Quantitative 3D video microscopy of HIV transfer across T cell virological synapses

Hübner W, McNerney GP, Chen P, Dale BM, Gordon RE, Chuang FYS, Li X-D, Asmuth DM, Huser T, Chen BK (2009)
Science (New York, N.Y.) 323(5922): 1743-1747.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
Autor*in
Hübner, WolfgangUniBi ; McNerney, Gregory P; Chen, Ping; Dale, Benjamin M; Gordon, Ronald E; Chuang, Frank Y S; Li, Xiao-Dong; Asmuth, David M; Huser, Thomas; Chen, Benjamin K
Einrichtung
Fakultät für Physik > AG Biomolekulare Photonik
Abstract / Bemerkung
The spread of HIV between immune cells is greatly enhanced by cell-cell adhesions called virological synapses, although the underlying mechanisms have been unclear. With use of an infectious, fluorescent clone of HIV, we tracked the movement of Gag in live CD4 T cells and captured the direct translocation of HIV across the virological synapse. Quantitative, high-speed three-dimensional (3D) video microscopy revealed the rapid formation of micrometer-sized "buttons" containing oligomerized viral Gag protein. Electron microscopy showed that these buttons were packed with budding viral crescents. Viral transfer events were observed to form virus-laden internal compartments within target cells. Continuous time-lapse monitoring showed preferential infection through synapses. Thus, HIV dissemination may be enhanced by virological synapse-mediated cell adhesion coupled to viral endocytosis.
Stichworte
Transmission; Electron; Microscopy; Confocal; Microscopy; Jurkat Cells; Three-Dimensional; Imaging; Humans; HIV/ultrastructure; HIV/physiology; Endocytosis; Cytochalasin D/pharmacology; Coculture Techniques; Cell Adhesion; CD4-Positive T-Lymphocytes/virology; CD4-Positive T-Lymphocytes/physiology; CD4-Positive T-Lymphocytes/ultrastructure; Microscopy; Video; Receptors; CCR5/metabolism; Receptors; CXCR4/metabolism; Recombinant Fusion Proteins/metabolism; Virus Internalization; gag Gene Products; Human Immunodeficiency Virus/metabolism
Erscheinungsjahr
2009
Zeitschriftentitel
Science (New York, N.Y.)
Band
323
Ausgabe
5922
Seite(n)
1743-1747
ISSN
0036-8075
eISSN
1095-9203
Page URI
https://pub.uni-bielefeld.de/record/2576787

Zitieren

Hübner W, McNerney GP, Chen P, et al. Quantitative 3D video microscopy of HIV transfer across T cell virological synapses. Science (New York, N.Y.). 2009;323(5922):1743-1747.
Hübner, W., McNerney, G. P., Chen, P., Dale, B. M., Gordon, R. E., Chuang, F. Y. S., Li, X. - D., et al. (2009). Quantitative 3D video microscopy of HIV transfer across T cell virological synapses. Science (New York, N.Y.), 323(5922), 1743-1747. doi:10.1126/science.1167525
Hübner, Wolfgang, McNerney, Gregory P, Chen, Ping, Dale, Benjamin M, Gordon, Ronald E, Chuang, Frank Y S, Li, Xiao-Dong, Asmuth, David M, Huser, Thomas, and Chen, Benjamin K. 2009. “Quantitative 3D video microscopy of HIV transfer across T cell virological synapses”. Science (New York, N.Y.) 323 (5922): 1743-1747.
Hübner, W., McNerney, G. P., Chen, P., Dale, B. M., Gordon, R. E., Chuang, F. Y. S., Li, X. - D., Asmuth, D. M., Huser, T., and Chen, B. K. (2009). Quantitative 3D video microscopy of HIV transfer across T cell virological synapses. Science (New York, N.Y.) 323, 1743-1747.
Hübner, W., et al., 2009. Quantitative 3D video microscopy of HIV transfer across T cell virological synapses. Science (New York, N.Y.), 323(5922), p 1743-1747.
