Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis
Mba'ning BM, Lenta BN, Noungoue DT, Antheaume C, Fongang YF, Ngouela SA, Boyom FF, Rosenthal PJ, Tsamo E, Sewald N, Laatsch H (2013)
Phytochemistry 96: 347-352.
Zeitschriftenaufsatz
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Autor*in
Mba'ning, Brice M.;
Lenta, Bruno N.;
Noungoue, Diderot T.;
Antheaume, Cyril;
Fongang, Yanick F.;
Ngouela, Silvere A.;
Boyom, Fabrice F.;
Rosenthal, Philip J.;
Tsamo, Etienne;
Sewald, NorbertUniBi 
;
Laatsch, Hartmut
;
Laatsch, HartmutEinrichtung
Abstract / Bemerkung
Phytochemical investigation of the seeds of Salacia longipes var. camerunensis led to the isolation of four sesquiterpenoid derivatives, salaterpene A (1) (1 alpha,2 beta,8 beta-triacetoxy-6 beta,9 beta-dibenzoyloxy-4 beta-hydroxy-dihydro-beta-agarofuran), salaterpene B (2) (1 alpha,2 beta,8 beta-triacetoxy-9 beta-benzoyloxy-6 beta-cinnamoyloxy-4 beta-hydroxy-dihydro-beta-agarofuran), salaterpene C (3) (1 alpha,2 beta-diacetoxy-6 beta,9 beta-dibenzoyloxy-4 beta-hydroxy-dihydro-beta-agarofuran) and salaterpene D (4) (2 beta-acetoxy-1 alpha,6 beta-dibenzoyloxy-4 beta-hydroxy-9 beta-nicotinoyloxy-dihydro-beta-agarofuran) together with two known compounds (5 and 6). The structures of the compounds were established by means of NMR spectroscopy. Compounds 1-4 and 6 were tested in vitro for their antiplasmodial activity against Plasmodium falciparum chloroquine-resistant strain W2. All the tested compounds exhibited a moderate potency with IC50 below 2.7 mu M. (C) 2013 Elsevier Ltd. All rights reserved.
Stichworte
Antiplasmodial activity;
Salaterpenes A-D;
Sesquiterpenes;
Salacia longipes;
Celastraceae
Erscheinungsjahr
2013
Zeitschriftentitel
Phytochemistry
Band
96
Seite(n)
347-352
ISSN
0031-9422
Page URI
https://pub.uni-bielefeld.de/record/2653706
Zitieren
Mba'ning BM, Lenta BN, Noungoue DT, et al. Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis. Phytochemistry. 2013;96:347-352.
Mba'ning, B. M., Lenta, B. N., Noungoue, D. T., Antheaume, C., Fongang, Y. F., Ngouela, S. A., Boyom, F. F., et al. (2013). Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis. Phytochemistry, 96, 347-352. doi:10.1016/j.phytochem.2013.06.022
Mba'ning, Brice M., Lenta, Bruno N., Noungoue, Diderot T., Antheaume, Cyril, Fongang, Yanick F., Ngouela, Silvere A., Boyom, Fabrice F., et al. 2013. “Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis”. Phytochemistry 96: 347-352.
Mba'ning, B. M., Lenta, B. N., Noungoue, D. T., Antheaume, C., Fongang, Y. F., Ngouela, S. A., Boyom, F. F., Rosenthal, P. J., Tsamo, E., Sewald, N., et al. (2013). Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis. Phytochemistry 96, 347-352.
Mba'ning, B.M., et al., 2013. Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis. Phytochemistry, 96, p 347-352.
B.M. Mba'ning, et al., “Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis”, Phytochemistry, vol. 96, 2013, pp. 347-352.
Mba'ning, B.M., Lenta, B.N., Noungoue, D.T., Antheaume, C., Fongang, Y.F., Ngouela, S.A., Boyom, F.F., Rosenthal, P.J., Tsamo, E., Sewald, N., Laatsch, H.: Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis. Phytochemistry. 96, 347-352 (2013).
Mba'ning, Brice M., Lenta, Bruno N., Noungoue, Diderot T., Antheaume, Cyril, Fongang, Yanick F., Ngouela, Silvere A., Boyom, Fabrice F., Rosenthal, Philip J., Tsamo, Etienne, Sewald, Norbert, and Laatsch, Hartmut. “Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis”. Phytochemistry 96 (2013): 347-352.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
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Daten bereitgestellt von Europe PubMed Central.
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PMID: 30823439
Wibowo M, Forster PI, Guymer GP, Hofmann A, Davis RA., Molecules 24(5), 2019
PMID: 30823439
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PMID: 29726465
Paz C, Heydenreich M, Schmidt B, Vadra N, Baggio R., Acta Crystallogr C Struct Chem 74(pt 5), 2018
PMID: 29726465
Compounds from Terminalia mantaly L. (Combretaceae) Stem Bark Exhibit Potent Inhibition against Some Pathogenic Yeasts and Enzymes of Metabolic Significance.
