Production and glucosylation of C50 and C40 carotenoids by metabolically engineered Corynebacterium glutamicum
Heider S, Peters-Wendisch P, Netzer R, Stafnes M, Brautaset T, Wendisch VF (2014)
Applied Microbiology and Biotechnology 98(3): 1223-1235.
Zeitschriftenaufsatz
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Autor*in
Heider, SabineUniBi;
Peters-Wendisch, PetraUniBi;
Netzer, Roman;
Stafnes, Marit;
Brautaset, Trygve;
Wendisch, Volker F.UniBi
Einrichtung
Abstract / Bemerkung
The yellow-pigmented soil bacterium Corynebacterium glutamicum ATCC13032 is accumulating the cyclic C-50 carotenoid decaprenoxanthin and its glucosides. Carotenoid pathway engineering was previously shown to allow for efficient lycopene production. Here, engineering of C. glutamicum for production of endogenous decaprenoxanthin as well as of the heterologous C-50 carotenoids C.p.450 and sarcinaxanthin is described. Plasmid-borne overexpression of genes for lycopene cyclization and hydroxylation from C. glutamicum, Dietzia sp., and Micrococcus luteus, in a lycopene-producing platform strain constructed here, resulted in accumulation of these three C-50 carotenoids to concentrations of about 3-4 mg/g CDW. Chromosomal deletion of a putative carotenoid glycosyltransferase gene cg0730/crtX in these strains entailed production of non-glucosylated derivatives of decaprenoxanthin, C.p.450, and sarcinaxanthin, respectively. Upon introduction of glucosyltransferase genes from M. luteus, C. glutamicum, and Pantoea ananatis, these hydroxylated C-50 carotenoids were glucosylated. We here also demonstrate production of the C-40 carotenoids beta-carotene and zeaxanthin in recombinant C. glutamicum strains and co-expression of the P. ananatis crtX gene was used to obtain glucosylated zeaxanthin. Together, our results show that C. glutamicum is a potentially valuable host for production of a wide range of glucosylated C-40 and C-50 carotenoids.
Stichworte
Zeaxanthin;
beta-carotene;
Lycopene;
Sarcinaxanthin;
Decaprenoxanthin;
Glucosyltransferase;
crtX;
Corynebacterium glutamicum;
C-50 carotenoid production
Erscheinungsjahr
2014
Zeitschriftentitel
Applied Microbiology and Biotechnology
Band
98
Ausgabe
3
Seite(n)
1223-1235
ISSN
0175-7598
eISSN
1432-0614
Page URI
https://pub.uni-bielefeld.de/record/2632272
Zitieren
Heider S, Peters-Wendisch P, Netzer R, Stafnes M, Brautaset T, Wendisch VF. Production and glucosylation of C50 and C40 carotenoids by metabolically engineered Corynebacterium glutamicum. Applied Microbiology and Biotechnology. 2014;98(3):1223-1235.
Heider, S., Peters-Wendisch, P., Netzer, R., Stafnes, M., Brautaset, T., & Wendisch, V. F. (2014). Production and glucosylation of C50 and C40 carotenoids by metabolically engineered Corynebacterium glutamicum. Applied Microbiology and Biotechnology, 98(3), 1223-1235. doi:10.1007/s00253-013-5359-y
Heider, Sabine, Peters-Wendisch, Petra, Netzer, Roman, Stafnes, Marit, Brautaset, Trygve, and Wendisch, Volker F. 2014. “Production and glucosylation of C50 and C40 carotenoids by metabolically engineered Corynebacterium glutamicum”. Applied Microbiology and Biotechnology 98 (3): 1223-1235.
Heider, S., Peters-Wendisch, P., Netzer, R., Stafnes, M., Brautaset, T., and Wendisch, V. F. (2014). Production and glucosylation of C50 and C40 carotenoids by metabolically engineered Corynebacterium glutamicum. Applied Microbiology and Biotechnology 98, 1223-1235.
Heider, S., et al., 2014. Production and glucosylation of C50 and C40 carotenoids by metabolically engineered Corynebacterium glutamicum. Applied Microbiology and Biotechnology, 98(3), p 1223-1235.
S. Heider, et al., “Production and glucosylation of C50 and C40 carotenoids by metabolically engineered Corynebacterium glutamicum”, Applied Microbiology and Biotechnology, vol. 98, 2014, pp. 1223-1235.
Heider, S., Peters-Wendisch, P., Netzer, R., Stafnes, M., Brautaset, T., Wendisch, V.F.: Production and glucosylation of C50 and C40 carotenoids by metabolically engineered Corynebacterium glutamicum. Applied Microbiology and Biotechnology. 98, 1223-1235 (2014).