W. Hübner, et al., “Quantitative 3D video microscopy of HIV transfer across T cell virological synapses”, Science (New York, N.Y.), vol. 323, 2009, pp. 1743-1747.
Hübner, W., McNerney, G.P., Chen, P., Dale, B.M., Gordon, R.E., Chuang, F.Y.S., Li, X.-D., Asmuth, D.M., Huser, T., Chen, B.K.: Quantitative 3D video microscopy of HIV transfer across T cell virological synapses. Science (New York, N.Y.). 323, 1743-1747 (2009).
Hübner, Wolfgang, McNerney, Gregory P, Chen, Ping, Dale, Benjamin M, Gordon, Ronald E, Chuang, Frank Y S, Li, Xiao-Dong, Asmuth, David M, Huser, Thomas, and Chen, Benjamin K. “Quantitative 3D video microscopy of HIV transfer across T cell virological synapses”. Science (New York, N.Y.) 323.5922 (2009): 1743-1747.

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Breed MW, Jordan AP, Aye PP, Lichtveld CF, Midkiff CC, Schiro FR, Haggarty BS, Sugimoto C, Alvarez X, Sandler NG, Douek DC, Kuroda MJ, Pahar B, Piatak M, Lifson JD, Keele BF, Hoxie JA, Lackner AA., J Virol 87(3), 2013
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A sensitive real-time PCR based assay to estimate the impact of amino acid substitutions on the competitive replication fitness of human immunodeficiency virus type 1 in cell culture.
Liu Y, Holte S, Rao U, McClure J, Konopa P, Swain JV, Lanxon-Cookson E, Kim M, Chen L, Mullins JI., J Virol Methods 189(1), 2013
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Cell-to-cell transmission of viruses.
Zhong P, Agosto LM, Munro JB, Mothes W., Curr Opin Virol 3(1), 2013
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Cell-cell transmission allows human T-lymphotropic virus 1 to circumvent tetherin restriction.
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Relative contribution of free-virus and synaptic transmission to the spread of HIV-1 through target cell populations.
Komarova NL, Anghelina D, Voznesensky I, Trinité B, Levy DN, Wodarz D., Biol Lett 9(1), 2013
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Mechanisms of enhanced HIV spread through T-cell virological synapses.
Dale BM, Alvarez RA, Chen BK., Immunol Rev 251(1), 2013
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Transfer of extracellular vesicles during immune cell-cell interactions.
Gutiérrez-Vázquez C, Villarroya-Beltri C, Mittelbrunn M, Sánchez-Madrid F., Immunol Rev 251(1), 2013
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Synaptic transmission and the susceptibility of HIV infection to anti-viral drugs.
Komarova NL, Levy DN, Wodarz D., Sci Rep 3(), 2013
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Evidence of ongoing replication in a human immunodeficiency virus type 1 persistently infected cell line.
Olivares I, Sánchez-Jiménez C, Vieira CR, Toledano V, Gutiérrez-Rivas M, López-Galíndez C., J Gen Virol 94(pt 5), 2013
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Is specific HIV eradication from the brain possible or needed?
Brew BJ, Gray L, Lewin S, Churchill M., Expert Opin Biol Ther 13(3), 2013
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Cell-to-cell transmission can overcome multiple donor and target cell barriers imposed on cell-free HIV.
Zhong P, Agosto LM, Ilinskaya A, Dorjbal B, Truong R, Derse D, Uchil PD, Heidecker G, Mothes W., PLoS One 8(1), 2013
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Komarova NL, Wodarz D., Math Biosci 242(2), 2013
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Live cell imaging of viral entry.
Sun E, He J, Zhuang X., Curr Opin Virol 3(1), 2013
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A doubly fluorescent HIV-1 reporter shows that the majority of integrated HIV-1 is latent shortly after infection.
Dahabieh MS, Ooms M, Simon V, Sadowski I., J Virol 87(8), 2013
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HIV-1 Gag associates with specific uropod-directed microdomains in a manner dependent on its MA highly basic region.
