An isogenic Actinobacillus pleuropneumoniae AasP mutant exhibits altered biofilm formation but retains virulence.

Tegetmeyer H, Fricke K, Baltes N (2009)
Veterinary Microbiology 137(3-4): 392-396.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Tegetmeyer, HalinaUniBi ; Fricke, Kerstin; Baltes, Nina
Abstract / Bemerkung
AasP, an autotransporter serine protease of Actinobacillus pleuropneumoniae, has been shown to be expressed in necrotic porcine lung tissue. Based on the hypothesis that AasP might play an important role in A. pleuropneumoniae adhesion and virulence by processing other surface-associated proteins, the predicted catalytic site of AasP was deleted and the isogenic mutant, AP76DeltaaasP, was compared to the wild-type strain in a biofilm assay as well as an aerosol infection model. AP76DeltaaasP showed increased adherence compared to the wild-type strain under standard culturing conditions as well as under NAD restriction. No significant differences between AP76 wild-type and AP76DeltaaasP were observed upon experimental infection of pigs, indicating that AasP does not play a crucial role in A. pleuropneumoniae virulence.
Erscheinungsjahr
2009
Zeitschriftentitel
Veterinary Microbiology
Band
137
Ausgabe
3-4
Seite(n)
392-396
ISSN
0378-1135
Page URI
https://pub.uni-bielefeld.de/record/2549375

Zitieren

Tegetmeyer H, Fricke K, Baltes N. An isogenic Actinobacillus pleuropneumoniae AasP mutant exhibits altered biofilm formation but retains virulence. Veterinary Microbiology. 2009;137(3-4):392-396.
Tegetmeyer, H., Fricke, K., & Baltes, N. (2009). An isogenic Actinobacillus pleuropneumoniae AasP mutant exhibits altered biofilm formation but retains virulence. Veterinary Microbiology, 137(3-4), 392-396. doi:10.1016/j.vetmic.2009.01.026
Tegetmeyer, Halina, Fricke, Kerstin, and Baltes, Nina. 2009. “An isogenic Actinobacillus pleuropneumoniae AasP mutant exhibits altered biofilm formation but retains virulence.”. Veterinary Microbiology 137 (3-4): 392-396.
Tegetmeyer, H., Fricke, K., and Baltes, N. (2009). An isogenic Actinobacillus pleuropneumoniae AasP mutant exhibits altered biofilm formation but retains virulence. Veterinary Microbiology 137, 392-396.
Tegetmeyer, H., Fricke, K., & Baltes, N., 2009. An isogenic Actinobacillus pleuropneumoniae AasP mutant exhibits altered biofilm formation but retains virulence. Veterinary Microbiology, 137(3-4), p 392-396.
H. Tegetmeyer, K. Fricke, and N. Baltes, “An isogenic Actinobacillus pleuropneumoniae AasP mutant exhibits altered biofilm formation but retains virulence.”, Veterinary Microbiology, vol. 137, 2009, pp. 392-396.
Tegetmeyer, H., Fricke, K., Baltes, N.: An isogenic Actinobacillus pleuropneumoniae AasP mutant exhibits altered biofilm formation but retains virulence. Veterinary Microbiology. 137, 392-396 (2009).
Tegetmeyer, Halina, Fricke, Kerstin, and Baltes, Nina. “An isogenic Actinobacillus pleuropneumoniae AasP mutant exhibits altered biofilm formation but retains virulence.”. Veterinary Microbiology 137.3-4 (2009): 392-396.

Link(s) zu Volltext(en)
Access Level
Restricted Closed Access

11 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Actinobacillus pleuropneumoniae biofilms: Role in pathogenicity and potential impact for vaccination development.
Hathroubi S, Loera-Muro A, Guerrero-Barrera AL, Tremblay YDN, Jacques M., Anim Health Res Rev 19(1), 2018
PMID: 29110751
Transcriptomics of Haemophilus (Glässerella) parasuis serovar 5 subjected to culture conditions partially mimetic to natural infection for the search of new vaccine antigens.
Álvarez-Estrada Á, Gutiérrez-Martín CB, Rodríguez-Ferri EF, Martínez-Martínez S., BMC Vet Res 14(1), 2018
PMID: 30400794
In Vitro Study of ISApl1-Mediated Mobilization of the Colistin Resistance Gene mcr-1.
Poirel L, Kieffer N, Nordmann P., Antimicrob Agents Chemother 61(7), 2017
PMID: 28416554
Absence of TolC Impairs Biofilm Formation in Actinobacillus pleuropneumoniae by Reducing Initial Attachment.
Li Y, Cao S, Zhang L, Yuan J, Lau GW, Wen Y, Wu R, Zhao Q, Huang X, Yan Q, Huang Y, Wen X., PLoS One 11(9), 2016
PMID: 27681876
Global effects of catecholamines on Actinobacillus pleuropneumoniae gene expression.
Li L, Xu Z, Zhou Y, Sun L, Liu Z, Chen H, Zhou R., PLoS One 7(2), 2012
PMID: 22347439
Effects of growth conditions on biofilm formation by Actinobacillus pleuropneumoniae.
Labrie J, Pelletier-Jacques G, Deslandes V, Ramjeet M, Auger E, Nash JH, Jacques M., Vet Res 41(1), 2010
PMID: 19737507
Biofilm formation in bacterial pathogens of veterinary importance.
Jacques M, Aragon V, Tremblay YD., Anim Health Res Rev 11(2), 2010
PMID: 20969814
AasP autotransporter protein of Actinobacillus pleuropneumoniae does not protect pigs against homologous challenge.
Oldfield NJ, Worrall KE, Rycroft AN, Ali T, Wooldridge KG, Ala'Aldeen DA., Vaccine 27(38), 2009
PMID: 19563888