Heider, Sabine, Peters-Wendisch, Petra, Netzer, Roman, Stafnes, Marit, Brautaset, Trygve, and Wendisch, Volker F. “Production and glucosylation of C50 and C40 carotenoids by metabolically engineered Corynebacterium glutamicum”. Applied Microbiology and Biotechnology 98.3 (2014): 1223-1235.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
28 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
Carotenoids from heterotrophic bacteria isolated from Fildes Peninsula, King George Island, Antarctica.
Vila E, Hornero-Méndez D, Azziz G, Lareo C, Saravia V., Biotechnol Rep (Amst) 21(), 2019
PMID: 30705834
Vila E, Hornero-Méndez D, Azziz G, Lareo C, Saravia V., Biotechnol Rep (Amst) 21(), 2019
PMID: 30705834
Modular systems metabolic engineering enables balancing of relevant pathways for l-histidine production with Corynebacterium glutamicum.
Schwentner A, Feith A, Münch E, Stiefelmaier J, Lauer I, Favilli L, Massner C, Öhrlein J, Grund B, Hüser A, Takors R, Blombach B., Biotechnol Biofuels 12(), 2019
PMID: 30962820
Schwentner A, Feith A, Münch E, Stiefelmaier J, Lauer I, Favilli L, Massner C, Öhrlein J, Grund B, Hüser A, Takors R, Blombach B., Biotechnol Biofuels 12(), 2019
PMID: 30962820
Simple glycolipids of microbes: Chemistry, biological activity and metabolic engineering.
Abdel-Mawgoud AM, Stephanopoulos G., Synth Syst Biotechnol 3(1), 2018
PMID: 29911195
Abdel-Mawgoud AM, Stephanopoulos G., Synth Syst Biotechnol 3(1), 2018
PMID: 29911195
Patchoulol Production with Metabolically Engineered Corynebacterium glutamicum.
Henke NA, Wichmann J, Baier T, Frohwitter J, Lauersen KJ, Risse JM, Peters-Wendisch P, Kruse O, Wendisch VF., Genes (Basel) 9(4), 2018
PMID: 29673223
Henke NA, Wichmann J, Baier T, Frohwitter J, Lauersen KJ, Risse JM, Peters-Wendisch P, Kruse O, Wendisch VF., Genes (Basel) 9(4), 2018
PMID: 29673223
Methylglucosylation of aromatic amino and phenolic moieties of drug-like biosynthons by combinatorial biosynthesis.
Xie L, Zhang L, Wang C, Wang X, Xu YM, Yu H, Wu P, Li S, Han L, Gunatilaka AAL, Wei X, Lin M, Molnár I, Xu Y., Proc Natl Acad Sci U S A 115(22), 2018
PMID: 29760061
Xie L, Zhang L, Wang C, Wang X, Xu YM, Yu H, Wu P, Li S, Han L, Gunatilaka AAL, Wei X, Lin M, Molnár I, Xu Y., Proc Natl Acad Sci U S A 115(22), 2018
PMID: 29760061
Recent advances in metabolic engineering of Corynebacterium glutamicum for bioproduction of value-added aromatic chemicals and natural products.
Kogure T, Inui M., Appl Microbiol Biotechnol 102(20), 2018
PMID: 30109397
Kogure T, Inui M., Appl Microbiol Biotechnol 102(20), 2018
PMID: 30109397
Synthetic biology approaches to access renewable carbon source utilization in Corynebacterium glutamicum.
Zhao N, Qian L, Luo G, Zheng S., Appl Microbiol Biotechnol 102(22), 2018
PMID: 30218378
Zhao N, Qian L, Luo G, Zheng S., Appl Microbiol Biotechnol 102(22), 2018
PMID: 30218378
Progress in Microbial Carotenoids Production.
Saini RK, Keum YS., Indian J Microbiol 57(1), 2017
PMID: 28148991
Saini RK, Keum YS., Indian J Microbiol 57(1), 2017
PMID: 28148991
Overexpression of the primary sigma factor gene sigA improved carotenoid production by Corynebacterium glutamicum: Application to production of β-carotene and the non-native linear C50 carotenoid bisanhydrobacterioruberin.
Taniguchi H, Henke NA, Heider SAE, Wendisch VF., Metab Eng Commun 4(), 2017
PMID: 29142827
Taniguchi H, Henke NA, Heider SAE, Wendisch VF., Metab Eng Commun 4(), 2017
PMID: 29142827
Isoprenoid Pyrophosphate-Dependent Transcriptional Regulation of Carotenogenesis in Corynebacterium glutamicum.
Henke NA, Heider SAE, Hannibal S, Wendisch VF, Peters-Wendisch P., Front Microbiol 8(), 2017
PMID: 28484430
Henke NA, Heider SAE, Hannibal S, Wendisch VF, Peters-Wendisch P., Front Microbiol 8(), 2017
PMID: 28484430
Production of amino acids - Genetic and metabolic engineering approaches.
