Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis
Mba'ning BM, Lenta BN, Noungoue DT, Antheaume C, Fongang YF, Ngouela SA, Boyom FF, Rosenthal PJ, Tsamo E, Sewald N, Laatsch H (2013)
Phytochemistry 96: 347-352.
Zeitschriftenaufsatz
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Autor*in
Mba'ning, Brice M.;
Lenta, Bruno N.;
Noungoue, Diderot T.;
Antheaume, Cyril;
Fongang, Yanick F.;
Ngouela, Silvere A.;
Boyom, Fabrice F.;
Rosenthal, Philip J.;
Tsamo, Etienne;
Sewald, NorbertUniBi 
;
Laatsch, Hartmut
;
Laatsch, HartmutEinrichtung
Abstract / Bemerkung
Phytochemical investigation of the seeds of Salacia longipes var. camerunensis led to the isolation of four sesquiterpenoid derivatives, salaterpene A (1) (1 alpha,2 beta,8 beta-triacetoxy-6 beta,9 beta-dibenzoyloxy-4 beta-hydroxy-dihydro-beta-agarofuran), salaterpene B (2) (1 alpha,2 beta,8 beta-triacetoxy-9 beta-benzoyloxy-6 beta-cinnamoyloxy-4 beta-hydroxy-dihydro-beta-agarofuran), salaterpene C (3) (1 alpha,2 beta-diacetoxy-6 beta,9 beta-dibenzoyloxy-4 beta-hydroxy-dihydro-beta-agarofuran) and salaterpene D (4) (2 beta-acetoxy-1 alpha,6 beta-dibenzoyloxy-4 beta-hydroxy-9 beta-nicotinoyloxy-dihydro-beta-agarofuran) together with two known compounds (5 and 6). The structures of the compounds were established by means of NMR spectroscopy. Compounds 1-4 and 6 were tested in vitro for their antiplasmodial activity against Plasmodium falciparum chloroquine-resistant strain W2. All the tested compounds exhibited a moderate potency with IC50 below 2.7 mu M. (C) 2013 Elsevier Ltd. All rights reserved.
Stichworte
Antiplasmodial activity;
Salaterpenes A-D;
Sesquiterpenes;
Salacia longipes;
Celastraceae
Erscheinungsjahr
2013
Zeitschriftentitel
Phytochemistry
Band
96
Seite(n)
347-352
ISSN
0031-9422
Page URI
https://pub.uni-bielefeld.de/record/2653706
Zitieren
Mba'ning BM, Lenta BN, Noungoue DT, et al. Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis. Phytochemistry. 2013;96:347-352.
Mba'ning, B. M., Lenta, B. N., Noungoue, D. T., Antheaume, C., Fongang, Y. F., Ngouela, S. A., Boyom, F. F., et al. (2013). Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis. Phytochemistry, 96, 347-352. doi:10.1016/j.phytochem.2013.06.022
Mba'ning, Brice M., Lenta, Bruno N., Noungoue, Diderot T., Antheaume, Cyril, Fongang, Yanick F., Ngouela, Silvere A., Boyom, Fabrice F., et al. 2013. “Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis”. Phytochemistry 96: 347-352.
Mba'ning, B. M., Lenta, B. N., Noungoue, D. T., Antheaume, C., Fongang, Y. F., Ngouela, S. A., Boyom, F. F., Rosenthal, P. J., Tsamo, E., Sewald, N., et al. (2013). Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis. Phytochemistry 96, 347-352.
Mba'ning, B.M., et al., 2013. Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis. Phytochemistry, 96, p 347-352.
B.M. Mba'ning, et al., “Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis”, Phytochemistry, vol. 96, 2013, pp. 347-352.
Mba'ning, B.M., Lenta, B.N., Noungoue, D.T., Antheaume, C., Fongang, Y.F., Ngouela, S.A., Boyom, F.F., Rosenthal, P.J., Tsamo, E., Sewald, N., Laatsch, H.: Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis. Phytochemistry. 96, 347-352 (2013).
Mba'ning, Brice M., Lenta, Bruno N., Noungoue, Diderot T., Antheaume, Cyril, Fongang, Yanick F., Ngouela, Silvere A., Boyom, Fabrice F., Rosenthal, Philip J., Tsamo, Etienne, Sewald, Norbert, and Laatsch, Hartmut. “Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis”. Phytochemistry 96 (2013): 347-352.
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