Dicarbonyl stress and glyoxalases in ovarian function

Tatone C, Eichenlaub-Ritter U, Amicarelli F (2014)
Biochemical Society Transactions 42(2): 433-438.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Tatone, Carla; Eichenlaub-Ritter, UrsulaUniBi; Amicarelli, Fernanda
Abstract / Bemerkung
The ovary is the main regulator of female fertility. Changes in maternal health and physiology can disrupt intraovarian homoeostasis thereby compromising oocyte competence and fertility. Research has only recently devoted attention to the involvement of dicarbonyl stress in ovarian function. On this basis, the present review focuses on clinical and experimental research supporting the role of dicarbonyl overload and AGES (advanced glycation end-products) as key contributors to perturbations of the ovarian microenvironment leading to lower fertility. Particular emphasis has been given to oocyte susceptibility to methylglyoxal, a powerful glycating agent, whose levels are known to increase during aging and metabolic disorders. According to the literature, the ovary and the oocyte itself can rely on the glyoxalase system to counteract the possible dicarbonyl overload such as that which may occur in reproductive-age women and patients with PCOS (polycystic ovarian syndrome) or diabetes. Overall, although biochemical methods for proper evaluation of dicarbonyl stress in oocytes and the ovarian microenvironment need to be established, AGEs can be proposed as predictive markers and/or therapeutic targets in new strategies for improving reproductive counselling and infertility therapies.
polycystic ovarian syndrome (PCOS); oxidative stress; ovarian aging; oocyte aging; advanced glycation end-product (AGE); female fertility
Biochemical Society Transactions
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Tatone C, Eichenlaub-Ritter U, Amicarelli F. Dicarbonyl stress and glyoxalases in ovarian function. Biochemical Society Transactions. 2014;42(2):433-438.
Tatone, C., Eichenlaub-Ritter, U., & Amicarelli, F. (2014). Dicarbonyl stress and glyoxalases in ovarian function. Biochemical Society Transactions, 42(2), 433-438. doi:10.1042/BST20140023
Tatone, Carla, Eichenlaub-Ritter, Ursula, and Amicarelli, Fernanda. 2014. “Dicarbonyl stress and glyoxalases in ovarian function”. Biochemical Society Transactions 42 (2): 433-438.
Tatone, C., Eichenlaub-Ritter, U., and Amicarelli, F. (2014). Dicarbonyl stress and glyoxalases in ovarian function. Biochemical Society Transactions 42, 433-438.
Tatone, C., Eichenlaub-Ritter, U., & Amicarelli, F., 2014. Dicarbonyl stress and glyoxalases in ovarian function. Biochemical Society Transactions, 42(2), p 433-438.
C. Tatone, U. Eichenlaub-Ritter, and F. Amicarelli, “Dicarbonyl stress and glyoxalases in ovarian function”, Biochemical Society Transactions, vol. 42, 2014, pp. 433-438.
Tatone, C., Eichenlaub-Ritter, U., Amicarelli, F.: Dicarbonyl stress and glyoxalases in ovarian function. Biochemical Society Transactions. 42, 433-438 (2014).
Tatone, Carla, Eichenlaub-Ritter, Ursula, and Amicarelli, Fernanda. “Dicarbonyl stress and glyoxalases in ovarian function”. Biochemical Society Transactions 42.2 (2014): 433-438.

9 Zitationen in Europe PMC

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Can cytoplasmic donation rescue aged oocytes?
Tanaka A, Watanabe S., Reprod Med Biol 18(2), 2019
PMID: 30996676
MECHANISMS IN ENDOCRINOLOGY: Nutrition as a mediator of oxidative stress in metabolic and reproductive disorders in women.
Diamanti-Kandarakis E, Papalou O, Kandaraki EA, Kassi G., Eur J Endocrinol 176(2), 2017
PMID: 27678478
Transcriptomic features of Pecten maximus oocyte quality and maturation.
Pauletto M, Milan M, Huvet A, Corporeau C, Suquet M, Planas JV, Moreira R, Figueras A, Novoa B, Patarnello T, Bargelloni L., PLoS One 12(3), 2017
PMID: 28253290
Regular and Moderate Exercise Counteracts the Decline of Antioxidant Protection but Not Methylglyoxal-Dependent Glycative Burden in the Ovary of Reproductively Aging Mice.
Falone S, Santini SJ, Cordone V, Grannonico M, Cacchio M, Di Emidio G, Tatone C, Amicarelli F., Oxid Med Cell Longev 2016(), 2016
PMID: 28116035
Oocyte ageing and epigenetics.
Ge ZJ, Schatten H, Zhang CL, Sun QY., Reproduction 149(3), 2015
PMID: 25391845
Sirtuin Functions in Female Fertility: Possible Role in Oxidative Stress and Aging.
Tatone C, Di Emidio G, Vitti M, Di Carlo M, Santini S, D'Alessandro AM, Falone S, Amicarelli F., Oxid Med Cell Longev 2015(), 2015
PMID: 26075037
SIRT1 signalling protects mouse oocytes against oxidative stress and is deregulated during aging.
Di Emidio G, Falone S, Vitti M, D'Alessandro AM, Vento M, Di Pietro C, Amicarelli F, Tatone C., Hum Reprod 29(9), 2014
PMID: 24963165
Increased levels of oxidative and carbonyl stress markers in normal ovarian cortex surrounding endometriotic cysts.
Di Emidio G, D'Alfonso A, Leocata P, Parisse V, Di Fonso A, Artini PG, Patacchiola F, Tatone C, Carta G., Gynecol Endocrinol 30(11), 2014
PMID: 25030845