Lee JH, Wendisch VF., Bioresour Technol 245(pt b), 2017
PMID: 28552565
Lee JH, Wendisch VF., Bioresour Technol 245(pt b), 2017
PMID: 28552565
Synthetic biology approaches for the production of plant metabolites in unicellular organisms.
Moses T, Mehrshahi P, Smith AG, Goossens A., J Exp Bot 68(15), 2017
PMID: 28449101
Moses T, Mehrshahi P, Smith AG, Goossens A., J Exp Bot 68(15), 2017
PMID: 28449101
Production of the Marine Carotenoid Astaxanthin by Metabolically Engineered Corynebacterium glutamicum.
Henke NA, Heider SA, Peters-Wendisch P, Wendisch VF., Mar Drugs 14(7), 2016
PMID: 27376307
Henke NA, Heider SA, Peters-Wendisch P, Wendisch VF., Mar Drugs 14(7), 2016
PMID: 27376307
Corynebacterium glutamicum possesses β-N-acetylglucosaminidase.
Matano C, Kolkenbrock S, Hamer SN, Sgobba E, Moerschbacher BM, Wendisch VF., BMC Microbiol 16(1), 2016
PMID: 27492186
Matano C, Kolkenbrock S, Hamer SN, Sgobba E, Moerschbacher BM, Wendisch VF., BMC Microbiol 16(1), 2016
PMID: 27492186
Light-Controlled Cell Factories: Employing Photocaged Isopropyl-β-d-Thiogalactopyranoside for Light-Mediated Optimization of lac Promoter-Based Gene Expression and (+)-Valencene Biosynthesis in Corynebacterium glutamicum.
Binder D, Frohwitter J, Mahr R, Bier C, Grünberger A, Loeschcke A, Peters-Wendisch P, Kohlheyer D, Pietruszka J, Frunzke J, Jaeger KE, Wendisch VF, Drepper T., Appl Environ Microbiol 82(20), 2016
PMID: 27520809
Binder D, Frohwitter J, Mahr R, Bier C, Grünberger A, Loeschcke A, Peters-Wendisch P, Kohlheyer D, Pietruszka J, Frunzke J, Jaeger KE, Wendisch VF, Drepper T., Appl Environ Microbiol 82(20), 2016
PMID: 27520809
Metabolic engineering of an ATP-neutral Embden-Meyerhof-Parnas pathway in Corynebacterium glutamicum: growth restoration by an adaptive point mutation in NADH dehydrogenase.
Komati Reddy G, Lindner SN, Wendisch VF., Appl Environ Microbiol 81(6), 2015
PMID: 25576602
Komati Reddy G, Lindner SN, Wendisch VF., Appl Environ Microbiol 81(6), 2015
PMID: 25576602
Advanced biotechnology: metabolically engineered cells for the bio-based production of chemicals and fuels, materials, and health-care products.
Becker J, Wittmann C., Angew Chem Int Ed Engl 54(11), 2015
PMID: 25684732
Becker J, Wittmann C., Angew Chem Int Ed Engl 54(11), 2015
PMID: 25684732
Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica.
Yang Y, Yatsunami R, Ando A, Miyoko N, Fukui T, Takaichi S, Nakamura S., J Bacteriol 197(9), 2015
PMID: 25712483
Yang Y, Yatsunami R, Ando A, Miyoko N, Fukui T, Takaichi S, Nakamura S., J Bacteriol 197(9), 2015
PMID: 25712483
Engineering microbial cell factories: Metabolic engineering of Corynebacterium glutamicum with a focus on non-natural products.
Heider SA, Wendisch VF., Biotechnol J 10(8), 2015
PMID: 26216246
Heider SA, Wendisch VF., Biotechnol J 10(8), 2015
PMID: 26216246
Flux Balance Analysis Inspired Bioprocess Upgrading for Lycopene Production by a Metabolically Engineered Strain of Yarrowia lipolytica.
Nambou K, Jian X, Zhang X, Wei L, Lou J, Madzak C, Hua Q., Metabolites 5(4), 2015
PMID: 26703753
Nambou K, Jian X, Zhang X, Wei L, Lou J, Madzak C, Hua Q., Metabolites 5(4), 2015
PMID: 26703753
Production of the sesquiterpene (+)-valencene by metabolically engineered Corynebacterium glutamicum.
Frohwitter J, Heider SA, Peters-Wendisch P, Beekwilder J, Wendisch VF., J Biotechnol 191(), 2014
PMID: 24910970
Frohwitter J, Heider SA, Peters-Wendisch P, Beekwilder J, Wendisch VF., J Biotechnol 191(), 2014
PMID: 24910970
Microbial production of amino acids and derived chemicals: synthetic biology approaches to strain development.
