Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses

Chen P, Hübner W, Spinelli MA, Chen BK (2007)
Journal of virology 81(22): 12582-12595.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Chen, Ping; Hübner, WolfgangUniBi ; Spinelli, Matthew A; Chen, Benjamin K
Abstract / Bemerkung
Cell-free human immunodeficiency virus type 1 (HIV-1) can initiate infections, but contact between infected and uninfected T cells can enhance viral spread through intercellular structures called virological synapses (VS). The relative contribution of VS to cell-free viral transfer has not been carefully measured. Using an ultrasensitive, fluorescent virus transfer assay, we estimate that when VS between HIV-expressing Jurkat T cells and primary CD4(+) T cells are formed, cell-associated transfer of virus is 18,000-fold more efficient than uptake of cell-free virus. Furthermore, in contrast to cell-free virus uptake, the VS deposits virus rapidly into focal, trypsin-resistant compartments in target T cells. This massive virus internalization requires Env-CD4 receptor interactions but is resistant to inhibition by patient-derived neutralizing antisera that inhibit homologous cell-free virus. Deleting the Env cytoplasmic tail does not abrogate VS-mediated transfer, but it renders the VS sensitive to neutralizing antibodies, suggesting that the tail limits exposure of VS-neutralizing epitopes on the surface of infected cells. Dynamic live imaging of the VS reveals that HIV-expressing cells are polarized and make sustained, Env-dependent contacts with target cells through uropod-like structures. The polarized T-cell morphology, Env-CD4 coordinated adhesion, and viral transfer from HIV-infected to uninfected cells suggest that VS allows HIV-1 to evade antibody neutralization and to disseminate efficiently. Future studies will discern to what extent this massive viral transfer contributes to productive infection or viral dissemination through the migration of virus-carrying T cells.
Sequence Deletion; CCR5/metabolism; Receptors; Membrane Fusion; Jurkat Cells; Immune Sera/immunology; Humans; HIV-1/immunology; Green Fluorescent Proteins/metabolism; Green Fluorescent Proteins/analysis; Cytoskeleton/metabolism; Cell Adhesion; CD4-Positive T-Lymphocytes/virology; Antibodies; Viral/immunology; CD4-Positive T-Lymphocytes/immunology; Virus Internalization; env Gene Products; Human Immunodeficiency Virus/genetics; env Gene Products; Human Immunodeficiency Virus/metabolism; gag Gene Products; Human Immunodeficiency Virus/analysis; gag Gene Products; Human Immunodeficiency Virus/metabolism
Journal of virology
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Chen P, Hübner W, Spinelli MA, Chen BK. Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses. Journal of virology. 2007;81(22):12582-12595.
Chen, P., Hübner, W., Spinelli, M. A., & Chen, B. K. (2007). Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses. Journal of virology, 81(22), 12582-12595. doi:10.1128/JVI.00381-07
Chen, Ping, Hübner, Wolfgang, Spinelli, Matthew A, and Chen, Benjamin K. 2007. “Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses”. Journal of virology 81 (22): 12582-12595.
Chen, P., Hübner, W., Spinelli, M. A., and Chen, B. K. (2007). Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses. Journal of virology 81, 12582-12595.
Chen, P., et al., 2007. Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses. Journal of virology, 81(22), p 12582-12595.
P. Chen, et al., “Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses”, Journal of virology, vol. 81, 2007, pp. 12582-12595.
Chen, P., Hübner, W., Spinelli, M.A., Chen, B.K.: Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses. Journal of virology. 81, 12582-12595 (2007).
Chen, Ping, Hübner, Wolfgang, Spinelli, Matthew A, and Chen, Benjamin K. “Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses”. Journal of virology 81.22 (2007): 12582-12595.

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Sequential trafficking of Env and Gag to HIV-1 T cell virological synapses revealed by live imaging.
Wang L, Izadmehr S, Kamau E, Kong XP, Chen BK., Retrovirology 16(1), 2019
PMID: 30646921
Cellular HIV Reservoirs and Viral Rebound from the Lymphoid Compartments of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine (EFdA)-Suppressed Humanized Mice.
Maidji E, Moreno ME, Rivera JM, Joshi P, Galkina SA, Kosikova G, Somsouk M, Stoddart CA., Viruses 11(3), 2019
PMID: 30871222
HIV Controllers Exhibit Effective CD8+ T Cell Recognition of HIV-1-Infected Non-activated CD4+ T Cells.
Monel B, McKeon A, Lamothe-Molina P, Jani P, Boucau J, Pacheco Y, Jones RB, Le Gall S, Walker BD., Cell Rep 27(1), 2019
PMID: 30943397
Efficient HIV-1 Trans Infection of CD4+ T Cells Occurs in the Presence of Antiretroviral Therapy.
Rappocciolo G, Sluis-Cremer N, Rinaldo CR., Open Forum Infect Dis 6(7), 2019
PMID: 31304185
The HIV-1 viral synapse signals human foreskin keratinocytes to secrete thymic stromal lymphopoietin facilitating HIV-1 foreskin entry.
Zhou Z, Xu L, Sennepin A, Federici C, Ganor Y, Tudor D, Damotte D, Barry Delongchamps N, Zerbib M, Bomsel M., Mucosal Immunol 11(1), 2018
PMID: 28443609
All-Round Manipulation of the Actin Cytoskeleton by HIV.
Ospina Stella A, Turville S., Viruses 10(2), 2018
PMID: 29401736
Mechanisms for Cell-to-Cell Transmission of HIV-1.
Bracq L, Xie M, Benichou S, Bouchet J., Front Immunol 9(), 2018
PMID: 29515578
Distinct functions for the membrane-proximal ectodomain region (MPER) of HIV-1 gp41 in cell-free and cell-cell viral transmission and cell-cell fusion.
Narasimhulu VGS, Bellamy-McIntyre AK, Laumaea AE, Lay CS, Harrison DN, King HAD, Drummer HE, Poumbourios P., J Biol Chem 293(16), 2018
PMID: 29496992
Accounting for Space—Quantification of Cell-To-Cell Transmission Kinetics Using Virus Dynamics Models.
Kumberger P, Durso-Cain K, Uprichard SL, Dahari H, Graw F., Viruses 10(4), 2018
PMID: 29673154
HIV transmission from infected CD4+ T cells to allogenic T and dendritic cells is inhibited by broadly neutralizing antibodies.
Ducloy C, Su B, Mayr L, Klingler J, Decoville T, Schmidt S, Laumond G, Salomé N, Bahram S, Moog C., AIDS 32(10), 2018
PMID: 29683853
HIV-1 gag recruits PACSIN2 to promote virus spreading.
Popov S, Popova E, Inoue M, Wu Y, Göttlinger H., Proc Natl Acad Sci U S A 115(27), 2018
PMID: 29891700
Mechanisms and Concepts in RNA Virus Population Dynamics and Evolution.
Dolan PT, Whitfield ZJ, Andino R., Annu Rev Virol 5(1), 2018
PMID: 30048219
HIV-1 cell-to-cell transmission and broadly neutralizing antibodies.
Dufloo J, Bruel T, Schwartz O., Retrovirology 15(1), 2018
PMID: 30055632
The N-Terminus of the HIV-1 p6 Gag Protein Regulates Susceptibility to Degradation by IDE.
Schmalen A, Karius-Fischer J, Rauch P, Setz C, Korn K, Henklein P, Fossen T, Schubert U., Viruses 10(12), 2018
PMID: 30545091
Gene Editing of HIV-1 Co-receptors to Prevent and/or Cure Virus Infection.
