ISApl1, a novel insertion element of Actinobacillus pleuropneumoniae, prevents ApxIV-based serological detection of serotype 7 strain AP76
Tegetmeyer H, Jones SCP, Langford PR, Baltes N (2008)
Veterinary Microbiology 128(3-4): 342-353.
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Autor*in
Tegetmeyer, HalinaUniBi ;
Jones, Sophie CP;
Langford, Paul R;
Baltes, Nina
Einrichtung
Abstract / Bemerkung
Actinobacillus pleuropneumoniae, a gram-negative rod of the Pasteurellaceae family, causes pleuropneumonia in pigs. Establishing A. pleuropneumoniae free herds is difficult due to the occurrence of persistently infected animals. The ApxIV toxin is expressed by A. pleuropneumoniae in vivo and an ELISA based on the toxin is used to detect infection and to differentiate between infected and vaccinated animals. In this study, we have identified a 1070bp insertion element of the IS30 family, designated ISApl1, in the A. pleuropneumoniae serotype 7 strain AP76. ISApl1 contains a 924bp ORF encoding a transposase, which is flanked by 27bp inverted repeats showing six mismatches. We investigated the occurrence of ISApl1 in other A. pleuropneumoniae strains, and its possible interference with virulence associated factors. Four insertion sites were identified in AP76: within the apxIVA toxin ORF, within a putative autotransporter adhesin ORF, upstream of a capsular polysaccharide biosynthesis gene cluster, and downstream of a beta-lactamase gene. ISApl1 is also present in some serotype 7 field isolates, but not in reference or field strains of other serotypes. In A. pleuropneumoniae AP76, the transposase gene is transcribed in vitro. The insertion in the apxIVA toxin gene remains stable after animal passage. Since this insertion should disrupt toxin expression, we tested 7 pigs infected with AP76 at day 21 post-infection. All were negative in the ApxIV ELISA but four out of seven were positive in an ApxII toxin ELISA. These results show that insertion elements can affect the detection of A. pleuropneumoniae infected animals.
Erscheinungsjahr
2008
Zeitschriftentitel
Veterinary Microbiology
Band
128
Ausgabe
3-4
Seite(n)
342-353
ISSN
0378-1135
Page URI
https://pub.uni-bielefeld.de/record/2549401
Zitieren
Tegetmeyer H, Jones SCP, Langford PR, Baltes N. ISApl1, a novel insertion element of Actinobacillus pleuropneumoniae, prevents ApxIV-based serological detection of serotype 7 strain AP76. Veterinary Microbiology. 2008;128(3-4):342-353.
Tegetmeyer, H., Jones, S. C. P., Langford, P. R., & Baltes, N. (2008). ISApl1, a novel insertion element of Actinobacillus pleuropneumoniae, prevents ApxIV-based serological detection of serotype 7 strain AP76. Veterinary Microbiology, 128(3-4), 342-353. doi:10.1016/j.vetmic.2007.10.025
Tegetmeyer, Halina, Jones, Sophie CP, Langford, Paul R, and Baltes, Nina. 2008. “ISApl1, a novel insertion element of Actinobacillus pleuropneumoniae, prevents ApxIV-based serological detection of serotype 7 strain AP76”. Veterinary Microbiology 128 (3-4): 342-353.
Tegetmeyer, H., Jones, S. C. P., Langford, P. R., and Baltes, N. (2008). ISApl1, a novel insertion element of Actinobacillus pleuropneumoniae, prevents ApxIV-based serological detection of serotype 7 strain AP76. Veterinary Microbiology 128, 342-353.
Tegetmeyer, H., et al., 2008. ISApl1, a novel insertion element of Actinobacillus pleuropneumoniae, prevents ApxIV-based serological detection of serotype 7 strain AP76. Veterinary Microbiology, 128(3-4), p 342-353.
H. Tegetmeyer, et al., “ISApl1, a novel insertion element of Actinobacillus pleuropneumoniae, prevents ApxIV-based serological detection of serotype 7 strain AP76”, Veterinary Microbiology, vol. 128, 2008, pp. 342-353.
Tegetmeyer, H., Jones, S.C.P., Langford, P.R., Baltes, N.: ISApl1, a novel insertion element of Actinobacillus pleuropneumoniae, prevents ApxIV-based serological detection of serotype 7 strain AP76. Veterinary Microbiology. 128, 342-353 (2008).
Tegetmeyer, Halina, Jones, Sophie CP, Langford, Paul R, and Baltes, Nina. “ISApl1, a novel insertion element of Actinobacillus pleuropneumoniae, prevents ApxIV-based serological detection of serotype 7 strain AP76”. Veterinary Microbiology 128.3-4 (2008): 342-353.
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Putative transposase (UNIPROT: A5HAV4)
Organism: Actinobacillus pleuropneumoniae
Download in FASTA format
Organism: Actinobacillus pleuropneumoniae
Download in FASTA format
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Schaller A, Kuhn R, Kuhnert P, Nicolet J, Anderson TJ, MacInnes JI, Segers RP, Frey J., Microbiology (Reading, Engl.) 145 ( Pt 8)(), 1999
PMID: 10463177
ISfinder: the reference centre for bacterial insertion sequences.
Siguier P, Perochon J, Lestrade L, Mahillon J, Chandler M., Nucleic Acids Res. 34(Database issue), 2006
PMID: 16381877
Siguier P, Perochon J, Lestrade L, Mahillon J, Chandler M., Nucleic Acids Res. 34(Database issue), 2006
PMID: 16381877
Importance of illegitimate recombination and transposition in IS30-associated excision events.
Szabo M, Kiss J, Kotany G, Olasz F., Plasmid 42(3), 1999
PMID: 10545262
Szabo M, Kiss J, Kotany G, Olasz F., Plasmid 42(3), 1999
PMID: 10545262
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