The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation
Holbein S, Scola S, Loll B, Dichtl BS, Hübner W, Meinhart A, Dichtl B (2011)
PloS one 6(12): e29139.
Zeitschriftenaufsatz
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Autor*in
Holbein, Sandra;
Scola, Simonetta;
Loll, Bernhard;
Dichtl, Beatriz Solange;
Hübner, WolfgangUniBi ;
Meinhart, Anton;
Dichtl, Bernhard
Einrichtung
Abstract / Bemerkung
Cleavage factor IA (CF IA), cleavage and polyadenylation factor (CPF), constitute major protein complexes required for pre-mRNA 3' end formation in yeast. The Clp1 protein associates with Pcf11, Rna15 and Rna14 in CF IA but its functional role remained unclear. Clp1 carries an evolutionarily conserved P-loop motif that was previously shown to bind ATP. Interestingly, human and archaean Clp1 homologues, but not the yeast protein, carry 5' RNA kinase activity. We show that depletion of Clp1 in yeast promoted defective 3' end formation and RNA polymerase II termination; however, cells expressing Clp1 with mutant P-loops displayed only minor defects in gene expression. Similarly, purified and reconstituted mutant CF IA factors that interfered with ATP binding complemented CF IA depleted extracts in coupled in vitro transcription/3' end processing reactions. We found that Clp1 was required to assemble recombinant CF IA and that certain P-loop mutants failed to interact with the CF IA subunit Pcf11. In contrast, mutations in Clp1 enhanced binding to the 3' endonuclease Ysh1 that is a component of CPF. Our results support a structural role for the Clp1 P-loop motif. ATP binding by Clp1 likely contributes to CF IA formation and cross-factor interactions during the dynamic process of 3' end formation.
Stichworte
Saccharomyces cerevisiae Proteins/metabolism;
Saccharomyces cerevisiae Proteins/genetics;
Saccharomyces cerevisiae Proteins/chemistry;
Saccharomyces cerevisiae/metabolism;
Saccharomyces cerevisiae/genetics;
Messenger/metabolism;
RNA;
RNA;
Fungal/metabolism;
Protein Binding;
Adenosine Triphosphate/metabolism;
Mutation;
Saccharomyces cerevisiae Proteins/physiology;
Transcription;
Genetic;
mRNA Cleavage and Polyadenylation Factors/chemistry;
mRNA Cleavage and Polyadenylation Factors/genetics;
mRNA Cleavage and Polyadenylation Factors/metabolism;
mRNA Cleavage and Polyadenylation Factors/physiology
Erscheinungsjahr
2011
Zeitschriftentitel
PloS one
Band
6
Ausgabe
12
Art.-Nr.
e29139
ISSN
1932-6203
eISSN
1932-6203
Page URI
https://pub.uni-bielefeld.de/record/2576799
Zitieren
Holbein S, Scola S, Loll B, et al. The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation. PloS one. 2011;6(12): e29139.
Holbein, S., Scola, S., Loll, B., Dichtl, B. S., Hübner, W., Meinhart, A., & Dichtl, B. (2011). The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation. PloS one, 6(12), e29139. doi:10.1371/journal.pone.0029139
Holbein, Sandra, Scola, Simonetta, Loll, Bernhard, Dichtl, Beatriz Solange, Hübner, Wolfgang, Meinhart, Anton, and Dichtl, Bernhard. 2011. “The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation”. PloS one 6 (12): e29139.
Holbein, S., Scola, S., Loll, B., Dichtl, B. S., Hübner, W., Meinhart, A., and Dichtl, B. (2011). The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation. PloS one 6:e29139.
Holbein, S., et al., 2011. The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation. PloS one, 6(12): e29139.
S. Holbein, et al., “The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation”, PloS one, vol. 6, 2011, : e29139.
Holbein, S., Scola, S., Loll, B., Dichtl, B.S., Hübner, W., Meinhart, A., Dichtl, B.: The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation. PloS one. 6, : e29139 (2011).
