Diversity and genomic insights into the uncultured Chloroflexi from the human microbiota

Campbell AG, Schwientek P, Vishnivetskaya T, Woyke T, Levy S, Beall CJ, Griffen A, Leys E, Podar M (2014)
Environmental Microbiology 16(9): 2635-2643.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Campbell, Alisha G.; Schwientek, PatrickUniBi; Vishnivetskaya, Tatiana; Woyke, Tanja; Levy, Shawn; Beall, Clifford J.; Griffen, Ann; Leys, Eugene; Podar, Mircea
Abstract / Bemerkung
Many microbial phyla that are widely distributed in open environments have few or no representatives within animal-associated microbiota. Among them, the Chloroflexi comprises taxonomically and physiologically diverse lineages adapted to a wide range of aquatic and terrestrial habitats. A distinct group of uncultured chloroflexi related to free-living anaerobic Anaerolineae inhabits the mammalian gastrointestinal tract and includes low-abundance human oral bacteria that appear to proliferate in periodontitis. Using a single-cell genomics approach, we obtained the first draft genomic reconstruction for these organisms and compared their inferred metabolic potential with free-living chloroflexi. Genomic data suggest that oral chloroflexi are anaerobic heterotrophs, encoding abundant carbohydrate transport and metabolism functionalities, similar to those seen in environmental Anaerolineae isolates. The presence of genes for a unique phosphotransferase system and N-acetylglucosamine metabolism suggests an important ecological niche for oral chloroflexi in scavenging material from lysed bacterial cells and the human tissue. The inferred ability to produce sialic acid for cell membrane decoration may enable them to evade the host defence system and colonize the subgingival space. As with other low abundance but persistent members of the microbiota, discerning community and host factors that influence the proliferation of oral chloroflexi may help understand the emergence of oral pathogens and the microbiota dynamics in health and disease states.
Erscheinungsjahr
2014
Zeitschriftentitel
Environmental Microbiology
Band
16
Ausgabe
9
Seite(n)
2635-2643
ISSN
1462-2912
Page URI
https://pub.uni-bielefeld.de/record/2694741

Zitieren

Campbell AG, Schwientek P, Vishnivetskaya T, et al. Diversity and genomic insights into the uncultured Chloroflexi from the human microbiota. Environmental Microbiology. 2014;16(9):2635-2643.
Campbell, A. G., Schwientek, P., Vishnivetskaya, T., Woyke, T., Levy, S., Beall, C. J., Griffen, A., et al. (2014). Diversity and genomic insights into the uncultured Chloroflexi from the human microbiota. Environmental Microbiology, 16(9), 2635-2643. doi:10.1111/1462-2920.12461
Campbell, Alisha G., Schwientek, Patrick, Vishnivetskaya, Tatiana, Woyke, Tanja, Levy, Shawn, Beall, Clifford J., Griffen, Ann, Leys, Eugene, and Podar, Mircea. 2014. “Diversity and genomic insights into the uncultured Chloroflexi from the human microbiota”. Environmental Microbiology 16 (9): 2635-2643.
Campbell, A. G., Schwientek, P., Vishnivetskaya, T., Woyke, T., Levy, S., Beall, C. J., Griffen, A., Leys, E., and Podar, M. (2014). Diversity and genomic insights into the uncultured Chloroflexi from the human microbiota. Environmental Microbiology 16, 2635-2643.
Campbell, A.G., et al., 2014. Diversity and genomic insights into the uncultured Chloroflexi from the human microbiota. Environmental Microbiology, 16(9), p 2635-2643.
A.G. Campbell, et al., “Diversity and genomic insights into the uncultured Chloroflexi from the human microbiota”, Environmental Microbiology, vol. 16, 2014, pp. 2635-2643.
Campbell, A.G., Schwientek, P., Vishnivetskaya, T., Woyke, T., Levy, S., Beall, C.J., Griffen, A., Leys, E., Podar, M.: Diversity and genomic insights into the uncultured Chloroflexi from the human microbiota. Environmental Microbiology. 16, 2635-2643 (2014).
