Shaping Memory Accuracy by Left Prefrontal Transcranial Direct Current Stimulation

Zwissler B, Sperber C, Aigeldinger S, Schindler S, Kißler J, Plewnia C (2014)
Journal of Neuroscience 34(11): 4022-4026.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
Zwissler, Bastian; Sperber, Christoph; Aigeldinger, Sina; Schindler, SebastianUniBi ; Kißler, JohannaUniBi; Plewnia, Christian
Abstract / Bemerkung
Human memory is dynamic and flexible but is also susceptible to distortions arising from adaptive as well as pathological processes. Both accurate and false memory formation require executive control that is critically mediated by the left prefrontal cortex (PFC). Transcranial direct current stimulation (tDCS) enables noninvasive modulation of cortical activity and associated behavior. The present study reports that tDCS applied to the left dorsolateral PFC (dlPFC) shaped accuracy of episodic memory via polaritiy-specific modulation of false recognition. When applied during encoding of pictures, anodal tDCS increased whereas cathodal stimulation reduced the number of false alarms to lure pictures in subsequent recognition memory testing. These data suggest that the enhancement of excitability in the dlPFC by anodal tDCS can be associated with blurred detail memory. In contrast, activity-reducing cathodal tDCS apparently acted as a noise filter inhibiting the development of imprecise memory traces and reducing the false memory rate. Consistently, the largest effect was found in the most active condition (i.e., for stimuli cued to be remembered). This first evidence for a polarity-specific, activity-dependent effect of tDCS on false memory opens new vistas for the understanding and potential treatment of disturbed memory control.
false memory; brain stimulation; memory encoding; dorsolateral prefrontal cortex; neuroenhancement; executive functions
Journal of Neuroscience
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Zwissler B, Sperber C, Aigeldinger S, Schindler S, Kißler J, Plewnia C. Shaping Memory Accuracy by Left Prefrontal Transcranial Direct Current Stimulation. Journal of Neuroscience. 2014;34(11):4022-4026.
Zwissler, B., Sperber, C., Aigeldinger, S., Schindler, S., Kißler, J., & Plewnia, C. (2014). Shaping Memory Accuracy by Left Prefrontal Transcranial Direct Current Stimulation. Journal of Neuroscience, 34(11), 4022-4026. doi:10.1523/JNEUROSCI.5407-13.2014
Zwissler, B., Sperber, C., Aigeldinger, S., Schindler, S., Kißler, J., and Plewnia, C. (2014). Shaping Memory Accuracy by Left Prefrontal Transcranial Direct Current Stimulation. Journal of Neuroscience 34, 4022-4026.
Zwissler, B., et al., 2014. Shaping Memory Accuracy by Left Prefrontal Transcranial Direct Current Stimulation. Journal of Neuroscience, 34(11), p 4022-4026.
B. Zwissler, et al., “Shaping Memory Accuracy by Left Prefrontal Transcranial Direct Current Stimulation”, Journal of Neuroscience, vol. 34, 2014, pp. 4022-4026.
Zwissler, B., Sperber, C., Aigeldinger, S., Schindler, S., Kißler, J., Plewnia, C.: Shaping Memory Accuracy by Left Prefrontal Transcranial Direct Current Stimulation. Journal of Neuroscience. 34, 4022-4026 (2014).
Zwissler, Bastian, Sperber, Christoph, Aigeldinger, Sina, Schindler, Sebastian, Kißler, Johanna, and Plewnia, Christian. “Shaping Memory Accuracy by Left Prefrontal Transcranial Direct Current Stimulation”. Journal of Neuroscience 34.11 (2014): 4022-4026.
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34 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Effects of Anodal Transcranial Direct Current Stimulation Over the Ventrolateral Prefrontal Cortex on Episodic Memory Formation and Retrieval.
Medvedeva A, Materassi M, Neacsu V, Beresford-Webb J, Hussin A, Khan N, Newton F, Galli G., Cereb Cortex 29(2), 2019
PMID: 29329367
Modulating Applied Task Performance via Transcranial Electrical Stimulation.
Brunyé TT, Hussey EK, Fontes EB, Ward N., Front Hum Neurosci 13(), 2019
PMID: 31114491
Multitarget transcranial direct current stimulation for freezing of gait in Parkinson's disease.
