Chimeric HIV-1 containing SIV matrix exhibit enhanced assembly in murine cells and replicate in a cell-type-dependent manner in human T cells

Chen P, Hübner W, Riviere K, Liu Y-X, Chen BK (2006)
Virology 349(1): 1-12.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Chen, Ping; Hübner, WolfgangUniBi ; Riviere, Kareen; Liu, Yu-Xin; Chen, Benjamin K
Abstract / Bemerkung
Murine fibroblasts expressing viral receptors and human cyclin T1 allow HIV-1 entry and viral gene expression but do not support efficient assembly. A chimeric HIV-1 carrying a non-homologous matrix (MA) from murine leukemia virus in place of HIV-1 MA can assemble efficiently in murine cells, yet has poor infectivity. Here, we assess the ability of a homologous MA from SIV MAC239 to complement assembly and infection in chimeric viruses designated SHIV(MA). The resulting SHIV(MA) chimeras produce more virus than native HIV-1 when transfected into murine cells. SHIV(MA) exhibits cell-type-specific replication in human T cell lines, replicating well in MT4 cells and poorly in Jurkat cells due to an incompatibility with the HIV-1 Env. The infectivity defects of SHIV(MA) are rescued by pseudotyping with VSV-G but not by truncation of the cytoplasmic tail of Env. Passage of SHIV(MA) in Jurkat cells produces variants with improved Env incorporation and improved replication in Jurkat but not in 3T3 TXC cells. The results indicate that cell-type-specific, or species-specific, host factors interact with MA to modulate the efficiency of assembly and its compatibility with Env. With additional selection, SIV/HIV-1 chimeras may be useful for the development of murine models of lentiviral infection.
Stichworte
Simian immunodeficiency virus/physiology; Simian immunodeficiency virus/genetics; Sequence Deletion; Genetic; Recombination; Recombinant Proteins/genetics; Mice; Membrane Glycoproteins/physiology; Membrane Glycoproteins/metabolism; Humans; HIV-1/physiology; HIV-1/genetics; HIV Envelope Protein gp160/genetics; gag/genetics; Gene Products; Fibroblasts/virology; Cell Line; Biological; Adaptation; Animals; T-Lymphocytes/virology; Viral Envelope Proteins/metabolism; Viral Envelope Proteins/physiology; Viral Matrix Proteins/genetics; Virus Assembly/genetics; Virus Assembly/physiology; Virus Replication/genetics; Virus Replication/physiology
Erscheinungsjahr
2006
Zeitschriftentitel
Virology
Band
349
Ausgabe
1
Seite(n)
1-12
ISSN
0042-6822
Page URI
https://pub.uni-bielefeld.de/record/2576973

Zitieren

Chen P, Hübner W, Riviere K, Liu Y-X, Chen BK. Chimeric HIV-1 containing SIV matrix exhibit enhanced assembly in murine cells and replicate in a cell-type-dependent manner in human T cells. Virology. 2006;349(1):1-12.
Chen, P., Hübner, W., Riviere, K., Liu, Y. - X., & Chen, B. K. (2006). Chimeric HIV-1 containing SIV matrix exhibit enhanced assembly in murine cells and replicate in a cell-type-dependent manner in human T cells. Virology, 349(1), 1-12. doi:10.1016/j.virol.2006.02.022
Chen, Ping, Hübner, Wolfgang, Riviere, Kareen, Liu, Yu-Xin, and Chen, Benjamin K. 2006. “Chimeric HIV-1 containing SIV matrix exhibit enhanced assembly in murine cells and replicate in a cell-type-dependent manner in human T cells”. Virology 349 (1): 1-12.
Chen, P., Hübner, W., Riviere, K., Liu, Y. - X., and Chen, B. K. (2006). Chimeric HIV-1 containing SIV matrix exhibit enhanced assembly in murine cells and replicate in a cell-type-dependent manner in human T cells. Virology 349, 1-12.
Chen, P., et al., 2006. Chimeric HIV-1 containing SIV matrix exhibit enhanced assembly in murine cells and replicate in a cell-type-dependent manner in human T cells. Virology, 349(1), p 1-12.
P. Chen, et al., “Chimeric HIV-1 containing SIV matrix exhibit enhanced assembly in murine cells and replicate in a cell-type-dependent manner in human T cells”, Virology, vol. 349, 2006, pp. 1-12.
Chen, P., Hübner, W., Riviere, K., Liu, Y.-X., Chen, B.K.: Chimeric HIV-1 containing SIV matrix exhibit enhanced assembly in murine cells and replicate in a cell-type-dependent manner in human T cells. Virology. 349, 1-12 (2006).
Chen, Ping, Hübner, Wolfgang, Riviere, Kareen, Liu, Yu-Xin, and Chen, Benjamin K. “Chimeric HIV-1 containing SIV matrix exhibit enhanced assembly in murine cells and replicate in a cell-type-dependent manner in human T cells”. Virology 349.1 (2006): 1-12.