Campbell, Alisha G., Schwientek, Patrick, Vishnivetskaya, Tatiana, Woyke, Tanja, Levy, Shawn, Beall, Clifford J., Griffen, Ann, Leys, Eugene, and Podar, Mircea. “Diversity and genomic insights into the uncultured Chloroflexi from the human microbiota”. Environmental Microbiology 16.9 (2014): 2635-2643.

13 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

The Life Aquatic at the Microscale.
Raina JB., mSystems 3(2), 2018
PMID: 29629412
Analysis of carbohydrate-active enzymes in Thermogemmatispora sp. strain T81 reveals carbohydrate degradation ability.
Tomazini A, Lal S, Munir R, Stott M, Henrissat B, Polikarpov I, Sparling R, Levin DB., Can J Microbiol 64(12), 2018
PMID: 30338698
SAR202 Genomes from the Dark Ocean Predict Pathways for the Oxidation of Recalcitrant Dissolved Organic Matter.
Landry Z, Swan BK, Herndl GJ, Stepanauskas R, Giovannoni SJ., MBio 8(2), 2017
PMID: 28420738
Isolation and characterization of Flexilinea flocculi gen. nov., sp. nov., a filamentous, anaerobic bacterium belonging to the class Anaerolineae in the phylum Chloroflexi.
Sun L, Toyonaga M, Ohashi A, Matsuura N, Tourlousse DM, Meng XY, Tamaki H, Hanada S, Cruz R, Yamaguchi T, Sekiguchi Y., Int J Syst Evol Microbiol 66(2), 2016
PMID: 26637817
In Vitro Cultivation of 'Unculturable' Oral Bacteria, Facilitated by Community Culture and Media Supplementation with Siderophores.
Vartoukian SR, Adamowska A, Lawlor M, Moazzez R, Dewhirst FE, Wade WG., PLoS One 11(1), 2016
PMID: 26764907
Genomic and in situ investigations of the novel uncultured Chloroflexi associated with 0092 morphotype filamentous bulking in activated sludge.
McIlroy SJ, Karst SM, Nierychlo M, Dueholm MS, Albertsen M, Kirkegaard RH, Seviour RJ, Nielsen PH., ISME J 10(9), 2016
PMID: 26905629
Temporal dynamics of sediment bacterial communities in monospecific stands of Juncus maritimus and Spartina maritima.
Cleary DF, Polónia AR, Sousa AI, Lillebø AI, Queiroga H, Gomes NC., Plant Biol (Stuttg) 18(5), 2016
PMID: 27061465
The human gut microbiome, a taxonomic conundrum.
Sankar SA, Lagier JC, Pontarotti P, Raoult D, Fournier PE., Syst Appl Microbiol 38(4), 2015
PMID: 25864640

63 References

Daten bereitgestellt von Europe PubMed Central.

The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation.
Abusleme L, Dupuy AK, Dutzan N, Silva N, Burleson JA, Strausbaugh LD, Gamonal J, Diaz PI., ISME J 7(5), 2013
PMID: 23303375
Basic local alignment search tool.
Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ., J. Mol. Biol. 215(3), 1990
PMID: 2231712
Multiple single-cell genomes provide insight into functions of uncultured Deltaproteobacteria in the human oral cavity.
Campbell AG, Campbell JH, Schwientek P, Woyke T, Sczyrba A, Allman S, Beall CJ, Griffen A, Leys E, Podar M., PLoS ONE 8(3), 2013
PMID: 23555659
UGA is an additional glycine codon in uncultured SR1 bacteria from the human microbiota.
Campbell JH, O'Donoghue P, Campbell AG, Schwientek P, Sczyrba A, Woyke T, Soll D, Podar M., Proc. Natl. Acad. Sci. U.S.A. 110(14), 2013
PMID: 23509275
Role of the Clp system in stress tolerance, biofilm formation, and intracellular invasion in Porphyromonas gingivalis.
