The impact of age on prefrontal cortex integrity during spatial working memory retrieval

Toepper M, Markowitsch HJ, Gebhardt H, Beblo T, Bauer E, Woermann FG, Driessen M, Sammer G (2014)
Neuropsychologia 59: 157-168.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
Healthy aging is accompanied by a decline in spatial working memory that is related to functional cerebral changes within the spatial working memory network. In the last decade, important findings were presented concerning the location (e.g., prefrontal), kind (e.g., 'underactivation,' 'overactivation'), and meaning (e.g., functional deficits, compensation) of these changes. Less is known about how functional connections between specific brain regions are affected by age and how these changes are related to behavioral performance. To address these issues, we used functional magnetic resonance imaging to examine retrieval-related brain activation and functional connectivity in 18 younger individuals and 18 older individuals. We assessed working memory with a modified version of the Corsi Block-Tapping test, which requires the storage and reproduction of spatial target sequences. Analyses of group differences in brain activation and functional connectivity included comparisons between younger individuals, older individuals, older high-performers, and older low-performers. In addition, we conducted a functional connectivity analysis by using a seed region approach. In comparison to younger individuals, older individuals showed lower right-hemispheric dorsolateral prefrontal activation and lower functional connectivity between the right dorsolateral prefrontal cortex and the bilateral orbitofrontal cortex. Older high-performers showed higher right dorsolateral and anterior prefrontal cortex activation than older low-performers, as well as higher functional connectivity between these brain regions. The present results suggest age-related reductions of prefrontal activation during spatial working memory retrieval. Moreover, task-related functional connectivity appears to be lower in older adults. Performance accuracy in older adults is associated with right dorsolateral and anterior prefrontal cortex activation, and with the functional connection between these regions. (C) 2014 Elsevier Ltd. All rights reserved.
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Neuropsychologia
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59
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157-168
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Toepper M, Markowitsch HJ, Gebhardt H, et al. The impact of age on prefrontal cortex integrity during spatial working memory retrieval. Neuropsychologia. 2014;59:157-168.
Toepper, M., Markowitsch, H. J., Gebhardt, H., Beblo, T., Bauer, E., Woermann, F. G., Driessen, M., et al. (2014). The impact of age on prefrontal cortex integrity during spatial working memory retrieval. Neuropsychologia, 59, 157-168. doi:10.1016/j.neuropsychologia.2014.04.020
Toepper, M., Markowitsch, H. J., Gebhardt, H., Beblo, T., Bauer, E., Woermann, F. G., Driessen, M., and Sammer, G. (2014). The impact of age on prefrontal cortex integrity during spatial working memory retrieval. Neuropsychologia 59, 157-168.
Toepper, M., et al., 2014. The impact of age on prefrontal cortex integrity during spatial working memory retrieval. Neuropsychologia, 59, p 157-168.
M. Toepper, et al., “The impact of age on prefrontal cortex integrity during spatial working memory retrieval”, Neuropsychologia, vol. 59, 2014, pp. 157-168.
Toepper, M., Markowitsch, H.J., Gebhardt, H., Beblo, T., Bauer, E., Woermann, F.G., Driessen, M., Sammer, G.: The impact of age on prefrontal cortex integrity during spatial working memory retrieval. Neuropsychologia. 59, 157-168 (2014).
Toepper, Max, Markowitsch, Hans J., Gebhardt, Helge, Beblo, Thomas, Bauer, Eva, Woermann, Friedrich G., Driessen, Martin, and Sammer, Gebhard. “The impact of age on prefrontal cortex integrity during spatial working memory retrieval”. Neuropsychologia 59 (2014): 157-168.

