Yhh1p/Cft1p directly links poly(A) site recognition and RNA polymerase II transcription termination

Dichtl B, Blank D, Sadowski M, Hübner W, Weiser S, Keller W (2002)
The EMBO journal 21(15): 4125-4135.

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RNA polymerase II (pol II) transcription termination requires co-transcriptional recognition of a functional polyadenylation signal, but the molecular mechanisms that transduce this signal to pol II remain unclear. We show that Yhh1p/Cft1p, the yeast homologue of the mammalian AAUAAA interacting protein CPSF 160, is an RNA-binding protein and provide evidence that it participates in poly(A) site recognition. Interestingly, RNA binding is mediated by a central domain composed of predicted beta-propeller-forming repeats, which occurs in proteins of diverse cellular functions. We also found that Yhh1p/Cft1p bound specifically to the phosphorylated C-terminal domain (CTD) of pol II in vitro and in a two-hybrid test in vivo. Furthermore, transcriptional run-on analysis demonstrated that yhh1 mutants were defective in transcription termination, suggesting that Yhh1p/Cft1p functions in the coupling of transcription and 3'-end formation. We propose that direct interactions of Yhh1p/Cft1p with both the RNA transcript and the CTD are required to communicate poly(A) site recognition to elongating pol II to initiate transcription termination.
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The EMBO journal
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21
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15
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4125-4135
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Dichtl B, Blank D, Sadowski M, Hübner W, Weiser S, Keller W. Yhh1p/Cft1p directly links poly(A) site recognition and RNA polymerase II transcription termination. The EMBO journal. 2002;21(15):4125-4135.
Dichtl, B., Blank, D., Sadowski, M., Hübner, W., Weiser, S., & Keller, W. (2002). Yhh1p/Cft1p directly links poly(A) site recognition and RNA polymerase II transcription termination. The EMBO journal, 21(15), 4125-4135. doi:10.1093/emboj/cdf390
Dichtl, B., Blank, D., Sadowski, M., Hübner, W., Weiser, S., and Keller, W. (2002). Yhh1p/Cft1p directly links poly(A) site recognition and RNA polymerase II transcription termination. The EMBO journal 21, 4125-4135.
Dichtl, B., et al., 2002. Yhh1p/Cft1p directly links poly(A) site recognition and RNA polymerase II transcription termination. The EMBO journal, 21(15), p 4125-4135.
B. Dichtl, et al., “Yhh1p/Cft1p directly links poly(A) site recognition and RNA polymerase II transcription termination”, The EMBO journal, vol. 21, 2002, pp. 4125-4135.
Dichtl, B., Blank, D., Sadowski, M., Hübner, W., Weiser, S., Keller, W.: Yhh1p/Cft1p directly links poly(A) site recognition and RNA polymerase II transcription termination. The EMBO journal. 21, 4125-4135 (2002).
Dichtl, Bernhard, Blank, Diana, Sadowski, Martin, Hübner, Wolfgang, Weiser, Stefan, and Keller, Walter. “Yhh1p/Cft1p directly links poly(A) site recognition and RNA polymerase II transcription termination”. The EMBO journal 21.15 (2002): 4125-4135.

84 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Targeting the Polyadenylation Signal of Pre-mRNA: A New Gene Silencing Approach for Facioscapulohumeral Dystrophy.
Marsollier AC, Joubert R, Mariot V, Dumonceaux J., Int J Mol Sci 19(5), 2018
PMID: 29751519
Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma.
Ogorodnikov A, Levin M, Tattikota S, Tokalov S, Hoque M, Scherzinger D, Marini F, Poetsch A, Binder H, Macher-Göppinger S, Probst HC, Tian B, Schaefer M, Lackner KJ, Westermann F, Danckwardt S., Nat Commun 9(1), 2018
PMID: 30552333
Cleavage and polyadenylation: Ending the message expands gene regulation.
Neve J, Patel R, Wang Z, Louey A, Furger AM., RNA Biol 14(7), 2017
PMID: 28453393
Binding to RNA regulates Set1 function.
Luciano P, Jeon J, El-Kaoutari A, Challal D, Bonnet A, Barucco M, Candelli T, Jourquin F, Lesage P, Kim J, Libri D, Géli V., Cell Discov 3(), 2017
PMID: 29071121
The Nrd1-like protein Seb1 coordinates cotranscriptional 3' end processing and polyadenylation site selection.