Capestany CA, Tribble GD, Maeda K, Demuth DR, Lamont RJ., J. Bacteriol. 190(4), 2007
PMID: 18065546
QIIME allows analysis of high-throughput community sequencing data.
Caporaso JG, Kuczynski J, Stombaugh J, Bittinger K, Bushman FD, Costello EK, Fierer N, Pena AG, Goodrich JK, Gordon JI, Huttley GA, Kelley ST, Knights D, Koenig JE, Ley RE, Lozupone CA, McDonald D, Muegge BD, Pirrung M, Reeder J, Sevinsky JR, Turnbaugh PJ, Walters WA, Widmann J, Yatsunenko T, Zaneveld J, Knight R., Nat. Methods 7(5), 2010
PMID: 20383131
The impact of the gut microbiota on human health: an integrative view.
Clemente JC, Ursell LK, Parfrey LW, Knight R., Cell 148(6), 2012
PMID: 22424233
Mauve: multiple alignment of conserved genomic sequence with rearrangements.
Darling AC, Mau B, Blattner FR, Perna NT., Genome Res. 14(7), 2004
PMID: 15231754
Novel subgingival bacterial phylotypes detected using multiple universal polymerase chain reaction primer sets.
de Lillo A, Ashley FP, Palmer RM, Munson MA, Kyriacou L, Weightman AJ, Wade WG., Oral Microbiol. Immunol. 21(1), 2006
PMID: 16390343
The Mucin degrader Akkermansia muciniphila is an abundant resident of the human intestinal tract.
Derrien M, Collado MC, Ben-Amor K, Salminen S, de Vos WM., Appl. Environ. Microbiol. 74(5), 2007
PMID: 18083887
The human oral microbiome.
Dewhirst FE, Chen T, Izard J, Paster BJ, Tanner AC, Yu WH, Lakshmanan A, Wade WG., J. Bacteriol. 192(19), 2010
PMID: 20656903
The canine oral microbiome.
Dewhirst FE, Klein EA, Thompson EC, Blanton JM, Chen T, Milella L, Buckley CM, Davis IJ, Bennett ML, Marshall-Jones ZV., PLoS ONE 7(4), 2012
PMID: 22558330
The human gut and groundwater harbor non-photosynthetic bacteria belonging to a new candidate phylum sibling to Cyanobacteria.
Di Rienzi SC, Sharon I, Wrighton KC, Koren O, Hug LA, Thomas BC, Goodrich JK, Bell JT, Spector TD, Banfield JF, Ley RE., Elife 2(), 2013
PMID: 24137540

Drummond AJ, Ashton B, Buxton S, Cheung M, Cooper A, Duran C., 2011
Phylum BVI, Chloroflexi phy. nov.
Garrity G, Holt J., 2001
Molecular and biochemical characterization of two tungsten- and selenium-containing formate dehydrogenases from Eubacterium acidaminophilum that are associated with components of an iron-only hydrogenase
Graentzdoerffer A, Rauh D, Pich A, Andreesen JR., 2003
Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing.
Griffen AL, Beall CJ, Campbell JH, Firestone ND, Kumar PS, Yang ZK, Podar M, Leys EJ., ISME J 6(6), 2011
PMID: 22170420
Community genomic analyses constrain the distribution of metabolic traits across the Chloroflexi phylum and indicate roles in sediment carbon cycling.
Hug LA, Castelle CJ, Wrighton KC, Thomas BC, Sharon I, Frischkorn KR, Williams KH, Tringe SG, Banfield JF., Microbiome 1(1), 2013
PMID: 24450983
Impact of culture-independent studies on the emerging phylogenetic view of bacterial diversity.
Hugenholtz P, Goebel BM, Pace NR., J. Bacteriol. 180(18), 1998
PMID: 9733676
Structure, function and diversity of the healthy human microbiome.