Dagan M, Herman T, Harrison R, Zhou J, Giladi N, Ruffini G, Manor B, Hausdorff JM., Mov Disord 33(4), 2018
PMID: 29436740
Impact of oscillatory tDCS targeting left prefrontal cortex on source memory retrieval.
Mizrak E, Kim K, Roberts B, Ragland DJ, Carter C, Ranganath C., Cogn Neurosci 9(3-4), 2018
PMID: 30124354
Transcranial Electrical Stimulation: What We Know and Do Not Know About Mechanisms.
Fertonani A, Miniussi C., Neuroscientist 23(2), 2017
PMID: 26873962
Transcranial Electrical Stimulation to Enhance Cognitive Performance of Healthy Minors: A Complex Governance Challenge.
Schuijer JW, de Jong IM, Kupper F, van Atteveldt NM., Front Hum Neurosci 11(), 2017
PMID: 28396631
Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines.
Antal A, Alekseichuk I, Bikson M, Brockmöller J, Brunoni AR, Chen R, Cohen LG, Dowthwaite G, Ellrich J, Flöel A, Fregni F, George MS, Hamilton R, Haueisen J, Herrmann CS, Hummel FC, Lefaucheur JP, Liebetanz D, Loo CK, McCaig CD, Miniussi C, Miranda PC, Moliadze V, Nitsche MA, Nowak R, Padberg F, Pascual-Leone A, Poppendieck W, Priori A, Rossi S, Rossini PM, Rothwell J, Rueger MA, Ruffini G, Schellhorn K, Siebner HR, Ugawa Y, Wexler A, Ziemann U, Hallett M, Paulus W., Clin Neurophysiol 128(9), 2017
PMID: 28709880
Therapeutic effect of transcranial direct current stimulation on neuropsychological symptoms of an elderly patient: A case report.
Iannone A, Brasil-Neto J, Cruz APM, Satler C, Allam N., Dement Neuropsychol 11(3), 2017
PMID: 29213529
Oscillatory Reinstatement Enhances Declarative Memory.
Javadi AH, Glen JC, Halkiopoulos S, Schulz M, Spiers HJ., J Neurosci 37(41), 2017
PMID: 28912159
A proof-of-concept study on the combination of repetitive transcranial magnetic stimulation and relaxation techniques in chronic tinnitus.
Kreuzer PM, Poeppl TB, Bulla J, Schlee W, Lehner A, Langguth B, Schecklmann M., J Neural Transm (Vienna) 123(10), 2016
PMID: 27315823
Genetic Modulation of Transcranial Direct Current Stimulation Effects on Cognition.
Wiegand A, Nieratschker V, Plewnia C., Front Hum Neurosci 10(), 2016
PMID: 28066217
Understanding the behavioural consequences of noninvasive brain stimulation.
Bestmann S, de Berker AO, Bonaiuto J., Trends Cogn Sci 19(1), 2015
PMID: 25467129
Targeting the biased brain: non-invasive brain stimulation to ameliorate cognitive control.
Plewnia C, Schroeder PA, Wolkenstein L., Lancet Psychiatry 2(4), 2015
PMID: 26360088
Keep calm and carry on: improved frustration tolerance and processing speed by transcranial direct current stimulation (tDCS).
Plewnia C, Schroeder PA, Kunze R, Faehling F, Wolkenstein L., PLoS One 10(4), 2015
PMID: 25837520
Modulating human sense of agency with non-invasive brain stimulation.
Khalighinejad N, Haggard P., Cortex 69(), 2015
PMID: 26004997
Short-Term Memory Impairment and Left Dorsolateral Prefrontal Cortex Dysfunction in the Orthostatic Position: A Single Case Study of Sinking Skin Flap Syndrome.
Sebastianelli L, Stoll V, Versace V, Martignago S, Obletter S, Lavoriero M, Malfertheiner K, Gisser G, Saltuari L., Case Rep Neurol Med 2015(), 2015
PMID: 26600956
Language and Memory Improvements following tDCS of Left Lateral Prefrontal Cortex.
Hussey EK, Ward N, Christianson K, Kramer AF., PLoS One 10(11), 2015
PMID: 26528814
'Forget me (not)?' - Remembering Forget-Items Versus Un-Cued Items in Directed Forgetting.
Zwissler B, Schindler S, Fischer H, Plewnia C, Kissler JM., Front Psychol 6(), 2015
PMID: 26635657
Emotional Distraction and Bodily Reaction: Modulation of Autonomous Responses by Anodal tDCS to the Prefrontal Cortex.
Schroeder PA, Ehlis AC, Wolkenstein L, Fallgatter AJ, Plewnia C., Front Cell Neurosci 9(), 2015
PMID: 26733808
Transcranial direct current stimulation for memory enhancement: from clinical research to animal models.
Bennabi D, Pedron S, Haffen E, Monnin J, Peterschmitt Y, Van Waes V., Front Syst Neurosci 8(), 2014
PMID: 25237299
Current science.
Machado A., Neuromodulation 17(7), 2014
PMID: 25413868