Lemay JF, Marguerat S, Larochelle M, Liu X, van Nues R, Hunyadkürti J, Hoque M, Tian B, Granneman S, Bähler J, Bachand F., Genes Dev 30(13), 2016
PMID: 27401558
A unified model for yeast transcript definition.
de Boer CG, van Bakel H, Tsui K, Li J, Morris QD, Nislow C, Greenblatt JF, Hughes TR., Genome Res 24(1), 2014
PMID: 24170600
Delineating the structural blueprint of the pre-mRNA 3'-end processing machinery.
Xiang K, Tong L, Manley JL., Mol Cell Biol 34(11), 2014
PMID: 24591651
CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3' processing.
Chan SL, Huppertz I, Yao C, Weng L, Moresco JJ, Yates JR, Ule J, Manley JL, Shi Y., Genes Dev 28(21), 2014
PMID: 25301780
Reconstitution of CPSF active in polyadenylation: recognition of the polyadenylation signal by WDR33.
Schönemann L, Kühn U, Martin G, Schäfer P, Gruber AR, Keller W, Zavolan M, Wahle E., Genes Dev 28(21), 2014
PMID: 25301781
Disengaging polymerase: terminating RNA polymerase II transcription in budding yeast.
Mischo HE, Proudfoot NJ., Biochim Biophys Acta 1829(1), 2013
PMID: 23085255
Mutual relationships between transcription and pre-mRNA processing in the synthesis of mRNA.
Lenasi T, Barboric M., Wiley Interdiscip Rev RNA 4(2), 2013
PMID: 23184646
Srb5/Med18-mediated termination of transcription is dependent on gene looping.
Mukundan B, Ansari A., J Biol Chem 288(16), 2013
PMID: 23476016
Species-specific factors mediate extensive heterogeneity of mRNA 3' ends in yeasts.
Moqtaderi Z, Geisberg JV, Jin Y, Fan X, Struhl K., Proc Natl Acad Sci U S A 110(27), 2013
PMID: 23776204
DNA damage induces targeted, genome-wide variation of poly(A) sites in budding yeast.
Graber JH, Nazeer FI, Yeh PC, Kuehner JN, Borikar S, Hoskinson D, Moore CL., Genome Res 23(10), 2013
PMID: 23788651
Emerging roles for RNA polymerase II CTD in Arabidopsis.
Hajheidari M, Koncz C, Eick D., Trends Plant Sci 18(11), 2013
PMID: 23910452
mRNA quality control goes transcriptional.
Kilchert C, Vasiljeva L., Biochem Soc Trans 41(6), 2013
PMID: 24256272
The interaction of Pcf11 and Clp1 is needed for mRNA 3'-end formation and is modulated by amino acids in the ATP-binding site.
Ghazy MA, Gordon JM, Lee SD, Singh BN, Bohm A, Hampsey M, Moore C., Nucleic Acids Res 40(3), 2012
PMID: 21993299
Signals for pre-mRNA cleavage and polyadenylation.
Tian B, Graber JH., Wiley Interdiscip Rev RNA 3(3), 2012
PMID: 22012871
mRNA 3' end processing factors: a phylogenetic comparison.
Darmon SK, Lutz CS., Comp Funct Genomics 2012(), 2012
PMID: 22400011
Emerging Views on the CTD Code.
Zhang DW, Rodríguez-Molina JB, Tietjen JR, Nemec CM, Ansari AZ., Genet Res Int 2012(), 2012
PMID: 22567385
Gene-specific requirement of RNA polymerase II CTD phosphorylation.
Drogat J, Hermand D., Mol Microbiol 84(6), 2012
PMID: 22553990
The RNA polymerase II CTD coordinates transcription and RNA processing.
Hsin JP, Manley JL., Genes Dev 26(19), 2012
PMID: 23028141
Pre-mRNA 3'-end processing complex assembly and function.
Chan S, Choi EA, Shi Y., Wiley Interdiscip Rev RNA 2(3), 2011
PMID: 21957020
Unravelling the means to an end: RNA polymerase II transcription termination.
Kuehner JN, Pearson EL, Moore C., Nat Rev Mol Cell Biol 12(5), 2011
PMID: 21487437
Structural biology of poly(A) site definition.
Yang Q, Doublié S., Wiley Interdiscip Rev RNA 2(5), 2011
PMID: 21823232
Evidence for a complex of transcription factor IIB with poly(A) polymerase and cleavage factor 1 subunits required for gene looping.
