In vitro Effects of New Generation Oxazaphosphorines on Human Promyelocytic Leukemia Cells

Mazur L, Opydo-Chanek M, Stojak M, Niemeyer, IIT-GmbH U (2013)
Folia Biologica 61(1): 31-40.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Mazur, Lidia; Opydo-Chanek, Malgorzata; Stojak, Marta; Niemeyer, IIT-GmbH, UlfUniBi
Abstract / Bemerkung
MAZUR L., OPYDo-CHANEK M., STOJAK M., NIEMEYER U. 2013. In vitro activity of new generation oxazaphosphorines against human promyelocytic leukemia cells. Folia Biologica (Krakow) 61: 31-40. Mafosfamide cyclohexylamine salt (D-17272), 4-hydro-peroxy-tyclophosphamide (D-18864) and glufosfamide (D-19575, beta-D-glucose-isophosphoramide mustard) are new generation oxazaphosphorine agents. The present investigation was undertaken to determine the activity of these three oxazaphosphorines in human promyelocytic leukemia HL-60 cells. The research was conducted using the spectrophotometric MTT assay and the electronic Beckman Coulter and microscopy methods. Functional and morphological changes were observed after exposure of HL-60 cells to the oxazaphosphorine agents. The various patterns of temporary alterations in cell viability, size and count, and also in the frequency of leukemic cells undergoing mitotic catastrophe, apoptosis and necrosis, were shown. Different leukemic cell responses to the action of the three oxazaphosphorines were evaluated. These are the first data comparing the in vitro activity of D-17272, D-18864 and D-19575 against human promyelocytic leukemia cells.
Stichworte
catastrophe; mitotic; volume and count; oxazaphosphorines; cell viability; necrosis; apoptosis
Erscheinungsjahr
2013
Zeitschriftentitel
Folia Biologica
Band
61
Ausgabe
1
Seite(n)
31-40
ISSN
0015-5497
eISSN
1734-9168
Page URI
https://pub.uni-bielefeld.de/record/2565636

Zitieren

Mazur L, Opydo-Chanek M, Stojak M, Niemeyer, IIT-GmbH U. In vitro Effects of New Generation Oxazaphosphorines on Human Promyelocytic Leukemia Cells. Folia Biologica. 2013;61(1):31-40.
Mazur, L., Opydo-Chanek, M., Stojak, M., & Niemeyer, IIT-GmbH, U. (2013). In vitro Effects of New Generation Oxazaphosphorines on Human Promyelocytic Leukemia Cells. Folia Biologica, 61(1), 31-40. doi:10.3409/fb61_1-2.31
Mazur, L., Opydo-Chanek, M., Stojak, M., and Niemeyer, IIT-GmbH, U. (2013). In vitro Effects of New Generation Oxazaphosphorines on Human Promyelocytic Leukemia Cells. Folia Biologica 61, 31-40.
Mazur, L., et al., 2013. In vitro Effects of New Generation Oxazaphosphorines on Human Promyelocytic Leukemia Cells. Folia Biologica, 61(1), p 31-40.
L. Mazur, et al., “In vitro Effects of New Generation Oxazaphosphorines on Human Promyelocytic Leukemia Cells”, Folia Biologica, vol. 61, 2013, pp. 31-40.
Mazur, L., Opydo-Chanek, M., Stojak, M., Niemeyer, IIT-GmbH, U.: In vitro Effects of New Generation Oxazaphosphorines on Human Promyelocytic Leukemia Cells. Folia Biologica. 61, 31-40 (2013).
Mazur, Lidia, Opydo-Chanek, Malgorzata, Stojak, Marta, and Niemeyer, IIT-GmbH, Ulf. “In vitro Effects of New Generation Oxazaphosphorines on Human Promyelocytic Leukemia Cells”. Folia Biologica 61.1 (2013): 31-40.

2 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Comparison of in vitro antileukemic activity of obatoclax and ABT-737.
Opydo-Chanek M, Mazur L., Tumour Biol 37(8), 2016
PMID: 26880588

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 23767290
PubMed | Europe PMC

Suchen in

Google Scholar