Shaping Memory Accuracy by Left Prefrontal Transcranial Direct Current Stimulation

Zwissler B, Sperber C, Aigeldinger S, Schindler S, Kißler J, Plewnia C (2014)
Journal of Neuroscience 34(11): 4022-4026.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Human memory is dynamic and flexible but is also susceptible to distortions arising from adaptive as well as pathological processes. Both accurate and false memory formation require executive control that is critically mediated by the left prefrontal cortex (PFC). Transcranial direct current stimulation (tDCS) enables noninvasive modulation of cortical activity and associated behavior. The present study reports that tDCS applied to the left dorsolateral PFC (dlPFC) shaped accuracy of episodic memory via polaritiy-specific modulation of false recognition. When applied during encoding of pictures, anodal tDCS increased whereas cathodal stimulation reduced the number of false alarms to lure pictures in subsequent recognition memory testing. These data suggest that the enhancement of excitability in the dlPFC by anodal tDCS can be associated with blurred detail memory. In contrast, activity-reducing cathodal tDCS apparently acted as a noise filter inhibiting the development of imprecise memory traces and reducing the false memory rate. Consistently, the largest effect was found in the most active condition (i.e., for stimuli cued to be remembered). This first evidence for a polarity-specific, activity-dependent effect of tDCS on false memory opens new vistas for the understanding and potential treatment of disturbed memory control.
Stichworte
false memory; brain stimulation; memory encoding; dorsolateral prefrontal cortex; neuroenhancement; executive functions
Erscheinungsjahr
2014
Zeitschriftentitel
Journal of Neuroscience
Band
34
Ausgabe
11
Seite(n)
4022-4026
ISSN
0270-6474
eISSN
1529-2401
Page URI
https://pub.uni-bielefeld.de/record/2673677

Zitieren

Zwissler B, Sperber C, Aigeldinger S, Schindler S, Kißler J, Plewnia C. Shaping Memory Accuracy by Left Prefrontal Transcranial Direct Current Stimulation. Journal of Neuroscience. 2014;34(11):4022-4026.
Zwissler, B., Sperber, C., Aigeldinger, S., Schindler, S., Kißler, J., & Plewnia, C. (2014). Shaping Memory Accuracy by Left Prefrontal Transcranial Direct Current Stimulation. Journal of Neuroscience, 34(11), 4022-4026. doi:10.1523/JNEUROSCI.5407-13.2014
Zwissler, B., Sperber, C., Aigeldinger, S., Schindler, S., Kißler, J., and Plewnia, C. (2014). Shaping Memory Accuracy by Left Prefrontal Transcranial Direct Current Stimulation. Journal of Neuroscience 34, 4022-4026.
Zwissler, B., et al., 2014. Shaping Memory Accuracy by Left Prefrontal Transcranial Direct Current Stimulation. Journal of Neuroscience, 34(11), p 4022-4026.
B. Zwissler, et al., “Shaping Memory Accuracy by Left Prefrontal Transcranial Direct Current Stimulation”, Journal of Neuroscience, vol. 34, 2014, pp. 4022-4026.
Zwissler, B., Sperber, C., Aigeldinger, S., Schindler, S., Kißler, J., Plewnia, C.: Shaping Memory Accuracy by Left Prefrontal Transcranial Direct Current Stimulation. Journal of Neuroscience. 34, 4022-4026 (2014).
Zwissler, Bastian, Sperber, Christoph, Aigeldinger, Sina, Schindler, Sebastian, Kißler, Johanna, and Plewnia, Christian. “Shaping Memory Accuracy by Left Prefrontal Transcranial Direct Current Stimulation”. Journal of Neuroscience 34.11 (2014): 4022-4026.
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