In silico prediction of conserved vaccine targets in Streptococcus agalactiae strains isolated from fish, cattle, and human samples

Pereira, U. P.; Soares, S. C.; Blom, J.; Leal, C. A. G.; Ramos, R. T. J.; Guimarães, L. C.; Oliveira, L. C.; Almeida, S. S.; Hassan, S. S.; Santos, A. R.; Miyoshi, A.; Silva, A.; Tauch, Andreas; Barh, D.; Azevedo, V.; Figueiredo, H. C. P.

In silico prediction of conserved vaccine targets in Streptococcus agalactiae strains isolated from fish, cattle, and human samples

Pereira UP, Soares SC, Blom J, Leal CAG, Ramos RTJ, Guimarães LC, Oliveira LC, Almeida SS, Hassan SS, Santos AR, Miyoshi A, et al. (2013)
Genetics and molecular research : GMR 12(3): 2902-2912.

Zeitschriftenaufsatz | Veröffentlicht | Englisch

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DOI

https://doi.org/10.4238/2013.August.12.6

Autor*in

Pereira, U. P.; Soares, S. C.; Blom, J.; Leal, C. A. G.; Ramos, R. T. J.; Guimarães, L. C.; Oliveira, L. C.; Almeida, S. S.; Hassan, S. S.; Santos, A. R.; Miyoshi, A.; Silva, A.
Alle

Einrichtung

Centrum für Biotechnologie > Arbeitsgruppe A. Tauch

Abstract / Bemerkung

Streptococcus agalactiae (Lancefield group B; group B streptococci) is a major pathogen that causes meningoencephalitis in fish, mastitis in cows, and neonatal sepsis and meningitis in humans. The available prophylactic measures for conserving human and animal health are not totally effective and have limitations. Effective vaccines against the different serotypes or genotypes of pathogenic strains from the various hosts would be useful. We used an in silico strategy to identify conserved vaccine candidates in 15 genomes of group B streptococci strains isolated from human, bovine, and fish samples. The degree of conservation, subcellular localization, and immunogenic potential of S. agalactiae proteins were investigated. We identified 36 antigenic proteins that were conserved in all 15 genomes. Among these proteins, 5 and 23 were shared only by human or fish strains, respectively. These potential vaccine targets may help develop effective vaccines that will help prevent S. agalactiae infection.

Erscheinungsjahr

2013

Zeitschriftentitel

Genetics and molecular research : GMR

Band

Ausgabe

Seite(n)

2902-2912

ISSN

1676-5680

eISSN

1676-5680

Page URI

https://pub.uni-bielefeld.de/record/2632081

Zitieren

Pereira UP, Soares SC, Blom J, et al. In silico prediction of conserved vaccine targets in Streptococcus agalactiae strains isolated from fish, cattle, and human samples. Genetics and molecular research : GMR. 2013;12(3):2902-2912.

Pereira, U. P., Soares, S. C., Blom, J., Leal, C. A. G., Ramos, R. T. J., Guimarães, L. C., Oliveira, L. C., et al. (2013). In silico prediction of conserved vaccine targets in Streptococcus agalactiae strains isolated from fish, cattle, and human samples. Genetics and molecular research : GMR, 12(3), 2902-2912. https://doi.org/10.4238/2013.August.12.6

Pereira, U. P., Soares, S. C., Blom, J., Leal, C. A. G., Ramos, R. T. J., Guimarães, L. C., Oliveira, L. C., et al. 2013. “In silico prediction of conserved vaccine targets in Streptococcus agalactiae strains isolated from fish, cattle, and human samples”. Genetics and molecular research : GMR 12 (3): 2902-2912.

Pereira, U. P., Soares, S. C., Blom, J., Leal, C. A. G., Ramos, R. T. J., Guimarães, L. C., Oliveira, L. C., Almeida, S. S., Hassan, S. S., Santos, A. R., et al. (2013). In silico prediction of conserved vaccine targets in Streptococcus agalactiae strains isolated from fish, cattle, and human samples. Genetics and molecular research : GMR 12, 2902-2912.