39 References

Daten bereitgestellt von Europe PubMed Central.

Direct current stimulation over V5 enhances visuomotor coordination by improving motion perception in humans.
Antal A, Nitsche MA, Kruse W, Kincses TZ, Hoffmann KP, Paulus W., J Cogn Neurosci 16(4), 2004
PMID: 15165345
Directed forgetting in implicit and explicit memory tests: a comparison of methods
Basden BH, Basden DR, Gargano GJ., 1993

Brainerd CJ, Reyna VF., 2005
Learning, memory, and transcranial direct current stimulation.
Brasil-Neto JP., Front Psychiatry 3(), 2012
PMID: 22969734
Test d2: Aufmerksamkeits-Belastungs-Test
Brickenkamp R., 1994
Noninvasive brain stimulation: from physiology to network dynamics and back.
Dayan E, Censor N, Buch ER, Sandrini M, Cohen LG., Nat. Neurosci. 16(7), 2013
PMID: 23799477
Enhancement of planning ability by transcranial direct current stimulation.
Dockery CA, Hueckel-Weng R, Birbaumer N, Plewnia C., J. Neurosci. 29(22), 2009
PMID: 19494149
Retrospective attention enhances visual working memory in the young but not the old: an ERP study.
Duarte A, Hearons P, Jiang Y, Delvin MC, Newsome RN, Verhaeghen P., Psychophysiology 50(5), 2013
PMID: 23445536
Top-down modulation: bridging selective attention and working memory.
Gazzaley A, Nobre AC., Trends Cogn. Sci. (Regul. Ed.) 16(2), 2011
PMID: 22209601
Effects of maintenance rehearsal on human memory
Greene RL., 1987
Directed forgetting of visual symbols: evidence for nonverbal selective rehearsal.
Hourihan KL, Ozubko JD, MacLeod CM., Mem Cognit 37(8), 2009
PMID: 19933451
tDCS polarity effects in motor and cognitive domains: a meta-analytical review.
Jacobson L, Koslowsky M, Lavidor M., Exp Brain Res 216(1), 2011
PMID: 21989847
Prefrontal hemodynamic activity predicts false memory--a near-infrared spectroscopy study.
Kubota Y, Toichi M, Shimizu M, Mason RA, Findling RL, Yamamoto K, Calabrese JR., Neuroimage 31(4), 2006
PMID: 16545964
Effects of transcranial electrical stimulation on cognition.
Kuo MF, Nitsche MA., Clin EEG Neurosci 43(3), 2012
PMID: 22956647
How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain?
Lang N, Siebner HR, Ward NS, Lee L, Nitsche MA, Paulus W, Rothwell JC, Lemon RN, Frackowiak RS., Eur. J. Neurosci. 22(2), 2005
PMID: 16045502
Modelling non-invasive brain stimulation in cognitive neuroscience.
Miniussi C, Harris JA, Ruzzoli M., Neurosci Biobehav Rev 37(8), 2013
PMID: 23827785
The assessment and analysis of handedness: the Edinburgh inventory.
Oldfield RC., Neuropsychologia 9(1), 1971
PMID: 5146491
The impact of stress on neutral and emotional aspects of episodic memory.
Payne JD, Jackson ED, Ryan L, Hoscheidt S, Jacobs JW, Nadel L., Memory 14(1), 2006
PMID: 16423737
Lie-specific involvement of dorsolateral prefrontal cortex in deception.
Priori A, Mameli F, Cogiamanian F, Marceglia S, Tiriticco M, Mrakic-Sposta S, Ferrucci R, Zago S, Polezzi D, Sartori G., Cereb. Cortex 18(2), 2007
PMID: 17584853
Comparing the brain areas supporting nondeclarative categorization and recognition memory.
Reber PJ, Wong EC, Buxton RB., Brain Res Cogn Brain Res 14(2), 2002
PMID: 12067697
Temporal dynamics of memory trace formation in the human prefrontal cortex.
Rossi S, Innocenti I, Polizzotto NR, Feurra M, De Capua A, Ulivelli M, Bartalini S, Cappa SF., Cereb. Cortex 21(2), 2010
PMID: 20530217
The cognitive neuroscience of constructive memory: remembering the past and imagining the future.
Schacter DL, Addis DR., Philos. Trans. R. Soc. Lond., B, Biol. Sci. 362(1481), 2007
PMID: 17395575
The cognitive neuroscience of memory distortion.
Schacter DL, Slotnick SD., Neuron 44(1), 2004
PMID: 15450167
Forgetting as an active process: an FMRI investigation of item-method-directed forgetting.
Wylie GR, Foxe JJ, Taylor TL., Cereb. Cortex 18(3), 2007
PMID: 17617657
Acute psycho-social stress does not disrupt item-method directed forgetting, emotional stimulus content does.
Zwissler B, Koessler S, Engler H, Schedlowski M, Kissler J., Neurobiol Learn Mem 95(3), 2011
PMID: 21295148


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