Effect of direct eye contact in PTSD related to interpersonal trauma: an fMRI study of activation of an innate alarm system

Steuwe C, Daniels JK, Frewen PA, Densmore M, Pannasch S, Beblo T, Reiss J, Lanius RA (2014)
Social Cognitive and Affective Neuroscience 9(1): 88-97.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Steuwe, Carolin; Daniels, Judith K.; Frewen, Paul A.; Densmore, Maria; Pannasch, Sebastian; Beblo, ThomasUniBi; Reiss, Jeffrey; Lanius, Ruth A.
Abstract / Bemerkung
In healthy individuals, direct eye contact initially leads to activation of a fast subcortical pathway, which then modulates a cortical route eliciting social cognitive processes. The aim of this study was to gain insight into the neurobiological effects of direct eye-to-eye contact using a virtual reality paradigm in individuals with posttraumatic stress disorder (PTSD) related to prolonged childhood abuse. We examined 16 healthy comparison subjects and 16 patients with a primary diagnosis of PTSD using a virtual reality functional magnetic resonance imaging paradigm involving direct vs averted gaze (happy, sad, neutral) as developed by Schrammel et al. in 2009. Irrespective of the displayed emotion, controls exhibited an increased blood oxygenation level-dependent response during direct vs averted gaze within the dorsomedial prefrontal cortex, left temporoparietal junction and right temporal pole. Under the same conditions, individuals with PTSD showed increased activation within the superior colliculus (SC)/periaqueductal gray (PAG) and locus coeruleus. Our findings suggest that healthy controls react to the exposure of direct gaze with an activation of a cortical route that enhances evaluative 'top-down' processes underlying social interactions. In individuals with PTSD, however, direct gaze leads to sustained activation of a subcortical route of eye-contact processing, an innate alarm system involving the SC and the underlying circuits of the PAG.
Stichworte
social cognition; fMRI; childhood abuse; dorsomedial prefrontal; superior colliculus; cortex; PTSD
Erscheinungsjahr
2014
Zeitschriftentitel
Social Cognitive and Affective Neuroscience
Band
9
Ausgabe
1
Seite(n)
88-97
ISSN
1749-5016
eISSN
1749-5024
Page URI
https://pub.uni-bielefeld.de/record/2684392

Zitieren

Steuwe C, Daniels JK, Frewen PA, et al. Effect of direct eye contact in PTSD related to interpersonal trauma: an fMRI study of activation of an innate alarm system. Social Cognitive and Affective Neuroscience. 2014;9(1):88-97.
Steuwe, C., Daniels, J. K., Frewen, P. A., Densmore, M., Pannasch, S., Beblo, T., Reiss, J., et al. (2014). Effect of direct eye contact in PTSD related to interpersonal trauma: an fMRI study of activation of an innate alarm system. Social Cognitive and Affective Neuroscience, 9(1), 88-97. doi:10.1093/scan/nss105
Steuwe, C., Daniels, J. K., Frewen, P. A., Densmore, M., Pannasch, S., Beblo, T., Reiss, J., and Lanius, R. A. (2014). Effect of direct eye contact in PTSD related to interpersonal trauma: an fMRI study of activation of an innate alarm system. Social Cognitive and Affective Neuroscience 9, 88-97.
Steuwe, C., et al., 2014. Effect of direct eye contact in PTSD related to interpersonal trauma: an fMRI study of activation of an innate alarm system. Social Cognitive and Affective Neuroscience, 9(1), p 88-97.
C. Steuwe, et al., “Effect of direct eye contact in PTSD related to interpersonal trauma: an fMRI study of activation of an innate alarm system”, Social Cognitive and Affective Neuroscience, vol. 9, 2014, pp. 88-97.
Steuwe, C., Daniels, J.K., Frewen, P.A., Densmore, M., Pannasch, S., Beblo, T., Reiss, J., Lanius, R.A.: Effect of direct eye contact in PTSD related to interpersonal trauma: an fMRI study of activation of an innate alarm system. Social Cognitive and Affective Neuroscience. 9, 88-97 (2014).
Steuwe, Carolin, Daniels, Judith K., Frewen, Paul A., Densmore, Maria, Pannasch, Sebastian, Beblo, Thomas, Reiss, Jeffrey, and Lanius, Ruth A. “Effect of direct eye contact in PTSD related to interpersonal trauma: an fMRI study of activation of an innate alarm system”. Social Cognitive and Affective Neuroscience 9.1 (2014): 88-97.

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