Allen AG, Chung CH, Atkins A, Dampier W, Khalili K, Nonnemacher MR, Wigdahl B., Front Microbiol 9(), 2018
PMID: 30619107
Broadly neutralizing antibodies: An approach to control HIV-1 infection.
Yaseen MM, Yaseen MM, Alqudah MA., Int Rev Immunol 36(1), 2017
PMID: 27739924
A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors.
Park RJ, Wang T, Koundakjian D, Hultquist JF, Lamothe-Molina P, Monel B, Schumann K, Yu H, Krupzcak KM, Garcia-Beltran W, Piechocka-Trocha A, Krogan NJ, Marson A, Sabatini DM, Lander ES, Hacohen N, Walker BD., Nat Genet 49(2), 2017
PMID: 27992415
HIV-1 Activates T Cell Signaling Independently of Antigen to Drive Viral Spread.
Len ACL, Starling S, Shivkumar M, Jolly C., Cell Rep 18(4), 2017
PMID: 28122231
Collective Infectious Units in Viruses.
Sanjuán R., Trends Microbiol 25(5), 2017
PMID: 28262512
Early phase dynamics of traceable mCherry fluorescent protein-carrying HIV-1 infection in human peripheral blood mononuclear cells-transplanted NOD/SCID/Jak3-/- mice.
Higashi-Kuwata N, Ogata-Aoki H, Hattori SI, Hayashi H, Danish M, Aoki M, Shiotsu C, Kawamura T, Ihn H, Kobayashi H, Okada S, Mitsuya H., Antiviral Res 144(), 2017
PMID: 28392419
JAK-STAT Signaling Pathways and Inhibitors Affect Reversion of Envelope-Mutated HIV-1.
Quan Y, Xu H, Han Y, Mesplède T, Wainberg MA., J Virol 91(9), 2017
PMID: 28202754
The pentameric complex drives immunologically covert cell-cell transmission of wild-type human cytomegalovirus.
Murrell I, Bedford C, Ladell K, Miners KL, Price DA, Tomasec P, Wilkinson GWG, Stanton RJ., Proc Natl Acad Sci U S A 114(23), 2017
PMID: 28533400
Number of infection events per cell during HIV-1 cell-free infection.
Ito Y, Remion A, Tauzin A, Ejima K, Nakaoka S, Iwasa Y, Iwami S, Mammano F., Sci Rep 7(1), 2017
PMID: 28747624
Spatial and temporal epithelial ovarian cancer cell heterogeneity impacts Maraba virus oncolytic potential.
Tong JG, Valdes YR, Sivapragasam M, Barrett JW, Bell JC, Stojdl D, DiMattia GE, Shepherd TG., BMC Cancer 17(1), 2017
PMID: 28854921
Non-Neutralizing Antibodies Directed against HIV and Their Functions.
Mayr LM, Su B, Moog C., Front Immunol 8(), 2017
PMID: 29209323
T Cell-Macrophage Fusion Triggers Multinucleated Giant Cell Formation for HIV-1 Spreading.
Bracq L, Xie M, Lambelé M, Vu LT, Matz J, Schmitt A, Delon J, Zhou P, Randriamampita C, Bouchet J, Benichou S., J Virol 91(24), 2017
PMID: 28978713
HIV-1 Adapts To Replicate in Cells Expressing Common Marmoset APOBEC3G and BST2.
Fernández-Oliva A, Finzi A, Haim H, Menéndez-Arias L, Sodroski J, Pacheco B., J Virol 90(2), 2016
PMID: 26512082
Mechanisms of HIV Neuropathogenesis: Role of Cellular Communication Systems.
Malik S, Eugenin EA., Curr HIV Res 14(5), 2016
PMID: 27009098
Multiscale modeling of virus replication and spread.
Kumberger P, Frey F, Schwarz US, Graw F., FEBS Lett 590(13), 2016
PMID: 26878104
The role of NK cells in HIV-1 protection: autologous, allogeneic or both?
Hens J, Jennes W, Kestens L., AIDS Res Ther 13(), 2016
PMID: 26997965
Viruses exploit the tissue physiology of the host to spread in vivo.
Sewald X, Motamedi N, Mothes W., Curr Opin Cell Biol 41(), 2016
PMID: 27149407
Modeling Viral Spread.
Graw F, Perelson AS., Annu Rev Virol 3(1), 2016
PMID: 27618637
Recent Insights into the HIV/AIDS Pandemic.
Becerra JC, Bildstein LS, Gach JS., Microb Cell 3(9), 2016
PMID: 28357381
The Envelope Cytoplasmic Tail of HIV-1 Subtype C Contributes to Poor Replication Capacity through Low Viral Infectivity and Cell-to-Cell Transmission.
Santos da Silva E, Mulinge M, Lemaire M, Masquelier C, Beraud C, Rybicki A, Servais JY, Iserentant G, Schmit JC, Seguin-Devaux C, Perez Bercoff D., PLoS One 11(9), 2016
PMID: 27598717
HIV Cell-to-Cell Spread Results in Earlier Onset of Viral Gene Expression by Multiple Infections per Cell.
Boullé M, Müller TG, Dähling S, Ganga Y, Jackson L, Mahamed D, Oom L, Lustig G, Neher RA, Sigal A., PLoS Pathog 12(11), 2016
PMID: 27812216
HIV Envelope gp120 Alters T Cell Receptor Mobilization in the Immunological Synapse of Uninfected CD4 T Cells and Augments T Cell Activation.
Deng J, Mitsuki YY, Shen G, Ray JC, Cicala C, Arthos J, Dustin ML, Hioe CE., J Virol 90(23), 2016
PMID: 27630246
Rapid 3D fluorescence imaging of individual optically trapped living immune cells.
Wolfson D, Steck M, Persson M, McNerney G, Popovich A, Goksör M, Huser T., J Biophotonics 8(3), 2015
PMID: 24420444
Contact-induced mitochondrial polarization supports HIV-1 virological synapse formation.
Groppelli E, Starling S, Jolly C., J Virol 89(1), 2015
PMID: 25320323
HIV reservoir dynamics in the face of highly active antiretroviral therapy.
Costiniuk CT, Jenabian MA., AIDS Patient Care STDS 29(2), 2015
PMID: 25412339
Mitochondria polarization in the contact regions of virus-infected effector cells during cell-to-cell transmission of HIV-1.
Wang SF, Tseng SP, Huang SW, Yen CH, Hong YW, Chen M, Chen YM., AIDS Res Hum Retroviruses 31(2), 2015
PMID: 25680076
Potent restriction of HIV-1 and SIVmac239 replication by African green monkey TRIM5α.
Coren LV, Trivett MT, Jain S, Ayala VI, Del Prete GQ, Ohlen C, Ott DE., Retrovirology 12(), 2015
PMID: 25809491
HIV cell-to-cell transmission: effects on pathogenesis and antiretroviral therapy.
Agosto LM, Uchil PD, Mothes W., Trends Microbiol 23(5), 2015
PMID: 25766144
HIV-1 non-macrophage-tropic R5 envelope glycoproteins are not more tropic for entry into primary CD4+ T-cells than envelopes highly adapted for macrophages.
Musich T, O'Connell O, Gonzalez-Perez MP, Derdeyn CA, Peters PJ, Clapham PR., Retrovirology 12(), 2015
PMID: 25809903
Quantification of Hepatitis C Virus Cell-to-Cell Spread Using a Stochastic Modeling Approach.
Graw F, Martin DN, Perelson AS, Uprichard SL, Dahari H., J Virol 89(13), 2015
PMID: 25833046
Cell-to-cell contact facilitates HIV transmission from lymphocytes to astrocytes via CXCR4.
