Characterization and inhibition of AF10-mediated interaction

Hagen S, Mattay D, Raeuber C, Müller K, Arndt KM (2014)
Journal of Peptide Science 20(6): 385-397.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Hagen, Sven; Mattay, Dinah; Raeuber, Christina; Müller, KristianUniBi ; Arndt, Katja M.
Abstract / Bemerkung
The non-random chromosomal translocations t(10;11)(p13;q23) and t(10;11)(p13;q14-21) result in leukemogenic fusion proteins comprising the coiled coil domain of the transcription factor AF10 and the proteins MLL or CALM, respectively, and subsequently cause certain types of acute leukemia. The AF10 coiled-coil domain, which is crucial for the leukemogenic effect, has been shown to interact with GAS41, a protein previously identified as the product of an amplified gene in glioblastoma. Using sequential synthetic peptides, we mapped the potential AF10/GAS41 interaction site, which was subsequently be used as scaffold for a library targeting the AF10 coiled-coil domain. Using phage display, we selected a peptide that binds the AF10 coiled-coil domain with higher affinity than the respective coiled-coil region of wild-type GAS41, as demonstrated by phage ELISA, CD, and PCAs. Furthermore, we were able to successfully deploy the inhibitory peptide in a mammalian cell line to lower the expression of Hoxa genes that have been described to be overexpressed in these leukemias. This work dissects molecular determinants mediating AF10-directed interactions in leukemic fusions comprising the N-terminal parts of the proteins MLL or CALM and the C-terminal coiled-coil domain of AF10. Furthermore, it outlines the first steps in recognizing and blocking the leukemia-associated AF10 interaction in histiocytic lymphoma cells and therefore, may have significant implications in future diagnostics and therapeutics. Copyright (c) 2014 European Peptide Society and John Wiley & Sons, Ltd.
Stichworte
protein design and selection; protein; engineering; coiled coil; AF10; leucine zipper; protein-protein interaction
Erscheinungsjahr
2014
Zeitschriftentitel
Journal of Peptide Science
Band
20
Ausgabe
6
Seite(n)
385-397
ISSN
1075-2617
Page URI
https://pub.uni-bielefeld.de/record/2679640

Zitieren

Hagen S, Mattay D, Raeuber C, Müller K, Arndt KM. Characterization and inhibition of AF10-mediated interaction. Journal of Peptide Science. 2014;20(6):385-397.
Hagen, S., Mattay, D., Raeuber, C., Müller, K., & Arndt, K. M. (2014). Characterization and inhibition of AF10-mediated interaction. Journal of Peptide Science, 20(6), 385-397. doi:10.1002/psc.2626
Hagen, Sven, Mattay, Dinah, Raeuber, Christina, Müller, Kristian, and Arndt, Katja M. 2014. “Characterization and inhibition of AF10-mediated interaction”. Journal of Peptide Science 20 (6): 385-397.
Hagen, S., Mattay, D., Raeuber, C., Müller, K., and Arndt, K. M. (2014). Characterization and inhibition of AF10-mediated interaction. Journal of Peptide Science 20, 385-397.
Hagen, S., et al., 2014. Characterization and inhibition of AF10-mediated interaction. Journal of Peptide Science, 20(6), p 385-397.
S. Hagen, et al., “Characterization and inhibition of AF10-mediated interaction”, Journal of Peptide Science, vol. 20, 2014, pp. 385-397.
Hagen, S., Mattay, D., Raeuber, C., Müller, K., Arndt, K.M.: Characterization and inhibition of AF10-mediated interaction. Journal of Peptide Science. 20, 385-397 (2014).
Hagen, Sven, Mattay, Dinah, Raeuber, Christina, Müller, Kristian, and Arndt, Katja M. “Characterization and inhibition of AF10-mediated interaction”. Journal of Peptide Science 20.6 (2014): 385-397.

2 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.
Zhang H, Zhou B, Qin S, Xu J, Harding R, Tempel W, Nayak V, Li Y, Loppnau P, Dou Y, Min J., Genes Dev 32(5-6), 2018
PMID: 29563185
Designing helical peptide inhibitors of protein-protein interactions.
Rezaei Araghi R, Keating AE., Curr Opin Struct Biol 39(), 2016
PMID: 27123812

53 References

Daten bereitgestellt von Europe PubMed Central.