11 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Default mode network modifications in Fabry disease: A resting-state fMRI study with structural correlations.
Cocozza S, Pontillo G, Quarantelli M, Saccà F, Riccio E, Costabile T, Olivo G, Brescia Morra V, Pisani A, Brunetti A, Tedeschi E, AFFINITY study group., Hum Brain Mapp 39(4), 2018
PMID: 29315984
Requiring collaboration: Hippocampal-prefrontal networks needed in spatial working memory and ageing. A multivariate analysis approach.
Zancada-Menendez C, Alvarez-Suarez P, Sampedro-Piquero P, Cuesta M, Begega A., Neurobiol Learn Mem 140(), 2017
PMID: 28213065
Chronic curcumin treatment improves spatial working memory but not recognition memory in middle-aged rhesus monkeys.
Moore TL, Bowley B, Shultz P, Calderazzo S, Shobin E, Killiany RJ, Rosene DL, Moss MB., Geroscience 39(5-6), 2017
PMID: 29047012
Improvement of encoding and retrieval in normal and pathological aging with word-picture paradigm.
Iodice R, Meilán JJ, Carro J., Aging Ment Health 19(10), 2015
PMID: 25560063
Connectomics and graph theory analyses: Novel insights into network abnormalities in epilepsy.
Gleichgerrcht E, Kocher M, Bonilha L., Epilepsia 56(11), 2015
PMID: 26391203
Hemodynamic Response Pattern of Spatial Cueing is Different for Social and Symbolic Cues.
Lockhofen DE, Gruppe H, Ruprecht C, Gallhofer B, Sammer G., Front Hum Neurosci 8(), 2014
PMID: 25426057

99 References

Daten bereitgestellt von Europe PubMed Central.

Study design in fMRI: basic principles.
Amaro E Jr, Barker GJ., Brain Cogn 60(3), 2006
PMID: 16427175

Baddeley, 1986
Is the rostro-caudal axis of the frontal lobe hierarchical?
Badre D, D'Esposito M., Nat. Rev. Neurosci. 10(9), 2009
PMID: 19672274
Lateral prefrontal cortex is organized into parallel dorsal and ventral streams along the rostro-caudal axis.
Blumenfeld RS, Nomura EM, Gratton C, D'Esposito M., Cereb. Cortex 23(10), 2012
PMID: 22879354
Frontal lobe involvement in spatial span: converging studies of normal and impaired function.
Bor D, Duncan J, Lee AC, Parr A, Owen AM., Neuropsychologia 44(2), 2005
PMID: 15979109
Dissociable components of rule-guided behavior depend on distinct medial and prefrontal regions.
Buckley MJ, Mansouri FA, Hoda H, Mahboubi M, Browning PG, Kwok SC, Phillips A, Tanaka K., Science 325(5936), 2009
PMID: 19574382
Task-independent and task-specific age effects on brain activity during working memory, visual attention and episodic retrieval.
Cabeza R, Daselaar SM, Dolcos F, Prince SE, Budde M, Nyberg L., Cereb. Cortex 14(4), 2004
PMID: 15028641
Imaging cognition II: An empirical review of 275 PET and fMRI studies.
Cabeza R, Nyberg L., J Cogn Neurosci 12(1), 2000
PMID: 10769304
Age differences in the frontoparietal cognitive control network: implications for distractibility.
Campbell KL, Grady CL, Ng C, Hasher L., Neuropsychologia 50(9), 2012
PMID: 22659108
Age differences in the neural representation of working memory revealed by multi-voxel pattern analysis.
Carp J, Gmeindl L, Reuter-Lorenz PA., Front Hum Neurosci 4(), 2010
PMID: 21151373
The frontopolar Cortex and human cognition: Evidence for a rostrocaudal hierarchical organization within the human prefrontal cortex
Christoff, Psychobiology 28(), 2000
An area specialized for spatial working memory in human frontal cortex.
Courtney SM, Petit L, Maisog JM, Ungerleider LG, Haxby JV., Science 279(5355), 1998
PMID: 9478894
Human memory and the medial temporal region of the brain
Corsi, Dissertation Abstracts International 34(), 1972
Que PASA? The posterior-anterior shift in aging.
Davis SW, Dennis NA, Daselaar SM, Fleck MS, Cabeza R., Cereb. Cortex 18(5), 2007
PMID: 17925295
Maintenance versus manipulation of information held in working memory: an event-related fMRI study.
D'Esposito M, Postle BR, Ballard D, Lease J., Brain Cogn 41(1), 1999
PMID: 10536086
Neural mechanisms of a genome-wide supported psychosis variant.
Esslinger C, Walter H, Kirsch P, Erk S, Schnell K, Arnold C, Haddad L, Mier D, Opitz von Boberfeld C, Raab K, Witt SH, Rietschel M, Cichon S, Meyer-Lindenberg A., Science 324(5927), 2009
PMID: 19407193
"Mini-mental state". A practical method for grading the cognitive state of patients for the clinician.
Folstein MF, Folstein SE, McHugh PR., J Psychiatr Res 12(3), 1975
PMID: 1202204
A voxel-based morphometric study of ageing in 465 normal adult human brains.
Good CD, Johnsrude IS, Ashburner J, Henson RN, Friston KJ, Frackowiak RS., Neuroimage 14(1 Pt 1), 2001
PMID: 11525331
A multivariate analysis of age-related differences in default mode and task-positive networks across multiple cognitive domains.
Grady CL, Protzner AB, Kovacevic N, Strother SC, Afshin-Pour B, Wojtowicz M, Anderson JA, Churchill N, McIntosh AR., Cereb. Cortex 20(6), 2009
PMID: 19789183
Aging and the neural correlates of successful picture encoding: frontal activations compensate for decreased medial-temporal activity.
Gutchess AH, Welsh RC, Hedden T, Bangert A, Minear M, Liu LL, Park DC., J Cogn Neurosci 17(1), 2005
PMID: 15701241
Age effects on load-dependent brain activations in working memory for novel material.
Holtzer R, Rakitin BC, Steffener J, Flynn J, Kumar A, Stern Y., Brain Res. 1249(), 2008
PMID: 18983833
An age-related deficit in prefrontal cortical function associated with refreshing information.
Johnson MK, Mitchell KJ, Raye CL, Greene EJ., Psychol Sci 15(2), 2004
PMID: 14738520
Functional brain connectivity at rest changes after working memory training.
Jolles DD, van Buchem MA, Crone EA, Rombouts SA., Hum Brain Mapp 34(2), 2011
PMID: 22076823
Age differences in behavior and PET activation reveal differences in interference resolution in verbal working memory.
Jonides J, Marshuetz C, Smith EE, Reuter-Lorenz PA, Koeppe RA, Hartley A., J Cogn Neurosci 12(1), 2000
PMID: 10769315
Brain mechanisms of proactive interference in working memory.
Jonides J, Nee DE., Neuroscience 139(1), 2005
PMID: 16337090