5 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

A novel self-replicating chimeric lentivirus-like particle.
Jurgens CK, Young KR, Madden VJ, Johnson PR, Johnston RE., J Virol 86(1), 2012
PMID: 22013035
Inability of human immunodeficiency virus type 1 produced in murine cells to selectively incorporate primer formula.
Wei M, Yang Y, Niu M, Desfosse L, Kennedy R, Musier-Forsyth K, Kleiman L., J Virol 82(24), 2008
PMID: 18842718

45 References

Daten bereitgestellt von Europe PubMed Central.

Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone.
Adachi A, Gendelman HE, Koenig S, Folks T, Willey R, Rabson A, Martin MA., J. Virol. 59(2), 1986
PMID: 3016298

AUTHOR UNKNOWN, 2003
Efficient assembly of an HIV-1/MLV Gag-chimeric virus in murine cells.
Chen BK, Rousso I, Shim S, Kim PS., Proc. Natl. Acad. Sci. U.S.A. 98(26), 2001
PMID: 11742097
AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly.
Dong X, Li H, Derdowski A, Ding L, Burnett A, Chen X, Peters TR, Dermody TS, Woodruff E, Wang JJ, Spearman P., Cell 120(5), 2005
PMID: 15766529
Single amino acid changes in the human immunodeficiency virus type 1 matrix protein block virus particle production.
Freed EO, Orenstein JM, Buckler-White AJ, Martin MA., J. Virol. 68(8), 1994
PMID: 8035531
The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein.
Garber ME, Wei P, KewalRamani VN, Mayall TP, Herrmann CH, Rice AP, Littman DR, Jones KA., Genes Dev. 12(22), 1998
PMID: 9832504
The matrix protein of HIV-1 is not sufficient for assembly and release of virus-like particles.
Giddings AM, Ritter GD Jr, Mulligan MJ., Virology 248(1), 1998
PMID: 9705260
Assembly of the matrix protein of simian immunodeficiency virus into virus-like particles.
Gonzalez SA, Affranchino JL, Gelderblom HR, Burny A., Virology 194(2), 1993
PMID: 8503172
Species-specific tropism determinants in the human immunodeficiency virus type 1 capsid.
Hatziioannou T, Cowan S, Von Schwedler UK, Sundquist WI, Bieniasz PD., J. Virol. 78(11), 2004
PMID: 15140998
Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: implications for membrane association and assembly.
Hill CP, Worthylake D, Bancroft DP, Christensen AM, Sundquist WI., Proc. Natl. Acad. Sci. U.S.A. 93(7), 1996
PMID: 8610175
Influence of gag on human immunodeficiency virus type 1 species-specific tropism.
Ikeda Y, Ylinen LM, Kahar-Bador M, Towers GJ., J. Virol. 78(21), 2004
PMID: 15479823
Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus.
Kestler H, Kodama T, Ringler D, Marthas M, Pedersen N, Lackner A, Regier D, Sehgal P, Daniel M, King N., Science 248(4959), 1990
PMID: 2160735
Significance of premature stop codons in env of simian immunodeficiency virus.
Kodama T, Wooley DP, Naidu YM, Kestler HW 3rd, Daniel MD, Li Y, Desrosiers RC., J. Virol. 63(11), 1989
PMID: 2795718
A single amino acid determinant governs the species-specific sensitivity of APOBEC3G to Vif action.
Mangeat B, Turelli P, Liao S, Trono D., J. Biol. Chem. 279(15), 2004
PMID: 14966139
A block to human immunodeficiency virus type 1 assembly in murine cells.
Mariani R, Rutter G, Harris ME, Hope TJ, Krausslich HG, Landau NR., J. Virol. 74(8), 2000
PMID: 10729160
Mouse-human heterokaryons support efficient human immunodeficiency virus type 1 assembly.