Pereira, U.P., et al., 2013. In silico prediction of conserved vaccine targets in Streptococcus agalactiae strains isolated from fish, cattle, and human samples. Genetics and molecular research : GMR, 12(3), p 2902-2912.

U.P. Pereira, et al., “In silico prediction of conserved vaccine targets in Streptococcus agalactiae strains isolated from fish, cattle, and human samples”, Genetics and molecular research : GMR, vol. 12, 2013, pp. 2902-2912.

Pereira, U.P., Soares, S.C., Blom, J., Leal, C.A.G., Ramos, R.T.J., Guimarães, L.C., Oliveira, L.C., Almeida, S.S., Hassan, S.S., Santos, A.R., Miyoshi, A., Silva, A., Tauch, A., Barh, D., Azevedo, V., Figueiredo, H.C.P.: In silico prediction of conserved vaccine targets in Streptococcus agalactiae strains isolated from fish, cattle, and human samples. Genetics and molecular research : GMR. 12, 2902-2912 (2013).

Pereira, U. P., Soares, S. C., Blom, J., Leal, C. A. G., Ramos, R. T. J., Guimarães, L. C., Oliveira, L. C., Almeida, S. S., Hassan, S. S., Santos, A. R., Miyoshi, A., Silva, A., Tauch, Andreas, Barh, D., Azevedo, V., and Figueiredo, H. C. P. “In silico prediction of conserved vaccine targets in Streptococcus agalactiae strains isolated from fish, cattle, and human samples”. Genetics and molecular research : GMR 12.3 (2013): 2902-2912.

Daten bereitgestellt von European Bioinformatics Institute (EBI)

7 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Delineation of the pan-proteome of fish-pathogenic Streptococcus agalactiae strains using a label-free shotgun approach.
Tavares GC, Pereira FL, Barony GM, Rezende CP, da Silva WM, de Souza GHMF, Verano-Braga T, de Carvalho Azevedo VA, Leal CAG, Figueiredo HCP., BMC Genomics 20(1), 2019
PMID: 30616502

Safety and immunogenicity of mammalian cell derived and Modified Vaccinia Ankara vectored African swine fever subunit antigens in swine.
Lopera-Madrid J, Osorio JE, He Y, Xiang Z, Adams LG, Laughlin RC, Mwangi W, Subramanya S, Neilan J, Brake D, Burrage TG, Brown WC, Clavijo A, Bounpheng MA., Vet Immunol Immunopathol 185(), 2017
PMID: 28241999

Development of a single-dose recombinant CAMP factor entrapping poly(lactide-co-glycolide) microspheres-based vaccine against Streptococcus agalactiae.
Liu G, Yin J, Barkema HW, Chen L, Shahid M, Szenci O, De Buck J, Kastelic JP, Han B., Vaccine 35(9), 2017
PMID: 28162819

Antibiotic Resistance Determinant-Focused Acinetobacter baumannii Vaccine Designed Using Reverse Vaccinology.
Ni Z, Chen Y, Ong E, He Y., Int J Mol Sci 18(2), 2017
PMID: 28230771

Complete Genome Sequence of Streptococcus agalactiae Strain S25 Isolated from Peritoneal Liquid of Nile Tilapia.
Mainardi RM, Lima Júnior EA, Ribeiro Júnior JC, Beloti V, Carmo AO, Kalapothakis E, Gonçalves DD, Padua SB, Pereira UP., Genome Announc 4(4), 2016
PMID: 27491974

Ontology-supported research on vaccine efficacy, safety and integrative biological networks.
He Y., Expert Rev Vaccines 13(7), 2014
PMID: 24909153

A recombinant truncated surface immunogenic protein (tSip) plus adjuvant FIA confers active protection against Group B streptococcus infection in tilapia.
He Y, Wang KY, Xiao D, Chen DF, Huang L, Liu T, Wang J, Geng Y, Wang EL, Yang Q., Vaccine 32(51), 2014
PMID: 25446833