Wendisch VF., Curr Opin Biotechnol 30(), 2014
PMID: 24922334
Wendisch VF., Curr Opin Biotechnol 30(), 2014
PMID: 24922334
Optimization of the IPP Precursor Supply for the Production of Lycopene, Decaprenoxanthin and Astaxanthin by Corynebacterium glutamicum.
Heider SA, Wolf N, Hofemeier A, Peters-Wendisch P, Wendisch VF., Front Bioeng Biotechnol 2(), 2014
PMID: 25191655
Heider SA, Wolf N, Hofemeier A, Peters-Wendisch P, Wendisch VF., Front Bioeng Biotechnol 2(), 2014
PMID: 25191655
The astaxanthin dideoxyglycoside biosynthesis pathway in Sphingomonas sp. PB304.
Kim SH, Kim JH, Lee BY, Lee PC., Appl Microbiol Biotechnol 98(24), 2014
PMID: 25193422
Kim SH, Kim JH, Lee BY, Lee PC., Appl Microbiol Biotechnol 98(24), 2014
PMID: 25193422
Synthetic biology and metabolic engineering for marine carotenoids: new opportunities and future prospects.
Wang C, Kim JH, Kim SW., Mar Drugs 12(9), 2014
PMID: 25233369
Wang C, Kim JH, Kim SW., Mar Drugs 12(9), 2014
PMID: 25233369
IdsA is the major geranylgeranyl pyrophosphate synthase involved in carotenogenesis in Corynebacterium glutamicum.
Heider SA, Peters-Wendisch P, Beekwilder J, Wendisch VF., FEBS J 281(21), 2014
PMID: 25181035
Heider SA, Peters-Wendisch P, Beekwilder J, Wendisch VF., FEBS J 281(21), 2014
PMID: 25181035
Production of carotenoids by Arthrobacter arilaitensis strains isolated from smear-ripened cheeses.
Sutthiwong N, Dufossé L., FEMS Microbiol Lett 360(2), 2014
PMID: 25236332
Sutthiwong N, Dufossé L., FEMS Microbiol Lett 360(2), 2014
PMID: 25236332
L-citrulline production by metabolically engineered Corynebacterium glutamicum from glucose and alternative carbon sources.
Eberhardt D, Jensen JV, Wendisch VF., AMB Express 4(1), 2014
PMID: 26267114
Eberhardt D, Jensen JV, Wendisch VF., AMB Express 4(1), 2014
PMID: 26267114
65 References
Daten bereitgestellt von Europe PubMed Central.
S, J Gen Appl Microbiol 13(), 1967
Basic local alignment search tool.
Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ., J. Mol. Biol. 215(3), 1990
PMID: 2231712
Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ., J. Mol. Biol. 215(3), 1990
PMID: 2231712
G, 2008
G, 2004
Characterization of bacterial beta-carotene 3,3'-hydroxylases, CrtZ, and P450 in astaxanthin biosynthetic pathway and adonirubin production by gene combination in Escherichia coli.
Choi SK, Matsuda S, Hoshino T, Peng X, Misawa N., Appl. Microbiol. Biotechnol. 72(6), 2006
PMID: 16614859
Choi SK, Matsuda S, Hoshino T, Peng X, Misawa N., Appl. Microbiol. Biotechnol. 72(6), 2006
PMID: 16614859
An evolving hierarchical family classification for glycosyltransferases.
Coutinho PM, Deleury E, Davies GJ, Henrissat B., J. Mol. Biol. 328(2), 2003
PMID: 12691742
Coutinho PM, Deleury E, Davies GJ, Henrissat B., J. Mol. Biol. 328(2), 2003
PMID: 12691742
From crude glycerol to carotenoids by using a Rhodotorula glutinis mutant
Cutzu R, Coi A, Rosso F, Bardi L, Ciani M, Budroni M, Zara G, Zara S, Mannazzu I., World J. Microbiol. Biotechnol. 29(6), 2013
PMID: IND500664511
Cutzu R, Coi A, Rosso F, Bardi L, Ciani M, Budroni M, Zara G, Zara S, Mannazzu I., World J. Microbiol. Biotechnol. 29(6), 2013
PMID: IND500664511
AUTHOR UNKNOWN, 0
L, 2005
Cloning, sequence analysis, expression, and inactivation of the Corynebacterium glutamicum icd gene encoding isocitrate dehydrogenase and biochemical characterization of the enzyme.
Eikmanns BJ, Rittmann D, Sahm H., J. Bacteriol. 177(3), 1995
PMID: 7836312
Eikmanns BJ, Rittmann D, Sahm H., J. Bacteriol. 177(3), 1995
PMID: 7836312
Enzymatic assembly of DNA molecules up to several hundred kilobases.