Llewellyn GN, Grover JR, Olety B, Ono A., J Virol 87(11), 2013
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Forced virus evolution reveals functional crosstalk between the disulfide bonded region and membrane proximal ectodomain region of HIV-1 gp41.
Khasawneh AI, Laumaea A, Harrison DN, Bellamy-McIntyre AK, Drummer HE, Poumbourios P., Retrovirology 10(), 2013
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Basic residues in the matrix domain and multimerization target murine leukemia virus Gag to the virological synapse.
Li F, Jin J, Herrmann C, Mothes W., J Virol 87(12), 2013
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Clustering and mobility of HIV-1 Env at viral assembly sites predict its propensity to induce cell-cell fusion.
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Rinaldo CR., Scientifica (Cairo) 2013(), 2013
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Productive entry of HIV-1 during cell-to-cell transmission via dynamin-dependent endocytosis.
Sloan RD, Kuhl BD, Mesplède T, Münch J, Donahue DA, Wainberg MA., J Virol 87(14), 2013
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Multiple proviral integration events after virological synapse-mediated HIV-1 spread.
Russell RA, Martin N, Mitar I, Jones E, Sattentau QJ., Virology 443(1), 2013
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Cell-cell contact-mediated hepatitis C virus (HCV) transfer, productive infection, and replication and their requirement for HCV receptors.
Liu Z, He JJ., J Virol 87(15), 2013
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Multilamellar structures and filament bundles are found on the cell surface during bunyavirus egress.
Sanz-Sánchez L, Risco C., PLoS One 8(6), 2013
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The immunological synapse: the gateway to the HIV reservoir.
Kulpa DA, Brehm JH, Fromentin R, Cooper A, Cooper C, Ahlers J, Chomont N, Sékaly RP., Immunol Rev 254(1), 2013
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Cellular and Biochemical Mechanisms of the Retroviral Restriction Factor SAMHD1.
Wu L., ISRN Biochem 2013(), 2013
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HIV-1 Nef promotes the localization of Gag to the cell membrane and facilitates viral cell-to-cell transfer.
Malbec M, Sourisseau M, Guivel-Benhassine F, Porrot F, Blanchet F, Schwartz O, Casartelli N., Retrovirology 10(), 2013
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Actin-binding protein drebrin regulates HIV-1-triggered actin polymerization and viral infection.
Gordón-Alonso M, Rocha-Perugini V, Álvarez S, Ursa Á, Izquierdo-Useros N, Martinez-Picado J, Muñoz-Fernández MA, Sánchez-Madrid F., J Biol Chem 288(39), 2013
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Fusion of mature HIV-1 particles leads to complete release of a gag-GFP-based content marker and raises the intraviral pH.
Padilla-Parra S, Marin M, Gahlaut N, Suter R, Kondo N, Melikyan GB., PLoS One 8(8), 2013
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Immune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptors.
Wei B, Han L, Abbink TE, Groppelli E, Lim D, Thaker YR, Gao W, Zhai R, Wang J, Lever A, Jolly C, Wang H, Rudd CE., Retrovirology 10(), 2013
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Intravital microscopy in BLT-humanized mice to study cellular dynamics in HIV infection.
Murooka TT, Mempel TR., J Infect Dis 208 Suppl 2(), 2013
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The cortical actin determines different susceptibility of naïve and memory CD4+ T cells to HIV-1 cell-to-cell transmission and infection.
Permanyer M, Pauls E, Badia R, Esté JA, Ballana E., PLoS One 8(11), 2013
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Can non-lytic CD8+ T cells drive HIV-1 escape?
Seich Al Basatena NK, Chatzimichalis K, Graw F, Frost SD, Regoes RR, Asquith B., PLoS Pathog 9(11), 2013
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Intracellular nucleic acid delivery by the supercharged dengue virus capsid protein.
Freire JM, Veiga AS, Conceição TM, Kowalczyk W, Mohana-Borges R, Andreu D, Santos NC, Da Poian AT, Castanho MA., PLoS One 8(12), 2013
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Protease inhibitors effectively block cell-to-cell spread of HIV-1 between T cells.