Tchuente Tchuenmogne MA, Kammalac TN, Gohlke S, Kouipou RMT, Aslan A, Kuzu M, Comakli V, Demirdag R, Ngouela SA, Tsamo E, Sewald N, Lenta BN, Boyom FF., Medicines (Basel) 4(1), 2017
PMID: 28930221
Tchuente Tchuenmogne MA, Kammalac TN, Gohlke S, Kouipou RMT, Aslan A, Kuzu M, Comakli V, Demirdag R, Ngouela SA, Tsamo E, Sewald N, Lenta BN, Boyom FF., Medicines (Basel) 4(1), 2017
PMID: 28930221
A dihydro-β-agarofuran sesquiterpene from Maytenus boaria.
Paz C, von Dossow D, Tiznado V, Suarez S, Cukiernik FD, Baggio R., Acta Crystallogr C Struct Chem 73(pt 6), 2017
PMID: 28579566
Paz C, von Dossow D, Tiznado V, Suarez S, Cukiernik FD, Baggio R., Acta Crystallogr C Struct Chem 73(pt 6), 2017
PMID: 28579566
24 References
Daten bereitgestellt von Europe PubMed Central.
Übersicht Über Die Celastraceen Inhalstsstoffe: Chemie, Chemotaxonomie, Biosynthese, Pharmakologie
Brüning, Phytochemistry 17(), 1978
Brüning, Phytochemistry 17(), 1978
Cytotoxic dihydroagarofuranoid sesquiterpenes from the stem of Microtropis fokienensis.
Chen JJ, Chou TH, Duh CY, Chen IS., J. Nat. Prod. 69(4), 2006
PMID: 16643054
Chen JJ, Chou TH, Duh CY, Chen IS., J. Nat. Prod. 69(4), 2006
PMID: 16643054
Antitubercular dihydroagarofuranoid sesquiterpenes from the roots of Microtropis fokienensis.
Chen JJ, Chou TH, Peng CF, Chen IS, Yang SZ., J. Nat. Prod. 70(2), 2007
PMID: 17315960
Chen JJ, Chou TH, Peng CF, Chen IS, Yang SZ., J. Nat. Prod. 70(2), 2007
PMID: 17315960
Dihydroagarofuranoid sesquiterpenes, a lignan derivative, a benzenoid, and antitubercular constituents from the stem of Microtropis japonica.
Chen JJ, Yang CS, Peng CF, Chen IS, Miaw CL., J. Nat. Prod. 71(6), 2008
PMID: 18471021
Chen JJ, Yang CS, Peng CF, Chen IS, Miaw CL., J. Nat. Prod. 71(6), 2008
PMID: 18471021
Plants used in traditional medicine in eastern Tanzania. II. Angiosperms (Capparidaceae to Ebenaceae).
Chhabra SC, Mahunnah RL, Mshiu EN., J Ethnopharmacol 25(3), 1989
PMID: 2664355
Chhabra SC, Mahunnah RL, Mshiu EN., J Ethnopharmacol 25(3), 1989
PMID: 2664355
A new dihydroagarofuranoid sesquiterpene from Microtropis fokienensis with antituberculosis activity
Chou, Chem. Biodiversity 4(), 2007
Chou, Chem. Biodiversity 4(), 2007
Novel sesquiterpene esters with alkaloid and monoterpene and related compounds from Tripterygium hypoglaucum. A new class of potent anti-HIV agents
Duan, Tetrahedron Lett. 40(), 1999
Duan, Tetrahedron Lett. 40(), 1999
The dihydro-beta-agarofuran sesquiterpenoids.
Gao JM, Wu WJ, Zhang JW, Konishi Y., Nat Prod Rep 24(5), 2007
PMID: 17898902
Gao JM, Wu WJ, Zhang JW, Konishi Y., Nat Prod Rep 24(5), 2007
PMID: 17898902
Screening Tanzanian medicinal plants for antimalarial activity.
Gessler MC, Nkunya MH, Mwasumbi LB, Heinrich M, Tanner M., Acta Trop. 56(1), 1994
PMID: 8203297
Gessler MC, Nkunya MH, Mwasumbi LB, Heinrich M, Tanner M., Acta Trop. 56(1), 1994
PMID: 8203297
Minor sesquiterpenes from Maytenus chubutensis.
Gonzalez AG, Nunez MP, Ravelo AG, Luis JG, Jimenez IA, Munoz OM., J. Nat. Prod. 53(2), 1990
PMID: 2380720
Gonzalez AG, Nunez MP, Ravelo AG, Luis JG, Jimenez IA, Munoz OM., J. Nat. Prod. 53(2), 1990
PMID: 2380720
Minor sesquiterpenes from Maytenus magellanzca
González, J. Nat. Prod. 56(), 1993
González, J. Nat. Prod. 56(), 1993
Anti-tumor promoting effects of sesquiterpenes from Maytenus cuzcoina (Celastraceae).