Human Microbiome Project Consortium, Huttenhower C, Gevers D, Knight R, Abubucker S, Badger JH, Chinwalla AT, Creasy HH, Earl AM, FitzGerald MG, Fulton RS, Giglio MG, Hallsworth-Pepin K, Lobos EA, Madupu R, Magrini V, Martin JC, Mitreva M, Muzny DM, Sodergren EJ, Versalovic J, Wollam AM, Worley KC, Wortman JR, Young SK, Zeng Q, Aagaard KM, Abolude OO, Allen-Vercoe E, Alm EJ, Alvarado L, Andersen GL, Anderson S, Appelbaum E, Arachchi HM, Armitage G, Arze CA, Ayvaz T, Baker CC, Begg L, Belachew T, Bhonagiri V, Bihan M, Blaser MJ, Bloom T, Bonazzi V, Brooks J, Buck GA, Buhay CJ, Busam DA, Campbell JL, Canon SR, Cantarel BL, Chain PS, Chen IM, Chen L, Chhibba S, Chu K, Ciulla DM, Clemente JC, Clifton SW, Conlan S, Crabtree J, Cutting MA, Davidovics NJ, Davis CC, DeSantis TZ, Deal C, Delehaunty KD, Dewhirst FE, Deych E, Ding Y, Dooling DJ, Dugan SP, Dunne WM, Durkin A, Edgar RC, Erlich RL, Farmer CN, Farrell RM, Faust K, Feldgarden M, Felix VM, Fisher S, Fodor AA, Forney LJ, Foster L, Di Francesco V, Friedman J, Friedrich DC, Fronick CC, Fulton LL, Gao H, Garcia N, Giannoukos G, Giblin C, Giovanni MY, Goldberg JM, Goll J, Gonzalez A, Griggs A, Gujja S, Haake SK, Haas BJ, Hamilton HA, Harris EL, Hepburn TA, Herter B, Hoffmann DE, Holder ME, Howarth C, Huang KH, Huse SM, Izard J, Jansson JK, Jiang H, Jordan C, Joshi V, Katancik JA, Keitel WA, Kelley ST, Kells C, King NB, Knights D, Kong HH, Koren O, Koren S, Kota KC, Kovar CL, Kyrpides NC, La Rosa PS, Lee SL, Lemon KP, Lennon N, Lewis CM, Lewis L, Ley RE, Li K, Liolios K, Liu B, Liu Y, Lo CC, Lozupone CA, Lunsford R, Madden T, Mahurkar AA, Mannon PJ, Mardis ER, Markowitz VM, Mavromatis K, McCorrison JM, McDonald D, McEwen J, McGuire AL, McInnes P, Mehta T, Mihindukulasuriya KA, Miller JR, Minx PJ, Newsham I, Nusbaum C, O'Laughlin M, Orvis J, Pagani I, Palaniappan K, Patel SM, Pearson M, Peterson J, Podar M, Pohl C, Pollard KS, Pop M, Priest ME, Proctor LM, Qin X, Raes J, Ravel J, Reid JG, Rho M, Rhodes R, Riehle KP, Rivera MC, Rodriguez-Mueller B, Rogers YH, Ross MC, Russ C, Sanka RK, Sankar P, Sathirapongsasuti J, Schloss JA, Schloss PD, Schmidt TM, Scholz M, Schriml L, Schubert AM, Segata N, Segre JA, Shannon WD, Sharp RR, Sharpton TJ, Shenoy N, Sheth NU, Simone GA, Singh I, Smillie CS, Sobel JD, Sommer DD, Spicer P, Sutton GG, Sykes SM, Tabbaa DG, Thiagarajan M, Tomlinson CM, Torralba M, Treangen TJ, Truty RM, Vishnivetskaya TA, Walker J, Wang L, Wang Z, Ward DV, Warren W, Watson MA, Wellington C, Wetterstrand KA, White JR, Wilczek-Boney K, Wu Y, Wylie KM, Wylie T, Yandava C, Ye L, Ye Y, Yooseph S, Youmans BP, Zhang L, Zhou Y, Zhu Y, Zoloth L, Zucker JD, Birren BW, Gibbs RA, Highlander SK, Methe BA, Nelson KE, Petrosino JF, Weinstock GM, Wilson RK, White O., Nature 486(7402), 2012
PMID: 22699609
Ecophysiological interaction between nitrifying bacteria and heterotrophic bacteria in autotrophic nitrifying biofilms as determined by microautoradiography-fluorescence in situ hybridization
Kindaichi T, Ito T, Okabe S., 2004
Community ecology of hot spring cyanobacterial mats: predominant populations and their functional potential.