Titanji BK, Aasa-Chapman M, Pillay D, Jolly C., Retrovirology 10(), 2013
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Stable and transient periodic oscillations in a mathematical model for CTL response to HTLV-I infection.
Lang J, Li MY., J Math Biol 65(1), 2012
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Real-time optical detection of single human and bacterial viruses based on dark-field interferometry.
Mitra A, Ignatovich F, Novotny L., Biosens Bioelectron 31(1), 2012
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Role of O-glycosylation and expression of CD43 and CD45 on the surfaces of effector T cells in human T cell leukemia virus type 1 cell-to-cell infection.
Mazurov D, Ilinskaya A, Heidecker G, Filatov A., J Virol 86(5), 2012
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Macrophage internal HIV-1 is protected from neutralizing antibodies.
Koppensteiner H, Banning C, Schneider C, Hohenberg H, Schindler M., J Virol 86(5), 2012
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In vivo imaging of virological synapses.
Sewald X, Gonzalez DG, Haberman AM, Mothes W., Nat Commun 3(), 2012
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HIV cell-to-cell transmission requires the production of infectious virus particles and does not proceed through env-mediated fusion pores.
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Cannabinoid receptor 2-mediated attenuation of CXCR4-tropic HIV infection in primary CD4+ T cells.
Costantino CM, Gupta A, Yewdall AW, Dale BM, Devi LA, Chen BK., PLoS One 7(3), 2012
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Infection of HIV-specific CD4 T helper cells and the clonal composition of the response.
Roy SM, Wodarz D., J Theor Biol 304(), 2012
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Cell-cell transmission enables HIV-1 to evade inhibition by potent CD4bs directed antibodies.
Abela IA, Berlinger L, Schanz M, Reynell L, Günthard HF, Rusert P, Trkola A., PLoS Pathog 8(4), 2012
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Neutralization resistance of virological synapse-mediated HIV-1 Infection is regulated by the gp41 cytoplasmic tail.
Durham ND, Yewdall AW, Chen P, Lee R, Zony C, Robinson JE, Chen BK., J Virol 86(14), 2012
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Quantitative live-cell imaging of human immunodeficiency virus (HIV-1) assembly.
Baumgärtel V, Müller B, Lamb DC., Viruses 4(5), 2012
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Increased burst size in multiply infected cells can alter basic virus dynamics.
Cummings KW, Levy DN, Wodarz D., Biol Direct 7(), 2012
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Modulation of HIV pathogenesis and T-cell signaling by HIV-1 Nef.
Saxena SK, Shrivastava G, Tiwari S, Swamy MA, Nair MP., Future Virol 7(6), 2012
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Mobilization of HIV spread by diaphanous 2 dependent filopodia in infected dendritic cells.
Aggarwal A, Iemma TL, Shih I, Newsome TP, McAllery S, Cunningham AL, Turville SG., PLoS Pathog 8(6), 2012
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A mutant retroviral receptor restricts virus superinfection interference and productive infection.
Liu M, Eiden MV., Retrovirology 9(), 2012
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Antiretroviral agents effectively block HIV replication after cell-to-cell transfer.
Permanyer M, Ballana E, Ruiz A, Badia R, Riveira-Munoz E, Gonzalo E, Clotet B, Esté JA., J Virol 86(16), 2012
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HIV-1 assembly, budding, and maturation.
Sundquist WI, Kräusslich HG., Cold Spring Harb Perspect Med 2(7), 2012
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Ectopic ATP synthase facilitates transfer of HIV-1 from antigen-presenting cells to CD4(+) target cells.
Yavlovich A, Viard M, Zhou M, Veenstra TD, Wang JM, Gong W, Heldman E, Blumenthal R, Raviv Y., Blood 120(6), 2012
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Nanofluidic preconcentration and detection of nanoparticles.
Mitra A, Ignatovich F, Novotny L., J Appl Phys 112(1), 2012
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Dynamic Association between HIV-1 Gag and Membrane Domains.