Mariani R, Rasala BA, Rutter G, Wiegers K, Brandt SM, Krausslich HG, Landau NR., J. Virol. 75(7), 2001
PMID: 11238841
Three-dimensional structure of the human immunodeficiency virus type 1 matrix protein.
Massiah MA, Starich MR, Paschall C, Summers MF, Christensen AM, Sundquist WI., J. Mol. Biol. 244(2), 1994
PMID: 7966331
Structural similarity between the p17 matrix protein of HIV-1 and interferon-gamma.
Matthews S, Barlow P, Boyd J, Barton G, Russell R, Mills H, Cunningham M, Meyers N, Burns N, Clark N., Nature 370(6491), 1994
PMID: 8065455
Dissociation of gp120 from HIV-1 virions induced by soluble CD4.
Moore JP, McKeating JA, Weiss RA, Sattentau QJ., Science 250(4984), 1990
PMID: 2251501
Primary human immunodeficiency virus type 2 (HIV-2) isolates, like HIV-1 isolates, frequently use CCR5 but show promiscuity in coreceptor usage.
Morner A, Bjorndal A, Albert J, Kewalramani VN, Littman DR, Inoue R, Thorstensson R, Fenyo EM, Bjorling E., J. Virol. 73(3), 1999
PMID: 9971817
A stable human-derived packaging cell line for production of high titer retrovirus/vesicular stomatitis virus G pseudotypes.
Ory DS, Neugeboren BA, Mulligan RC., Proc. Natl. Acad. Sci. U.S.A. 93(21), 1996
PMID: 8876147
UCSF Chimera--a visualization system for exploratory research and analysis.
Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, Meng EC, Ferrin TE., J Comput Chem 25(13), 2004
PMID: 15264254
Crystal structure of SIV matrix antigen and implications for virus assembly.
Rao Z, Belyaev AS, Fry E, Roy P, Jones IM, Stuart DI., Nature 378(6558), 1995
PMID: 7501025
Chimeric human immunodeficiency virus type 1 containing murine leukemia virus matrix assembles in murine cells.
Reed M, Mariani R, Sheppard L, Pekrun K, Landau NR, Soong NW., J. Virol. 76(1), 2002
PMID: 11739711
The complete nucleotide sequence of a pathogenic molecular clone of simian immunodeficiency virus.
Regier DA, Desrosiers RC., AIDS Res. Hum. Retroviruses 6(11), 1990
PMID: 2078405
Efficient HIV-1 replication can occur in the absence of the viral matrix protein.
Reil H, Bukovsky AA, Gelderblom HR, Gottlinger HG., EMBO J. 17(9), 1998
PMID: 9564051
A single amino acid of APOBEC3G controls its species-specific interaction with virion infectivity factor (Vif).
Schrofelbauer B, Chen D, Landau NR., Proc. Natl. Acad. Sci. U.S.A. 101(11), 2004
PMID: 14978281
Retroviral mRNA nuclear export elements regulate protein function and virion assembly.
Swanson CM, Puffer BA, Ahmad KM, Doms RW, Malim MH., EMBO J. 23(13), 2004
PMID: 15201866
Structure of the N-terminal 283-residue fragment of the immature HIV-1 Gag polyprotein.
Tang C, Ndassa Y, Summers MF., Nat. Struct. Biol. 9(7), 2002
PMID: 12032547
Entropic switch regulates myristate exposure in the HIV-1 matrix protein.
Tang C, Loeliger E, Luncsford P, Kinde I, Beckett D, Summers MF., Proc. Natl. Acad. Sci. U.S.A. 101(2), 2003
PMID: 14699046
Human p32 protein relieves a post-transcriptional block to HIV replication in murine cells.
Zheng YH, Yu HF, Peterlin BM., Nat. Cell Biol. 5(7), 2003
PMID: 12833064
Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®
Quellen

PMID: 16563454
PubMed | Europe PMC

Suchen in

Google Scholar