Gibson DG, Young L, Chuang RY, Venter JC, Hutchison CA 3rd, Smith HO., Nat. Methods 6(5), 2009
PMID: 19363495
Gibson DG, Young L, Chuang RY, Venter JC, Hutchison CA 3rd, Smith HO., Nat. Methods 6(5), 2009
PMID: 19363495
Amino acid production from rice straw and wheat bran hydrolysates by recombinant pentose-utilizing Corynebacterium glutamicum.
Gopinath V, Meiswinkel TM, Wendisch VF, Nampoothiri KM., Appl. Microbiol. Biotechnol. 92(5), 2011
PMID: 21796382
Gopinath V, Meiswinkel TM, Wendisch VF, Nampoothiri KM., Appl. Microbiol. Biotechnol. 92(5), 2011
PMID: 21796382
A new bioinformatics analysis tools framework at EMBL-EBI.
Goujon M, McWilliam H, Li W, Valentin F, Squizzato S, Paern J, Lopez R., Nucleic Acids Res. 38(Web Server issue), 2010
PMID: 20439314
Goujon M, McWilliam H, Li W, Valentin F, Squizzato S, Paern J, Lopez R., Nucleic Acids Res. 38(Web Server issue), 2010
PMID: 20439314
The biosynthetic pathway for myxol-2' fucoside (myxoxanthophyll) in the cyanobacterium Synechococcus sp. strain PCC 7002.
Graham JE, Bryant DA., J. Bacteriol. 191(10), 2009
PMID: 19304845
Graham JE, Bryant DA., J. Bacteriol. 191(10), 2009
PMID: 19304845
Studies on transformation of Escherichia coli with plasmids.
Hanahan D., J. Mol. Biol. 166(4), 1983
PMID: 6345791
Hanahan D., J. Mol. Biol. 166(4), 1983
PMID: 6345791
Carotenoid biosynthesis and overproduction in Corynebacterium glutamicum.
Heider SA, Peters-Wendisch P, Wendisch VF., BMC Microbiol. 12(), 2012
PMID: 22963379
Heider SA, Peters-Wendisch P, Wendisch VF., BMC Microbiol. 12(), 2012
PMID: 22963379
The isolation and description of two marine micro-organisms with special reference to their pigment production.
HODGKISS W, LISTON J, GOODWIN TW, JAMIKORN M., J. Gen. Microbiol. 11(3), 1954
PMID: 13221765
HODGKISS W, LISTON J, GOODWIN TW, JAMIKORN M., J. Gen. Microbiol. 11(3), 1954
PMID: 13221765
Functional assignment of Erwinia herbicola Eho10 carotenoid genes expressed in Escherichia coli.
Hundle B, Alberti M, Nievelstein V, Beyer P, Kleinig H, Armstrong GA, Burke DH, Hearst JE., Mol. Gen. Genet. 245(4), 1994
PMID: 7808389
Hundle B, Alberti M, Nievelstein V, Beyer P, Kleinig H, Armstrong GA, Burke DH, Hearst JE., Mol. Gen. Genet. 245(4), 1994
PMID: 7808389
Functional expression of zeaxanthin glucosyltransferase from Erwinia herbicola and a proposed uridine diphosphate binding site.
Hundle BS, O'Brien DA, Alberti M, Beyer P, Hearst JE., Proc. Natl. Acad. Sci. U.S.A. 89(19), 1992
PMID: 1409639
Hundle BS, O'Brien DA, Alberti M, Beyer P, Hearst JE., Proc. Natl. Acad. Sci. U.S.A. 89(19), 1992
PMID: 1409639
The chemistry of novel xanthophyll carotenoids.
Jackson H, Braun CL, Ernst H., Am. J. Cardiol. 101(10A), 2008
PMID: 18474275
Jackson H, Braun CL, Ernst H., Am. J. Cardiol. 101(10A), 2008
PMID: 18474275
Microbial carotenoids.
Johnson EA, Schroeder WA., Adv. Biochem. Eng. Biotechnol. 53(), 1996
PMID: 8578971
Johnson EA, Schroeder WA., Adv. Biochem. Eng. Biotechnol. 53(), 1996
PMID: 8578971
Expression and functional analysis of a gene cluster involved in the synthesis of decaprenoxanthin reveals the mechanisms for C50 carotenoid formation.
Krubasik P, Kobayashi M, Sandmann G., Eur. J. Biochem. 268(13), 2001
PMID: 11432736
Krubasik P, Kobayashi M, Sandmann G., Eur. J. Biochem. 268(13), 2001
PMID: 11432736
A carotenogenic gene cluster from Brevibacterium linens with novel lycopene cyclase genes involved in the synthesis of aromatic carotenoids.