Hogue IB, Llewellyn GN, Ono A., Mol Biol Int 2012(), 2012
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A hybrid stochastic-deterministic computational model accurately describes spatial dynamics and virus diffusion in HIV-1 growth competition assay.
Immonen T, Gibson R, Leitner T, Miller MA, Arts EJ, Somersalo E, Calvetti D., J Theor Biol 312(), 2012
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Trans-infection but not infection from within endosomal compartments after cell-to-cell HIV-1 transfer to CD4+ T cells.
Permanyer M, Ballana E, Badia R, Pauls E, Clotet B, Esté JA., J Biol Chem 287(38), 2012
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HIV-infected T cells are migratory vehicles for viral dissemination.
Murooka TT, Deruaz M, Marangoni F, Vrbanac VD, Seung E, von Andrian UH, Tager AM, Luster AD, Mempel TR., Nature 490(7419), 2012
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As good as it gets? The problem of HIV persistence despite antiretroviral drugs.
Sigal A, Baltimore D., Cell Host Microbe 12(2), 2012
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HIV: cell binding and entry.
Wilen CB, Tilton JC, Doms RW., Cold Spring Harb Perspect Med 2(8), 2012
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Tetherin/BST-2 is essential for the formation of the intracellular virus-containing compartment in HIV-infected macrophages.
Chu H, Wang JJ, Qi M, Yoon JJ, Chen X, Wen X, Hammonds J, Ding L, Spearman P., Cell Host Microbe 12(3), 2012
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Innate immune recognition of HIV-1.
Iwasaki A., Immunity 37(3), 2012
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Neutralizing antibodies inhibit HIV-1 transfer from primary dendritic cells to autologous CD4 T lymphocytes.
Su B, Xu K, Lederle A, Peressin M, Biedma ME, Laumond G, Schmidt S, Decoville T, Proust A, Lambotin M, Holl V, Moog C., Blood 120(18), 2012
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Intercellular adhesion molecule 1 promotes HIV-1 attachment but not fusion to target cells.
Kondo N, Melikyan GB., PLoS One 7(9), 2012
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Alphaherpesvirus axon-to-cell spread involves limited virion transmission.
Taylor MP, Kobiler O, Enquist LW., Proc Natl Acad Sci U S A 109(42), 2012
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Pathways of cell-cell transmission of HTLV-1.
Pique C, Jones KS., Front Microbiol 3(), 2012
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HIV-specific antibody-dependent cellular cytotoxicity: a novel vaccine modality.
Madhavi V, Kent SJ, Stratov I., Expert Rev Clin Immunol 8(8), 2012
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Effect of synaptic transmission on viral fitness in HIV infection.
Komarova NL, Levy DN, Wodarz D., PLoS One 7(11), 2012
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T cell virological synapses and HIV-1 pathogenesis.
Chen BK., Immunol Res 54(1-3), 2012
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Nevirapine Inhibits Cell-Free Human Immunodeficiency Virus (HIV)-1 Infection In Vitro More Efficiently Than Cell-Cell HIV Infection at Concentrations Found in Human Breastmilk.
Dorosko SM, Housman ML, Connor RI., Breastfeed Med (), 2012
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Tracking and quantitation of fluorescent HIV during cell-to-cell transmission.
Dale BM, McNerney GP, Hübner W, Huser TR, Chen BK., Methods 53(1), 2011
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Effect of different modes of viral spread on the dynamics of multiply infected cells in human immunodeficiency virus infection.
Wodarz D, Levy DN., J R Soc Interface 8(55), 2011
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HIV-1 transmission in the male genital tract.
Ganor Y, Bomsel M., Am J Reprod Immunol 65(3), 2011
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Cell-to-cell transmission of retroviruses: Innate immunity and interferon-induced restriction factors.
Jolly C., Virology 411(2), 2011
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Innate sensing of HIV-infected cells.