Molecular analysis of the CALM/AF10 fusion: identical rearrangements in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma patients.
Bohlander SK, Muschinsky V, Schrader K, Siebert R, Schlegelberger B, Harder L, Schemmel V, Fonatsch C, Ludwig WD, Hiddemann W, Dreyling MH., Leukemia 14(1), 2000
PMID: 10637482
The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family.
Dreyling MH, Martinez-Climent JA, Zheng M, Mao J, Rowley JD, Bohlander SK., Proc. Natl. Acad. Sci. U.S.A. 93(10), 1996
PMID: 8643484
The MLL recombinome of acute leukemias in 2013.
Meyer C, Hofmann J, Burmeister T, Groger D, Park TS, Emerenciano M, Pombo de Oliveira M, Renneville A, Villarese P, Macintyre E, Cave H, Clappier E, Mass-Malo K, Zuna J, Trka J, De Braekeleer E, De Braekeleer M, Oh SH, Tsaur G, Fechina L, van der Velden VH, van Dongen JJ, Delabesse E, Binato R, Silva ML, Kustanovich A, Aleinikova O, Harris MH, Lund-Aho T, Juvonen V, Heidenreich O, Vormoor J, Choi WW, Jarosova M, Kolenova A, Bueno C, Menendez P, Wehner S, Eckert C, Talmant P, Tondeur S, Lippert E, Launay E, Henry C, Ballerini P, Lapillone H, Callanan MB, Cayuela JM, Herbaux C, Cazzaniga G, Kakadiya PM, Bohlander S, Ahlmann M, Choi JR, Gameiro P, Lee DS, Krauter J, Cornillet-Lefebvre P, Te Kronnie G, Schafer BW, Kubetzko S, Alonso CN, zur Stadt U, Sutton R, Venn NC, Izraeli S, Trakhtenbrot L, Madsen HO, Archer P, Hancock J, Cerveira N, Teixeira MR, Lo Nigro L, Moricke A, Stanulla M, Schrappe M, Sedek L, Szczepanski T, Zwaan CM, Coenen EA, van den Heuvel-Eibrink MM, Strehl S, Dworzak M, Panzer-Grumayer R, Dingermann T, Klingebiel T, Marschalek R., Leukemia 27(11), 2013
PMID: 23628958
Biochemical analyses of the AF10 protein: the extended LAP/PHD-finger mediates oligomerisation.
Linder B, Newman R, Jones LK, Debernardi S, Young BD, Freemont P, Verrijzer CP, Saha V., J. Mol. Biol. 299(2), 2000
PMID: 10860745
The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex.
Debernardi S, Bassini A, Jones LK, Chaplin T, Linder B, de Bruijn DR, Meese E, Young BD., Blood 99(1), 2002
PMID: 11756182
Cloning of a novel transcription factor-like gene amplified in human glioma including astrocytoma grade I.
Fischer U, Heckel D, Michel A, Janka M, Hulsebos T, Meese E., Hum. Mol. Genet. 6(11), 1997
PMID: 9302258
A CALM-derived nuclear export signal is essential for CALM-AF10-mediated leukemogenesis.
Conway AE, Scotland PB, Lavau CP, Wechsler DS., Blood 121(23), 2013
PMID: 23487024
hDOT1L links histone methylation to leukemogenesis.
Okada Y, Feng Q, Lin Y, Jiang Q, Li Y, Coffield VM, Su L, Xu G, Zhang Y., Cell 121(2), 2005
PMID: 15851025
Leukaemic transformation by CALM-AF10 involves upregulation of Hoxa5 by hDOT1L.
Okada Y, Jiang Q, Lemieux M, Jeannotte L, Su L, Zhang Y., Nat. Cell Biol. 8(9), 2006
PMID: 16921363
CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes.
Dik WA, Brahim W, Braun C, Asnafi V, Dastugue N, Bernard OA, van Dongen JJ, Langerak AW, Macintyre EA, Delabesse E., Leukemia 19(11), 2005
PMID: 16107895
The clathrin-binding domain of CALM and the OM-LZ domain of AF10 are sufficient to induce acute myeloid leukemia in mice.
Deshpande AJ, Rouhi A, Lin Y, Stadler C, Greif PA, Arseni N, Opatz S, Quintanilla-Fend L, Holzmann K, Hiddemann W, Dohner K, Dohner H, Xu G, Armstrong SA, Bohlander SK, Buske C., Leukemia 25(11), 2011
PMID: 21681188
MultiCoil: a program for predicting two- and three-stranded coiled coils.
Wolf E, Kim PS, Berger B., Protein Sci. 6(6), 1997
PMID: 9194178
The design of coiled-coil structures and assemblies.
Woolfson DN., Adv. Protein Chem. 70(), 2005
PMID: 15837514
The structure of alpha-helical coiled coils.
Lupas AN, Gruber M., Adv. Protein Chem. 70(), 2005
PMID: 15837513
Comparison of in vivo selection and rational design of heterodimeric coiled coils.
Arndt KM, Pelletier JN, Muller KM, Pluckthun A, Alber T., Structure 10(9), 2002
PMID: 12220495
Peptide 'Velcro': design of a heterodimeric coiled coil.
O'Shea EK, Lumb KJ, Kim PS., Curr. Biol. 3(10), 1993
PMID: 15335856
Considerations in the design and optimization of coiled coil structures.
Mason JM, Muller KM, Arndt KM., Methods Mol. Biol. 352(), 2007
PMID: 17041258
Semirational design of Jun-Fos coiled coils with increased affinity: Universal implications for leucine zipper prediction and design.
Mason JM, Schmitz MA, Muller KM, Arndt KM., Proc. Natl. Acad. Sci. U.S.A. 103(24), 2006
PMID: 16754880
Selectional and mutational scope of peptides sequestering the Jun-Fos coiled-coil domain.
Hagemann UB, Mason JM, Muller KM, Arndt KM., J. Mol. Biol. 381(1), 2008
PMID: 18586270
Targeting the c-Myc coiled coil with interfering peptides.
Jouaux EM, Schmidtkunz K, Muller KM, Arndt KM., J. Pept. Sci. 14(9), 2008
PMID: 18465834
The leucine zippers of the HLH-LZ proteins Max and c-Myc preferentially form heterodimers.
Muhle-Goll C, Nilges M, Pastore A., Biochemistry 34(41), 1995
PMID: 7577944
Establishment and characterization of a human histiocytic lymphoma cell line (U-937).
Sundstrom C, Nilsson K., Int. J. Cancer 17(5), 1976
PMID: 178611
Stringent doxycycline-dependent control of gene activities using an episomal one-vector system.
Bornkamm GW, Berens C, Kuklik-Roos C, Bechet JM, Laux G, Bachl J, Korndoerfer M, Schlee M, Holzel M, Malamoussi A, Chapman RD, Nimmerjahn F, Mautner J, Hillen W, Bujard H, Feuillard J., Nucleic Acids Res. 33(16), 2005
PMID: 16147984

