Recent approaches for the synthesis of modified cryptophycins

Weiss C, Sammet B, Sewald N (2013)
Natural Product Reports 30(7): 924-940.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Autor/in
Abstract / Bemerkung
Cryptophycins are a family of antimitotic depsipeptides with very high cytotoxicity even against multi-drug resistant (MDR) cancer cells. The first representative was isolated from cyanobacteria Nostoc sp. in 1990. Their bioactivity is based on their interaction with the protein tubulin. Cryptophycins were found to induce apoptosis due to inhibition of the microtubule dynamics. Consequently, cryptophycin analogues are considered as potential antitumour agents. Retrosynthetically, cryptophycins can be subdivided into four building blocks, namely units A-D, to be assembled in the total synthesis. Since the discovery of this compound class, numerous synthetic analogues have been designed for structure-activity relationship (SAR) studies. This review gives a critical overview on cryptophycins, while the main focus lies on the synthetic challenges of recently published cryptophycins, together with emerging concepts on cryptophycin bioconjugation and prodrug design.
Erscheinungsjahr
2013
Zeitschriftentitel
Natural Product Reports
Band
30
Ausgabe
7
Seite(n)
924-940
ISSN
0265-0568
eISSN
1460-4752
Page URI
https://pub.uni-bielefeld.de/record/2613107

Zitieren

Weiss C, Sammet B, Sewald N. Recent approaches for the synthesis of modified cryptophycins. Natural Product Reports. 2013;30(7):924-940.
Weiss, C., Sammet, B., & Sewald, N. (2013). Recent approaches for the synthesis of modified cryptophycins. Natural Product Reports, 30(7), 924-940. doi:10.1039/c3np70022d
Weiss, C., Sammet, B., and Sewald, N. (2013). Recent approaches for the synthesis of modified cryptophycins. Natural Product Reports 30, 924-940.
Weiss, C., Sammet, B., & Sewald, N., 2013. Recent approaches for the synthesis of modified cryptophycins. Natural Product Reports, 30(7), p 924-940.
C. Weiss, B. Sammet, and N. Sewald, “Recent approaches for the synthesis of modified cryptophycins”, Natural Product Reports, vol. 30, 2013, pp. 924-940.
Weiss, C., Sammet, B., Sewald, N.: Recent approaches for the synthesis of modified cryptophycins. Natural Product Reports. 30, 924-940 (2013).
Weiss, Christine, Sammet, Benedikt, and Sewald, Norbert. “Recent approaches for the synthesis of modified cryptophycins”. Natural Product Reports 30.7 (2013): 924-940.

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 23732943
PubMed | Europe PMC

Suchen in

Google Scholar