Lepelley A, Louis S, Sourisseau M, Law HK, Pothlichet J, Schilte C, Chaperot L, Plumas J, Randall RE, Si-Tahar M, Mammano F, Albert ML, Schwartz O., PLoS Pathog 7(2), 2011
PMID: 21379343
Virological synapses allow HIV-1 uptake and gene expression in renal tubular epithelial cells.
Chen P, Chen BK, Mosoian A, Hays T, Ross MJ, Klotman PE, Klotman ME., J Am Soc Nephrol 22(3), 2011
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Coreceptors and HIV-1 pathogenesis.
Gorry PR, Ancuta P., Curr HIV/AIDS Rep 8(1), 2011
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Early events of HIV-1 infection: can signaling be the next therapeutic target?
Jones KL, Smyth RP, Pereira CF, Cameron PU, Lewin SR, Jaworowski A, Mak J., J Neuroimmune Pharmacol 6(2), 2011
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Cellular entry via an actin and clathrin-dependent route is required for Lv2 restriction of HIV-2.
Harrison IP, McKnight A., Virology 415(1), 2011
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Multiploid inheritance of HIV-1 during cell-to-cell infection.
Del Portillo A, Tripodi J, Najfeld V, Wodarz D, Levy DN, Chen BK., J Virol 85(14), 2011
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WFDC1 expression identifies memory CD4 T-lymphocytes rendered vulnerable to cell-cell HIV-1 transfer by promoting intercellular adhesive junctions.
Alvarez RA, Thorborn G, Reading JL, Reddy SK, Vyakarnam A., Retrovirology 8(), 2011
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Viral determinants of polarized assembly for the murine leukemia virus.
Jin J, Li F, Mothes W., J Virol 85(15), 2011
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Host factors involved in retroviral budding and release.
Martin-Serrano J, Neil SJ., Nat Rev Microbiol 9(7), 2011
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Visualizing HIV-1 assembly.
Jouvenet N, Simon SM, Bieniasz PD., J Mol Biol 410(4), 2011
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Molecular determinants that regulate plasma membrane association of HIV-1 Gag.
Chukkapalli V, Ono A., J Mol Biol 410(4), 2011
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Vpu-mediated tetherin antagonism of ongoing HIV-1 infection in CD4(+) T-cells is not directly related to the extent of tetherin cell surface downmodulation.
Kuhl BD, Sloan RD, Donahue DA, Liang C, Wainberg MA., Virology 417(2), 2011
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Effect of multiple infection of cells on the evolutionary dynamics of HIV in vivo: implications for host adaptation mechanisms.
Wodarz D, Levy DN., Exp Biol Med (Maywood) 236(8), 2011
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New insights into HIV assembly and trafficking.
Balasubramaniam M, Freed EO., Physiology (Bethesda) 26(4), 2011
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Lensfree super-resolution holographic microscopy using wetting films on a chip.
Mudanyali O, Bishara W, Ozcan A., Opt Express 19(18), 2011
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HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin (LtxA).
Hioe CE, Tuen M, Vasiliver-Shamis G, Alvarez Y, Prins KC, Banerjee S, Nádas A, Cho MW, Dustin ML, Kachlany SC., PLoS One 6(8), 2011
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Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection.
Séror C, Melki MT, Subra F, Raza SQ, Bras M, Saïdi H, Nardacci R, Voisin L, Paoletti A, Law F, Martins I, Amendola A, Abdul-Sater AA, Ciccosanti F, Delelis O, Niedergang F, Thierry S, Said-Sadier N, Lamaze C, Métivier D, Estaquier J, Fimia GM, Falasca L, Casetti R, Modjtahedi N, Kanellopoulos J, Mouscadet JF, Ojcius DM, Piacentini M, Gougeon ML, Kroemer G, Perfettini JL., J Exp Med 208(9), 2011
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The regulated secretory pathway in CD4(+) T cells contributes to human immunodeficiency virus type-1 cell-to-cell spread at the virological synapse.
Jolly C, Welsch S, Michor S, Sattentau QJ., PLoS Pathog 7(9), 2011
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How HIV-1 takes advantage of the cytoskeleton during replication and cell-to-cell transmission.