Krubasik P, Sandmann G., Mol. Gen. Genet. 263(3), 2000
PMID: 10821176
Krubasik P, Sandmann G., Mol. Gen. Genet. 263(3), 2000
PMID: 10821176
Detailed biosynthetic pathway to decaprenoxanthin diglucoside in Corynebacterium glutamicum and identification of novel intermediates.
Krubasik P, Takaichi S, Maoka T, Kobayashi M, Masamoto K, Sandmann G., Arch. Microbiol. 176(3), 2001
PMID: 11511870
Krubasik P, Takaichi S, Maoka T, Kobayashi M, Masamoto K, Sandmann G., Arch. Microbiol. 176(3), 2001
PMID: 11511870
Continuous control of the flow in biochemical pathways through 5' untranslated region sequence modifications in mRNA expressed from the broad-host-range promoter Pm.
Lale R, Berg L, Stuttgen F, Netzer R, Stafsnes M, Brautaset T, Vee Aune TE, Valla S., Appl. Environ. Microbiol. 77(8), 2011
PMID: 21335387
Lale R, Berg L, Stuttgen F, Netzer R, Stafsnes M, Brautaset T, Vee Aune TE, Valla S., Appl. Environ. Microbiol. 77(8), 2011
PMID: 21335387
PC, Appl Microbiol Biotechnol 60(1–2), 2002
Two genes encoding new carotenoid-modifying enzymes in the green sulfur bacterium Chlorobium tepidum.
Maresca JA, Bryant DA., J. Bacteriol. 188(17), 2006
PMID: 16923888
Maresca JA, Bryant DA., J. Bacteriol. 188(17), 2006
PMID: 16923888
TM, Bioresour Technol (), 2013
AUTHOR UNKNOWN, 0
Antioxidant activities of carotenes and xanthophylls.
Miller NJ, Sampson J, Candeias LP, Bramley PM, Rice-Evans CA., FEBS Lett. 384(3), 1996
PMID: 8617362
Miller NJ, Sampson J, Candeias LP, Bramley PM, Rice-Evans CA., FEBS Lett. 384(3), 1996
PMID: 8617362
Elucidation of the Erwinia uredovora carotenoid biosynthetic pathway by functional analysis of gene products expressed in Escherichia coli.
Misawa N, Nakagawa M, Kobayashi K, Yamano S, Izawa Y, Nakamura K, Harashima K., J. Bacteriol. 172(12), 1990
PMID: 2254247
Misawa N, Nakagawa M, Kobayashi K, Yamano S, Izawa Y, Nakamura K, Harashima K., J. Bacteriol. 172(12), 1990
PMID: 2254247
Antioxidant activities of astaxanthin and related carotenoids.
Naguib YM., J. Agric. Food Chem. 48(4), 2000
PMID: 10775364
Naguib YM., J. Agric. Food Chem. 48(4), 2000
PMID: 10775364
Biosynthetic pathway for γ-cyclic sarcinaxanthin in Micrococcus luteus: heterologous expression and evidence for diverse and multiple catalytic functions of C(50) carotenoid cyclases.
Netzer R, Stafsnes MH, Andreassen T, Goksoyr A, Bruheim P, Brautaset T., J. Bacteriol. 192(21), 2010
PMID: 20802040
Netzer R, Stafsnes MH, Andreassen T, Goksoyr A, Bruheim P, Brautaset T., J. Bacteriol. 192(21), 2010
PMID: 20802040
Characterization and antioxidative activities of rare C(50) carotenoids-sarcinaxanthin, sarcinaxanthin monoglucoside, and sarcinaxanthin diglucoside-obtained from Micrococcus yunnanensis.
Osawa A, Ishii Y, Sasamura N, Morita M, Kasai H, Maoka T, Shindo K., J Oleo Sci 59(12), 2010
PMID: 21099143
Osawa A, Ishii Y, Sasamura N, Morita M, Kasai H, Maoka T, Shindo K., J Oleo Sci 59(12), 2010
PMID: 21099143
Structure and biosynthesis of staphyloxanthin from Staphylococcus aureus.
Pelz A, Wieland KP, Putzbach K, Hentschel P, Albert K, Gotz F., J. Biol. Chem. 280(37), 2005
PMID: 16020541
Pelz A, Wieland KP, Putzbach K, Hentschel P, Albert K, Gotz F., J. Biol. Chem. 280(37), 2005
PMID: 16020541
Pyruvate carboxylase is a major bottleneck for glutamate and lysine production by Corynebacterium glutamicum.
Peters-Wendisch PG, Schiel B, Wendisch VF, Katsoulidis E, Mockel B, Sahm H, Eikmanns BJ., J. Mol. Microbiol. Biotechnol. 3(2), 2001
PMID: 11321586
Peters-Wendisch PG, Schiel B, Wendisch VF, Katsoulidis E, Mockel B, Sahm H, Eikmanns BJ., J. Mol. Microbiol. Biotechnol. 3(2), 2001
PMID: 11321586
AUTHOR UNKNOWN, 0
The GeneOptimizer Algorithm: using a sliding window approach to cope with the vast sequence space in multiparameter DNA sequence optimization.
