Analysis of Volatile and Oxidation Sensitive Compounds Using a Cold Inlet System and Electron Impact Mass Spectrometry

Sproß J (2014)
Journal of Visualized Experiments (91): e51858.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
This video presents a protocol for the mass spectrometrical analysis of volatile and oxidation sensitive compounds using electron impact ionization. The analysis of volatile and oxidation sensitive compounds by mass spectrometry is not easily achieved, as all state-of-the-art mass spectrometric methods require at least one sample preparation step, e. g., dissolution and dilution of the analyte (electrospray ionization), co-crystallization of the analyte with a matrix compound (matrix-assisted laser desorption/ionization), or transfer of the prepared samples into the ionization source of the mass spectrometer, to be conducted under atmospheric conditions. Here, the use of a sample inlet system is described which enables the analysis of volatile metal organyls, silanes, and phosphanes using a sector field mass spectrometer equipped with an electron impact ionization source. All sample preparation steps and the sample introduction into the ion source of the mass spectrometer take place either under air-free conditions or under vacuum, enabling the analysis of compounds highly susceptible to oxidation. The presented technique is especially of interest for inorganic chemists, working with metal organyls, silanes, or phosphanes, which have to be handled using inert conditions, such as the Schlenk technique. The principle of operation is presented in this video.
Stichworte
electron impact; mass spectrometry; Chemistry; Issue 91; volatile; inlet system; air sensitive
Erscheinungsjahr
2014
Zeitschriftentitel
Journal of Visualized Experiments
Ausgabe
91
Seite(n)
e51858
ISSN
1940-087X
Page URI
https://pub.uni-bielefeld.de/record/2723903

Zitieren

Sproß J. Analysis of Volatile and Oxidation Sensitive Compounds Using a Cold Inlet System and Electron Impact Mass Spectrometry. Journal of Visualized Experiments. 2014;(91):e51858.
Sproß, J. (2014). Analysis of Volatile and Oxidation Sensitive Compounds Using a Cold Inlet System and Electron Impact Mass Spectrometry. Journal of Visualized Experiments(91), e51858. doi:10.3791/51858
Sproß, Jens. 2014. “Analysis of Volatile and Oxidation Sensitive Compounds Using a Cold Inlet System and Electron Impact Mass Spectrometry”. Journal of Visualized Experiments, no. 91: e51858.
Sproß, J. (2014). Analysis of Volatile and Oxidation Sensitive Compounds Using a Cold Inlet System and Electron Impact Mass Spectrometry. Journal of Visualized Experiments, e51858.
Sproß, J., 2014. Analysis of Volatile and Oxidation Sensitive Compounds Using a Cold Inlet System and Electron Impact Mass Spectrometry. Journal of Visualized Experiments, (91), p e51858.
J. Sproß, “Analysis of Volatile and Oxidation Sensitive Compounds Using a Cold Inlet System and Electron Impact Mass Spectrometry”, Journal of Visualized Experiments, 2014, pp. e51858.
Sproß, J.: Analysis of Volatile and Oxidation Sensitive Compounds Using a Cold Inlet System and Electron Impact Mass Spectrometry. Journal of Visualized Experiments. e51858 (2014).
Sproß, Jens. “Analysis of Volatile and Oxidation Sensitive Compounds Using a Cold Inlet System and Electron Impact Mass Spectrometry”. Journal of Visualized Experiments 91 (2014): e51858.

1 Zitation in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

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14 References

Daten bereitgestellt von Europe PubMed Central.


Field FH, Franklin JL., 1957
An Improved Mass Spectrometer Ion Source
Schaeffer OA., 1954
Electrospray Ion Source - Another Variation of the Free-Jet Theme
Yamashita M, Fenn JB., 1984
Coupling an electrospray ionization mass spectrometer with a glovebox: A straightforward, powerful, and convenient combination for analysis of air-sensitive organometallics
Lubben AT, McIndoe JS, Weller AS., 2008
Structural and Compositional Control in {M12} Cobalt and Nickel Coordination Clusters Detected Magnetochemically and with Cryospray Mass Spectrometry
Cooper GJT., 2007
Detection of reactive 1,2,3-hexatriene-5-one monomer by low-temperature atmospheric pressure ionization mass spectrometry
Wang WS, Tseng PW, Chou CH, Shiea J., 1998
Detection of a thermally unstable intermediate in the Wittig reaction using low-temperature liquid secondary ion and atmospheric pressure ionization mass spectrometry
Wang CH., 1998
Shining new light on an old problem: Retooling MALDI mass spectrometry for organotransition-metal catalysis
Eelman MD, Blacquiere JM, Moriarty MM, Fogg DE., 2008
Liquid injection field desorption ionization: a new tool for soft ionization of samples including air-sensitive catalysts and non-polar hydrocarbons
Linden HB., 2004
Liquid injection field desorption/ionization of reactive transition metal complexes.
Gross JH, Nieth N, Linden HB, Blumbach U, Richter FJ, Tauchert ME, Tompers R, Hofmann P., Anal Bioanal Chem 386(1), 2006
PMID: 16773301
Mass Spectrometer All-Glass Heated Inlet
Peterson L., 1962
A mass spectrometer all-glass heated inlet
Stafford C, Morgan TD, Brunfeldt RJ., 1968
Chlorobis(pentafluoroethyl)phosphane: Improved Synthesis and Molecular Structure in the Gas Phase
Hayes SA, Berger RJF, Mitzel NW, Bader J, Hoge B., 2011
Functionalized Bis(pentafluoroethyl)phosphanes: Improved Syntheses and Molecular Structures in the Gas Phase
Zakharov AV., 2013
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