AUTHOR UNKNOWN, 0
Polyethylenimine, a cost-effective transfection reagent
Ehrhardt, Signal Transduct. 6(), 2006
Predicting coiled coils from protein sequences.
Lupas A, Van Dyke M, Stock J., Science 252(5009), 1991
PMID: 2031185
Predicting coiled coils by use of pairwise residue correlations.
Berger B, Wilson DB, Wolf E, Tonchev T, Milla M, Kim PS., Proc. Natl. Acad. Sci. U.S.A. 92(18), 1995
PMID: 7667278
Paircoil2: improved prediction of coiled coils from sequence.
McDonnell AV, Jiang T, Keating AE, Berger B., Bioinformatics 22(3), 2005
PMID: 16317077
Predicting specificity in bZIP coiled-coil protein interactions.
Fong JH, Keating AE, Singh M., Genome Biol. 5(2), 2004
PMID: 14759261
A heterodimeric coiled-coil peptide pair selected in vivo from a designed library-versus-library ensemble.
Arndt KM, Pelletier JN, Muller KM, Alber T, Michnick SW, Pluckthun A., J. Mol. Biol. 295(3), 2000
PMID: 10623552
An in vivo library-versus-library selection of optimized protein-protein interactions.
Pelletier JN, Arndt KM, Pluckthun A, Michnick SW., Nat. Biotechnol. 17(7), 1999
PMID: 10404162
Predicting oligomerization states of coiled coils.
Woolfson DN, Alber T., Protein Sci. 4(8), 1995
PMID: 8520486
Sequence-based design of a peptide probe for the APC tumor suppressor protein.
Sharma VA, Logan J, King DS, White R, Alber T., Curr. Biol. 8(14), 1998
PMID: 9663391
An engineered leucine zipper a position mutant with an unusual three-state unfolding pathway.
Zhu H, Celinski SA, Scholtz JM, Hu JC., Protein Sci. 10(1), 2001
PMID: 11266591
Peptide containing the BCR oligomerization domain (AA 1-160) reverses the transformed phenotype of p210bcr-abl positive 32D myeloid leukemia cells.
Guo XY, Cuillerot JM, Wang T, Wu Y, Arlinghaus R, Claxton D, Bachier C, Greenberger J, Colombowala I, Deisseroth AB., Oncogene 17(7), 1998
PMID: 9779999
Targeting the oligomerization domain of ETO interferes with RUNX1/ETO oncogenic activity in t(8;21)-positive leukemic cells.
Wichmann C, Chen L, Heinrich M, Baus D, Pfitzner E, Zornig M, Ottmann OG, Grez M., Cancer Res. 67(5), 2007
PMID: 17332359
WebLogo: a sequence logo generator.
Crooks GE, Hon G, Chandonia JM, Brenner SE., Genome Res. 14(6), 2004
PMID: 15173120
Sequence logos: a new way to display consensus sequences.
Schneider TD, Stephens RM., Nucleic Acids Res. 18(20), 1990
PMID: 2172928
Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®
Quellen

PMID: 24692230
PubMed | Europe PMC

Suchen in

Google Scholar