Lehmann M, Nikolic DS, Piguet V., Viruses 3(9), 2011
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Substance P induces rapid and transient membrane blebbing in U373MG cells in a p21-activated kinase-dependent manner.
Meshki J, Douglas SD, Hu M, Leeman SE, Tuluc F., PLoS One 6(9), 2011
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Live-cell real-time imaging reveals role of mitochondria in cell-to-cell transmission of HIV-1.
Lee-Huang S, Lin Huang P, Lee Huang P., Biochem Biophys Res Commun 415(2), 2011
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An inducible cell-cell fusion system with integrated ability to measure the efficiency and specificity of HIV-1 entry inhibitors.
Herschhorn A, Finzi A, Jones DM, Courter JR, Sugawara A, Smith AB, Sodroski JG., PLoS One 6(11), 2011
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Tamiflu-resistant but HA-mediated cell-to-cell transmission through apical membranes of cell-associated influenza viruses.
Mori K, Haruyama T, Nagata K., PLoS One 6(11), 2011
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For HIV, it's never too late to grow up.
Thali M., Cell Host Microbe 10(6), 2011
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Cell-to-cell transfer of HIV-1 via virological synapses leads to endosomal virion maturation that activates viral membrane fusion.
Dale BM, McNerney GP, Thompson DL, Hubner W, de Los Reyes K, Chuang FY, Huser T, Chen BK., Cell Host Microbe 10(6), 2011
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Protease cleavage sites in HIV-1 gp120 recognized by antigen processing enzymes are conserved and located at receptor binding sites.
Yu B, Fonseca DP, O'Rourke SM, Berman PW., J Virol 84(3), 2010
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Rapid dissociation of HIV-1 from cultured cells severely limits infectivity assays, causes the inactivation ascribed to entry inhibitors, and masks the inherently high level of infectivity of virions.
Platt EJ, Kozak SL, Durnin JP, Hope TJ, Kabat D., J Virol 84(6), 2010
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Directional spread of surface-associated retroviruses regulated by differential virus-cell interactions.
Sherer NM, Jin J, Mothes W., J Virol 84(7), 2010
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Virological synapse-mediated spread of human immunodeficiency virus type 1 between T cells is sensitive to entry inhibition.
Martin N, Welsch S, Jolly C, Briggs JA, Vaux D, Sattentau QJ., J Virol 84(7), 2010
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Quantitative comparison of HTLV-1 and HIV-1 cell-to-cell infection with new replication dependent vectors.
Mazurov D, Ilinskaya A, Heidecker G, Lloyd P, Derse D., PLoS Pathog 6(2), 2010
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Immunology and the elusive AIDS vaccine.
Virgin HW, Walker BD., Nature 464(7286), 2010
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Polymer live-cell array for real-time kinetic imaging of immune cells.
Zurgil N, Afrimzon E, Deutsch A, Namer Y, Shafran Y, Sobolev M, Tauber Y, Ravid-Hermesh O, Deutsch M., Biomaterials 31(18), 2010
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Relationships between plasma membrane microdomains and HIV-1 assembly.
Ono A., Biol Cell 102(6), 2010
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Manipulating CD4+ T cells by optical tweezers for the initiation of cell-cell transfer of HIV-1.
McNerney GP, Hübner W, Chen BK, Huser T., J Biophotonics 3(4), 2010
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Benaroch P, Billard E, Gaudin R, Schindler M, Jouve M., Retrovirology 7(), 2010
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Mothes W, Sherer NM, Jin J, Zhong P., J Virol 84(17), 2010
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Ono A., Vaccine 28 Suppl 2(), 2010
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HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse.
Vasiliver-Shamis G, Dustin ML, Hioe CE., Viruses 2(5), 2010
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Potent and broad neutralizing activity of a single chain antibody fragment against cell-free and cell-associated HIV-1.