26 References

Daten bereitgestellt von Europe PubMed Central.

Functional characterization of AasP, a maturation protease autotransporter protein of Actinobacillus pleuropneumoniae.
Ali T, Oldfield NJ, Wooldridge KG, Turner DP, Ala'Aldeen DA., Infect. Immun. 76(12), 2008
PMID: 18852244
Actinobacillus pleuropneumoniae serotype 7 siderophore receptor FhuA is not required for virulence.
Baltes N, Tonpitak W, Hennig-Pauka I, Gruber AD, Gerlach GF., FEMS Microbiol. Lett. 220(1), 2003
PMID: 12644226
Actinobacillus pleuropneumoniae iron transport and urease activity: effects on bacterial virulence and host immune response.
Baltes N, Tonpitak W, Gerlach GF, Hennig-Pauka I, Hoffmann-Moujahid A, Ganter M, Rothkotter HJ., Infect. Immun. 69(1), 2001
PMID: 11119539
Role of adhesin release for mucosal colonization by a bacterial pathogen.
Coutte L, Alonso S, Reveneau N, Willery E, Quatannens B, Locht C, Jacob-Dubuisson F., J. Exp. Med. 197(6), 2003
PMID: 12629063
Subtilisin-like autotransporter serves as maturation protease in a bacterial secretion pathway.
Coutte L, Antoine R, Drobecq H, Locht C, Jacob-Dubuisson F., EMBO J. 20(18), 2001
PMID: 11566869
Transcriptional profiling of Actinobacillus pleuropneumoniae under iron-restricted conditions.
Deslandes V, Nash JH, Harel J, Coulton JW, Jacques M., BMC Genomics 8(), 2007
PMID: 17355629
Microtiter plate assay for assessment of Listeria monocytogenes biofilm formation.
Djordjevic D, Wiedmann M, McLandsborough LA., Appl. Environ. Microbiol. 68(6), 2002
PMID: 12039754
Porcine pleuropneumonia.
Fenwick B, Henry S., J. Am. Vet. Med. Assoc. 204(9), 1994
PMID: 8050966
Actinobacillus pleuropneumoniae infections in pigs: the role of virulence factors in pathogenesis and protection.
Haesebrouck F, Chiers K, Van Overbeke I, Ducatelle R., Vet. Microbiol. 58(2-4), 1997
PMID: 9453134
Genes involved in the synthesis and degradation of matrix polysaccharide in Actinobacillus actinomycetemcomitans and Actinobacillus pleuropneumoniae biofilms.
Kaplan JB, Velliyagounder K, Ragunath C, Rohde H, Mack D, Knobloch JK, Ramasubbu N., J. Bacteriol. 186(24), 2004
PMID: 15576769
Virtual Footprint and PRODORIC: an integrative framework for regulon prediction in prokaryotes.
Munch R, Hiller K, Grote A, Scheer M, Klein J, Schobert M, Jahn D., Bioinformatics 21(22), 2005
PMID: 16109747
Isolation and characterization of LPS mutants of Actinobacillus pleuropneumoniae serotype 1.
Rioux S, Begin C, Dubreuil JD, Jacques M., Curr. Microbiol. 35(3), 1997
PMID: 9236294

Sambrook, 1989
Characterization of the in vitro adhesion of Actinobacillus pleuropneumoniae to swine alveolar epithelial cells.
Van Overbeke I, Chiers K, Charlier G, Vandenberghe I, Van Beeumen J, Ducatelle R, Haesebrouck F., Vet. Microbiol. 88(1), 2002
PMID: 12119138
Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®
Quellen

PMID: 19217220
PubMed | Europe PMC

Suchen in

Google Scholar