Medler S, Al Husini N, Raghunayakula S, Mukundan B, Aldea A, Ansari A., J Biol Chem 286(39), 2011
PMID: 21835917
Molecular mechanisms of eukaryotic pre-mRNA 3' end processing regulation.
Millevoi S, Vagner S., Nucleic Acids Res 38(9), 2010
PMID: 20044349
Cordycepin interferes with 3' end formation in yeast independently of its potential to terminate RNA chain elongation.
Holbein S, Wengi A, Decourty L, Freimoser FM, Jacquier A, Dichtl B., RNA 15(5), 2009
PMID: 19324962
Transcription termination by nuclear RNA polymerases.
Richard P, Manley JL., Genes Dev 23(11), 2009
PMID: 19487567
How eukaryotic genes are transcribed.
Venters BJ, Pugh BF., Crit Rev Biochem Mol Biol 44(2-3), 2009
PMID: 19514890
Distinct roles of non-canonical poly(A) polymerases in RNA metabolism.
San Paolo S, Vanacova S, Schenk L, Scherrer T, Blank D, Keller W, Gerber AP., PLoS Genet 5(7), 2009
PMID: 19593367
Involvement of Pta1, Pcf11 and a KlCYC1 AU-rich element in alternative RNA 3'-end processing selection in yeast.
Seoane S, Lamas-Maceiras M, Rodríguez-Torres AM, Freire-Picos MA., FEBS Lett 583(17), 2009
PMID: 19646984
Protein factors in pre-mRNA 3'-end processing.
Mandel CR, Bai Y, Tong L., Cell Mol Life Sci 65(7-8), 2008
PMID: 18158581
Cracking the RNA polymerase II CTD code.
Egloff S, Murphy S., Trends Genet 24(6), 2008
PMID: 18457900
Genes involved in pre-mRNA 3'-end formation and transcription termination revealed by a lin-15 operon Muv suppressor screen.
Cui M, Allen MA, Larsen A, Macmorris M, Han M, Blumenthal T., Proc Natl Acad Sci U S A 105(43), 2008
PMID: 18946043
Coupling of transcription termination to RNAi.
Bahman Bahramian M., J Theor Biol 245(2), 2007
PMID: 17157879
Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factor.
Noble CG, Beuth B, Taylor IA., Nucleic Acids Res 35(1), 2007
PMID: 17151076
Crystal structure of murine CstF-77: dimeric association and implications for polyadenylation of mRNA precursors.
Bai Y, Auperin TC, Chou CY, Chang GG, Manley JL, Tong L., Mol Cell 25(6), 2007
PMID: 17386263
The poly(A)-dependent transcriptional pause is mediated by CPSF acting on the body of the polymerase.
Nag A, Narsinh K, Martinson HG., Nat Struct Mol Biol 14(7), 2007
PMID: 17572685
A subcomplex of RNA polymerase III subunits involved in transcription termination and reinitiation.
Landrieux E, Alic N, Ducrot C, Acker J, Riva M, Carles C., EMBO J 25(1), 2006
PMID: 16362040
The role of the Brr5/Ysh1 C-terminal domain and its homolog Syc1 in mRNA 3'-end processing in Saccharomyces cerevisiae.
Zhelkovsky A, Tacahashi Y, Nasser T, He X, Sterzer U, Jensen TH, Domdey H, Moore C., RNA 12(3), 2006
PMID: 16431986
Structural perspective on mutations affecting the function of multisubunit RNA polymerases.
Trinh V, Langelier MF, Archambault J, Coulombe B., Microbiol Mol Biol Rev 70(1), 2006
PMID: 16524917
Ddb1 controls genome stability and meiosis in fission yeast.
Holmberg C, Fleck O, Hansen HA, Liu C, Slaaby R, Carr AM, Nielsen O., Genes Dev 19(7), 2005
PMID: 15805471
Crosstalk between RNA metabolic pathways: an RNOMICS approach.
Beggs JD, Tollervey D., Nat Rev Mol Cell Biol 6(5), 2005
PMID: 15956981
Interdependence between transcription and mRNP processing and export, and its impact on genetic stability.
Luna R, Jimeno S, Marín M, Huertas P, García-Rubio M, Aguilera A., Mol Cell 18(6), 2005
PMID: 15949445
Entamoeba histolytica: comparative genomics of the pre-mRNA 3' end processing machinery.