Klatt CG, Wood JM, Rusch DB, Bateson MM, Hamamura N, Heidelberg JF, Grossman AR, Bhaya D, Cohan FM, Kuhl M, Bryant DA, Ward DM., ISME J 5(8), 2011
PMID: 21697961
Genomic sequencing of uncultured microorganisms from single cells.
Lasken RS., Nat. Rev. Microbiol. 10(9), 2012
PMID: 22890147
Worlds within worlds: evolution of the vertebrate gut microbiota.
Ley RE, Lozupone CA, Hamady M, Knight R, Gordon JI., Nat. Rev. Microbiol. 6(10), 2008
PMID: 18794915
Obesity alters gut microbial ecology.
Ley RE, Backhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI., Proc. Natl. Acad. Sci. U.S.A. 102(31), 2005
PMID: 16033867
Evolution of mammals and their gut microbes.
Ley RE, Hamady M, Lozupone C, Turnbaugh PJ, Ramey RR, Bircher JS, Schlegel ML, Tucker TA, Schrenzel MD, Knight R, Gordon JI., Science 320(5883), 2008
PMID: 18497261
Inactivation of clpB in the pathogen Leptospira interrogans reduces virulence and resistance to stress conditions.
Lourdault K, Cerqueira GM, Wunder EA Jr, Picardeau M., Infect. Immun. 79(9), 2011
PMID: 21730091
ARB: a software environment for sequence data.
Ludwig W, Strunk O, Westram R, Richter L, Meier H, Yadhukumar , Buchner A, Lai T, Steppi S, Jobb G, Forster W, Brettske I, Gerber S, Ginhart AW, Gross O, Grumann S, Hermann S, Jost R, Konig A, Liss T, Lussmann R, May M, Nonhoff B, Reichel B, Strehlow R, Stamatakis A, Stuckmann N, Vilbig A, Lenke M, Ludwig T, Bode A, Schleifer KH., Nucleic Acids Res. 32(4), 2004
PMID: 14985472
Dissecting biological "dark matter" with single-cell genetic analysis of rare and uncultivated TM7 microbes from the human mouth.
Marcy Y, Ouverney C, Bik EM, Losekann T, Ivanova N, Martin HG, Szeto E, Platt D, Hugenholtz P, Relman DA, Quake SR., Proc. Natl. Acad. Sci. U.S.A. 104(29), 2007
PMID: 17620602
IMG: the Integrated Microbial Genomes database and comparative analysis system.
Markowitz VM, Chen IM, Palaniappan K, Chu K, Szeto E, Grechkin Y, Ratner A, Jacob B, Huang J, Williams P, Huntemann M, Anderson I, Mavromatis K, Ivanova NN, Kyrpides NC., Nucleic Acids Res. 40(Database issue), 2012
PMID: 22194640
Structure, function and diversity of the healthy human microbiome.