Holbein, Sandra, Scola, Simonetta, Loll, Bernhard, Dichtl, Beatriz Solange, Hübner, Wolfgang, Meinhart, Anton, and Dichtl, Bernhard. “The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation”. PloS one 6.12 (2011): e29139.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
UNIPROT
14 Einträge gefunden, die diesen Artikel zitieren von denen 10 angezeigt werden
Protein PCF11 (UNIPROT: P39081)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Siderophore iron transporter ENB1 (UNIPROT: Q08299)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
54S ribosomal protein L17, mitochondrial (UNIPROT: P36528)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
D-3-phosphoglycerate dehydrogenase 1 (UNIPROT: P40054)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Protein NRD1 (UNIPROT: P53617)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Trafficking protein particle complex subunit 31 (UNIPROT: Q03337)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Endoribonuclease YSH1 (UNIPROT: Q06224)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
60S ribosomal protein L28 (UNIPROT: P02406)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Phosphate permease PHO89 (UNIPROT: P38361)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Guanine nucleotide-binding protein subunit beta-like protein (UNIPROT: P38011)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
INTERPRO
1 Eintrag gefunden, die diesen Artikel zitieren
Pre-mRNA_cleavage_Clp1 (INTERPRO: IPR010655)
Protein family/domain name: Pre-mRNA cleavage complex subunit Clp1
Protein family/domain name: Pre-mRNA cleavage complex subunit Clp1
16 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
Activation of the Endonuclease that Defines mRNA 3' Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex.
Hill CH, Boreikaitė V, Kumar A, Casañal A, Kubík P, Degliesposti G, Maslen S, Mariani A, von Loeffelholz O, Girbig M, Skehel M, Passmore LA., Mol Cell 73(6), 2019
PMID: 30737185
Hill CH, Boreikaitė V, Kumar A, Casañal A, Kubík P, Degliesposti G, Maslen S, Mariani A, von Loeffelholz O, Girbig M, Skehel M, Passmore LA., Mol Cell 73(6), 2019
PMID: 30737185
Characterization of the molecular crosstalk within the essential Grc3/Las1 pre-rRNA processing complex.
Pillon MC, Sobhany M, Stanley RE., RNA 24(5), 2018
PMID: 29440475
Pillon MC, Sobhany M, Stanley RE., RNA 24(5), 2018
PMID: 29440475
RNA Polymerase II Transcription Attenuation at the Yeast DNA Repair Gene, DEF1, Involves Sen1-Dependent and Polyadenylation Site-Dependent Termination.
Whalen C, Tuohy C, Tallo T, Kaufman JW, Moore C, Kuehner JN., G3 (Bethesda) 8(6), 2018
PMID: 29686108
Whalen C, Tuohy C, Tallo T, Kaufman JW, Moore C, Kuehner JN., G3 (Bethesda) 8(6), 2018
PMID: 29686108
Reconstitution of mammalian cleavage factor II involved in 3' processing of mRNA precursors.
Schäfer P, Tüting C, Schönemann L, Kühn U, Treiber T, Treiber N, Ihling C, Graber A, Keller W, Meister G, Sinz A, Wahle E., RNA 24(12), 2018
PMID: 30139799
Schäfer P, Tüting C, Schönemann L, Kühn U, Treiber T, Treiber N, Ihling C, Graber A, Keller W, Meister G, Sinz A, Wahle E., RNA 24(12), 2018
PMID: 30139799
The C terminus of Pcf11 forms a novel zinc-finger structure that plays an essential role in mRNA 3'-end processing.
Yang F, Hsu P, Lee SD, Yang W, Hoskinson D, Xu W, Moore C, Varani G., RNA 23(1), 2017
PMID: 27780845
Yang F, Hsu P, Lee SD, Yang W, Hoskinson D, Xu W, Moore C, Varani G., RNA 23(1), 2017
PMID: 27780845
An investigation into the role of ATP in the mammalian pre-mRNA 3' cleavage reaction.
Khleborodova A, Pan X, Nagre NN, Ryan K., Biochimie 125(), 2016
PMID: 27060432
Khleborodova A, Pan X, Nagre NN, Ryan K., Biochimie 125(), 2016
PMID: 27060432
CLP1 as a novel player in linking tRNA splicing to neurodegenerative disorders.
Weitzer S, Hanada T, Penninger JM, Martinez J., Wiley Interdiscip Rev RNA 6(1), 2015
PMID: 25142875
Weitzer S, Hanada T, Penninger JM, Martinez J., Wiley Interdiscip Rev RNA 6(1), 2015
PMID: 25142875
Structural basis for ATP loss by Clp1p in a G135R mutant protein.
Dupin AF, Fribourg S., Biochimie 101(), 2014
PMID: 24508575
Dupin AF, Fribourg S., Biochimie 101(), 2014
PMID: 24508575
Delineating the structural blueprint of the pre-mRNA 3'-end processing machinery.
