Alternative Generation of CNS Neural Stem Cells and PNS Derivatives from Neural Crest Derived Peripheral Stem Cells

Weber M, Apostolova G, Widera D, Mittelbronn M, Dechant G, Kaltschmidt B, Rohrer H (2015)
Stem Cells 33(2): 574-588.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Weber, M; Apostolova, G; Widera, DariusUniBi ; Mittelbronn, M; Dechant, G; Kaltschmidt, BarbaraUniBi; Rohrer, H
Abstract / Bemerkung
Neural crest-derived stem cells (NCSCs) from the embryonic peripheral nervous system (PNS) can be reprogrammed in neurosphere (NS) culture to rNCSCs that produce central nervous system (CNS) progeny, including myelinating oligodendrocytes. Using global gene expression analysis we now demonstrate that rNCSCs completely lose their previous PNS characteristics and acquire the identity of neural stem cells derived from embryonic spinal cord. Reprogramming proceeds rapidly and results in a homogenous population of Olig2-, Sox3-, and Lex-positive CNS stem cells. Low-level expression of pluripotency inducing genes Oct4, Nanog, and Klf4 argues against a transient pluripotent state during reprogramming. The acquisition of CNS properties is prevented in the presence of BMP4 (BMP NCSCs) as shown by marker gene expression and the potential to produce PNS neurons and glia. In addition, genes characteristic for mesenchymal and perivascular progenitors are expressed, which suggests that BMP NCSCs are directed toward a pericyte progenitor/mesenchymal stem cell (MSC) fate. Adult NCSCs from mouse palate, an easily accessible source of adult NCSCs, display strikingly similar properties. They do not generate cells with CNS characteristics but lose the neural crest markers Sox10 and p75 and produce MSC-like cells. These findings show that embryonic NCSCs acquire a full CNS identity in NS culture. In contrast, MSC-like cells are generated from BMP NCSCs and pNCSCs, which reveals that postmigratory NCSCs are a source for MSC-like cells up to the adult stage.
Stichworte
Reprogramming; Central nervous system; Peripheral nervous system; Neural crest; Neural stem cell
Erscheinungsjahr
2015
Zeitschriftentitel
Stem Cells
Band
33
Ausgabe
2
Seite(n)
574-588
ISSN
1066-5099
eISSN
1549-4918
Page URI
https://pub.uni-bielefeld.de/record/2713743

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Weber M, Apostolova G, Widera D, et al. Alternative Generation of CNS Neural Stem Cells and PNS Derivatives from Neural Crest Derived Peripheral Stem Cells. Stem Cells. 2015;33(2):574-588.
Weber, M., Apostolova, G., Widera, D., Mittelbronn, M., Dechant, G., Kaltschmidt, B., & Rohrer, H. (2015). Alternative Generation of CNS Neural Stem Cells and PNS Derivatives from Neural Crest Derived Peripheral Stem Cells. Stem Cells, 33(2), 574-588. doi:10.1002/stem.1880
Weber, M., Apostolova, G., Widera, D., Mittelbronn, M., Dechant, G., Kaltschmidt, B., and Rohrer, H. (2015). Alternative Generation of CNS Neural Stem Cells and PNS Derivatives from Neural Crest Derived Peripheral Stem Cells. Stem Cells 33, 574-588.
Weber, M., et al., 2015. Alternative Generation of CNS Neural Stem Cells and PNS Derivatives from Neural Crest Derived Peripheral Stem Cells. Stem Cells, 33(2), p 574-588.
M. Weber, et al., “Alternative Generation of CNS Neural Stem Cells and PNS Derivatives from Neural Crest Derived Peripheral Stem Cells”, Stem Cells, vol. 33, 2015, pp. 574-588.
Weber, M., Apostolova, G., Widera, D., Mittelbronn, M., Dechant, G., Kaltschmidt, B., Rohrer, H.: Alternative Generation of CNS Neural Stem Cells and PNS Derivatives from Neural Crest Derived Peripheral Stem Cells. Stem Cells. 33, 574-588 (2015).
Weber, M, Apostolova, G, Widera, Darius, Mittelbronn, M, Dechant, G, Kaltschmidt, Barbara, and Rohrer, H. “Alternative Generation of CNS Neural Stem Cells and PNS Derivatives from Neural Crest Derived Peripheral Stem Cells”. Stem Cells 33.2 (2015): 574-588.

6 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Comparative Analysis of Biological Properties of Large-Scale Expanded Adult Neural Crest-Derived Stem Cells Isolated from Human Hair Follicle and Skin Dermis.
Vasyliev RG, Gubar OS, Gordiienko IM, Litvinova LS, Rodnichenko AE, Shupletsova VV, Zlatska AV, Yurova KA, Todosenko NM, Khadzhynova VE, Shulha MV, Novikova SN, Zubov DO., Stem Cells Int 2019(), 2019
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SOX10-positive cells emerge in the rat pituitary gland during late embryogenesis and start to express S100β.
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Takagi T, Yoshimura S, Sakuma R, Nakano-Doi A, Matsuyama T, Nakagomi T., Transl Stroke Res 8(6), 2017
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Folate Receptor Alpha Upregulates Oct4, Sox2 and Klf4 and Downregulates miR-138 and miR-let-7 in Cranial Neural Crest Cells.
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