Li GH, Anderson C, Jaeger L, Do T, Major EO, Nath A., AIDS 29(7), 2015
PMID: 25985398
Hybrid spreading mechanisms and T cell activation shape the dynamics of HIV-1 infection.
Zhang C, Zhou S, Groppelli E, Pellegrino P, Williams I, Borrow P, Chain BM, Jolly C., PLoS Comput Biol 11(4), 2015
PMID: 25837979
Exosomes are unlikely involved in intercellular Nef transfer.
Luo X, Fan Y, Park IW, He JJ., PLoS One 10(4), 2015
PMID: 25919665
Inhibitory Effect of Individual or Combinations of Broadly Neutralizing Antibodies and Antiviral Reagents against Cell-Free and Cell-to-Cell HIV-1 Transmission.
Gombos RB, Kolodkin-Gal D, Eslamizar L, Owuor JO, Mazzola E, Gonzalez AM, Korioth-Schmitz B, Gelman RS, Montefiori DC, Haynes BF, Schmitz JE., J Virol 89(15), 2015
PMID: 25995259
Capacity of Broadly Neutralizing Antibodies to Inhibit HIV-1 Cell-Cell Transmission Is Strain- and Epitope-Dependent.
Reh L, Magnus C, Schanz M, Weber J, Uhr T, Rusert P, Trkola A., PLoS Pathog 11(7), 2015
PMID: 26158270
Cell-to-cell infection by HIV contributes over half of virus infection.
Iwami S, Takeuchi JS, Nakaoka S, Mammano F, Clavel F, Inaba H, Kobayashi T, Misawa N, Aihara K, Koyanagi Y, Sato K., Elife 4(), 2015
PMID: 26441404
In Vitro Evolution of Bovine Foamy Virus Variants with Enhanced Cell-Free Virus Titers and Transmission.
Bao Q, Hipp M, Hugo A, Lei J, Liu Y, Kehl T, Hechler T, Löchelt M., Viruses 7(11), 2015
PMID: 26569290
Slit2N Inhibits Transmission of HIV-1 from Dendritic Cells to T-cells by Modulating Novel Cytoskeletal Elements.
Shrivastava A, Prasad A, Kuzontkoski PM, Yu J, Groopman JE., Sci Rep 5(), 2015
PMID: 26582347
High-multiplicity HIV-1 infection and neutralizing antibody evasion mediated by the macrophage-T cell virological synapse.
Duncan CJ, Williams JP, Schiffner T, Gärtner K, Ochsenbauer C, Kappes J, Russell RA, Frater J, Sattentau QJ., J Virol 88(4), 2014
PMID: 24307588
Highly active antiretroviral therapies are effective against HIV-1 cell-to-cell transmission.
Agosto LM, Zhong P, Munro J, Mothes W., PLoS Pathog 10(2), 2014
PMID: 24586176
HIV-1 vaginal transmission: cell-free or cell-associated virus?
Barreto-de-Souza V, Arakelyan A, Margolis L, Vanpouille C., Am J Reprod Immunol 71(6), 2014
PMID: 24730358
Ezrin is a component of the HIV-1 virological presynapse and contributes to the inhibition of cell-cell fusion.
Roy NH, Lambelé M, Chan J, Symeonides M, Thali M., J Virol 88(13), 2014
PMID: 24760896
PIP2: choreographer of actin-adaptor proteins in the HIV-1 dance.
Rocha-Perugini V, Gordon-Alonso M, Sánchez-Madrid F., Trends Microbiol 22(7), 2014
PMID: 24768560
Regulatory T Cells Diminish HIV Infection in Dendritic Cells - Conventional CD4(+) T Cell Clusters.
Moreno-Fernandez ME, Joedicke JJ, Chougnet CA., Front Immunol 5(), 2014
PMID: 24847325
Vaccine-induced HIV-1 envelope gp120 constant region 1-specific antibodies expose a CD4-inducible epitope and block the interaction of HIV-1 gp140 with galactosylceramide.
Dennison SM, Anasti KM, Jaeger FH, Stewart SM, Pollara J, Liu P, Kunz EL, Zhang R, Vandergrift N, Permar S, Ferrari G, Tomaras GD, Bonsignori M, Michael NL, Kim JH, Kaewkungwal J, Nitayaphan S, Pitisuttithum P, Rerks-Ngarm S, Liao HX, Haynes BF, Alam SM., J Virol 88(16), 2014
PMID: 24920809
Which Antibody Functions are Important for an HIV Vaccine?
Su B, Moog C., Front Immunol 5(), 2014
PMID: 24995008
Murine leukemia virus Gag localizes to the uropod of migrating primary lymphocytes.
Li F, Sewald X, Jin J, Sherer NM, Mothes W., J Virol 88(18), 2014
PMID: 24965475
Live Cell Imaging of Retroviral Entry.
Hulme AE, Hope TJ., Annu Rev Virol 1(1), 2014
PMID: 26958731
P2X-selective purinergic antagonists are strong inhibitors of HIV-1 fusion during both cell-to-cell and cell-free infection.
Swartz TH, Esposito AM, Durham ND, Hartmann BM, Chen BK., J Virol 88(19), 2014
PMID: 25031337
Cell-to-cell transfer of HIV infection: implications for HIV viral persistence.
Costiniuk CT, Jenabian MA., J Gen Virol 95(pt 11), 2014
PMID: 25146006
HIV-1 cell-to-cell spread: CD63-gp41 interaction at the virological synapse.
Ivanusic D., AIDS Res Hum Retroviruses 30(9), 2014
PMID: 25184547
HIV-1 entry in SupT1-R5, CEM-ss, and primary CD4+ T cells occurs at the plasma membrane and does not require endocytosis.
Herold N, Anders-Ößwein M, Glass B, Eckhardt M, Müller B, Kräusslich HG., J Virol 88(24), 2014
PMID: 25253335
Partial rescue of V1V2 mutant infectivity by HIV-1 cell-cell transmission supports the domain's exceptional capacity for sequence variation.
Brandenberg OF, Rusert P, Magnus C, Weber J, Böni J, Günthard HF, Regoes RR, Trkola A., Retrovirology 11(), 2014
PMID: 25287422
Renal epithelial cells produce and spread HIV-1 via T-cell contact.
Blasi M, Balakumaran B, Chen P, Negri DR, Cara A, Chen BK, Klotman ME., AIDS 28(16), 2014
PMID: 25062092
Visualization of HIV-1 budding structures.
Ivanusic D, Madela K, Laue M, Denner J., AIDS Res Hum Retroviruses 30(10), 2014
PMID: 25172012
Neutralisation of HIV-1 cell-cell spread by human and llama antibodies.
McCoy LE, Groppelli E, Blanchetot C, de Haard H, Verrips T, Rutten L, Weiss RA, Jolly C., Retrovirology 11(), 2014
PMID: 25700025
Loss of infectivity of HIV-1 particles produced by mobile lymphocytes.
Chazal M, Nzounza P, Pique C, Ramirez BC., PLoS One 9(10), 2014
PMID: 25295863
The role of cell-associated virus in mother-to-child HIV transmission.
Milligan C, Overbaugh J., J Infect Dis 210 Suppl 3(), 2014
PMID: 25414417
Modeling mucosal cell-associated HIV type 1 transmission in vitro.
Anderson DJ., J Infect Dis 210 Suppl 3(), 2014
PMID: 25414419
Cell-to-cell communication in plants, animals, and fungi: a comparative review.
Bloemendal S, Kück U., Naturwissenschaften 100(1), 2013
PMID: 23128987
Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression.