Xiang K, Tong L, Manley JL., Mol Cell Biol 34(11), 2014
PMID: 24591651
Xiang K, Tong L, Manley JL., Mol Cell Biol 34(11), 2014
PMID: 24591651
Structure and function of pre-mRNA 5'-end capping quality control and 3'-end processing.
Jurado AR, Tan D, Jiao X, Kiledjian M, Tong L., Biochemistry 53(12), 2014
PMID: 24617759
Jurado AR, Tan D, Jiao X, Kiledjian M, Tong L., Biochemistry 53(12), 2014
PMID: 24617759
RNA specificity and regulation of catalysis in the eukaryotic polynucleotide kinase Clp1.
Dikfidan A, Loll B, Zeymer C, Magler I, Clausen T, Meinhart A., Mol Cell 54(6), 2014
PMID: 24813946
Dikfidan A, Loll B, Zeymer C, Magler I, Clausen T, Meinhart A., Mol Cell 54(6), 2014
PMID: 24813946
Disengaging polymerase: terminating RNA polymerase II transcription in budding yeast.
Mischo HE, Proudfoot NJ., Biochim Biophys Acta 1829(1), 2013
PMID: 23085255
Mischo HE, Proudfoot NJ., Biochim Biophys Acta 1829(1), 2013
PMID: 23085255
CLP1 links tRNA metabolism to progressive motor-neuron loss.
Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, Rainer J, Kofler R, Yaron A, Eggan KC, Woolf CJ, Glatzel M, Herbst R, Martinez J, Penninger JM., Nature 495(7442), 2013
PMID: 23474986
Hanada T, Weitzer S, Mair B, Bernreuther C, Wainger BJ, Ichida J, Hanada R, Orthofer M, Cronin SJ, Komnenovic V, Minis A, Sato F, Mimata H, Yoshimura A, Tamir I, Rainer J, Kofler R, Yaron A, Eggan KC, Woolf CJ, Glatzel M, Herbst R, Martinez J, Penninger JM., Nature 495(7442), 2013
PMID: 23474986
Intron excision from precursor tRNA molecules in mammalian cells requires ATP hydrolysis and phosphorylation of tRNA-splicing endonuclease components.
Mair B, Popow J, Mechtler K, Weitzer S, Martinez J., Biochem Soc Trans 41(4), 2013
PMID: 23863140
Mair B, Popow J, Mechtler K, Weitzer S, Martinez J., Biochem Soc Trans 41(4), 2013
PMID: 23863140
A role for CF1A 3' end processing complex in promoter-associated transcription.
Al Husini N, Kudla P, Ansari A., PLoS Genet 9(8), 2013
PMID: 23966880
Al Husini N, Kudla P, Ansari A., PLoS Genet 9(8), 2013
PMID: 23966880
The regulatory role of Pcf11-similar-4 (PCFS4) in Arabidopsis development by genome-wide physical interactions with target loci.
Xing D, Wang Y, Xu R, Ye X, Yang D, Li QQ., BMC Genomics 14(), 2013
PMID: 24004414
Xing D, Wang Y, Xu R, Ye X, Yang D, Li QQ., BMC Genomics 14(), 2013
PMID: 24004414
36 References
Daten bereitgestellt von Europe PubMed Central.
Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors.
de Vries H, Ruegsegger U, Hubner W, Friedlein A, Langen H, Keller W., EMBO J. 19(21), 2000
PMID: 11060040
de Vries H, Ruegsegger U, Hubner W, Friedlein A, Langen H, Keller W., EMBO J. 19(21), 2000
PMID: 11060040
Cordycepin interferes with 3' end formation in yeast independently of its potential to terminate RNA chain elongation.
Holbein S, Wengi A, Decourty L, Freimoser FM, Jacquier A, Dichtl B., RNA 15(5), 2009
PMID: 19324962
Holbein S, Wengi A, Decourty L, Freimoser FM, Jacquier A, Dichtl B., RNA 15(5), 2009
PMID: 19324962
RNA-binding protein Nrd1 directs poly(A)-independent 3'-end formation of RNA polymerase II transcripts.
Steinmetz EJ, Conrad NK, Brow DA, Corden JL., Nature 413(6853), 2001
PMID: 11565036
Steinmetz EJ, Conrad NK, Brow DA, Corden JL., Nature 413(6853), 2001
PMID: 11565036
Functional analysis of yeast snoRNA and snRNA 3'-end formation mediated by uncoupling of cleavage and polyadenylation.
