Marsh JW, Koneru B, Staschak S, Stieber A, Gordon RD., JAMA 260(17), 1988
PMID: 3050180
Liver transplantation in patients with alcoholic cirrhosis: selection criteria and rates of survival and relapse.
Bird GL, O'Grady JG, Harvey FA, Calne RY, Williams R., BMJ 301(6742), 1990
PMID: 2383700
Quality of life after liver transplantation for alcoholic liver disease.
Pereira SP, Howard LM, Muiesan P, Rela M, Heaton N, Williams R., Liver Transpl. 6(6), 2000
PMID: 11084065
Liver transplantation for alcohol-related cirrhosis: a single centre long-term clinical and histological follow-up.
Schmeding M, Heidenhain C, Neuhaus R, Neuhaus P, Neumann UP., Dig. Dis. Sci. 56(1), 2010
PMID: 20499174
Liver transplantation for alcoholic liver disease: a retrospective analysis of recidivism, survival and risk factors predisposing to alcohol relapse.
Deruytter E, Van Steenkiste C, Trepo E, Geerts A, Van Vlierberghe H, Berrevoet F, de Hemptinne B, Rogiers X, Troisi R, Colle I., Acta Gastroenterol. Belg. 76(3), 2013
PMID: 24261021

Gutmann T, Fateh-Moghadam B., 2003
Ecstasy induced fatal hepatic failure.
Colak Y, Tuncer I, Enc FY, Ozturk O, Kiziltas S, Ulasoglu C., J Gastrointestin Liver Dis 20(2), 2011
PMID: 21725523
Changing etiologies and outcomes of acute liver failure: perspectives from 6 transplant centers in Argentina.
Mendizabal M, Marciano S, Videla MG, Anders M, Zerega A, Balderramo DC, Chan D, Barrabino M, Gil O, Mastai R, Yantorno S, Gadano A, Silva MO., Liver Transpl. 20(4), 2014
PMID: 24425668
Self-efficacy mediates the effects of topiramate and GRIK1 genotype on drinking
Kranzler HR, Armeli S, Wetherill R, Feinn R, Tennen H, Gelernter J, Covault J, Pond T., 2014
Alcohol addiction: a molecular biology perspective.
Ferraguti G, Pascale E, Lucarelli M., Curr. Med. Chem. 22(6), 2015
PMID: 25544474
Long-term outcome of living donor liver transplantation for patients with alcoholic liver disease.
Ahn CS, Hwang S, Kim KH, Moon DB, Ha TY, Song GW, Jung DH, Park GC, Kang SH, Jung BH, Kim N, Lee SG., Transplant. Proc. 46(3), 2014
PMID: 24767343
Liver transplantation for alcoholic liver disease: evaluation of a selection protocol.
Anand AC, Ferraz-Neto BH, Nightingale P, Mirza DF, White AC, McMaster P, Neuberger JM., Hepatology 25(6), 1997
PMID: 9185771
Liver transplantation for alcoholic liver disease.
Anantharaju A, Van Thiel DH., Alcohol Res Health 27(3), 2003
PMID: 15535454
Public and professional attitudes to transplanting alcoholic patients.
Neuberger J., Liver Transpl. 13(11 Suppl 2), 2007
PMID: 17969090
A critical review of candidacy for orthotopic liver transplantation in alcoholic liver disease.
Kotlyar DS, Burke A, Campbell MS, Weinrieb RM., Am. J. Gastroenterol. 103(3), 2007
PMID: 18081918
Albumin dialysis and Molecular Adsorbents Recirculating System (MARS) for acute Wilson's disease.
Sen S, Felldin M, Steiner C, Larsson B, Gillett GT, Olausson M, Williams R, Jalan R., Liver Transpl. 8(10), 2002
PMID: 12360442
Artificial liver support system combined with liver transplantation in the treatment of patients with acute-on-chronic liver failure.
Xu X, Liu X, Ling Q, Wei Q, Liu Z, Xu X, Zhou L, Zhang M, Wu J, Huang J, Sheng J, Zheng S, Li L., PLoS ONE 8(3), 2013
PMID: 23516546
Downgrading MELD improves the outcomes after liver transplantation in patients with acute-on-chronic hepatitis B liver failure.
Ling Q, Xu X, Wei Q, Liu X, Guo H, Zhuang L, Chen J, Xia Q, Xie H, Wu J, Zheng S, Li L., PLoS ONE 7(1), 2012
PMID: 22291934
Intensive care of the patient with cirrhosis.
Olson JC, Wendon JA, Kramer DJ, Arroyo V, Jalan R, Garcia-Tsao G, Kamath PS., Hepatology 54(5), 2011
PMID: 21898477
Should length of sobriety be a major determinant in liver transplant selection?
Rice JP, Lucey MR., Curr Opin Organ Transplant 18(3), 2013
PMID: 23492643
General Assembly resolution 217A

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

PMID: 25892898
PubMed | Europe PMC

Suchen in

Google Scholar