Breed MW, Jordan AP, Aye PP, Lichtveld CF, Midkiff CC, Schiro FR, Haggarty BS, Sugimoto C, Alvarez X, Sandler NG, Douek DC, Kuroda MJ, Pahar B, Piatak M, Lifson JD, Keele BF, Hoxie JA, Lackner AA., J Virol 87(3), 2013
PMID: 23152518
Cell-to-cell transmission of viruses.
Zhong P, Agosto LM, Munro JB, Mothes W., Curr Opin Virol 3(1), 2013
PMID: 23219376
Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations.
Komarova NL, Anghelina D, Voznesensky I, Trinité B, Levy DN, Wodarz D., Biol Lett 9(1), 2013
PMID: 23269844
SAMHD1 restricts HIV-1 cell-to-cell transmission and limits immune detection in monocyte-derived dendritic cells.
Puigdomènech I, Casartelli N, Porrot F, Schwartz O., J Virol 87(5), 2013
PMID: 23269793
Mechanisms of enhanced HIV spread through T-cell virological synapses.
Dale BM, Alvarez RA, Chen BK., Immunol Rev 251(1), 2013
PMID: 23278744
Synaptic transmission and the susceptibility of HIV infection to anti-viral drugs.
Komarova NL, Levy DN, Wodarz D., Sci Rep 3(), 2013
PMID: 23811684
Evidence of ongoing replication in a human immunodeficiency virus type 1 persistently infected cell line.
Olivares I, Sánchez-Jiménez C, Vieira CR, Toledano V, Gutiérrez-Rivas M, López-Galíndez C., J Gen Virol 94(pt 5), 2013
PMID: 23288426
Cell-to-cell transmission can overcome multiple donor and target cell barriers imposed on cell-free HIV.
Zhong P, Agosto LM, Ilinskaya A, Dorjbal B, Truong R, Derse D, Uchil PD, Heidecker G, Mothes W., PLoS One 8(1), 2013
PMID: 23308151
Proteomic analysis of early HIV-1 nucleoprotein complexes.
Schweitzer CJ, Jagadish T, Haverland N, Ciborowski P, Belshan M., J Proteome Res 12(2), 2013
PMID: 23282062
Virus dynamics in the presence of synaptic transmission.
Komarova NL, Wodarz D., Math Biosci 242(2), 2013
PMID: 23357287
The infectious synapse formed between mature dendritic cells and CD4(+) T cells is independent of the presence of the HIV-1 envelope glycoprotein.
Rodriguez-Plata MT, Puigdomènech I, Izquierdo-Useros N, Puertas MC, Carrillo J, Erkizia I, Clotet B, Blanco J, Martinez-Picado J., Retrovirology 10(), 2013
PMID: 23590845
Productive entry of HIV-1 during cell-to-cell transmission via dynamin-dependent endocytosis.
Sloan RD, Kuhl BD, Mesplède T, Münch J, Donahue DA, Wainberg MA., J Virol 87(14), 2013
PMID: 23678185
Multiple proviral integration events after virological synapse-mediated HIV-1 spread.
Russell RA, Martin N, Mitar I, Jones E, Sattentau QJ., Virology 443(1), 2013
PMID: 23722103
Single cell analysis of lymph node tissue from HIV-1 infected patients reveals that the majority of CD4+ T-cells contain one HIV-1 DNA molecule.
Josefsson L, Palmer S, Faria NR, Lemey P, Casazza J, Ambrozak D, Kearney M, Shao W, Kottilil S, Sneller M, Mellors J, Coffin JM, Maldarelli F., PLoS Pathog 9(6), 2013
PMID: 23818847
The immunological synapse: the gateway to the HIV reservoir.
Kulpa DA, Brehm JH, Fromentin R, Cooper A, Cooper C, Ahlers J, Chomont N, Sékaly RP., Immunol Rev 254(1), 2013
PMID: 23772628
Catching HIV 'in the act' with 3D electron microscopy.
Earl LA, Lifson JD, Subramaniam S., Trends Microbiol 21(8), 2013
PMID: 23850373
HIV-1 Nef promotes the localization of Gag to the cell membrane and facilitates viral cell-to-cell transfer.
Malbec M, Sourisseau M, Guivel-Benhassine F, Porrot F, Blanchet F, Schwartz O, Casartelli N., Retrovirology 10(), 2013
PMID: 23899341
Postintegration HIV-1 infection of cervical epithelial cells mediates contact-dependent productive infection of T cells.
Micsenyi AM, Zony C, Alvarez RA, Durham ND, Chen BK, Klotman ME., J Infect Dis 208(11), 2013
PMID: 23908485
Gag-dependent enrichment of HIV-1 RNA near the uropod membrane of polarized T cells.
Hatch SC, Sardo L, Chen J, Burdick R, Gorelick R, Fivash MJ, Pathak VK, Hu WS., J Virol 87(21), 2013
PMID: 23966405
HIV-1 Tat protein induces viral internalization through Env-mediated interactions in dose-dependent manner.
Poon S, Moscoso CG, Yenigun OM, Kolatkar PR, Cheng RH, Vahlne A., AIDS 27(15), 2013
PMID: 23842123
Membrane nanotubes: novel communication between distant cells.
Zhang J, Zhang Y., Sci China Life Sci 56(11), 2013
PMID: 24008389
Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors.
Wei B, Han L, Abbink TE, Groppelli E, Lim D, Thaker YR, Gao W, Zhai R, Wang J, Lever A, Jolly C, Wang H, Rudd CE., Retrovirology 10(), 2013
PMID: 24047317
HIV trafficking in host cells: motors wanted!
Gaudin R, de Alencar BC, Arhel N, Benaroch P., Trends Cell Biol 23(12), 2013
PMID: 24119663
The microvesicle component of HIV-1 inocula modulates dendritic cell infection and maturation and enhances adhesion to and activation of T lymphocytes.
Mercier SK, Donaghy H, Botting RA, Turville SG, Harman AN, Nasr N, Ji H, Kusebauch U, Mendoza L, Shteynberg D, Sandgren K, Simpson RJ, Moritz RL, Cunningham AL., PLoS Pathog 9(10), 2013
PMID: 24204260
CD36-specific antibodies block release of HIV-1 from infected primary macrophages and its transmission to T cells.
Berre S, Gaudin R, Cunha de Alencar B, Desdouits M, Chabaud M, Naffakh N, Rabaza-Gairi M, Gobert FX, Jouve M, Benaroch P., J Exp Med 210(12), 2013
PMID: 24145510
Intravital microscopy in BLT-humanized mice to study cellular dynamics in HIV infection.
Murooka TT, Mempel TR., J Infect Dis 208 Suppl 2(), 2013
PMID: 24151320
Efficient BST2 antagonism by Vpu is critical for early HIV-1 dissemination in humanized mice.
Dave VP, Hajjar F, Dieng MM, Haddad É, Cohen ÉA., Retrovirology 10(), 2013
PMID: 24195843
Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission.
Malbec M, Porrot F, Rua R, Horwitz J, Klein F, Halper-Stromberg A, Scheid JF, Eden C, Mouquet H, Nussenzweig MC, Schwartz O., J Exp Med 210(13), 2013
PMID: 24277152
Platelets and erythrocyte-bound platelets bind infectious HIV-1 in plasma of chronically infected patients.
Beck Z, Jagodzinski LL, Eller MA, Thelian D, Matyas GR, Kunz AN, Alving CR., PLoS One 8(11), 2013
PMID: 24282562
Protease inhibitors effectively block cell-to-cell spread of HIV-1 between T cells.
Titanji BK, Aasa-Chapman M, Pillay D, Jolly C., Retrovirology 10(), 2013
PMID: 24364896
In vitro activities of candidate microbicides against cell-associated HIV.