Morlando M, Greco P, Dichtl B, Fatica A, Keller W, Bozzoni I., Mol. Cell. Biol. 22(5), 2002
PMID: 11839805
Morlando M, Greco P, Dichtl B, Fatica A, Keller W, Bozzoni I., Mol. Cell. Biol. 22(5), 2002
PMID: 11839805
A role for SSU72 in balancing RNA polymerase II transcription elongation and termination.
Dichtl B, Blank D, Ohnacker M, Friedlein A, Roeder D, Langen H, Keller W., Mol. Cell 10(5), 2002
PMID: 12453421
Dichtl B, Blank D, Ohnacker M, Friedlein A, Roeder D, Langen H, Keller W., Mol. Cell 10(5), 2002
PMID: 12453421
The role of the yeast cleavage and polyadenylation factor subunit Ydh1p/Cft2p in pre-mRNA 3'-end formation.
Kyburz A, Sadowski M, Dichtl B, Keller W., Nucleic Acids Res. 31(14), 2003
PMID: 12853609
Kyburz A, Sadowski M, Dichtl B, Keller W., Nucleic Acids Res. 31(14), 2003
PMID: 12853609
Organization and function of APT, a subcomplex of the yeast cleavage and polyadenylation factor involved in the formation of mRNA and small nucleolar RNA 3'-ends.
Nedea E, He X, Kim M, Pootoolal J, Zhong G, Canadien V, Hughes T, Buratowski S, Moore CL, Greenblatt J., J. Biol. Chem. 278(35), 2003
PMID: 12819204
Nedea E, He X, Kim M, Pootoolal J, Zhong G, Canadien V, Hughes T, Buratowski S, Moore CL, Greenblatt J., J. Biol. Chem. 278(35), 2003
PMID: 12819204
Evidence that polyadenylation factor CPSF-73 is the mRNA 3' processing endonuclease.
Ryan K, Calvo O, Manley JL., RNA 10(4), 2004
PMID: 15037765
Ryan K, Calvo O, Manley JL., RNA 10(4), 2004
PMID: 15037765
A non-conserved sequence in the 5'region of the CYH2 intron from Saccharomyces cerevisiae controls splicing efficiency of the pre-mRNA.
Swida U, Thuroff E, Steinert E, Kaufer NF., Yeast 4(3), 1988
PMID: 3059718
Swida U, Thuroff E, Steinert E, Kaufer NF., Yeast 4(3), 1988
PMID: 3059718
A strategy for the generation of conditional mutations by protein destabilization.
Park EC, Finley D, Szostak JW., Proc. Natl. Acad. Sci. U.S.A. 89(4), 1992
PMID: 1311090
Park EC, Finley D, Szostak JW., Proc. Natl. Acad. Sci. U.S.A. 89(4), 1992
PMID: 1311090
Effects of mutations in the Saccharomyces cerevisiae RNA14, RNA15, and PAP1 genes on polyadenylation in vivo.
Mandart E, Parker R., Mol. Cell. Biol. 15(12), 1995
PMID: 8524265
Mandart E, Parker R., Mol. Cell. Biol. 15(12), 1995
PMID: 8524265
Purification of the Saccharomyces cerevisiae cleavage/polyadenylation factor I. Separation into two components that are required for both cleavage and polyadenylation of mRNA 3' ends.
Kessler MM, Zhao J, Moore CL., J. Biol. Chem. 271(43), 1996
PMID: 8900210
Kessler MM, Zhao J, Moore CL., J. Biol. Chem. 271(43), 1996
PMID: 8900210
Sequence similarity between the 73-kilodalton protein of mammalian CPSF and a subunit of yeast polyadenylation factor I.
Jenny A, Minvielle-Sebastia L, Preker PJ, Keller W., Science 274(5292), 1996
PMID: 8929409
Jenny A, Minvielle-Sebastia L, Preker PJ, Keller W., Science 274(5292), 1996
PMID: 8929409
The C-terminal domain of RNA polymerase II couples mRNA processing to transcription.
McCracken S, Fong N, Yankulov K, Ballantyne S, Pan G, Greenblatt J, Patterson SD, Wickens M, Bentley DL., Nature 385(6614), 1997
PMID: 9002523
McCracken S, Fong N, Yankulov K, Ballantyne S, Pan G, Greenblatt J, Patterson SD, Wickens M, Bentley DL., Nature 385(6614), 1997
PMID: 9002523
PCF11 encodes a third protein component of yeast cleavage and polyadenylation factor I.