Gonzalez AG, Tincusi BM, Bazzocchi IL, Tokuda H, Nishino H, Konoshima T, Jimenez IA, Ravelo AG., Bioorg. Med. Chem. 8(7), 2000
PMID: 10976526
Gonzalez AG, Tincusi BM, Bazzocchi IL, Tokuda H, Nishino H, Konoshima T, Jimenez IA, Ravelo AG., Bioorg. Med. Chem. 8(7), 2000
PMID: 10976526
Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production.
Jin HZ, Hwang BY, Kim HS, Lee JH, Kim YH, Lee JJ., J. Nat. Prod. 65(1), 2002
PMID: 11809076
Jin HZ, Hwang BY, Kim HS, Lee JH, Kim YH, Lee JJ., J. Nat. Prod. 65(1), 2002
PMID: 11809076
Chemosensitization of a multidrug-resistant Leishmania tropica line by new sesquiterpenes from Maytenus magellanica and Maytenus chubutensis.
Kennedy ML, Cortes-Selva F, Perez-Victoria JM, Jimenez IA, Gonzalez AG, Munoz OM, Gamarro F, Castanys S, Ravelo AG., J. Med. Chem. 44(26), 2001
PMID: 11741484
Kennedy ML, Cortes-Selva F, Perez-Victoria JM, Jimenez IA, Gonzalez AG, Munoz OM, Gamarro F, Castanys S, Ravelo AG., J. Med. Chem. 44(26), 2001
PMID: 11741484
Two new macrolide sesquiterpene pyridine alkaloids from Maytenus emarginata: emarginatine G and the cytotoxic emarginatine F.
Kuo YH, King ML, Chen CF, Chen HY, Chen CH, Chen K, Lee KH., J. Nat. Prod. 57(2), 1994
PMID: 8176403
Kuo YH, King ML, Chen CF, Chen HY, Chen CH, Chen K, Lee KH., J. Nat. Prod. 57(2), 1994
PMID: 8176403
Synchronization of Plasmodium falciparum erythrocytic stages in culture
Lambros, J. Parasitology 65(), 1979
Lambros, J. Parasitology 65(), 1979
Reversion of human Pgp-dependent multidrug resistance by new sesquiterpenes from Zinowiewia costaricensis.
Munoz-Martinez F, Mendoza CR, Bazzocchi IL, Castanys S, Jimenez IA, Gamarro F., J. Med. Chem. 48(13), 2005
PMID: 15974580
Munoz-Martinez F, Mendoza CR, Bazzocchi IL, Castanys S, Jimenez IA, Gamarro F., J. Med. Chem. 48(13), 2005
PMID: 15974580
Comparison of efficacies of cysteine protease inhibitors against five strains of Plasmodium falciparum.
Singh A, Rosenthal PJ., Antimicrob. Agents Chemother. 45(3), 2001
PMID: 11181388
Singh A, Rosenthal PJ., Antimicrob. Agents Chemother. 45(3), 2001
PMID: 11181388
Celastraceae sesquiterpenoids: biological activity and synthesis.
Spivey AC, Weston M, Woodhead S., Chem Soc Rev 31(1), 2002
PMID: 12108982
Spivey AC, Weston M, Woodhead S., Chem Soc Rev 31(1), 2002
PMID: 12108982
Sesquiterpene esters from Tripterygium wilfordii
Takaishi, Phytochemistry 31(), 1992
Takaishi, Phytochemistry 31(), 1992
Inhibitory effects of dihydroagarofuran sesquiterpenes on Epstein-Barr virus activation.
Takaishi Y, Ujita K, Tokuda H, Nishino H, Iwashima A, Fujita T., Cancer Lett. 65(1), 1992
PMID: 1324784
Takaishi Y, Ujita K, Tokuda H, Nishino H, Iwashima A, Fujita T., Cancer Lett. 65(1), 1992
PMID: 1324784
Novel triterpenoids from Microtropis triflora with antitumor activities
Wang, Helv. Chim. Acta 90(), 2007
Wang, Helv. Chim. Acta 90(), 2007
Five new insecticidal sesquiterpenoids from Celastrus angulatus.
Wu W, Wang M, Zhu J, Zhou W, Hu Z, Ji Z., J. Nat. Prod. 64(3), 2001
PMID: 11277758
Wu W, Wang M, Zhu J, Zhou W, Hu Z, Ji Z., J. Nat. Prod. 64(3), 2001
PMID: 11277758
Immunosuppressive effects of wilfortrine andenonine
Zheng, Acta Pharm. Sin. 24(), 1989
Zheng, Acta Pharm. Sin. 24(), 1989
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