Genome sequence of Corynebacterium pseudotuberculosis biovar equi strain 258 and prediction of antigenic targets to improve biotechnological vaccine production

Soares SC, Trost E, Ramos RTJ, Carneiro AR, Santos AR, Pinto AC, Barbosa E, Aburjaile F, Ali A, Diniz CAA, Hassan SS, et al. (2013)
Journal of Biotechnology 167(2): 135-141.

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Autor*in
Soares, Siomar C.; Trost, EvaUniBi ; Ramos, Rommel T. J.; Carneiro, Adriana R.; Santos, Anderson R.; Pinto, Anne C.; Barbosa, Eudes; Aburjaile, Flávia; Ali, Amjad; Diniz, Carlos A. A.; Hassan, Syed S.; Fiaux, Karina
Alle
Abstract / Bemerkung
Corynebacterium pseudotuberculosis is the causative agent of several veterinary diseases in a broad range of economically important hosts, which can vary from caseous lymphadenitis in sheep and goats (biovar ovis) to ulcerative lymphangitis in cattle and horses (biovar equi). Existing vaccines against C. pseudotuberculosis are mainly intended for small ruminants and, even in these hosts, they still present remarkable limitations. In this study, we present the complete genome sequence of C. pseudotuberculosis biovar equi strain 258, isolated from a horse with ulcerative lymphangitis. The genome has a total size of 2,314,404bp and contains 2088 predicted protein-coding regions. Using in silico analysis, eleven pathogenicity islands were detected in the genome sequence of C. pseudotuberculosis 258. The application of a reverse vaccinology strategy identified 49 putative antigenic proteins, which can be used as candidate vaccine targets in future works.
Erscheinungsjahr
2013
Zeitschriftentitel
Journal of Biotechnology
Band
167
Ausgabe
2
Seite(n)
135-141
ISSN
0168-1656
Page URI
https://pub.uni-bielefeld.de/record/2614869

Zitieren

Soares SC, Trost E, Ramos RTJ, et al. Genome sequence of Corynebacterium pseudotuberculosis biovar equi strain 258 and prediction of antigenic targets to improve biotechnological vaccine production. Journal of Biotechnology. 2013;167(2):135-141.
Soares, S. C., Trost, E., Ramos, R. T. J., Carneiro, A. R., Santos, A. R., Pinto, A. C., Barbosa, E., et al. (2013). Genome sequence of Corynebacterium pseudotuberculosis biovar equi strain 258 and prediction of antigenic targets to improve biotechnological vaccine production. Journal of Biotechnology, 167(2), 135-141. doi:10.1016/j.jbiotec.2012.11.003
Soares, Siomar C., Trost, Eva, Ramos, Rommel T. J., Carneiro, Adriana R., Santos, Anderson R., Pinto, Anne C., Barbosa, Eudes, et al. 2013. “Genome sequence of Corynebacterium pseudotuberculosis biovar equi strain 258 and prediction of antigenic targets to improve biotechnological vaccine production”. Journal of Biotechnology 167 (2): 135-141.
Soares, S. C., Trost, E., Ramos, R. T. J., Carneiro, A. R., Santos, A. R., Pinto, A. C., Barbosa, E., Aburjaile, F., Ali, A., Diniz, C. A. A., et al. (2013). Genome sequence of Corynebacterium pseudotuberculosis biovar equi strain 258 and prediction of antigenic targets to improve biotechnological vaccine production. Journal of Biotechnology 167, 135-141.
Soares, S.C., et al., 2013. Genome sequence of Corynebacterium pseudotuberculosis biovar equi strain 258 and prediction of antigenic targets to improve biotechnological vaccine production. Journal of Biotechnology, 167(2), p 135-141.
S.C. Soares, et al., “Genome sequence of Corynebacterium pseudotuberculosis biovar equi strain 258 and prediction of antigenic targets to improve biotechnological vaccine production”, Journal of Biotechnology, vol. 167, 2013, pp. 135-141.
Soares, S.C., Trost, E., Ramos, R.T.J., Carneiro, A.R., Santos, A.R., Pinto, A.C., Barbosa, E., Aburjaile, F., Ali, A., Diniz, C.A.A., Hassan, S.S., Fiaux, K., Guimarães, L.C., Bakhtiar, S.M., Pereira, U., Almeida, S.S., Abreu, V.A.C., Rocha, F.S., Dorella, F.A., Miyoshi, A., Silva, A., Azevedo, V., Tauch, A.: Genome sequence of Corynebacterium pseudotuberculosis biovar equi strain 258 and prediction of antigenic targets to improve biotechnological vaccine production. Journal of Biotechnology. 167, 135-141 (2013).
Soares, Siomar C., Trost, Eva, Ramos, Rommel T. J., Carneiro, Adriana R., Santos, Anderson R., Pinto, Anne C., Barbosa, Eudes, Aburjaile, Flávia, Ali, Amjad, Diniz, Carlos A. A., Hassan, Syed S., Fiaux, Karina, Guimarães, Luis C., Bakhtiar, Syeda M., Pereira, Ulisses, Almeida, Sintia S., Abreu, Vinícius A. C., Rocha, Flávia S., Dorella, Fernanda A., Miyoshi, Anderson, Silva, Artur, Azevedo, Vasco, and Tauch, Andreas. “Genome sequence of Corynebacterium pseudotuberculosis biovar equi strain 258 and prediction of antigenic targets to improve biotechnological vaccine production”. Journal of Biotechnology 167.2 (2013): 135-141.

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