SOM-based Peptide Prototyping for Mass Spectrometry Peak Intensity Prediction

Scherbart A, Timm W, Böcker S, Nattkemper TW (2007)
In: Proceedings of the 6th Workshop on Self-Organizing Maps (WSOM 07). Bielefeld: Bielefeld University.

Konferenzbeitrag | Veröffentlicht | Englisch
 
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Autor*in
Scherbart, Alexandra; Timm, Wiebke; Böcker, Sebastian; Nattkemper, Tim WilhelmUniBi
Abstract / Bemerkung
In todays bioinformatics, Mass spectrometry (MS) is the key technique for the identification of proteins. A prediction of spectrum peak intensities from pre computed molecular features would pave the way to better understanding of spectrometry data and improved spectrum evaluation. We propose a neural network architecture of Local Linear Map (LLM)-type based on Self-Organizing Maps (SOMs) for peptide prototyping and learning locally tuned regression functions for peak intensity prediction in MALDI-TOF mass spectra. We obtain results comparable to those obtained by nu-Support Vector Regression and show how the SOM learning architecture provides a basis for peptide feature profiling and visualisation.
Erscheinungsjahr
2007
Titel des Konferenzbandes
Proceedings of the 6th Workshop on Self-Organizing Maps (WSOM 07)
Konferenz
Proceedings of the 6th Workshop on Self-Organizing Maps (WSOM 07)
Konferenzort
Bielefeld, Germany
Konferenzdatum
2007-09-03 – 2007-09-06
ISBN
978-3-00-022473-7
Page URI
https://pub.uni-bielefeld.de/record/2714045

Zitieren

Scherbart A, Timm W, Böcker S, Nattkemper TW. SOM-based Peptide Prototyping for Mass Spectrometry Peak Intensity Prediction. In: Proceedings of the 6th Workshop on Self-Organizing Maps (WSOM 07). Bielefeld: Bielefeld University; 2007.
Scherbart, A., Timm, W., Böcker, S., & Nattkemper, T. W. (2007). SOM-based Peptide Prototyping for Mass Spectrometry Peak Intensity Prediction. Proceedings of the 6th Workshop on Self-Organizing Maps (WSOM 07) Bielefeld: Bielefeld University. doi:10.2390/biecoll-wsom2007-157
Scherbart, A., Timm, W., Böcker, S., and Nattkemper, T. W. (2007). “SOM-based Peptide Prototyping for Mass Spectrometry Peak Intensity Prediction” in Proceedings of the 6th Workshop on Self-Organizing Maps (WSOM 07) (Bielefeld: Bielefeld University).
Scherbart, A., et al., 2007. SOM-based Peptide Prototyping for Mass Spectrometry Peak Intensity Prediction. In Proceedings of the 6th Workshop on Self-Organizing Maps (WSOM 07). Bielefeld: Bielefeld University.
A. Scherbart, et al., “SOM-based Peptide Prototyping for Mass Spectrometry Peak Intensity Prediction”, Proceedings of the 6th Workshop on Self-Organizing Maps (WSOM 07), Bielefeld: Bielefeld University, 2007.
Scherbart, A., Timm, W., Böcker, S., Nattkemper, T.W.: SOM-based Peptide Prototyping for Mass Spectrometry Peak Intensity Prediction. Proceedings of the 6th Workshop on Self-Organizing Maps (WSOM 07). Bielefeld University, Bielefeld (2007).
Scherbart, Alexandra, Timm, Wiebke, Böcker, Sebastian, and Nattkemper, Tim Wilhelm. “SOM-based Peptide Prototyping for Mass Spectrometry Peak Intensity Prediction”. Proceedings of the 6th Workshop on Self-Organizing Maps (WSOM 07). Bielefeld: Bielefeld University, 2007.

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