López-Camarillo C, Orozco E, Marchat LA., Exp Parasitol 110(3), 2005
PMID: 15955310
The last CTD repeat of the mammalian RNA polymerase II large subunit is important for its stability.
Chapman RD, Palancade B, Lang A, Bensaude O, Eick D., Nucleic Acids Res 32(1), 2004
PMID: 14704341
Transitions in RNA polymerase II elongation complexes at the 3' ends of genes.
Kim M, Ahn SH, Krogan NJ, Greenblatt JF, Buratowski S., EMBO J 23(2), 2004
PMID: 14739930
Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase.
Kaufmann I, Martin G, Friedlein A, Langen H, Keller W., EMBO J 23(3), 2004
PMID: 14749727
Identification of factors regulating poly(A) tail synthesis and maturation.
Mangus DA, Smith MM, McSweeney JM, Jacobson A., Mol Cell Biol 24(10), 2004
PMID: 15121841
Molecular cloning and biochemical characterization of Candida albicans acyl-CoA:sterol acyltransferase, a potential target of antifungal agents.
Kim KY, Shin YK, Park JC, Kim JH, Yang H, Han DM, Paik YK., Biochem Biophys Res Commun 319(3), 2004
PMID: 15184069
Molecular biology: termination by torpedo.
Tollervey D., Nature 432(7016), 2004
PMID: 15565140
The C-terminal domain of pol II and a DRB-sensitive kinase are required for 3' processing of U2 snRNA.
Medlin JE, Uguen P, Taylor A, Bentley DL, Murphy S., EMBO J 22(4), 2003
PMID: 12574128
Functional interactions between the transcription and mRNA 3' end processing machineries mediated by Ssu72 and Sub1.
He X, Khan AU, Cheng H, Pappas DL, Hampsey M, Moore CL., Genes Dev 17(8), 2003
PMID: 12704082
Early formation of mRNP: license for export or quality control?
Jensen TH, Dower K, Libri D, Rosbash M., Mol Cell 11(5), 2003
PMID: 12769839
The role of the yeast cleavage and polyadenylation factor subunit Ydh1p/Cft2p in pre-mRNA 3'-end formation.
Kyburz A, Sadowski M, Dichtl B, Keller W., Nucleic Acids Res 31(14), 2003
PMID: 12853609
A neuronal isoform of the aplysia CPEB has prion-like properties.
Si K, Lindquist S, Kandel ER., Cell 115(7), 2003
PMID: 14697205
A role for SSU72 in balancing RNA polymerase II transcription elongation and termination.
Dichtl B, Blank D, Ohnacker M, Friedlein A, Roeder D, Langen H, Keller W., Mol Cell 10(5), 2002
PMID: 12453421
Polyadenylation: a tail of two complexes.
Proudfoot N, O'Sullivan J., Curr Biol 12(24), 2002
PMID: 12498707

44 References

Daten bereitgestellt von Europe PubMed Central.

Transcription factor TFIID recruits factor CPSF for formation of 3' end of mRNA.
Dantonel JC, Murthy KG, Manley JL, Tora L., Nature 389(6649), 1997
PMID: 9311784
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.
Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ., Nucleic Acids Res. 25(17), 1997
PMID: 9254694
5'-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II.
McCracken S, Fong N, Rosonina E, Yankulov K, Brothers G, Siderovski D, Hessel A, Foster S, Shuman S, Bentley DL., Genes Dev. 11(24), 1997
PMID: 9407024
Coupling termination of transcription to messenger RNA maturation in yeast.
Birse CE, Minvielle-Sebastia L, Lee BA, Keller W, Proudfoot NJ., Science 280(5361), 1998
PMID: 9535662
RNA polymerase II is an essential mRNA polyadenylation factor.
Hirose Y, Manley JL., Nature 395(6697), 1998
PMID: 9738505
Control of cleavage site selection during mRNA 3' end formation by a yeast hnRNP.
Minvielle-Sebastia L, Beyer K, Krecic AM, Hector RE, Swanson MS, Keller W., EMBO J. 17(24), 1998
PMID: 9857200
Genomic detection of new yeast pre-mRNA 3'-end-processing signals.
Graber JH, Cantor CR, Mohr SC, Smith TF., Nucleic Acids Res. 27(3), 1999
PMID: 9889288
The WD repeat: a common architecture for diverse functions.