Human Microbiome Project Consortium, Huttenhower C, Gevers D, Knight R, Abubucker S, Badger JH, Chinwalla AT, Creasy HH, Earl AM, FitzGerald MG, Fulton RS, Giglio MG, Hallsworth-Pepin K, Lobos EA, Madupu R, Magrini V, Martin JC, Mitreva M, Muzny DM, Sodergren EJ, Versalovic J, Wollam AM, Worley KC, Wortman JR, Young SK, Zeng Q, Aagaard KM, Abolude OO, Allen-Vercoe E, Alm EJ, Alvarado L, Andersen GL, Anderson S, Appelbaum E, Arachchi HM, Armitage G, Arze CA, Ayvaz T, Baker CC, Begg L, Belachew T, Bhonagiri V, Bihan M, Blaser MJ, Bloom T, Bonazzi V, Brooks J, Buck GA, Buhay CJ, Busam DA, Campbell JL, Canon SR, Cantarel BL, Chain PS, Chen IM, Chen L, Chhibba S, Chu K, Ciulla DM, Clemente JC, Clifton SW, Conlan S, Crabtree J, Cutting MA, Davidovics NJ, Davis CC, DeSantis TZ, Deal C, Delehaunty KD, Dewhirst FE, Deych E, Ding Y, Dooling DJ, Dugan SP, Dunne WM, Durkin A, Edgar RC, Erlich RL, Farmer CN, Farrell RM, Faust K, Feldgarden M, Felix VM, Fisher S, Fodor AA, Forney LJ, Foster L, Di Francesco V, Friedman J, Friedrich DC, Fronick CC, Fulton LL, Gao H, Garcia N, Giannoukos G, Giblin C, Giovanni MY, Goldberg JM, Goll J, Gonzalez A, Griggs A, Gujja S, Haake SK, Haas BJ, Hamilton HA, Harris EL, Hepburn TA, Herter B, Hoffmann DE, Holder ME, Howarth C, Huang KH, Huse SM, Izard J, Jansson JK, Jiang H, Jordan C, Joshi V, Katancik JA, Keitel WA, Kelley ST, Kells C, King NB, Knights D, Kong HH, Koren O, Koren S, Kota KC, Kovar CL, Kyrpides NC, La Rosa PS, Lee SL, Lemon KP, Lennon N, Lewis CM, Lewis L, Ley RE, Li K, Liolios K, Liu B, Liu Y, Lo CC, Lozupone CA, Lunsford R, Madden T, Mahurkar AA, Mannon PJ, Mardis ER, Markowitz VM, Mavromatis K, McCorrison JM, McDonald D, McEwen J, McGuire AL, McInnes P, Mehta T, Mihindukulasuriya KA, Miller JR, Minx PJ, Newsham I, Nusbaum C, O'Laughlin M, Orvis J, Pagani I, Palaniappan K, Patel SM, Pearson M, Peterson J, Podar M, Pohl C, Pollard KS, Pop M, Priest ME, Proctor LM, Qin X, Raes J, Ravel J, Reid JG, Rho M, Rhodes R, Riehle KP, Rivera MC, Rodriguez-Mueller B, Rogers YH, Ross MC, Russ C, Sanka RK, Sankar P, Sathirapongsasuti J, Schloss JA, Schloss PD, Schmidt TM, Scholz M, Schriml L, Schubert AM, Segata N, Segre JA, Shannon WD, Sharp RR, Sharpton TJ, Shenoy N, Sheth NU, Simone GA, Singh I, Smillie CS, Sobel JD, Sommer DD, Spicer P, Sutton GG, Sykes SM, Tabbaa DG, Thiagarajan M, Tomlinson CM, Torralba M, Treangen TJ, Truty RM, Vishnivetskaya TA, Walker J, Wang L, Wang Z, Ward DV, Warren W, Watson MA, Wellington C, Wetterstrand KA, White JR, Wilczek-Boney K, Wu Y, Wylie KM, Wylie T, Yandava C, Ye L, Ye Y, Yooseph S, Youmans BP, Zhang L, Zhou Y, Zhu Y, Zoloth L, Zucker JD, Birren BW, Gibbs RA, Highlander SK, Methe BA, Nelson KE, Petrosino JF, Weinstock GM, Wilson RK, White O., Nature 486(7402), 2012
PMID: 22699609
Biodiversity and functional genomics in the human microbiome.
Morgan XC, Segata N, Huttenhower C., Trends Genet. 29(1), 2012
PMID: 23140990
Fate of 14C-labeled microbial products derived from nitrifying bacteria in autotrophic nitrifying biofilms
Okabe S, Kindaichi T, Ito T., 2005
Single-cell sequencing provides clues about the host interactions of segmented filamentous bacteria (SFB).
