Retrieval-induced forgetting under psychosocial stress: No reduction by delayed stress and beta-adrenergic blockade

Dreifus L, Engler H, Kißler J (2014)
Neurobiology of Learning and Memory 110: 35-46.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Dreifus, Laura; Engler, Harald; Kißler, JohannaUniBi
Abstract / Bemerkung
Retrieval-induced forgetting (RIF) is the phenomenon that 'retrieval-practice', the repeated retrieval of a subset of initially learned material, can impair the recall of episodically related memories. Previous studies showed that RIF is eliminated when retrieval-practice is carried out under psycho-social stress, anxiety, or in negative mood. However, pharmacological manipulation by hydrocortisone did not eliminate the effect. This study investigated the effect of beta-adrenergic blockade on stress-induced modulations of RIF, addressing possible interactive effects of the glucocorticoid and sympatho-adrenomedullary systems. Participants learned categorized word lists and then received either 60 mg propranolol or a placebo. After 90 min they were exposed to the TSST. A third group did not receive any medication and performed a non-stressful control task with the same timing as the other two groups. Finally, all participants underwent retrieval-practice and final recall. Both TSST groups exhibited a stress-induced increase in cortisol-levels, and the placebo group also exhibited large increases in markers of sympathetic nervous system activity and more psychological distress at the time of retrieval-practice. Although, overall recall was poorer under stress, an overall RIF effect emerged irrespective of group and showed no clear modulation by stress with or without beta-adrenergic blockade. In previous demonstrations of RIF elimination by negative emotion, state induction and retrieval-practice followed very briefly after initial learning. Given that both the previous study of hydrocortisone effects on RIF and the present study used longer delays between learning and retrieval-practice, the possibility that stress effects on retrieval-practice eliminate RIF only relatively briefly after learning is discussed. (C) 2014 Elsevier Inc. All rights reserved.
Beta-blockade; Trier Social Stress Test; Adrenergic system; HPA-axis; Psychosocial stress; Memory; Retrieval-induced forgetting
Neurobiology of Learning and Memory
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Dreifus L, Engler H, Kißler J. Retrieval-induced forgetting under psychosocial stress: No reduction by delayed stress and beta-adrenergic blockade. Neurobiology of Learning and Memory. 2014;110:35-46.
Dreifus, L., Engler, H., & Kißler, J. (2014). Retrieval-induced forgetting under psychosocial stress: No reduction by delayed stress and beta-adrenergic blockade. Neurobiology of Learning and Memory, 110, 35-46. doi:10.1016/j.nlm.2014.01.010
Dreifus, Laura, Engler, Harald, and Kißler, Johanna. 2014. “Retrieval-induced forgetting under psychosocial stress: No reduction by delayed stress and beta-adrenergic blockade”. Neurobiology of Learning and Memory 110: 35-46.
Dreifus, L., Engler, H., and Kißler, J. (2014). Retrieval-induced forgetting under psychosocial stress: No reduction by delayed stress and beta-adrenergic blockade. Neurobiology of Learning and Memory 110, 35-46.
Dreifus, L., Engler, H., & Kißler, J., 2014. Retrieval-induced forgetting under psychosocial stress: No reduction by delayed stress and beta-adrenergic blockade. Neurobiology of Learning and Memory, 110, p 35-46.
L. Dreifus, H. Engler, and J. Kißler, “Retrieval-induced forgetting under psychosocial stress: No reduction by delayed stress and beta-adrenergic blockade”, Neurobiology of Learning and Memory, vol. 110, 2014, pp. 35-46.
Dreifus, L., Engler, H., Kißler, J.: Retrieval-induced forgetting under psychosocial stress: No reduction by delayed stress and beta-adrenergic blockade. Neurobiology of Learning and Memory. 110, 35-46 (2014).
Dreifus, Laura, Engler, Harald, and Kißler, Johanna. “Retrieval-induced forgetting under psychosocial stress: No reduction by delayed stress and beta-adrenergic blockade”. Neurobiology of Learning and Memory 110 (2014): 35-46.

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