50 References

Daten bereitgestellt von Europe PubMed Central.

Study an egg today to make an embryo tomorrow.
Zuccotti M, Redi CA, Garagna S., Int. J. Dev. Biol. 56(10-12), 2012
PMID: 23417397
In vivo and in vitro environmental effects on mammalian oocyte quality.
Krisher RL., Annu Rev Anim Biosci 1(), 2012
PMID: 25387025
The aging ovary--the poor granulosa cells.
Tatone C, Amicarelli F., Fertil. Steril. 99(1), 2013
PMID: 23273984
The effects of oxidative stress on female reproduction: a review.
Agarwal A, Aponte-Mellado A, Premkumar BJ, Shaman A, Gupta S., Reprod. Biol. Endocrinol. 10(), 2012
PMID: 22748101
Dicarbonyl intermediates in the maillard reaction.
Thornalley PJ., Ann. N. Y. Acad. Sci. 1043(), 2005
PMID: 16037229
Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome.
Rabbani N, Thornalley PJ., Amino Acids 42(4), 2010
PMID: 20963454
Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause.
Faddy MJ, Gosden RG, Gougeon A, Richardson SJ, Nelson JF., Hum. Reprod. 7(10), 1992
PMID: 1291557
Oocyte ageing and its cellular basis.
Eichenlaub-Ritter U., Int. J. Dev. Biol. 56(10-12), 2012
PMID: 23417406
Cellular and molecular aspects of ovarian follicle ageing.
Tatone C, Amicarelli F, Carbone MC, Monteleone P, Caserta D, Marci R, Artini PG, Piomboni P, Focarelli R., Hum. Reprod. Update 14(2), 2008
PMID: 18239135
Theca: the forgotten cell of the ovarian follicle.
Young JM, McNeilly AS., Reproduction 140(4), 2010
PMID: 20628033
The antral follicle: a microenvironment for oocyte differentiation.
Hennet ML, Combelles CM., Int. J. Dev. Biol. 56(10-12), 2012
PMID: 23417404
Increased serum levels of the specific AGE-compound methylglyoxal-derived hydroimidazolone in patients with type 2 diabetes.
Kilhovd BK, Giardino I, Torjesen PA, Birkeland KI, Berg TJ, Thornalley PJ, Brownlee M, Hanssen KF., Metab. Clin. Exp. 52(2), 2003
PMID: 12601626
Immunohistochemical localization of advanced glycation end-products (AGEs) and their receptor (RAGE) in polycystic and normal ovaries.
Diamanti-Kandarakis E, Piperi C, Patsouris E, Korkolopoulou P, Panidis D, Pawelczyk L, Papavassiliou AG, Duleba AJ., Histochem. Cell Biol. 127(6), 2007
PMID: 17205306
Female reproductive dysfunction during ageing: role of methylglyoxal in the formation of advanced glycation endproducts in ovaries of reproductively-aged mice.
Tatone C, Carbone MC, Campanella G, Festuccia C, Artini PG, Talesa V, Focarelli R, Amicarelli F., J. Biol. Regul. Homeost. Agents 24(1), 2010
PMID: 20385072
Evidence that carbonyl stress by methylglyoxal exposure induces DNA damage and spindle aberrations, affects mitochondrial integrity in mammalian oocytes and contributes to oocyte ageing.
Tatone C, Heizenrieder T, Di Emidio G, Treffon P, Amicarelli F, Seidel T, Eichenlaub-Ritter U., Hum. Reprod. 26(7), 2011
PMID: 21558076
Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality.
Gilchrist RB, Lane M, Thompson JG., Hum. Reprod. Update 14(2), 2008
PMID: 18175787
The pivotal role of glucose metabolism in determining oocyte developmental competence.
Sutton-McDowall ML, Gilchrist RB, Thompson JG., Reproduction 139(4), 2010
PMID: 20089664
Proteome of mouse oocytes at different developmental stages.
Wang S, Kou Z, Jing Z, Zhang Y, Guo X, Dong M, Wilmut I, Gao S., Proc. Natl. Acad. Sci. U.S.A. 107(41), 2010
PMID: 20876089
Redistribution of mitochondria leads to bursts of ATP production during spontaneous mouse oocyte maturation.
Yu Y, Dumollard R, Rossbach A, Lai FA, Swann K., J. Cell. Physiol. 224(3), 2010
PMID: 20578238
Molecular enzymology of the glyoxalase system.