Amrani N, Minet M, Wyers F, Dufour ME, Aggerbeck LP, Lacroute F., Mol. Cell. Biol. 17(3), 1997
PMID: 9032237
Amrani N, Minet M, Wyers F, Dufour ME, Aggerbeck LP, Lacroute F., Mol. Cell. Biol. 17(3), 1997
PMID: 9032237
Cleavage factor II of Saccharomyces cerevisiae contains homologues to subunits of the mammalian Cleavage/ polyadenylation specificity factor and exhibits sequence-specific, ATP-dependent interaction with precursor RNA.
Zhao J, Kessler MM, Moore CL., J. Biol. Chem. 272(16), 1997
PMID: 9099738
Zhao J, Kessler MM, Moore CL., J. Biol. Chem. 272(16), 1997
PMID: 9099738
The major yeast poly(A)-binding protein is associated with cleavage factor IA and functions in premessenger RNA 3'-end formation.
Minvielle-Sebastia L, Preker PJ, Wiederkehr T, Strahm Y, Keller W., Proc. Natl. Acad. Sci. U.S.A. 94(15), 1997
PMID: 9223284
Minvielle-Sebastia L, Preker PJ, Wiederkehr T, Strahm Y, Keller W., Proc. Natl. Acad. Sci. U.S.A. 94(15), 1997
PMID: 9223284
A multisubunit 3' end processing factor from yeast containing poly(A) polymerase and homologues of the subunits of mammalian cleavage and polyadenylation specificity factor.
Preker PJ, Ohnacker M, Minvielle-Sebastia L, Keller W., EMBO J. 16(15), 1997
PMID: 9303317
Preker PJ, Ohnacker M, Minvielle-Sebastia L, Keller W., EMBO J. 16(15), 1997
PMID: 9303317
Hrp1, a sequence-specific RNA-binding protein that shuttles between the nucleus and the cytoplasm, is required for mRNA 3'-end formation in yeast.
Kessler MM, Henry MF, Shen E, Zhao J, Gross S, Silver PA, Moore CL., Genes Dev. 11(19), 1997
PMID: 9334319
Kessler MM, Henry MF, Shen E, Zhao J, Gross S, Silver PA, Moore CL., Genes Dev. 11(19), 1997
PMID: 9334319
Control of cleavage site selection during mRNA 3' end formation by a yeast hnRNP.
Minvielle-Sebastia L, Beyer K, Krecic AM, Hector RE, Swanson MS, Keller W., EMBO J. 17(24), 1998
PMID: 9857200
Minvielle-Sebastia L, Beyer K, Krecic AM, Hector RE, Swanson MS, Keller W., EMBO J. 17(24), 1998
PMID: 9857200
Formation of mRNA 3' ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis.
Zhao J, Hyman L, Moore C., Microbiol. Mol. Biol. Rev. 63(2), 1999
PMID: 10357856
Zhao J, Hyman L, Moore C., Microbiol. Mol. Biol. Rev. 63(2), 1999
PMID: 10357856
Regulation of yeast NRD1 expression by premature transcription termination.
Arigo JT, Carroll KL, Ames JM, Corden JL., Mol. Cell 21(5), 2006
PMID: 16507362
Arigo JT, Carroll KL, Ames JM, Corden JL., Mol. Cell 21(5), 2006
PMID: 16507362
Distinct pathways for snoRNA and mRNA termination.
Kim M, Vasiljeva L, Rando OJ, Zhelkovsky A, Moore C, Buratowski S., Mol. Cell 24(5), 2006
PMID: 17157255
Kim M, Vasiljeva L, Rando OJ, Zhelkovsky A, Moore C, Buratowski S., Mol. Cell 24(5), 2006
PMID: 17157255
Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease.
Mandel CR, Kaneko S, Zhang H, Gebauer D, Vethantham V, Manley JL, Tong L., Nature 444(7121), 2006
PMID: 17128255
Mandel CR, Kaneko S, Zhang H, Gebauer D, Vethantham V, Manley JL, Tong L., Nature 444(7121), 2006
PMID: 17128255
Structure of a nucleotide-bound Clp1-Pcf11 polyadenylation factor.
