Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid

Furtado GC, Marinkovic T, Martin AP, Garin A, Hoch B, Hübner W, Chen BK, Genden E, Skobe M, Lira SA (2007)
Proceedings of the National Academy of Sciences of the United States of America 104(12): 5026-5031.

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DOI
Autor*in
Furtado, Glaucia C; Marinkovic, Tatjana; Martin, Andrea P; Garin, Alexandre; Hoch, Benjamin; Hübner, WolfgangUniBi ; Chen, Benjamin K; Genden, Eric; Skobe, Mihaela; Lira, Sergio A
Einrichtung
Fakultät für Physik > AG Biomolekulare Photonik
Abstract / Bemerkung
Infiltration of lymphocytes into the thyroid gland and formation of lymph node-like structures is a hallmark of Hashimoto's thyroiditis. Here we demonstrate that lymphatic vessels are present within these infiltrates. Mice overexpressing the chemokine CCL21 in the thyroid (TGCCL21 mice) developed similar lymphoid infiltrates and lymphatic vessels. TGCCL21 mice lacking mature T and B cells (RAGTGCCL21 mice) did not have cellular infiltrates or increased number of lymphatic vessels compared with controls. Transfer of CD3(+)CD4(+) T cells into RAGTGCCL21 mice promoted the development of LYVE-1(+)podoplanin(+)Prox-1(+) vessels in the thyroid. Genetic deletion of lymphotoxin beta receptor or lymphotoxin alpha abrogated development of lymphatic vessels in the inflamed areas in the thyroid but did not affect development of neighboring lymphatics. These results define a model for the study of inflammatory lymphangiogenesis in the thyroid and implicate lymphotoxin beta receptor signaling in this process.
Stichworte
Mice; Lymphotoxin-alpha/deficiency; CD4-Positive T-Lymphocytes/immunology; Animals; Chemokine CCL21; Cell Separation; Chemokines; CC/metabolism; Hashimoto Disease/immunology; Hashimoto Disease/pathology; Humans; Inflammation; Lymphangiogenesis/immunology; Lymphatic Vessels/immunology; Lymphatic Vessels/pathology; Lymphoid Tissue/immunology; Mice; Lymphoid Tissue/pathology; Lymphotoxin beta Receptor/metabolism; Lymphotoxin beta Receptor/deficiency; Transgenic; Signal Transduction; Thyroid Gland/immunology; Thyroid Gland/pathology
Erscheinungsjahr
2007
Zeitschriftentitel
Proceedings of the National Academy of Sciences of the United States of America
Band
104
Ausgabe
12
Seite(n)
5026-5031
ISSN
0027-8424
eISSN
1091-6490
Page URI
https://pub.uni-bielefeld.de/record/2576936

Zitieren

Furtado GC, Marinkovic T, Martin AP, et al. Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid. Proceedings of the National Academy of Sciences of the United States of America. 2007;104(12):5026-5031.
Furtado, G. C., Marinkovic, T., Martin, A. P., Garin, A., Hoch, B., Hübner, W., Chen, B. K., et al. (2007). Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid. Proceedings of the National Academy of Sciences of the United States of America, 104(12), 5026-5031. doi:10.1073/pnas.0606697104
Furtado, Glaucia C, Marinkovic, Tatjana, Martin, Andrea P, Garin, Alexandre, Hoch, Benjamin, Hübner, Wolfgang, Chen, Benjamin K, Genden, Eric, Skobe, Mihaela, and Lira, Sergio A. 2007. “Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid”. Proceedings of the National Academy of Sciences of the United States of America 104 (12): 5026-5031.
Furtado, G. C., Marinkovic, T., Martin, A. P., Garin, A., Hoch, B., Hübner, W., Chen, B. K., Genden, E., Skobe, M., and Lira, S. A. (2007). Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid. Proceedings of the National Academy of Sciences of the United States of America 104, 5026-5031.
Furtado, G.C., et al., 2007. Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid. Proceedings of the National Academy of Sciences of the United States of America, 104(12), p 5026-5031.
G.C. Furtado, et al., “Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid”, Proceedings of the National Academy of Sciences of the United States of America, vol. 104, 2007, pp. 5026-5031.
Furtado, G.C., Marinkovic, T., Martin, A.P., Garin, A., Hoch, B., Hübner, W., Chen, B.K., Genden, E., Skobe, M., Lira, S.A.: Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid. Proceedings of the National Academy of Sciences of the United States of America. 104, 5026-5031 (2007).
Furtado, Glaucia C, Marinkovic, Tatjana, Martin, Andrea P, Garin, Alexandre, Hoch, Benjamin, Hübner, Wolfgang, Chen, Benjamin K, Genden, Eric, Skobe, Mihaela, and Lira, Sergio A. “Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid”. Proceedings of the National Academy of Sciences of the United States of America 104.12 (2007): 5026-5031.

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