The Novel Desmin Mutant p.A120D Impairs Filament Formation, Prevents Intercalated Disk Localization, and Causes Sudden Cardiac Death
Brodehl A, Dieding M, Klauke B, Dec E, Madaan S, Huang T, Gargus J, Fatima A, Saric T, Cakar H, Walhorn V, et al. (2013)
Circulation: Cardiovascular Genetics 6(6): 615-623.
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Autor*in
Brodehl, Andreas;
Dieding, Mareike;
Klauke, Baerbel;
Dec, Eric;
Madaan, Shrestha;
Huang, Taosheng;
Gargus, John;
Fatima, Azra;
Saric, Tomo;
Cakar, Hamdin;
Walhorn, VolkerUniBi ;
Tönsing, KatjaUniBi
Alle
Alle
Abstract / Bemerkung
Background The intermediate filament protein desmin is encoded by the gene DES and contributes to the mechanical stabilization of the striated muscle sarcomere and cell contacts within the cardiac intercalated disk. DES mutations cause severe skeletal and cardiac muscle diseases with heterogeneous phenotypes. Recently, DES mutations were also found in patients with arrhythmogenic right ventricular cardiomyopathy. Currently, the cellular and molecular pathomechanisms of the DES mutations leading to this disease are not exactly known. Methods and Results We identified the 2 novel variants DES-p.A120D (c.359C>A) and DES-p.H326R (c.977A>G), which were characterized by cell culture experiments and atomic force microscopy. Family analysis indicated a broad spectrum of cardiomyopathies with a striking frequency of arrhythmias and sudden cardiac deaths. The in vitro experiments of desmin-p.A120D reveal a severe intrinsic filament formation defect causing cytoplasmic aggregates in cell lines and of the isolated recombinant protein. Model variants of codon 120 indicated that ionic interactions contribute to this filament formation defect. Ex vivo analysis of ventricular tissue slices revealed a loss of desmin staining within the intercalated disk and severe cytoplasmic aggregate formation, whereas z-band localization was not affected. The functional experiments of desmin-p.H326R did not demonstrate any differences from wild type. Conclusions Because of the functional in vivo and in vitro characterization, DES-p.A120D has to be regarded as a pathogenic mutation and DES-p.H326R as a rare variant with unknown significance. Presumably, the loss of the desmin-p. A120D filament localization at the intercalated disk explains its clinical arrhythmogenic potential.
Stichworte
desmin;
desmosomes;
sudden;
death;
cardiomyopathies;
arrhythmias;
cardiac;
intermediate filaments
Erscheinungsjahr
2013
Zeitschriftentitel
Circulation: Cardiovascular Genetics
Band
6
Ausgabe
6
Seite(n)
615-623
ISSN
1942-325X
eISSN
1942-3268
Page URI
https://pub.uni-bielefeld.de/record/2650833
Zitieren
Brodehl A, Dieding M, Klauke B, et al. The Novel Desmin Mutant p.A120D Impairs Filament Formation, Prevents Intercalated Disk Localization, and Causes Sudden Cardiac Death. Circulation: Cardiovascular Genetics. 2013;6(6):615-623.
Brodehl, A., Dieding, M., Klauke, B., Dec, E., Madaan, S., Huang, T., Gargus, J., et al. (2013). The Novel Desmin Mutant p.A120D Impairs Filament Formation, Prevents Intercalated Disk Localization, and Causes Sudden Cardiac Death. Circulation: Cardiovascular Genetics, 6(6), 615-623. doi:10.1161/CIRCGENETICS.113.000103
Brodehl, Andreas, Dieding, Mareike, Klauke, Baerbel, Dec, Eric, Madaan, Shrestha, Huang, Taosheng, Gargus, John, et al. 2013. “The Novel Desmin Mutant p.A120D Impairs Filament Formation, Prevents Intercalated Disk Localization, and Causes Sudden Cardiac Death”. Circulation: Cardiovascular Genetics 6 (6): 615-623.
Brodehl, A., Dieding, M., Klauke, B., Dec, E., Madaan, S., Huang, T., Gargus, J., Fatima, A., Saric, T., Cakar, H., et al. (2013). The Novel Desmin Mutant p.A120D Impairs Filament Formation, Prevents Intercalated Disk Localization, and Causes Sudden Cardiac Death. Circulation: Cardiovascular Genetics 6, 615-623.
Brodehl, A., et al., 2013. The Novel Desmin Mutant p.A120D Impairs Filament Formation, Prevents Intercalated Disk Localization, and Causes Sudden Cardiac Death. Circulation: Cardiovascular Genetics, 6(6), p 615-623.
A. Brodehl, et al., “The Novel Desmin Mutant p.A120D Impairs Filament Formation, Prevents Intercalated Disk Localization, and Causes Sudden Cardiac Death”, Circulation: Cardiovascular Genetics, vol. 6, 2013, pp. 615-623.
Brodehl, A., Dieding, M., Klauke, B., Dec, E., Madaan, S., Huang, T., Gargus, J., Fatima, A., Saric, T., Cakar, H., Walhorn, V., Tönsing, K., Skrzipczyk, T., Cebulla, R., Gerdes, D., Schulz, U., Gummert, J., Svendsen, J.H., Olesen, M.S., Anselmetti, D., Christensen, A.H., Kimonis, V., Milting, H.: The Novel Desmin Mutant p.A120D Impairs Filament Formation, Prevents Intercalated Disk Localization, and Causes Sudden Cardiac Death. Circulation: Cardiovascular Genetics. 6, 615-623 (2013).
Brodehl, Andreas, Dieding, Mareike, Klauke, Baerbel, Dec, Eric, Madaan, Shrestha, Huang, Taosheng, Gargus, John, Fatima, Azra, Saric, Tomo, Cakar, Hamdin, Walhorn, Volker, Tönsing, Katja, Skrzipczyk, Tim, Cebulla, Ramona, Gerdes, Desiree, Schulz, Uwe, Gummert, Jan, Svendsen, Jesper Hastrup, Olesen, Morten Salling, Anselmetti, Dario, Christensen, Alex Horby, Kimonis, Virginia, and Milting, Hendrik. “The Novel Desmin Mutant p.A120D Impairs Filament Formation, Prevents Intercalated Disk Localization, and Causes Sudden Cardiac Death”. Circulation: Cardiovascular Genetics 6.6 (2013): 615-623.
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cDNA FLJ61414, highly similar to Desmin (UNIPROT: B4DUI0)
Organism: Homo sapiens
Download in FASTA format
Organism: Homo sapiens
Download in FASTA format
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