Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients
Obed A, Stern S, Jarrad A, Lorf T (2015)
World Journal of Gastroenterology 21(14): 4423-4426.
Zeitschriftenaufsatz
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Autor*in
Obed, Aiman;
Stern, SteffenUniBi;
Jarrad, Anwar;
Lorf, Thomas
Einrichtung
Abstract / Bemerkung
Alcoholic liver disease (ALD) is the second most common diagnosis among patients undergoing liver transplantation (LT). The recovery results of patients transplanted for ALD are often at least as good as those of patients transplanted for other diagnoses and better than those suffering from hepatitis C virus, cryptogenic cirrhosis, or hepatocellular carcinoma. In the case of medically non-responding patients with severe acute alcoholic hepatitis or acute-on chronic liver failure, the refusal of LT is often based on the lack of the required alcohol abstinence period of six months. The obligatory abidance of a period of abstinence as a transplant eligibility requirement for medically non-responding patients seems unfair and inhumane, since the majority of these patients will not survive the six-month abstinence period. Data from various studies have challenged the 6-mo rule, while excellent survival results of LT have been observed in selected patients with severe alcoholic hepatitis not responding to medical therapy. Patients with severe advanced ALD should have legal access to LT. The mere lack of pre-LT abstinence should not be an obstacle for being listed.
Stichworte
Liver transplantation;
Abstinence;
Six month abstinence rule;
Cirrhosis;
Alcohol;
Alcoholic hepatitis
Erscheinungsjahr
2015
Zeitschriftentitel
World Journal of Gastroenterology
Band
21
Ausgabe
14
Seite(n)
4423-4426
ISSN
1007-9327
Page URI
https://pub.uni-bielefeld.de/record/2736448
Zitieren
Obed A, Stern S, Jarrad A, Lorf T. Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients. World Journal of Gastroenterology. 2015;21(14):4423-4426.
Obed, A., Stern, S., Jarrad, A., & Lorf, T. (2015). Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients. World Journal of Gastroenterology, 21(14), 4423-4426. doi:10.3748/wjg.v21.i14.4423
Obed, Aiman, Stern, Steffen, Jarrad, Anwar, and Lorf, Thomas. 2015. “Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients”. World Journal of Gastroenterology 21 (14): 4423-4426.
Obed, A., Stern, S., Jarrad, A., and Lorf, T. (2015). Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients. World Journal of Gastroenterology 21, 4423-4426.
Obed, A., et al., 2015. Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients. World Journal of Gastroenterology, 21(14), p 4423-4426.
A. Obed, et al., “Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients”, World Journal of Gastroenterology, vol. 21, 2015, pp. 4423-4426.
Obed, A., Stern, S., Jarrad, A., Lorf, T.: Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients. World Journal of Gastroenterology. 21, 4423-4426 (2015).
Obed, Aiman, Stern, Steffen, Jarrad, Anwar, and Lorf, Thomas. “Six month abstinence rule for liver transplantation in severe alcoholic liver disease patients”. World Journal of Gastroenterology 21.14 (2015): 4423-4426.
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Should length of sobriety be a major determinant in liver transplant selection?
Rice JP, Lucey MR., Curr Opin Organ Transplant 18(3), 2013
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Rice JP, Lucey MR., Curr Opin Organ Transplant 18(3), 2013
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General Assembly resolution 217A
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