Kaplan, 1983
DemTect: A new screening method to support diagnosis of dementia
Kessler, Psychologie 26(), 2000
Dopamine and frontostriatal networks in cognitive aging
Klostermann, Neurobiology of Aging 33(), 2012
Neurophysiology of old neurons and synapses
Kumar, 2007
Functional anatomy of temporal organisation and domain-specificity of episodic memory retrieval.
Kwok SC, Shallice T, Macaluso E., Neuropsychologia 50(12), 2012
PMID: 22877840
Automated labeling of the human brain: a preliminary report on the development and evaluation of a forward-transform method.
Lancaster JL, Rainey LH, Summerlin JL, Freitas CS, Fox PT, Evans AC, Toga AW, Mazziotta JC., Hum Brain Mapp 5(4), 1997
PMID: 20408222
Automated Talairach atlas labels for functional brain mapping.
Lancaster JL, Woldorff MG, Parsons LM, Liotti M, Freitas CS, Rainey L, Kochunov PV, Nickerson D, Mikiten SA, Fox PT., Hum Brain Mapp 10(3), 2000
PMID: 10912591

Lezak, 2004
Review of methods for functional brain connectivity detection using fMRI.
Li K, Guo L, Nie J, Li G, Liu T., Comput Med Imaging Graph 33(2), 2008
PMID: 19111443
Adult age differences in functional connectivity during executive control.
Madden DJ, Costello MC, Dennis NA, Davis SW, Shepler AM, Spaniol J, Bucur B, Cabeza R., Neuroimage 52(2), 2010
PMID: 20434565
An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets.
Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH., Neuroimage 19(3), 2003
PMID: 12880848
Neurophysiological correlates of age-related changes in working memory capacity.
Mattay VS, Fera F, Tessitore A, Hariri AR, Berman KF, Das S, Meyer-Lindenberg A, Goldberg TE, Callicott JH, Weinberger DR., Neurosci. Lett. 392(1-2), 2005
PMID: 16213083
Effects of age on the structure of functional connectivity networks during episodic and working memory demand.
Matthaus F, Schmidt JP, Banerjee A, Schulze TG, Demirakca T, Diener C., Brain Connect 2(3), 2012
PMID: 22698449
The impact of aging on gray matter structural covariance networks.
Montembeault M, Joubert S, Doyon J, Carrier J, Gagnon JF, Monchi O, Lungu O, Belleville S, Brambati SM., Neuroimage 63(2), 2012
PMID: 22776455
Working memory component processes: isolating BOLD signal changes.
Motes MA, Rypma B., Neuroimage 49(2), 2009
PMID: 19732840
Rey Auditory-Verbal Learning Test: structure of a modified German version.
Muller H, Hasse-Sander I, Horn R, Helmstaedter C, Elger CE., J Clin Psychol 53(7), 1997
PMID: 9356896
Performance level modulates adult age differences in brain activation during spatial working memory.
Nagel IE, Preuschhof C, Li SC, Nyberg L, Backman L, Lindenberger U, Heekeren HR., Proc. Natl. Acad. Sci. U.S.A. 106(52), 2009
PMID: 20018709
Load modulation of BOLD response and connectivity predicts working memory performance in younger and older adults.
Nagel IE, Preuschhof C, Li SC, Nyberg L, Backman L, Lindenberger U, Heekeren HR., J Cogn Neurosci 23(8), 2010
PMID: 20828302
A meta-analysis of executive components of working memory.
Nee DE, Brown JW, Askren MK, Berman MG, Demiralp E, Krawitz A, Jonides J., Cereb. Cortex 23(2), 2012
PMID: 22314046
Redefining the functional organization of working memory processes within human lateral prefrontal cortex.
Owen AM, Herrod NJ, Menon DK, Clark JC, Downey SP, Carpenter TA, Minhas PS, Turkheimer FE, Williams EJ, Robbins TW, Sahakian BJ, Petrides M, Pickard JD., Eur. J. Neurosci. 11(2), 1999
PMID: 10051756
Models of visuospatial and verbal memory across the adult life span.
Park DC, Lautenschlager G, Hedden T, Davidson NS, Smith AD, Smith PK., Psychol Aging 17(2), 2002
PMID: 12061414
Aging reduces neural specialization in ventral visual cortex.
Park DC, Polk TA, Park R, Minear M, Savage A, Smith MR., Proc. Natl. Acad. Sci. U.S.A. 101(35), 2004
PMID: 15322270
The adaptive brain: aging and neurocognitive scaffolding.
Park DC, Reuter-Lorenz P., Annu Rev Psychol 60(), 2009
PMID: 19035823
Selection requirements during verb generation: differential recruitment in older and younger adults.
Persson J, Sylvester CY, Nelson JK, Welsh KM, Jonides J, Reuter-Lorenz PA., Neuroimage 23(4), 2004
