Harnessing the Evolvability of Tricyclic Microviridins To Dissect Protease-Inhibitor Interactions

Weiz AR, Ishida K, Quitterer F, Meyer S, Kehr J-C, Müller K, Groll M, Hertweck C, Dittmann E (2014)
Angewandte Chemie International Edition 53(14): 3735-3738.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Weiz, Annika R.; Ishida, Keishi; Quitterer, Felix; Meyer, Sabine; Kehr, Jan-Christoph; Müller, KristianUniBi ; Groll, Michael; Hertweck, Christian; Dittmann, Elke
Abstract / Bemerkung
Understanding and controlling proteolysis is an important goal in therapeutic chemistry. Among the natural products specifically inhibiting proteases microviridins are particularly noteworthy. Microviridins are ribosomally produced and posttranslationally modified peptides that are processed into a unique, cagelike architecture. Here, we report a combined rational and random mutagenesis approach that provides fundamental insights into selectivity-conferring moieties of microviridins. The potent variant microviridin J was co-crystallized with trypsin, and for the first time the three-dimensional structure of microviridins was determined and the mode of inhibition revealed.
Stichworte
peptide engineering; cyanobacteria; RiPPs; structure elucidation; protease inhibitors
Erscheinungsjahr
2014
Zeitschriftentitel
Angewandte Chemie International Edition
Band
53
Ausgabe
14
Seite(n)
3735-3738
ISSN
1433-7851
Page URI
https://pub.uni-bielefeld.de/record/2684340

Zitieren

Weiz AR, Ishida K, Quitterer F, et al. Harnessing the Evolvability of Tricyclic Microviridins To Dissect Protease-Inhibitor Interactions. Angewandte Chemie International Edition. 2014;53(14):3735-3738.
Weiz, A. R., Ishida, K., Quitterer, F., Meyer, S., Kehr, J. - C., Müller, K., Groll, M., et al. (2014). Harnessing the Evolvability of Tricyclic Microviridins To Dissect Protease-Inhibitor Interactions. Angewandte Chemie International Edition, 53(14), 3735-3738. doi:10.1002/anie.201309721
Weiz, Annika R., Ishida, Keishi, Quitterer, Felix, Meyer, Sabine, Kehr, Jan-Christoph, Müller, Kristian, Groll, Michael, Hertweck, Christian, and Dittmann, Elke. 2014. “Harnessing the Evolvability of Tricyclic Microviridins To Dissect Protease-Inhibitor Interactions”. Angewandte Chemie International Edition 53 (14): 3735-3738.
Weiz, A. R., Ishida, K., Quitterer, F., Meyer, S., Kehr, J. - C., Müller, K., Groll, M., Hertweck, C., and Dittmann, E. (2014). Harnessing the Evolvability of Tricyclic Microviridins To Dissect Protease-Inhibitor Interactions. Angewandte Chemie International Edition 53, 3735-3738.
Weiz, A.R., et al., 2014. Harnessing the Evolvability of Tricyclic Microviridins To Dissect Protease-Inhibitor Interactions. Angewandte Chemie International Edition, 53(14), p 3735-3738.
A.R. Weiz, et al., “Harnessing the Evolvability of Tricyclic Microviridins To Dissect Protease-Inhibitor Interactions”, Angewandte Chemie International Edition, vol. 53, 2014, pp. 3735-3738.
Weiz, A.R., Ishida, K., Quitterer, F., Meyer, S., Kehr, J.-C., Müller, K., Groll, M., Hertweck, C., Dittmann, E.: Harnessing the Evolvability of Tricyclic Microviridins To Dissect Protease-Inhibitor Interactions. Angewandte Chemie International Edition. 53, 3735-3738 (2014).
Weiz, Annika R., Ishida, Keishi, Quitterer, Felix, Meyer, Sabine, Kehr, Jan-Christoph, Müller, Kristian, Groll, Michael, Hertweck, Christian, and Dittmann, Elke. “Harnessing the Evolvability of Tricyclic Microviridins To Dissect Protease-Inhibitor Interactions”. Angewandte Chemie International Edition 53.14 (2014): 3735-3738.

5 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

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