HSulf sulfatases catalyze processive and oriented 6-O-desulfation of heparan sulfate that differentially regulates fibroblast growth factor activity

Seffouh A, Milz F, Przybylski C, Laguri C, Oosterhof A, Bourcier S, Sadir R, Dutkowski E, Daniel R, van Kuppevelt TH, Dierks T, et al. (2013)
The Faseb Journal 27(6): 2431-2439.

Zeitschriftenaufsatz | Veröffentlicht| Englisch
 
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Autor*in
Seffouh, Amal; Milz, FabianUniBi; Przybylski, Cedric; Laguri, Cedric; Oosterhof, Arie; Bourcier, Sebastien; Sadir, Rabia; Dutkowski, Elodie; Daniel, Regis; van Kuppevelt, Toin H.; Dierks, ThomasUniBi; Lortat-Jacob, Hugues
Alle
Abstract / Bemerkung
Sulfs are extracellular sulfatases that have emerged recently as critical regulators of heparan sulfate (HS) activities through their ability to catalyze specific 6-O-desulfation of the polysaccharide. Consequently, Sulfs have been involved in many physiological and pathological processes, and notably for Sulf-2, in the development of cancers with poor prognosis. Despite growing interest, little is known about the structure and activity of these enzymes and the way they induce dynamic remodeling of HS 6-O-sulfation status. Here, we have combined an array of analytical approaches, including mass spectrometry, NMR, HS oligosaccharide sequencing, and FACS, to dissect HSulf-2 sulfatase activity, either on a purified octasaccharide used as a mimic of HS functional domains, or on intact cell-surface HS chains. In parallel, we have studied the functional consequences of HSulf-2 activity on fibroblast growth factor (FGF)-induced mitogenesis and found that the enzyme could differentially regulate FGF1 and FGF2 activities. Notably, these data supported the existence of precise 6-O-sulfation patterns for FGF activation and provided new insights into the saccharide structures involved. Altogether, our data bring to light an original processive enzymatic mechanism, by which HSulfs catalyze oriented alteration of HS 6-O-desulfation patterns and direct fine and differential regulation of HS functions.-Seffouh, A., Milz, F., Przybylski, C., Laguri, C., Oosterhof, A., Bourcier, S., Sadir, R., Dutkowski, E., Daniel, R., van Kuppevelt, T. H., Dierks, T., Lortat-Jacob, H., Vives, R. R. HSulf sulfatases catalyze processive and oriented 6-O-desulfation of heparan sulfate that differentially regulates fibroblast growth factor activity.
Stichworte
glycosaminoglycan; enzymatic mechanism; structure/function relationships; interaction; proteoglycan
Erscheinungsjahr
2013
Zeitschriftentitel
The Faseb Journal
Band
27
Ausgabe
6
Seite(n)
2431-2439
ISSN
0892-6638
eISSN
1530-6860
Page URI
https://pub.uni-bielefeld.de/record/2612942

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Seffouh A, Milz F, Przybylski C, et al. HSulf sulfatases catalyze processive and oriented 6-O-desulfation of heparan sulfate that differentially regulates fibroblast growth factor activity. The Faseb Journal. 2013;27(6):2431-2439.
Seffouh, A., Milz, F., Przybylski, C., Laguri, C., Oosterhof, A., Bourcier, S., Sadir, R., et al. (2013). HSulf sulfatases catalyze processive and oriented 6-O-desulfation of heparan sulfate that differentially regulates fibroblast growth factor activity. The Faseb Journal, 27(6), 2431-2439. doi:10.1096/fj.12-226373
Seffouh, A., Milz, F., Przybylski, C., Laguri, C., Oosterhof, A., Bourcier, S., Sadir, R., Dutkowski, E., Daniel, R., van Kuppevelt, T. H., et al. (2013). HSulf sulfatases catalyze processive and oriented 6-O-desulfation of heparan sulfate that differentially regulates fibroblast growth factor activity. The Faseb Journal 27, 2431-2439.
Seffouh, A., et al., 2013. HSulf sulfatases catalyze processive and oriented 6-O-desulfation of heparan sulfate that differentially regulates fibroblast growth factor activity. The Faseb Journal, 27(6), p 2431-2439.
A. Seffouh, et al., “HSulf sulfatases catalyze processive and oriented 6-O-desulfation of heparan sulfate that differentially regulates fibroblast growth factor activity”, The Faseb Journal, vol. 27, 2013, pp. 2431-2439.
Seffouh, A., Milz, F., Przybylski, C., Laguri, C., Oosterhof, A., Bourcier, S., Sadir, R., Dutkowski, E., Daniel, R., van Kuppevelt, T.H., Dierks, T., Lortat-Jacob, H., Vives, R.R.: HSulf sulfatases catalyze processive and oriented 6-O-desulfation of heparan sulfate that differentially regulates fibroblast growth factor activity. The Faseb Journal. 27, 2431-2439 (2013).
Seffouh, Amal, Milz, Fabian, Przybylski, Cedric, Laguri, Cedric, Oosterhof, Arie, Bourcier, Sebastien, Sadir, Rabia, Dutkowski, Elodie, Daniel, Regis, van Kuppevelt, Toin H., Dierks, Thomas, Lortat-Jacob, Hugues, and Vives, Romain R. “HSulf sulfatases catalyze processive and oriented 6-O-desulfation of heparan sulfate that differentially regulates fibroblast growth factor activity”. The Faseb Journal 27.6 (2013): 2431-2439.

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