PMID: 15589102
Age-associated losses of brain volume predict longitudinal cognitive declines over 8 to 20 years.
Rabbitt P, Ibrahim S, Lunn M, Scott M, Thacker N, Hutchinson C, Horan M, Pendleton N, Jackson A., Neuropsychology 22(1), 2008
PMID: 18211150
Aging of the brain and its impact on cognitive performance: Integration of structural and functional findings
Raz, 2008
Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter.
Raz N, Gunning FM, Head D, Dupuis JH, McQuain J, Briggs SD, Loken WJ, Thornton AE, Acker JD., Cereb. Cortex 7(3), 1997
PMID: 9143446
The relation of the trail making test to organic brain damage.
REITAN RM., J Consult Psychol 19(5), 1955
PMID: 13263471
Longitudinal magnetic resonance imaging studies of older adults: a shrinking brain.
Resnick SM, Pham DL, Kraut MA, Zonderman AB, Davatzikos C., J. Neurosci. 23(8), 2003
PMID: 12716936
Neurocognitive aging and the compensation hypothesis
Reuter-Lorenz, Current Directions in Psychological Science 17(), 2008
Age differences in the frontal lateralization of verbal and spatial working memory revealed by PET.
Reuter-Lorenz PA, Jonides J, Smith EE, Hartley A, Miller A, Marshuetz C, Koeppe RA., J Cogn Neurosci 12(1), 2000
PMID: 10769314
Brain aging: reorganizing discoveries about the aging mind.
Reuter-Lorenz PA, Lustig C., Curr. Opin. Neurobiol. 15(2), 2005
PMID: 15831410
Human neuroscience and the aging mind: A new look at old problems
Reuter-Lorenz, The Journals of Gerontology Series B: Psychological Sciences and Social Sciences 65(), 2010
The cognitive neuroscience of working memory and aging
Reuter-Lorenz, 2005
Neural system for controlling the contents of object working memory in humans.
Roth JK, Serences JT, Courtney SM., Cereb. Cortex 16(11), 2005
PMID: 16357333
Modelling neural correlates of working memory: a coordinate-based meta-analysis.
Rottschy C, Langner R, Dogan I, Reetz K, Laird AR, Schulz JB, Fox PT, Eickhoff SB., Neuroimage 60(1), 2011
PMID: 22178808
The influence of working-memory demand and subject performance on prefrontal cortical activity.
Rypma B, Berger JS, D'Esposito M., J Cogn Neurosci 14(5), 2002
PMID: 12167257
Dissociating age-related changes in cognitive strategy and neural efficiency using event-related fMRI.
Rypma B, Berger JS, Genova HM, Rebbechi D, D'Esposito M., Cortex 41(4), 2005
PMID: 16042034
Isolating the neural mechanisms of age-related changes in human working memory.
Rypma B, D'Esposito M., Nat. Neurosci. 3(5), 2000
PMID: 10769393
Age differences in prefrontal cortical activity in working memory.
Rypma B, Prabhakaran V, Desmond JE, Gabrieli JD., Psychol Aging 16(3), 2001
PMID: 11554517
Age-related alterations in default mode network: impact on working memory performance.
Sambataro F, Murty VP, Callicott JH, Tan HY, Das S, Weinberger DR, Mattay VS., Neurobiol. Aging 31(5), 2008
PMID: 18674847
Lifespan age differences in working memory: A two-component framework
Sander, Neuroscience & Biobehavioral Reviews 36(), 2012
Span, CRUNCH, and beyond: working memory capacity and the aging brain.
Schneider-Garces NJ, Gordon BA, Brumback-Peltz CR, Shin E, Lee Y, Sutton BP, Maclin EL, Gratton G, Fabiani M., J Cogn Neurosci 22(4), 2010
PMID: 19320550
Merkmalsanalyse von Uhrzeichnungen als Beitrag zur Diagnostik der Demenz vom Alzheimer Typ (DAT)
Schröder, Zeitschrift für Gerontopsychologie & -psychiatrie 12(), 1999
Motor control and aging: Links to age-related brain structural, functional, and biochemical effects
Seidler, Neuroscience & Biobehavioral Reviews 34(), 2010
Clock-drawing and dementia in the community: A longitudinal study
Shulman, International Journal of Geriatric Psychiatry 8(), 1993
Working memory: a view from neuroimaging.
Smith EE, Jonides J., Cogn Psychol 33(1), 1997
PMID: 9212720
Storage and executive processes in the frontal lobes.
Smith EE, Jonides J., Science 283(5408), 1999
PMID: 10073923
Age-related changes in task related functional network connectivity.
Steffener J, Habeck CG, Stern Y., PLoS ONE 7(9), 2012
PMID: 23028536

