Interactions of membranes with coarse-grain proteins: a comparison

Neder J, Nielaba P, West B, Schmid F (2012)
New Journal Of Physics 14(12): 125017.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Neder, Joerg; Nielaba, Peter; West, BeateUniBi; Schmid, Friederike
Abstract / Bemerkung
We study the interactions between lipid bilayers and rigid transmembrane proteins by Monte Carlo simulations of generic coarse-grain models. Different popular protein models are considered and compared with each other, and key parameters such as the hydrophobicity and the hydrophobic mismatch are varied systematically. Furthermore, the properties of the membrane are manipulated by applying different tensions. The response of the membrane to the insertion of single proteins is found to be mostly generic and independent of the choice of the protein model. Likewise, the orientational distributions of single proteins depend mainly on the hydrophobic mismatch and the hydrophobicity of the proteins, and are otherwise similar for all protein models. Orientational distributions are generally found to be very broad, i.e. tilt angles fluctuate very much, in agreement with experimental findings. Weakly hydrophobic proteins respond to positive hydrophobic mismatch by tilting. Strongly hydrophobic (strongly bound) proteins distort the surrounding membrane and tend to remain upright. For proteins with intermediate hydrophobicity, the two mechanisms compete, and as a result, the tilt only sets in if the hydrophobic mismatch exceeds a threshold. Clusters of several strongly hydrophobic proteins with negative positive mismatch may nucleate raft-like structures in membranes. This effect is more pronounced for proteins with rough, structured surfaces.
Erscheinungsjahr
2012
Zeitschriftentitel
New Journal Of Physics
Band
14
Ausgabe
12
Art.-Nr.
125017
ISSN
1367-2630
eISSN
1367-2630
Page URI
https://pub.uni-bielefeld.de/record/2553280

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Neder J, Nielaba P, West B, Schmid F. Interactions of membranes with coarse-grain proteins: a comparison. New Journal Of Physics. 2012;14(12): 125017.
Neder, J., Nielaba, P., West, B., & Schmid, F. (2012). Interactions of membranes with coarse-grain proteins: a comparison. New Journal Of Physics, 14(12), 125017. doi:10.1088/1367-2630/14/12/125017
Neder, J., Nielaba, P., West, B., and Schmid, F. (2012). Interactions of membranes with coarse-grain proteins: a comparison. New Journal Of Physics 14:125017.
Neder, J., et al., 2012. Interactions of membranes with coarse-grain proteins: a comparison. New Journal Of Physics, 14(12): 125017.
J. Neder, et al., “Interactions of membranes with coarse-grain proteins: a comparison”, New Journal Of Physics, vol. 14, 2012, : 125017.
Neder, J., Nielaba, P., West, B., Schmid, F.: Interactions of membranes with coarse-grain proteins: a comparison. New Journal Of Physics. 14, : 125017 (2012).
Neder, Joerg, Nielaba, Peter, West, Beate, and Schmid, Friederike. “Interactions of membranes with coarse-grain proteins: a comparison”. New Journal Of Physics 14.12 (2012): 125017.

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