An enzyme containing microemulsion based on skin friendly oil and surfactant as decontamination medium for organo phosphates: Phase behavior, structure, and enzyme activity

Stehle R, Schulreich C, Wellert S, Gaeb J, Blum M-M, Kehe K, Richardt A, Lapp A, Hellweg T (2014)
Journal Of Colloid And Interface Science 413: 127-132.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor/in
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Abstract / Bemerkung
The present contribution presents a microemulsion system containing cosmetic oil and sugar surfactant and the enzyme diisopropyl fluorophosphatase (DFPase) as active agent for the decontamination of human skin. The bicontinuous structure and the physical properties of the microemulsion are characterized by dynamic light scattering and small angle neutron scattering. The DFPase from the squid Loligo vulgaris is catalyzing the hydrolysis of highly toxic organophosphates. The effect of the enzyme on the structure of the microemulsion is investigated. Moreover, the enzyme/microemulsion system is also studied with respect to its activity using nuclear magnetic resonance spectroscopy leading to promising results. A fast decomposition of the nerve agent sarin is achieved. (C) 2013 Elsevier Inc. All rights reserved.
Stichworte
Decontamination; DFPase; Microemulsion; Dynamic light scattering; Small angle neutron scattering; GB; Protein
Erscheinungsjahr
2014
Zeitschriftentitel
Journal Of Colloid And Interface Science
Band
413
Seite(n)
127-132
ISSN
0021-9797
eISSN
1095-7103
Page URI
https://pub.uni-bielefeld.de/record/2645137

Zitieren

Stehle R, Schulreich C, Wellert S, et al. An enzyme containing microemulsion based on skin friendly oil and surfactant as decontamination medium for organo phosphates: Phase behavior, structure, and enzyme activity. Journal Of Colloid And Interface Science. 2014;413:127-132.
Stehle, R., Schulreich, C., Wellert, S., Gaeb, J., Blum, M. - M., Kehe, K., Richardt, A., et al. (2014). An enzyme containing microemulsion based on skin friendly oil and surfactant as decontamination medium for organo phosphates: Phase behavior, structure, and enzyme activity. Journal Of Colloid And Interface Science, 413, 127-132. doi:10.1016/jjcis.2013.09.027
Stehle, R., Schulreich, C., Wellert, S., Gaeb, J., Blum, M. - M., Kehe, K., Richardt, A., Lapp, A., and Hellweg, T. (2014). An enzyme containing microemulsion based on skin friendly oil and surfactant as decontamination medium for organo phosphates: Phase behavior, structure, and enzyme activity. Journal Of Colloid And Interface Science 413, 127-132.
Stehle, R., et al., 2014. An enzyme containing microemulsion based on skin friendly oil and surfactant as decontamination medium for organo phosphates: Phase behavior, structure, and enzyme activity. Journal Of Colloid And Interface Science, 413, p 127-132.
R. Stehle, et al., “An enzyme containing microemulsion based on skin friendly oil and surfactant as decontamination medium for organo phosphates: Phase behavior, structure, and enzyme activity”, Journal Of Colloid And Interface Science, vol. 413, 2014, pp. 127-132.
Stehle, R., Schulreich, C., Wellert, S., Gaeb, J., Blum, M.-M., Kehe, K., Richardt, A., Lapp, A., Hellweg, T.: An enzyme containing microemulsion based on skin friendly oil and surfactant as decontamination medium for organo phosphates: Phase behavior, structure, and enzyme activity. Journal Of Colloid And Interface Science. 413, 127-132 (2014).
Stehle, Ralf, Schulreich, Christoph, Wellert, Stefan, Gaeb, Jurgen, Blum, Marc-Michael, Kehe, Kai, Richardt, Andras, Lapp, Alain, and Hellweg, Thomas. “An enzyme containing microemulsion based on skin friendly oil and surfactant as decontamination medium for organo phosphates: Phase behavior, structure, and enzyme activity”. Journal Of Colloid And Interface Science 413 (2014): 127-132.

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