Zhang MY, Borges AR, Ptak RG, Wang Y, Dimitrov AS, Alam SM, Wieczorek L, Bouma P, Fouts T, Jiang S, Polonis VR, Haynes BF, Quinnan GV, Montefiori DC, Dimitrov DS., MAbs 2(3), 2010
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Role of the C-terminal domain of the HIV-1 glycoprotein in cell-to-cell viral transmission between T lymphocytes.
Emerson V, Haller C, Pfeiffer T, Fackler OT, Bosch V., Retrovirology 7(), 2010
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T cell polarization at the virological synapse.
Jolly C., Viruses 2(6), 2010
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Sattentau QJ., Viruses 2(6), 2010
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Tetherin restricts productive HIV-1 cell-to-cell transmission.
Casartelli N, Sourisseau M, Feldmann J, Guivel-Benhassine F, Mallet A, Marcelin AG, Guatelli J, Schwartz O., PLoS Pathog 6(6), 2010
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Within 1 h, HIV-1 uses viral synapses to enter efficiently the inner, but not outer, foreskin mucosa and engages Langerhans-T cell conjugates.
Ganor Y, Zhou Z, Tudor D, Schmitt A, Vacher-Lavenu MC, Gibault L, Thiounn N, Tomasini J, Wolf JP, Bomsel M., Mucosal Immunol 3(5), 2010
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The HTLV-1 Virological Synapse.
Nejmeddine M, Bangham CR., Viruses 2(7), 2010
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ADS-J1 inhibits HIV-1 entry by interacting with gp120 and does not block fusion-active gp41 core formation.
González-Ortega E, Mena MP, Permanyer M, Ballana E, Clotet B, Esté JA., Antimicrob Agents Chemother 54(10), 2010
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Tracking the green invaders: advances in imaging virus infection in plants.
Tilsner J, Oparka KJ., Biochem J 430(1), 2010
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Human immunodeficiency virus (HIV)-1 infects human hepatic stellate cells and promotes collagen I and monocyte chemoattractant protein-1 expression: implications for the pathogenesis of HIV/hepatitis C virus-induced liver fibrosis.
Tuyama AC, Hong F, Saiman Y, Wang C, Ozkok D, Mosoian A, Chen P, Chen BK, Klotman ME, Bansal MB., Hepatology 52(2), 2010
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Macrophages and Cell-Cell Spread of HIV-1.
Waki K, Freed EO., Viruses 2(8), 2010
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HIV-1 Virological Synapse: Live Imaging of Transmission.
Feldmann J, Schwartz O., Viruses 2(8), 2010
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Tethered virions are intermediates in the assembly and release of HIV-1 particles.
Karetnikov A, Suomalainen M., Virology 407(2), 2010
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Cell-cell spread of human immunodeficiency virus type 1 overcomes tetherin/BST-2-mediated restriction in T cells.
Jolly C, Booth NJ, Neil SJ., J Virol 84(23), 2010
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Visualizing cell-to-cell transfer of HIV using fluorescent clones of HIV and live confocal microscopy.
Dale B, McNerney GP, Thompson DL, Hübner W, Huser T, Chen BK., J Vis Exp (44), 2010
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In silico modeling indicates the development of HIV-1 resistance to multiple shRNA gene therapy differs to standard antiretroviral therapy.
Applegate TL, Birkett DJ, Mcintyre GJ, Jaramillo AB, Symonds G, Murray JM., Retrovirology 7(), 2010
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Nucleocapsid promotes localization of HIV-1 gag to uropods that participate in virological synapses between T cells.
Llewellyn GN, Hogue IB, Grover JR, Ono A., PLoS Pathog 6(10), 2010
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Tetherin restricts direct cell-to-cell infection of HIV-1.
Kuhl BD, Sloan RD, Donahue DA, Bar-Magen T, Liang C, Wainberg MA., Retrovirology 7(), 2010
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HIV endocytosis after dendritic cell to T cell viral transfer leads to productive virus infection.
Clotet-Codina I, Bosch B, Senserrich J, Fernández-Figueras MT, Peña R, Ballana E, Bofill M, Clotet B, Esté JA., Antiviral Res 83(1), 2009
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