Smith TF, Gaitatzes C, Saxena K, Neer EJ., Trends Biochem. Sci. 24(5), 1999
PMID: 10322433
Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155.
Das BK, Xia L, Palandjian L, Gozani O, Chyung Y, Reed R., Mol. Cell. Biol. 19(10), 1999
PMID: 10490618
Kin28, the TFIIH-associated carboxy-terminal domain kinase, facilitates the recruitment of mRNA processing machinery to RNA polymerase II.
Rodriguez CR, Cho EJ, Keogh MC, Moore CL, Greenleaf AL, Buratowski S., Mol. Cell. Biol. 20(1), 2000
PMID: 10594013
Statistical analysis of yeast genomic downstream sequences reveals putative polyadenylation signals.
van Helden J, del Olmo M, Perez-Ortin JE., Nucleic Acids Res. 28(4), 2000
PMID: 10648794
RNA polymerase II and the integration of nuclear events.
Hirose Y, Manley JL., Genes Dev. 14(12), 2000
PMID: 10859161
The ends of the affair: capping and polyadenylation.
Shatkin AJ, Manley JL., Nat. Struct. Biol. 7(10), 2000
PMID: 11017188
Transcriptional termination factors for RNA polymerase II in yeast.
Aranda A, Proudfoot N., Mol. Cell 7(5), 2001
PMID: 11389847
Mechanism of poly(A) signal transduction to RNA polymerase II in vitro.
Tran DP, Kim SJ, Park NJ, Jew TM, Martinson HG., Mol. Cell. Biol. 21(21), 2001
PMID: 11585929
Functional organization of the yeast proteome by systematic analysis of protein complexes.
Gavin AC, Bosche M, Krause R, Grandi P, Marzioch M, Bauer A, Schultz J, Rick JM, Michon AM, Cruciat CM, Remor M, Hofert C, Schelder M, Brajenovic M, Ruffner H, Merino A, Klein K, Hudak M, Dickson D, Rudi T, Gnau V, Bauch A, Bastuck S, Huhse B, Leutwein C, Heurtier MA, Copley RR, Edelmann A, Querfurth E, Rybin V, Drewes G, Raida M, Bouwmeester T, Bork P, Seraphin B, Kuster B, Neubauer G, Superti-Furga G., Nature 415(6868), 2002
PMID: 11805826
Integrating mRNA processing with transcription.
Proudfoot NJ, Furger A, Dye MJ., Cell 108(4), 2002
PMID: 11909521
Elevated recombination rates in transcriptionally active DNA.
Thomas BJ, Rothstein R., Cell 56(4), 1989
PMID: 2645056
How RNA polymerase II terminates transcription in higher eukaryotes.
Proudfoot NJ., Trends Biochem. Sci. 14(3), 1989
PMID: 2658217
Mammalian poly(A)-binding protein II. Physical properties and binding to polynucleotides.
Wahle E, Lustig A, Jeno P, Maurer P., J. Biol. Chem. 268(4), 1993
PMID: 8428968
A 127 kDa component of a UV-damaged DNA-binding complex, which is defective in some xeroderma pigmentosum group E patients, is homologous to a slime mold protein.
Takao M, Abramic M, Moos M Jr, Otrin VR, Wootton JC, McLenigan M, Levine AS, Protic M., Nucleic Acids Res. 21(17), 1993
PMID: 8371985
RNA14 and RNA15 proteins as components of a yeast pre-mRNA 3'-end processing factor.
Minvielle-Sebastia L, Preker PJ, Keller W., Science 266(5191), 1994
PMID: 7992054
The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins.
Yuryev A, Patturajan M, Litingtung Y, Joshi RV, Gentile C, Gebara M, Corden JL., Proc. Natl. Acad. Sci. U.S.A. 93(14), 1996
PMID: 8692929
The C-terminal domain of RNA polymerase II couples mRNA processing to transcription.
McCracken S, Fong N, Yankulov K, Ballantyne S, Pan G, Greenblatt J, Patterson SD, Wickens M, Bentley DL., Nature 385(6614), 1997
PMID: 9002523
Transcriptional termination signals for RNA polymerase II in fission yeast.
Birse CE, Lee BA, Hansen K, Proudfoot NJ., EMBO J. 16(12), 1997
PMID: 9218804
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.
Thompson JD, Gibson TJ, Plewniak F, Jeanmougin F, Higgins DG., Nucleic Acids Res. 25(24), 1997
PMID: 9396791

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