Selhorst P, Grupping K, Bourlet T, Delézay O, Ariën KK, Vanham G., Antimicrob Agents Chemother 56(2), 2012
PMID: 22083472
In vivo imaging of virological synapses.
Sewald X, Gonzalez DG, Haberman AM, Mothes W., Nat Commun 3(), 2012
PMID: 23271654
The scaffolding protein Dlg1 is a negative regulator of cell-free virus infectivity but not of cell-to-cell HIV-1 transmission in T cells.
Nzounza P, Chazal M, Guedj C, Schmitt A, Massé JM, Randriamampita C, Pique C, Ramirez BC., PLoS One 7(1), 2012
PMID: 22272285
Cannabinoid receptor 2-mediated attenuation of CXCR4-tropic HIV infection in primary CD4+ T cells.
Costantino CM, Gupta A, Yewdall AW, Dale BM, Devi LA, Chen BK., PLoS One 7(3), 2012
PMID: 22448282
Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies.
Abela IA, Berlinger L, Schanz M, Reynell L, Günthard HF, Rusert P, Trkola A., PLoS Pathog 8(4), 2012
PMID: 22496655
Neutralization resistance of virological synapse-mediated HIV-1 Infection is regulated by the gp41 cytoplasmic tail.
Durham ND, Yewdall AW, Chen P, Lee R, Zony C, Robinson JE, Chen BK., J Virol 86(14), 2012
PMID: 22553332
Antiretroviral agents effectively block HIV replication after cell-to-cell transfer.
Permanyer M, Ballana E, Ruiz A, Badia R, Riveira-Munoz E, Gonzalo E, Clotet B, Esté JA., J Virol 86(16), 2012
PMID: 22696642
HIV-1 assembly, budding, and maturation.
Sundquist WI, Kräusslich HG., Cold Spring Harb Perspect Med 2(7), 2012
PMID: 22762019
Dynamic Association between HIV-1 Gag and Membrane Domains.
Hogue IB, Llewellyn GN, Ono A., Mol Biol Int 2012(), 2012
PMID: 22830021
Trans-infection but not infection from within endosomal compartments after cell-to-cell HIV-1 transfer to CD4+ T cells.
Permanyer M, Ballana E, Badia R, Pauls E, Clotet B, Esté JA., J Biol Chem 287(38), 2012
PMID: 22846998
HIV-infected T cells are migratory vehicles for viral dissemination.
Murooka TT, Deruaz M, Marangoni F, Vrbanac VD, Seung E, von Andrian UH, Tager AM, Luster AD, Mempel TR., Nature 490(7419), 2012
PMID: 22854780
Breast milk from Tanzanian women has divergent effects on cell-free and cell-associated HIV-1 infection in vitro.
Lyimo MA, Mosi MN, Housman ML, Zain-Ul-Abideen M, Lee FV, Howell AL, Connor RI., PLoS One 7(8), 2012
PMID: 22952771
Neutralizing antibodies inhibit HIV-1 transfer from primary dendritic cells to autologous CD4 T lymphocytes.
Su B, Xu K, Lederle A, Peressin M, Biedma ME, Laumond G, Schmidt S, Decoville T, Proust A, Lambotin M, Holl V, Moog C., Blood 120(18), 2012
PMID: 22955927
Pathways of cell-cell transmission of HTLV-1.
Pique C, Jones KS., Front Microbiol 3(), 2012
PMID: 23109932
HIV-specific antibody-dependent cellular cytotoxicity: a novel vaccine modality.
Madhavi V, Kent SJ, Stratov I., Expert Rev Clin Immunol 8(8), 2012
PMID: 23167688
Effect of synaptic transmission on viral fitness in HIV infection.
Komarova NL, Levy DN, Wodarz D., PLoS One 7(11), 2012
PMID: 23166585
T cell virological synapses and HIV-1 pathogenesis.
Chen BK., Immunol Res 54(1-3), 2012
PMID: 22477441
Tracking and quantitation of fluorescent HIV during cell-to-cell transmission.
Dale BM, McNerney GP, Hübner W, Huser TR, Chen BK., Methods 53(1), 2011
PMID: 20627127
HIV-1 envelope, integrins and co-receptor use in mucosal transmission of HIV.
Cicala C, Arthos J, Fauci AS., J Transl Med 9 Suppl 1(), 2011
PMID: 21284901
Virological synapses allow HIV-1 uptake and gene expression in renal tubular epithelial cells.
Chen P, Chen BK, Mosoian A, Hays T, Ross MJ, Klotman PE, Klotman ME., J Am Soc Nephrol 22(3), 2011
PMID: 21335514
HIV-1 requires Arf6-mediated membrane dynamics to efficiently enter and infect T lymphocytes.
García-Expósito L, Barroso-González J, Puigdomènech I, Machado JD, Blanco J, Valenzuela-Fernández A., Mol Biol Cell 22(8), 2011
PMID: 21346189
Early events of HIV-1 infection: can signaling be the next therapeutic target?
Jones KL, Smyth RP, Pereira CF, Cameron PU, Lewin SR, Jaworowski A, Mak J., J Neuroimmune Pharmacol 6(2), 2011
PMID: 21373988
HIV sexual transmission and microbicides.
Ariën KK, Jespers V, Vanham G., Rev Med Virol 21(2), 2011
PMID: 21412935
The role of dynamin in HIV type 1 Env-mediated cell-cell fusion.
Lai W, Huang L, Ho P, Montefiori D, Chen CH., AIDS Res Hum Retroviruses 27(9), 2011
PMID: 21338326
Multiploid inheritance of HIV-1 during cell-to-cell infection.
Del Portillo A, Tripodi J, Najfeld V, Wodarz D, Levy DN, Chen BK., J Virol 85(14), 2011
PMID: 21543479
Viral determinants of polarized assembly for the murine leukemia virus.
Jin J, Li F, Mothes W., J Virol 85(15), 2011
PMID: 21593177
A cell-to-cell HIV transfer assay identifies humoral responses with broad neutralization activity.
Sánchez-Palomino S, Massanella M, Carrillo J, García A, García F, González N, Merino A, Alcamí J, Bofill M, Yuste E, Gatell JM, Clotet B, Blanco J., Vaccine 29(32), 2011
PMID: 21609746
Host factors involved in retroviral budding and release.
Martin-Serrano J, Neil SJ., Nat Rev Microbiol 9(7), 2011
PMID: 21677686
Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule.
Josefsson L, King MS, Makitalo B, Brännström J, Shao W, Maldarelli F, Kearney MF, Hu WS, Chen J, Gaines H, Mellors JW, Albert J, Coffin JM, Palmer SE., Proc Natl Acad Sci U S A 108(27), 2011
PMID: 21690402
Human immunodeficiency virus (HIV) immunopathogenesis and vaccine development: a review.
Girard MP, Osmanov S, Assossou OM, Kieny MP., Vaccine 29(37), 2011
PMID: 21718747
Live-cell real-time imaging reveals role of mitochondria in cell-to-cell transmission of HIV-1.
Lee-Huang S, Lin Huang P, Lee Huang P., Biochem Biophys Res Commun 415(2), 2011
PMID: 22037455
Cell-to-cell transfer of HIV-1 via virological synapses leads to endosomal virion maturation that activates viral membrane fusion.
Dale BM, McNerney GP, Thompson DL, Hubner W, de Los Reyes K, Chuang FY, Huser T, Chen BK., Cell Host Microbe 10(6), 2011
PMID: 22177560
Functional anatomy of T cell activation and synapse formation.