Raab D, Graf M, Notka F, Schodl T, Wagner R., Syst Synth Biol 4(3), 2010
PMID: 21189842
Raab D, Graf M, Notka F, Schodl T, Wagner R., Syst Synth Biol 4(3), 2010
PMID: 21189842
Carotenoid accumulation in bacteria with enhanced supply of isoprenoid precursors by upregulation of exogenous or endogenous pathways.
Rodriguez-Villalon A, Perez-Gil J, Rodriguez-Concepcion M., J. Biotechnol. 135(1), 2008
PMID: 18417238
Rodriguez-Villalon A, Perez-Gil J, Rodriguez-Concepcion M., J. Biotechnol. 135(1), 2008
PMID: 18417238
J, 2001
G, 2005
H, Appl Microbiol Biot 19(6), 1984
The ketonic carotenoid canthaxanthin isolated from a colour mutant of Corynebacterium michiganense.
SAPERSTEIN S, STARR MP., Biochem. J. 57(2), 1954
PMID: 13172179
SAPERSTEIN S, STARR MP., Biochem. J. 57(2), 1954
PMID: 13172179
Small mobilizable multi-purpose cloning vectors derived from the Escherichia coli plasmids pK18 and pK19: selection of defined deletions in the chromosome of Corynebacterium glutamicum.
Schafer A, Tauch A, Jager W, Kalinowski J, Thierbach G, Puhler A., Gene 145(1), 1994
PMID: 8045426
Schafer A, Tauch A, Jager W, Kalinowski J, Thierbach G, Puhler A., Gene 145(1), 1994
PMID: 8045426
T, Arch Microbiol 159(), 1993
Diversity of carotenoid synthesis gene clusters from environmental Enterobacteriaceae strains.
Sedkova N, Tao L, Rouviere PE, Cheng Q., Appl. Environ. Microbiol. 71(12), 2005
PMID: 16332796
Sedkova N, Tao L, Rouviere PE, Cheng Q., Appl. Environ. Microbiol. 71(12), 2005
PMID: 16332796
Utilization of soluble starch by a recombinant Corynebacterium glutamicum strain: growth and lysine production.
Seibold G, Auchter M, Berens S, Kalinowski J, Eikmanns BJ., J. Biotechnol. 124(2), 2006
PMID: 16488498
Seibold G, Auchter M, Berens S, Kalinowski J, Eikmanns BJ., J. Biotechnol. 124(2), 2006
PMID: 16488498
YB, J Microbiol Biotechn 19(12), 2009
Single-step production of polyhydroxybutyrate from starch by using α-amylase cell-surface displaying system of Corynebacterium glutamicum.
Song Y, Matsumoto K, Tanaka T, Kondo A, Taguchi S., J. Biosci. Bioeng. 115(1), 2012
PMID: 22959444
Song Y, Matsumoto K, Tanaka T, Kondo A, Taguchi S., J. Biosci. Bioeng. 115(1), 2012
PMID: 22959444
Characterization of a Corynebacterium glutamicum lactate utilization operon induced during temperature-triggered glutamate production.
Stansen C, Uy D, Delaunay S, Eggeling L, Goergen JL, Wendisch VF., Appl. Environ. Microbiol. 71(10), 2005
PMID: 16204505
Stansen C, Uy D, Delaunay S, Eggeling L, Goergen JL, Wendisch VF., Appl. Environ. Microbiol. 71(10), 2005
PMID: 16204505
Thiamine and the carotenoid pigments of Corynebacterium poinsettiae.
STARR MP, SAPERSTEIN S., Arch. Biochem. Biophys. 43(1), 1953
PMID: 13031671
STARR MP, SAPERSTEIN S., Arch. Biochem. Biophys. 43(1), 1953
PMID: 13031671
Carotenoids of Gemmatimonas aurantiaca (Gemmatimonadetes): identification of a novel carotenoid, deoxyoscillol 2-rhamnoside, and proposed biosynthetic pathway of oscillol 2,2'-dirhamnoside.
Takaichi S, Maoka T, Takasaki K, Hanada S., Microbiology (Reading, Engl.) 156(Pt 3), 2009
PMID: 19959572
Takaichi S, Maoka T, Takasaki K, Hanada S., Microbiology (Reading, Engl.) 156(Pt 3), 2009
PMID: 19959572
MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods.
Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S., Mol. Biol. Evol. 28(10), 2011
PMID: 21546353
Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S., Mol. Biol. Evol. 28(10), 2011
PMID: 21546353
Genes from a Dietzia sp. for synthesis of C40 and C50 beta-cyclic carotenoids.
