The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation
Holbein S, Scola S, Loll B, Dichtl BS, Hübner W, Meinhart A, Dichtl B (2011)
PloS one 6(12): e29139.
Zeitschriftenaufsatz
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Autor*in
Holbein, Sandra;
Scola, Simonetta;
Loll, Bernhard;
Dichtl, Beatriz Solange;
Hübner, WolfgangUniBi ;
Meinhart, Anton;
Dichtl, Bernhard
Einrichtung
Abstract / Bemerkung
Cleavage factor IA (CF IA), cleavage and polyadenylation factor (CPF), constitute major protein complexes required for pre-mRNA 3' end formation in yeast. The Clp1 protein associates with Pcf11, Rna15 and Rna14 in CF IA but its functional role remained unclear. Clp1 carries an evolutionarily conserved P-loop motif that was previously shown to bind ATP. Interestingly, human and archaean Clp1 homologues, but not the yeast protein, carry 5' RNA kinase activity. We show that depletion of Clp1 in yeast promoted defective 3' end formation and RNA polymerase II termination; however, cells expressing Clp1 with mutant P-loops displayed only minor defects in gene expression. Similarly, purified and reconstituted mutant CF IA factors that interfered with ATP binding complemented CF IA depleted extracts in coupled in vitro transcription/3' end processing reactions. We found that Clp1 was required to assemble recombinant CF IA and that certain P-loop mutants failed to interact with the CF IA subunit Pcf11. In contrast, mutations in Clp1 enhanced binding to the 3' endonuclease Ysh1 that is a component of CPF. Our results support a structural role for the Clp1 P-loop motif. ATP binding by Clp1 likely contributes to CF IA formation and cross-factor interactions during the dynamic process of 3' end formation.
Stichworte
Saccharomyces cerevisiae Proteins/metabolism;
Saccharomyces cerevisiae Proteins/genetics;
Saccharomyces cerevisiae Proteins/chemistry;
Saccharomyces cerevisiae/metabolism;
Saccharomyces cerevisiae/genetics;
Messenger/metabolism;
RNA;
RNA;
Fungal/metabolism;
Protein Binding;
Adenosine Triphosphate/metabolism;
Mutation;
Saccharomyces cerevisiae Proteins/physiology;
Transcription;
Genetic;
mRNA Cleavage and Polyadenylation Factors/chemistry;
mRNA Cleavage and Polyadenylation Factors/genetics;
mRNA Cleavage and Polyadenylation Factors/metabolism;
mRNA Cleavage and Polyadenylation Factors/physiology
Erscheinungsjahr
2011
Zeitschriftentitel
PloS one
Band
6
Ausgabe
12
Art.-Nr.
e29139
ISSN
1932-6203
eISSN
1932-6203
Page URI
https://pub.uni-bielefeld.de/record/2576799
Zitieren
Holbein S, Scola S, Loll B, et al. The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation. PloS one. 2011;6(12): e29139.
Holbein, S., Scola, S., Loll, B., Dichtl, B. S., Hübner, W., Meinhart, A., & Dichtl, B. (2011). The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation. PloS one, 6(12), e29139. doi:10.1371/journal.pone.0029139
Holbein, Sandra, Scola, Simonetta, Loll, Bernhard, Dichtl, Beatriz Solange, Hübner, Wolfgang, Meinhart, Anton, and Dichtl, Bernhard. 2011. “The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation”. PloS one 6 (12): e29139.
Holbein, S., Scola, S., Loll, B., Dichtl, B. S., Hübner, W., Meinhart, A., and Dichtl, B. (2011). The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation. PloS one 6:e29139.
Holbein, S., et al., 2011. The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation. PloS one, 6(12): e29139.
S. Holbein, et al., “The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation”, PloS one, vol. 6, 2011, : e29139.
Holbein, S., Scola, S., Loll, B., Dichtl, B.S., Hübner, W., Meinhart, A., Dichtl, B.: The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation. PloS one. 6, : e29139 (2011).
Holbein, Sandra, Scola, Simonetta, Loll, Bernhard, Dichtl, Beatriz Solange, Hübner, Wolfgang, Meinhart, Anton, and Dichtl, Bernhard. “The P-loop domain of yeast Clp1 mediates interactions between CF IA and CPF factors in pre-mRNA 3' end formation”. PloS one 6.12 (2011): e29139.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
INTERPRO
1 Eintrag gefunden, die diesen Artikel zitieren
Pre-mRNA_cleavage_Clp1 (INTERPRO: IPR010655)
Protein family/domain name: Pre-mRNA cleavage complex subunit Clp1
Protein family/domain name: Pre-mRNA cleavage complex subunit Clp1
UNIPROT
14 Einträge gefunden, die diesen Artikel zitieren von denen 10 angezeigt werden
Protein PCF11 (UNIPROT: P39081)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Siderophore iron transporter ENB1 (UNIPROT: Q08299)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
54S ribosomal protein L17, mitochondrial (UNIPROT: P36528)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
D-3-phosphoglycerate dehydrogenase 1 (UNIPROT: P40054)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Protein NRD1 (UNIPROT: P53617)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Trafficking protein particle complex subunit 31 (UNIPROT: Q03337)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Endoribonuclease YSH1 (UNIPROT: Q06224)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
60S ribosomal protein L28 (UNIPROT: P02406)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Phosphate permease PHO89 (UNIPROT: P38361)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Guanine nucleotide-binding protein subunit beta-like protein (UNIPROT: P38011)
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Download in FASTA format
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