Noble CG, Beuth B, Taylor IA., Nucleic Acids Res. 35(1), 2006
PMID: 17151076
Noble CG, Beuth B, Taylor IA., Nucleic Acids Res. 35(1), 2006
PMID: 17151076
The human RNA kinase hClp1 is active on 3' transfer RNA exons and short interfering RNAs.
Weitzer S, Martinez J., Nature 447(7141), 2007
PMID: 17495927
Weitzer S, Martinez J., Nature 447(7141), 2007
PMID: 17495927
Protein factors in pre-mRNA 3'-end processing.
Mandel CR, Bai Y, Tong L., Cell. Mol. Life Sci. 65(7-8), 2008
PMID: 18158581
Mandel CR, Bai Y, Tong L., Cell. Mol. Life Sci. 65(7-8), 2008
PMID: 18158581
Human RNA 5'-kinase (hClp1) can function as a tRNA splicing enzyme in vivo.
Ramirez A, Shuman S, Schwer B., RNA 14(9), 2008
PMID: 18648070
Ramirez A, Shuman S, Schwer B., RNA 14(9), 2008
PMID: 18648070
The role of the putative 3' end processing endonuclease Ysh1p in mRNA and snoRNA synthesis.
Garas M, Dichtl B, Keller W., RNA 14(12), 2008
PMID: 18971324
Garas M, Dichtl B, Keller W., RNA 14(12), 2008
PMID: 18971324
Cotranslational assembly of the yeast SET1C histone methyltransferase complex.
Halbach A, Zhang H, Wengi A, Jablonska Z, Gruber IM, Halbeisen RE, Dehe PM, Kemmeren P, Holstege F, Geli V, Gerber AP, Dichtl B., EMBO J. 28(19), 2009
PMID: 19713935
Halbach A, Zhang H, Wengi A, Jablonska Z, Gruber IM, Halbeisen RE, Dehe PM, Kemmeren P, Holstege F, Geli V, Gerber AP, Dichtl B., EMBO J. 28(19), 2009
PMID: 19713935
Coupled RNA polymerase II transcription and 3' end formation with yeast whole-cell extracts.
Mariconti L, Loll B, Schlinkmann K, Wengi A, Meinhart A, Dichtl B., RNA 16(11), 2010
PMID: 20810619
Mariconti L, Loll B, Schlinkmann K, Wengi A, Meinhart A, Dichtl B., RNA 16(11), 2010
PMID: 20810619
RiboSys, a high-resolution, quantitative approach to measure the in vivo kinetics of pre-mRNA splicing and 3'-end processing in Saccharomyces cerevisiae.
Alexander RD, Barrass JD, Dichtl B, Kos M, Obtulowicz T, Robert MC, Koper M, Karkusiewicz I, Mariconti L, Tollervey D, Dichtl B, Kufel J, Bertrand E, Beggs JD., RNA 16(12), 2010
PMID: 20974745
Alexander RD, Barrass JD, Dichtl B, Kos M, Obtulowicz T, Robert MC, Koper M, Karkusiewicz I, Mariconti L, Tollervey D, Dichtl B, Kufel J, Bertrand E, Beggs JD., RNA 16(12), 2010
PMID: 20974745
Arabidopsis CLP1-SIMILAR PROTEIN3, an ortholog of human polyadenylation factor CLP1, functions in gametophyte, embryo, and postembryonic development.
Xing D, Zhao H, Li QQ., Plant Physiol. 148(4), 2008
PMID: 18971429
Xing D, Zhao H, Li QQ., Plant Physiol. 148(4), 2008
PMID: 18971429
Cotranscriptional recruitment of the mRNA export factor Yra1 by direct interaction with the 3' end processing factor Pcf11.
Johnson SA, Cubberley G, Bentley DL., Mol. Cell 33(2), 2008
PMID: 19110458
Johnson SA, Cubberley G, Bentley DL., Mol. Cell 33(2), 2008
PMID: 19110458
Characterization of a thermostable archaeal polynucleotide kinase homologous to human Clp1.
Jain R, Shuman S., RNA 15(5), 2009
PMID: 19299550
Jain R, Shuman S., RNA 15(5), 2009
PMID: 19299550
Five subunits are required for reconstitution of the cleavage and polyadenylation activities of Saccharomyces cerevisiae cleavage factor I.
Gross S, Moore C., Proc. Natl. Acad. Sci. U.S.A. 98(11), 2001
PMID: 11344258
Gross S, Moore C., Proc. Natl. Acad. Sci. U.S.A. 98(11), 2001
PMID: 11344258
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