Mannervik B., Drug Metabol Drug Interact 23(1-2), 2008
PMID: 18533362
Maternal diabetes adversely affects AMP-activated protein kinase activity and cellular metabolism in murine oocytes.
Ratchford AM, Chang AS, Chi MM, Sheridan R, Moley KH., Am. J. Physiol. Endocrinol. Metab. 293(5), 2007
PMID: 17684106
The biology of the receptor for advanced glycation end products and its ligands.
Schmidt AM, Yan SD, Yan SF, Stern DM., Biochim. Biophys. Acta 1498(2-3), 2000
PMID: 11108954
Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE.
Wautier MP, Chappey O, Corda S, Stern DM, Schmidt AM, Wautier JL., Am. J. Physiol. Endocrinol. Metab. 280(5), 2001
PMID: 11287350
Concentrations of sRAGE in serum and follicular fluid in assisted reproductive cycles--a preliminary study.
Malickova K, Jarosova R, Rezabek K, Fait T, Masata J, Janatkova I, Zima T, Kalousova M., Clin. Lab. 56(9-10), 2010
PMID: 21086782
Intrafollicular soluble receptor for advanced glycation end products (sRAGE) and embryo quality in assisted reproduction.
Bonetti TC, Borges E Jr, Braga DP, Iaconelli A Jr, Kleine JP, Silva ID., Reprod. Biomed. Online 26(1), 2012
PMID: 23182743
TAGE (toxic AGEs) theory in diabetic complications.
Sato T, Iwaki M, Shimogaito N, Wu X, Yamagishi S, Takeuchi M., Curr. Mol. Med. 6(3), 2006
PMID: 16712480
Advanced glycation end-products accumulation compromises embryonic development and achievement of pregnancy by assisted reproductive technology.
Jinno M, Takeuchi M, Watanabe A, Teruya K, Hirohama J, Eguchi N, Miyazaki A., Hum. Reprod. 26(3), 2011
PMID: 21233108
Lysyl oxidase interacts with AGE signalling to modulate collagen synthesis in polycystic ovarian tissue.
Papachroni KK, Piperi C, Levidou G, Korkolopoulou P, Pawelczyk L, Diamanti-Kandarakis E, Papavassiliou AG., J. Cell. Mol. Med. 14(10), 2010
PMID: 19583806
Protein modification by methylglyoxal: chemical nature and synthetic mechanism of a major fluorescent adduct.
Shipanova IN, Glomb MA, Nagaraj RH., Arch. Biochem. Biophys. 344(1), 1997
PMID: 9244378
Type VI collagen expression during growth of human ovarian follicles.
Iwahashi M, Muragaki Y, Ooshima A, Nakano R., Fertil. Steril. 74(2), 2000
PMID: 10927056
Advanced glycation end products and their receptor contribute to ovarian ageing.
Stensen MH, Tanbo T, Storeng R, Fedorcsak P., Hum. Reprod. 29(1), 2013
PMID: 24256989
Increased levels of serum advanced glycation end-products in women with polycystic ovary syndrome.
Diamanti-Kandarakis E, Piperi C, Kalofoutis A, Creatsas G., Clin. Endocrinol. (Oxf) 62(1), 2005
PMID: 15638868
Strong and positive association of endothelin-1 with AGEs in PCOS: a causal relationship or a bystander?
Christakou C, Economou F, Livadas S, Piperi C, Adamopoulos C, Marinakis E, Jdiamanti-Kandarakis E., Hormones (Athens) 10(4), 2011
PMID: 22281885
Dietary glycotoxins affect scavenger receptor expression and the hormonal profile of female rats.
Chatzigeorgiou A, Kandaraki E, Piperi C, Livadas S, Papavassiliou AG, Koutsilieris M, Papalois A, Diamanti-Kandarakis E., J. Endocrinol. 218(3), 2013
PMID: 23823020
Tobacco smoke is a source of toxic reactive glycation products.
Cerami C, Founds H, Nicholl I, Mitsuhashi T, Giordano D, Vanpatten S, Lee A, Al-Abed Y, Vlassara H, Bucala R, Cerami A., Proc. Natl. Acad. Sci. U.S.A. 94(25), 1997
PMID: 9391127
Advanced glycation end products and nutrition.
Krajcovicova-Kudlackova M, Sebekova K, Schinzel R, Klvanova J., Physiol Res 51(3), 2002
PMID: 12234125

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