Pamp SJ, Harrington ED, Quake SR, Relman DA, Blainey PC., Genome Res. 22(6), 2012
PMID: 22434425
Bacterial diversity in human subgingival plaque.
Paster BJ, Boches SK, Galvin JL, Ericson RE, Lau CN, Levanos VA, Sahasrabudhe A, Dewhirst FE., J. Bacteriol. 183(12), 2001
PMID: 11371542
The SILVA ribosomal RNA gene database project: improved data processing and web-based tools.
Quast C, Pruesse E, Yilmaz P, Gerken J, Schweer T, Yarza P, Peplies J, Glockner FO., Nucleic Acids Res. 41(Database issue), 2012
PMID: 23193283
Shifting the genomic gold standard for the prokaryotic species definition.
Richter M, Rossello-Mora R., Proc. Natl. Acad. Sci. U.S.A. 106(45), 2009
PMID: 19855009
Insights into the phylogeny and coding potential of microbial dark matter.
Rinke C, Schwientek P, Sczyrba A, Ivanova NN, Anderson IJ, Cheng JF, Darling A, Malfatti S, Swan BK, Gies EA, Dodsworth JA, Hedlund BP, Tsiamis G, Sievert SM, Liu WT, Eisen JA, Hallam SJ, Kyrpides NC, Stepanauskas R, Rubin EM, Hugenholtz P, Woyke T., Nature 499(7459), 2013
PMID: 23851394
Introducing mothur: open-source, platform-independent, community-supported software for describing and comparing microbial communities
Schloss PD, Westcott SL, Ryabin T, Hall JR, Hartmann M, Hollister EB., 2009
Ecology drives a global network of gene exchange connecting the human microbiome.
Smillie CS, Smith MB, Friedman J, Cordero OX, David LA, Alm EJ., Nature 480(7376), 2011
PMID: 22037308
Sialic acid, periodontal pathogens and Tannerella forsythia: stick around and enjoy the feast!
Stafford G, Roy S, Honma K, Sharma A., Mol Oral Microbiol 27(1), 2011
PMID: 22230462
Potential for chemolithoautotrophy among ubiquitous bacteria lineages in the dark ocean.
Swan BK, Martinez-Garcia M, Preston CM, Sczyrba A, Woyke T, Lamy D, Reinthaler T, Poulton NJ, Masland ED, Gomez ML, Sieracki ME, DeLong EF, Herndl GJ, Stepanauskas R., Science 333(6047), 2011
PMID: 21885783
The oral microbiome in health and disease
Wade WG., 2012
The influence of iron availability on human salivary microbial community composition.
Wang R, Kaplan A, Guo L, Shi W, Zhou X, Lux R, He X., Microb. Ecol. 64(1), 2012
PMID: 22318873
Assembling the marine metagenome, one cell at a time.
Woyke T, Xie G, Copeland A, Gonzalez JM, Han C, Kiss H, Saw JH, Senin P, Yang C, Chatterji S, Cheng JF, Eisen JA, Sieracki ME, Stepanauskas R., PLoS ONE 4(4), 2009
PMID: 19390573
Single-cell genomics reveals organismal interactions in uncultivated marine protists.
Yoon HS, Price DC, Stepanauskas R, Rajah VD, Sieracki ME, Wilson WH, Yang EC, Duffy S, Bhattacharya D., Science 332(6030), 2011
PMID: 21551060
Analysis of the phylogenetic diversity of estrone-degrading bacteria in activated sewage sludge using microautoradiography-fluorescence in situ hybridization
Zang K, Kurisu F, Kasuga I, Furumai H, Yagi O., 2008
Biogeography of the ecosystems of the healthy human body.
Zhou Y, Gao H, Mihindukulasuriya KA, La Rosa PS, Wylie KM, Vishnivetskaya T, Podar M, Warner B, Tarr PI, Nelson DE, Fortenberry JD, Holland MJ, Burr SE, Shannon WD, Sodergren E, Weinstock GM., Genome Biol. 14(1), 2013
PMID: 23316946
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