Modelling the hierarchical structure in datasets with very small clusters: a simulation study to explore the effect of the proportion of clusters when the outcome is continuous

Sauzet O, Wright KC, Marston L, Brocklehurst P, Peacock JL (2013)
Statistics In Medicine 32(8): 1429-1438.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
In cluster-randomised trials, the problem of non-independence within clusters is well known, and appropriate statistical analysis documented. Clusters typically seen in cluster trials are large in size and few in number, whereas datasets of preterm infants incorporate clusters of size two (twins), size three (triplets) and so on, with the majority of infants being in clusters' of size one. In such situations, it is unclear whether adjustment for clustering is needed or even possible. In this paper, we compared analyses allowing for clustering (linear mixed model) with analyses ignoring clustering (linear regression). Through simulations based on two real datasets, we explored estimation bias in predictors of a continuous outcome in different size datasets typical of preterm samples, with varying percentages of twins. Overall, the biases for estimated coefficients were similar for linear regression and mixed models, but the standard errors were consistently much less well estimated when using a linear model. Non-convergence was rare but was observed in approximately 5% of mixed models for samples below 200 and percentage of twins 2% or less. We conclude that in datasets with small clusters, mixed models should be the method of choice irrespective of the percentage of twins. If the mixed model does not converge, a linear regression can be fitted, but standard error will be underestimated, and so type I error may be inflated. Copyright (c) 2012 John Wiley & Sons, Ltd.
Stichworte
mixed model; non-independent data; small clusters; linear regression; simulations
Erscheinungsjahr
2013
Zeitschriftentitel
Statistics In Medicine
Band
32
Ausgabe
8
Seite(n)
1429-1438
ISSN
0277-6715
Page URI
https://pub.uni-bielefeld.de/record/2578314

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Sauzet O, Wright KC, Marston L, Brocklehurst P, Peacock JL. Modelling the hierarchical structure in datasets with very small clusters: a simulation study to explore the effect of the proportion of clusters when the outcome is continuous. Statistics In Medicine. 2013;32(8):1429-1438.
Sauzet, O., Wright, K. C., Marston, L., Brocklehurst, P., & Peacock, J. L. (2013). Modelling the hierarchical structure in datasets with very small clusters: a simulation study to explore the effect of the proportion of clusters when the outcome is continuous. Statistics In Medicine, 32(8), 1429-1438. doi:10.1002/sim.5638
Sauzet, O., Wright, K. C., Marston, L., Brocklehurst, P., and Peacock, J. L. (2013). Modelling the hierarchical structure in datasets with very small clusters: a simulation study to explore the effect of the proportion of clusters when the outcome is continuous. Statistics In Medicine 32, 1429-1438.
Sauzet, O., et al., 2013. Modelling the hierarchical structure in datasets with very small clusters: a simulation study to explore the effect of the proportion of clusters when the outcome is continuous. Statistics In Medicine, 32(8), p 1429-1438.
O. Sauzet, et al., “Modelling the hierarchical structure in datasets with very small clusters: a simulation study to explore the effect of the proportion of clusters when the outcome is continuous”, Statistics In Medicine, vol. 32, 2013, pp. 1429-1438.
Sauzet, O., Wright, K.C., Marston, L., Brocklehurst, P., Peacock, J.L.: Modelling the hierarchical structure in datasets with very small clusters: a simulation study to explore the effect of the proportion of clusters when the outcome is continuous. Statistics In Medicine. 32, 1429-1438 (2013).
Sauzet, Odile, Wright, K. C., Marston, L., Brocklehurst, P., and Peacock, J. L. “Modelling the hierarchical structure in datasets with very small clusters: a simulation study to explore the effect of the proportion of clusters when the outcome is continuous”. Statistics In Medicine 32.8 (2013): 1429-1438.

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