Fooksman DR, Vardhana S, Vasiliver-Shamis G, Liese J, Blair DA, Waite J, Sacristán C, Victora GD, Zanin-Zhorov A, Dustin ML., Annu Rev Immunol 28(), 2010
PMID: 19968559
Virological synapse-mediated spread of human immunodeficiency virus type 1 between T cells is sensitive to entry inhibition.
Martin N, Welsch S, Jolly C, Briggs JA, Vaux D, Sattentau QJ., J Virol 84(7), 2010
PMID: 20089656
Stimulation of HIV-1 replication in immature dendritic cells in contact with primary CD4 T or B lymphocytes.
Holl V, Xu K, Peressin M, Lederle A, Biedma ME, Delaporte M, Decoville T, Schmidt S, Laumond G, Aubertin AM, Moog C., J Virol 84(9), 2010
PMID: 20147388
Quantitative comparison of HTLV-1 and HIV-1 cell-to-cell infection with new replication dependent vectors.
Mazurov D, Ilinskaya A, Heidecker G, Lloyd P, Derse D., PLoS Pathog 6(2), 2010
PMID: 20195464
Manipulating CD4+ T cells by optical tweezers for the initiation of cell-cell transfer of HIV-1.
McNerney GP, Hübner W, Chen BK, Huser T., J Biophotonics 3(4), 2010
PMID: 20301121
Virus cell-to-cell transmission.
Mothes W, Sherer NM, Jin J, Zhong P., J Virol 84(17), 2010
PMID: 20375157
HIV-1 assembly at the plasma membrane.
Ono A., Vaccine 28 Suppl 2(), 2010
PMID: 20510745
HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse.
Vasiliver-Shamis G, Dustin ML, Hioe CE., Viruses 2(5), 2010
PMID: 20890395
Role of the C-terminal domain of the HIV-1 glycoprotein in cell-to-cell viral transmission between T lymphocytes.
Emerson V, Haller C, Pfeiffer T, Fackler OT, Bosch V., Retrovirology 7(), 2010
PMID: 20459872
T cell polarization at the virological synapse.
Jolly C., Viruses 2(6), 2010
PMID: 21994679
Cell-to-Cell Spread of Retroviruses.
Sattentau QJ., Viruses 2(6), 2010
PMID: 21994681
Tetherin restricts productive HIV-1 cell-to-cell transmission.
Casartelli N, Sourisseau M, Feldmann J, Guivel-Benhassine F, Mallet A, Marcelin AG, Guatelli J, Schwartz O., PLoS Pathog 6(6), 2010
PMID: 20585562
Class II transactivator (CIITA) enhances cytoplasmic processing of HIV-1 Pr55Gag.
Porter KA, Kelley LN, George A, Harton JA, Duus KM., PLoS One 5(6), 2010
PMID: 20585587
PPARgamma and LXR signaling inhibit dendritic cell-mediated HIV-1 capture and trans-infection.
Hanley TM, Blay Puryear W, Gummuluru S, Viglianti GA., PLoS Pathog 6(), 2010
PMID: 20617179
3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells.
Felts RL, Narayan K, Estes JD, Shi D, Trubey CM, Fu J, Hartnell LM, Ruthel GT, Schneider DK, Nagashima K, Bess JW, Bavari S, Lowekamp BC, Bliss D, Lifson JD, Subramaniam S., Proc Natl Acad Sci U S A 107(30), 2010
PMID: 20624966
Tetherin restricts direct cell-to-cell infection of HIV-1.
Kuhl BD, Sloan RD, Donahue DA, Bar-Magen T, Liang C, Wainberg MA., Retrovirology 7(), 2010
PMID: 21184674
Human immunodeficiency virus type 1 chronic infection is associated with different gene expression in MT-4, H9 and U937 cell lines.
Olivares I, Ballester A, Lombardia L, Dominguez O, López-Galíndez C., Virus Res 139(1), 2009
PMID: 19000723
Antigp41 antibodies fail to block early events of virological synapses but inhibit HIV spread between T cells.
Massanella M, Puigdomènech I, Cabrera C, Fernandez-Figueras MT, Aucher A, Gaibelet G, Hudrisier D, García E, Bofill M, Clotet B, Blanco J., AIDS 23(2), 2009
PMID: 19098487
Quantitative 3D video microscopy of HIV transfer across T cell virological synapses.
Hübner W, McNerney GP, Chen P, Dale BM, Gordon RE, Chuang FY, Li XD, Asmuth DM, Huser T, Chen BK., Science 323(5922), 2009
PMID: 19325119
Cell-to-cell HIV-1 spread and its implications for immune evasion.
Martin N, Sattentau Q., Curr Opin HIV AIDS 4(2), 2009
PMID: 19339954
The virological synapse facilitates herpes simplex virus entry into T cells.
Aubert M, Yoon M, Sloan DD, Spear PG, Jerome KR., J Virol 83(12), 2009
PMID: 19339346
HIV endocytosis after dendritic cell to T cell viral transfer leads to productive virus infection.
Clotet-Codina I, Bosch B, Senserrich J, Fernández-Figueras MT, Peña R, Ballana E, Bofill M, Clotet B, Esté JA., Antiviral Res 83(1), 2009
PMID: 19501262
Simultaneous cell-to-cell transmission of human immunodeficiency virus to multiple targets through polysynapses.
Rudnicka D, Feldmann J, Porrot F, Wietgrefe S, Guadagnini S, Prévost MC, Estaquier J, Haase AT, Sol-Foulon N, Schwartz O., J Virol 83(12), 2009
PMID: 19369333
Bringing up the rear: defining the roles of the uropod.
Sánchez-Madrid F, Serrador JM., Nat Rev Mol Cell Biol 10(5), 2009
PMID: 19373240
Tunneling nanotubes (TNT): A potential mechanism for intercellular HIV trafficking.
Eugenin EA, Gaskill PJ, Berman JW., Commun Integr Biol 2(3), 2009
PMID: 19641744
Formation of syncytia is repressed by tetraspanins in human immunodeficiency virus type 1-producing cells.
Weng J, Krementsov DN, Khurana S, Roy NH, Thali M., J Virol 83(15), 2009
PMID: 19458002
Tetraspanins regulate cell-to-cell transmission of HIV-1.
Krementsov DN, Weng J, Lambelé M, Roy NH, Thali M., Retrovirology 6(), 2009
PMID: 19602278
Human immunodeficiency virus type 1 (HIV-1) protease inhibitors block cell-to-cell HIV-1 endocytosis in dendritic cells.
Muratori C, Ruggiero E, Sistigu A, Bona R, Federico M., J Gen Virol 90(pt 11), 2009
PMID: 19625465
Assembly of the murine leukemia virus is directed towards sites of cell-cell contact.
Jin J, Sherer NM, Heidecker G, Derse D, Mothes W., PLoS Biol 7(7), 2009
PMID: 19636361
The remarkable frequency of human immunodeficiency virus type 1 genetic recombination.
Onafuwa-Nuga A, Telesnitsky A., Microbiol Mol Biol Rev 73(3), 2009
PMID: 19721086
New virologic reagents for neutralizing antibody assays.
Ochsenbauer C, Kappes JC., Curr Opin HIV AIDS 4(5), 2009
PMID: 20048706
On the steps of cell-to-cell HIV transmission between CD4 T cells.
Puigdomènech I, Massanella M, Cabrera C, Clotet B, Blanco J., Retrovirology 6(), 2009
PMID: 19825175
HIV transfer between CD4 T cells does not require LFA-1 binding to ICAM-1 and is governed by the interaction of HIV envelope glycoprotein with CD4.
Puigdomènech I, Massanella M, Izquierdo-Useros N, Ruiz-Hernandez R, Curriu M, Bofill M, Martinez-Picado J, Juan M, Clotet B, Blanco J., Retrovirology 5(), 2008
PMID: 18377648
Membrane nanotubes: dynamic long-distance connections between animal cells.