Talairach, 1998
Brain localization of attentional control in different age groups by combining functional and structural MRI.
Thomsen T, Specht K, Rimol LM, Hammar A, Nyttingnes J, Ersland L, Hugdahl K., Neuroimage 22(2), 2004
PMID: 15193622
Functional correlates of distractor suppression during spatial working memory encoding.
Toepper M, Gebhardt H, Beblo T, Thomas C, Driessen M, Bischoff M, Blecker CR, Vaitl D, Sammer G., Neuroscience 165(4), 2009
PMID: 19925856
Hippocampal involvement in working memory encoding of changing locations: an fMRI study.
Toepper M, Markowitsch HJ, Gebhardt H, Beblo T, Thomas C, Gallhofer B, Driessen M, Sammer G., Brain Res. 1354(), 2010
PMID: 20678490
Neural correlates of impaired inhibitory processes in mild cognitive impairment
Toepper, Behavioural Neurology 3(), 2013
Trail Making Test A and B: normative data stratified by age and education.
Tombaugh TN., Arch Clin Neuropsychol 19(2), 2004
PMID: 15010086
Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain.
Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, Mazoyer B, Joliot M., Neuroimage 15(1), 2002
PMID: 11771995
Orbitofrontal cortex as a cognitive map of task space.
Wilson RC, Takahashi YK, Schoenbaum G, Niv Y., Neuron 81(2), 2014
PMID: 24462094
Age-related changes in brain activation during a delayed item recognition task.
Zarahn E, Rakitin B, Abela D, Flynn J, Stern Y., Neurobiol. Aging 28(5), 2006
PMID: 16621168

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