Tao L, Yao H, Cheng Q., Gene 386(1-2), 2006
PMID: 17008032
Tao L, Yao H, Cheng Q., Gene 386(1-2), 2006
PMID: 17008032
Inactivation of Corynebacterium glutamicum NCgl0452 and the role of MgtA in the biosynthesis of a novel mannosylated glycolipid involved in lipomannan biosynthesis.
Tatituri RV, Illarionov PA, Dover LG, Nigou J, Gilleron M, Hitchen P, Krumbach K, Morris HR, Spencer N, Dell A, Eggeling L, Besra GS., J. Biol. Chem. 282(7), 2006
PMID: 17179146
Tatituri RV, Illarionov PA, Dover LG, Nigou J, Gilleron M, Hitchen P, Krumbach K, Morris HR, Spencer N, Dell A, Eggeling L, Besra GS., J. Biol. Chem. 282(7), 2006
PMID: 17179146
Biosynthesis of novel carotenoid families based on unnatural carbon backbones: a model for diversification of natural product pathways.
Tobias AV, Arnold FH., Biochim. Biophys. Acta 1761(2), 2006
PMID: 16478677
Tobias AV, Arnold FH., Biochim. Biophys. Acta 1761(2), 2006
PMID: 16478677
Glutamate production from β-glucan using endoglucanase-secreting Corynebacterium glutamicum.
Tsuchidate T, Tateno T, Okai N, Tanaka T, Ogino C, Kondo A., Appl. Microbiol. Biotechnol. 90(3), 2011
PMID: 21305281
Tsuchidate T, Tateno T, Okai N, Tanaka T, Ogino C, Kondo A., Appl. Microbiol. Biotechnol. 90(3), 2011
PMID: 21305281
Glucosamine as carbon source for amino acid-producing Corynebacterium glutamicum.
Uhde A, Youn JW, Maeda T, Clermont L, Matano C, Kramer R, Wendisch VF, Seibold GM, Marin K., Appl. Microbiol. Biotechnol. 97(4), 2012
PMID: 22854894
Uhde A, Youn JW, Maeda T, Clermont L, Matano C, Kramer R, Wendisch VF, Seibold GM, Marin K., Appl. Microbiol. Biotechnol. 97(4), 2012
PMID: 22854894
A heat shock following electroporation induces highly efficient transformation of Corynebacterium glutamicum with xenogeneic plasmid DNA.
van der Rest ME, Lange C, Molenaar D., Appl. Microbiol. Biotechnol. 52(4), 1999
PMID: 10570802
van der Rest ME, Lange C, Molenaar D., Appl. Microbiol. Biotechnol. 52(4), 1999
PMID: 10570802
Biological functions of carotenoids--diversity and evolution.
Vershinin A., Biofactors 10(2-3), 1999
PMID: 10609869
Vershinin A., Biofactors 10(2-3), 1999
PMID: 10609869
High-level production of beta-carotene in Saccharomyces cerevisiae by successive transformation with carotenogenic genes from Xanthophyllomyces dendrorhous.
Verwaal R, Wang J, Meijnen JP, Visser H, Sandmann G, van den Berg JA, van Ooyen AJ., Appl. Environ. Microbiol. 73(13), 2007
PMID: 17496128
Verwaal R, Wang J, Meijnen JP, Visser H, Sandmann G, van den Berg JA, van Ooyen AJ., Appl. Environ. Microbiol. 73(13), 2007
PMID: 17496128
Pathway engineering strategies for production of beneficial carotenoids in microbial hosts.
Ye VM, Bhatia SK., Biotechnol. Lett. 34(8), 2012
PMID: 22488437
Ye VM, Bhatia SK., Biotechnol. Lett. 34(8), 2012
PMID: 22488437
A, Tetrahedron Lett 39(22), 1998
Just-in-time transcription program in metabolic pathways.
Zaslaver A, Mayo AE, Rosenberg R, Bashkin P, Sberro H, Tsalyuk M, Surette MG, Alon U., Nat. Genet. 36(5), 2004
PMID: 15107854
Zaslaver A, Mayo AE, Rosenberg R, Bashkin P, Sberro H, Tsalyuk M, Surette MG, Alon U., Nat. Genet. 36(5), 2004
PMID: 15107854
Engineering central metabolic modules of Escherichia coli for improving β-carotene production.
Zhao J, Li Q, Sun T, Zhu X, Xu H, Tang J, Zhang X, Ma Y., Metab. Eng. 17(), 2013
PMID: 23500001
Zhao J, Li Q, Sun T, Zhu X, Xu H, Tang J, Zhang X, Ma Y., Metab. Eng. 17(), 2013
PMID: 23500001
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