Davis DM, Sowinski S., Nat Rev Mol Cell Biol 9(6), 2008
PMID: 18431401
Critical issues in mucosal immunity for HIV-1 vaccine development.
Haynes BF, Shattock RJ., J Allergy Clin Immunol 122(1), 2008
PMID: 18468671
Species barrier of HIV-1 and its jumping by virus engineering.
Nomaguchi M, Doi N, Kamada K, Adachi A., Rev Med Virol 18(4), 2008
PMID: 18386279
Role of HIV-1 Vpu protein for virus spread and pathogenesis.
Nomaguchi M, Fujita M, Adachi A., Microbes Infect 10(9), 2008
PMID: 18672082
Human herpesvirus-6 induces MVB formation, and virus egress occurs by an exosomal release pathway.
Mori Y, Koike M, Moriishi E, Kawabata A, Tang H, Oyaizu H, Uchiyama Y, Yamanishi K., Traffic 9(10), 2008
PMID: 18637904
Human immunodeficiency virus type 1 envelope gp120 induces a stop signal and virological synapse formation in noninfected CD4+ T cells.
Vasiliver-Shamis G, Tuen M, Wu TW, Starr T, Cameron TO, Thomson R, Kaur G, Liu J, Visciano ML, Li H, Kumar R, Ansari R, Han DP, Cho MW, Dustin ML, Hioe CE., J Virol 82(19), 2008
PMID: 18632854
Biology of HIV mucosal transmission.
Wu L., Curr Opin HIV AIDS 3(5), 2008
PMID: 18802490
HIV-1 at the immunological and T-lymphocytic virological synapse.
Haller C, Fackler OT., Biol Chem 389(10), 2008
PMID: 18713012
Live cell imaging of the HIV-1 life cycle.
Campbell EM, Hope TJ., Trends Microbiol 16(12), 2008
PMID: 18977142
Avoiding the void: cell-to-cell spread of human viruses.
Sattentau Q., Nat Rev Microbiol 6(11), 2008
PMID: 18923409

67 References

Daten bereitgestellt von Europe PubMed Central.

Endocytic entry of HIV-1.
Fackler OT, Peterlin BM., Curr. Biol. 10(16), 2000
PMID: 10985390
Human immunodeficiency virus type 1 spinoculation enhances infection through virus binding.
O'Doherty U, Swiggard WJ, Malim MH., J. Virol. 74(21), 2000
PMID: 11024136
Factors underlying spontaneous inactivation and susceptibility to neutralization of human immunodeficiency virus.
Layne SP, Merges MJ, Dembo M, Spouge JL, Conley SR, Moore JP, Raina JL, Renz H, Gelderblom HR, Nara PL., Virology 189(2), 1992
PMID: 1386485
Morphometric analysis of envelope glycoprotein gp120 distribution on HIV-1 virions.
Hart TK, Klinkner AM, Ventre J, Bugelski PJ., J. Histochem. Cytochem. 41(2), 1993
PMID: 7678271
Quantitation of human immunodeficiency virus type 1 infection kinetics.
Dimitrov DS, Willey RL, Sato H, Chang LJ, Blumenthal R, Martin MA., J. Virol. 67(4), 1993
PMID: 8445728
High level of coreceptor-independent HIV transfer induced by contacts between primary CD4 T cells.
Blanco J, Bosch B, Fernandez-Figueras MT, Barretina J, Clotet B, Este JA., J. Biol. Chem. 279(49), 2004
PMID: 15371410
Role of the cytoskeleton in cell-to-cell transmission of human immunodeficiency virus.
Pearce-Pratt R, Malamud D, Phillips DM., J. Virol. 68(5), 1994
PMID: 8151760
HIV and T cell expansion in splenic white pulps is accompanied by infiltration of HIV-specific cytotoxic T lymphocytes.
Cheynier R, Henrichwark S, Hadida F, Pelletier E, Oksenhendler E, Autran B, Wain-Hobson S., Cell 78(3), 1994
PMID: 7914835
Viral dynamics in human immunodeficiency virus type 1 infection.
Wei X, Ghosh SK, Taylor ME, Johnson VA, Emini EA, Deutsch P, Lifson JD, Bonhoeffer S, Nowak MA, Hahn BH., Nature 373(6510), 1995
PMID: 7529365
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection.
Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M., Nature 373(6510), 1995
PMID: 7816094
Preparation and characterization of human HIV type 1 neutralizing reference sera.
Vujcic LK, Quinnan GV Jr., AIDS Res. Hum. Retroviruses 11(7), 1995
PMID: 7546904
Changes in plasma HIV-1 RNA and CD4+ lymphocyte counts and the risk of progression to AIDS. Veterans Affairs Cooperative Study Group on AIDS.
O'Brien WA, Hartigan PM, Martin D, Esinhart J, Hill A, Benoit S, Rubin M, Simberkoff MS, Hamilton JD., N. Engl. J. Med. 334(7), 1996
PMID: 8552144
HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time.
Perelson AS, Neumann AU, Markowitz M, Leonard JM, Ho DD., Science 271(5255), 1996
PMID: 8599114
Directional budding of human immunodeficiency virus from monocytes.
Perotti ME, Tan X, Phillips DM., J. Virol. 70(9), 1996
PMID: 8709212
The relation of virologic and immunologic markers to clinical outcomes after nucleoside therapy in HIV-infected adults with 200 to 500 CD4 cells per cubic millimeter. AIDS Clinical Trials Group Study 175 Virology Study Team.
Katzenstein DA, Hammer SM, Hughes MD, Gundacker H, Jackson JB, Fiscus S, Rasheed S, Elbeik T, Reichman R, Japour A, Merigan TC, Hirsch MS., N. Engl. J. Med. 335(15), 1996
PMID: 8813039
Maternal viral load, zidovudine treatment, and the risk of transmission of human immunodeficiency virus type 1 from mother to infant. Pediatric AIDS Clinical Trials Group Protocol 076 Study Group.
Sperling RS, Shapiro DE, Coombs RW, Todd JA, Herman SA, McSherry GD, O'Sullivan MJ, Van Dyke RB, Jimenez E, Rouzioux C, Flynn PM, Sullivan JL., N. Engl. J. Med. 335(22), 1996
PMID: 8965861
Efficient HIV-1 replication can occur in the absence of the viral matrix protein.
Reil H, Bukovsky AA, Gelderblom HR, Gottlinger HG., EMBO J. 17(9), 1998
PMID: 9564051
Intracellular neutralization of HIV transcytosis across tight epithelial barriers by anti-HIV envelope protein dIgA or IgM.
Bomsel M, Heyman M, Hocini H, Lagaye S, Belec L, Dupont C, Desgranges C., Immunity 9(2), 1998
PMID: 9729048
Polarized human immunodeficiency virus budding in lymphocytes involves a tyrosine-based signal and favors cell-to-cell viral transmission.
Deschambeault J, Lalonde JP, Cervantes-Acosta G, Lodge R, Cohen EA, Lemay G., J. Virol. 73(6), 1999
PMID: 10233963
Development of calibrated viral load standards for group M subtypes of human immunodeficiency virus type 1 and performance of an improved AMPLICOR HIV-1 MONITOR test with isolates of diverse subtypes.
Michael NL, Herman SA, Kwok S, Dreyer K, Wang J, Christopherson C, Spadoro JP, Young KK, Polonis V, McCutchan FE, Carr J, Mascola JR, Jagodzinski LL, Robb ML., J. Clin. Microbiol. 37(8), 1999
PMID: 10405401
OsiriX: an open-source software for navigating in multidimensional DICOM images.
Rosset A, Spadola L, Ratib O., J Digit Imaging 17(3), 2004
PMID: 15534753
Involvement of clathrin-mediated endocytosis in human immunodeficiency virus type 1 entry.
Daecke J, Fackler OT, Dittmar MT, Krausslich HG., J. Virol. 79(3), 2005
PMID: 15650184
Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells.
Li Q, Duan L, Estes JD, Ma ZM, Rourke T, Wang Y, Reilly C, Carlis J, Miller CJ, Haase AT., Nature 434(7037), 2005
PMID: 15793562
Regulation of human immunodeficiency virus type 1 envelope glycoprotein fusion by a membrane-interactive domain in the gp41 cytoplasmic tail.
Wyss S, Dimitrov AS, Baribaud F, Edwards TG, Blumenthal R, Hoxie JA., J. Virol. 79(19), 2005
PMID: 16160149
Dynamic imaging of the immune system: progress, pitfalls and promise.
Germain RN, Miller MJ, Dustin ML, Nussenzweig MC., Nat. Rev. Immunol. 6(7), 2006
PMID: 16799470
Inhibition of viral assembly in murine cells by HIV-1 matrix.
Hubner W, Chen BK., Virology 352(1), 2006
PMID: 16750235
Highly restricted spread of HIV-1 and multiply infected cells within splenic germinal centers.
Gratton S, Cheynier R, Dumaurier MJ, Oksenhendler E, Wain-Hobson S., Proc. Natl. Acad. Sci. U.S.A. 97(26), 2000
PMID: 11121058
Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5+ cells.
Meng G, Wei X, Wu X, Sellers MT, Decker JM, Moldoveanu Z, Orenstein JM, Graham MF, Kappes JC, Mestecky J, Shaw GM, Smith PD., Nat. Med. 8(2), 2002
PMID: 11821899
Envelope glycoprotein incorporation, not shedding of surface envelope glycoprotein (gp120/SU), Is the primary determinant of SU content of purified human immunodeficiency virus type 1 and simian immunodeficiency virus.
Chertova E, Bess JW Jr, Crise BJ, Sowder II RC, Schaden TM, Hilburn JM, Hoxie JA, Benveniste RE, Lifson JD, Henderson LE, Arthur LO., J. Virol. 76(11), 2002
PMID: 11991960
Recombination: Multiply infected spleen cells in HIV patients.
Jung A, Maier R, Vartanian JP, Bocharov G, Jung V, Fischer U, Meese E, Wain-Hobson S, Meyerhans A., Nature 418(6894), 2002
PMID: 12110879
Inhibition of endosomal/lysosomal degradation increases the infectivity of human immunodeficiency virus.
Fredericksen BL, Wei BL, Yao J, Luo T, Garcia JV., J. Virol. 76(22), 2002
PMID: 12388705
Heterogeneity of envelope molecules expressed on primary human immunodeficiency virus type 1 particles as probed by the binding of neutralizing and nonneutralizing antibodies.
Poignard P, Moulard M, Golez E, Vivona V, Franti M, Venturini S, Wang M, Parren PW, Burton DR., J. Virol. 77(1), 2003
PMID: 12477840
Role of Rho-family GTPase Cdc42 in polarized expression of lymphocyte appendages.
Ratner S, Piechocki MP, Galy A., J. Leukoc. Biol. 73(6), 2003
PMID: 12773516
Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions.
Zhu P, Chertova E, Bess J Jr, Lifson JD, Arthur LO, Liu J, Taylor KA, Roux KH., Proc. Natl. Acad. Sci. U.S.A. 100(26), 2003
PMID: 14668432
HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse.
Jolly C, Kashefi K, Hollinshead M, Sattentau QJ., J. Exp. Med. 199(2), 2004
PMID: 14734528
Coupling of human immunodeficiency virus type 1 fusion to virion maturation: a novel role of the gp41 cytoplasmic tail.
Wyma DJ, Jiang J, Shi J, Zhou J, Lineberger JE, Miller MD, Aiken C., J. Virol. 78(7), 2004
PMID: 15016865
HIV-1 dynamics in vivo: implications for therapy.
Simon V, Ho DD., Nat. Rev. Microbiol. 1(3), 2003
PMID: 15035022
Roles of substrate availability and infection of resting and activated CD4+ T cells in transmission and acute simian immunodeficiency virus infection.
Zhang ZQ, Wietgrefe SW, Li Q, Shore MD, Duan L, Reilly C, Lifson JD, Haase AT., Proc. Natl. Acad. Sci. U.S.A. 101(15), 2004
PMID: 15064398
The stoichiometry of Gag protein in HIV-1.
Briggs JA, Simon MN, Gross I, Krausslich HG, Fuller SD, Vogt VM, Johnson MC., Nat. Struct. Mol. Biol. 11(7), 2004
PMID: 15208690
Dangerous liaisons at the virological synapse.
Piguet V, Sattentau Q., J. Clin. Invest. 114(5), 2004
PMID: 15343375
Stop and go traffic to tune T cell responses.
Dustin ML., Immunity 21(3), 2004
PMID: 15357942
Relationships between infectious titer, capsid protein levels, and reverse transcriptase activities of diverse human immunodeficiency virus type 1 isolates.
Marozsan AJ, Fraundorf E, Abraha A, Baird H, Moore D, Troyer R, Nankja I, Arts EJ., J. Virol. 78(20), 2004
PMID: 15452233
Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone.
Adachi A, Gendelman HE, Koenig S, Folks T, Willey R, Rabson A, Martin MA., J. Virol. 59(2), 1986
PMID: 3016298
Quantitation of human immunodeficiency virus type 1 in the blood of infected persons.
Ho DD, Moudgil T, Alam M., N. Engl. J. Med. 321(24), 1989
PMID: 2586564
Plasma viremia in human immunodeficiency virus infection.
Coombs RW, Collier AC, Allain JP, Nikora B, Leuther M, Gjerset GF, Corey L., N. Engl. J. Med. 321(24), 1989
PMID: 2511447
HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain.
O'Brien WA, Koyanagi Y, Namazie A, Zhao JQ, Diagne A, Idler K, Zack JA, Chen IS., Nature 348(6296), 1990
PMID: 2172833
Dissociation of gp120 from HIV-1 virions induced by soluble CD4.
Moore JP, McKeating JA, Weiss RA, Sattentau QJ., Science 250(4984), 1990
PMID: 2251501
Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4+ T cells.
Cameron PU, Freudenthal PS, Barker JM, Gezelter S, Inaba K, Steinman RM., Science 257(5068), 1992
PMID: 1352913
Inefficient human immunodeficiency virus replication in mobile lymphocytes.
Sourisseau M, Sol-Foulon N, Porrot F, Blanchet F, Schwartz O., J. Virol. 81(2), 2006
PMID: 17079292
High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR.
Piatak M Jr, Saag MS, Yang LC, Clark SJ, Kappes JC, Luk KC, Hahn BH, Shaw GM, Lifson JD., Science 259(5102), 1993
PMID: 8096089
Sexual transmission and propagation of SIV and HIV in resting and activated CD4+ T cells.
Zhang Z, Schuler T, Zupancic M, Wietgrefe S, Staskus KA, Reimann KA, Reinhart TA, Rogan M, Cavert W, Miller CJ, Veazey RS, Notermans D, Little S, Danner SA, Richman DD, Havlir D, Wong J, Jordan HL, Schacker TW, Racz P, Tenner-Racz K, Letvin NL, Wolinsky S, Haase AT., Science 286(5443), 1999
PMID: 10558989

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