Total synthesis and biological evaluation of fluorinated cryptophycins

Weiß C, Bogner T, Sammet B, Sewald N (2012)
Beilstein Journal Of Organic Chemistry 8: 2060-2066.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
Abstract / Bemerkung
Cryptophycins are cytotoxic natural products that exhibit considerable activities even against multi-drug-resistant tumor cell lines. As fluorinated pharmaceuticals have become more and more important during the past decades, fluorine-functionalized cryptophycins were synthesized and evaluated in cell-based cytotoxicity assays. The unit A trifluoromethyl-modified cryptophycin proved to be highly active against KB-3-1 cells and exhibited an IC50 value in the low picomolar range. However, the replacement of the 3-chloro-4-methoxyphenyl-substituent in unit B by a pentafluorophenyl moiety resulted in a significant loss of activity.
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Beilstein Journal Of Organic Chemistry
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8
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2060-2066
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Weiß C, Bogner T, Sammet B, Sewald N. Total synthesis and biological evaluation of fluorinated cryptophycins. Beilstein Journal Of Organic Chemistry. 2012;8:2060-2066.
Weiß, C., Bogner, T., Sammet, B., & Sewald, N. (2012). Total synthesis and biological evaluation of fluorinated cryptophycins. Beilstein Journal Of Organic Chemistry, 8, 2060-2066. doi:10.3762/bjoc.8.231
Weiß, C., Bogner, T., Sammet, B., and Sewald, N. (2012). Total synthesis and biological evaluation of fluorinated cryptophycins. Beilstein Journal Of Organic Chemistry 8, 2060-2066.
Weiß, C., et al., 2012. Total synthesis and biological evaluation of fluorinated cryptophycins. Beilstein Journal Of Organic Chemistry, 8, p 2060-2066.
C. Weiß, et al., “Total synthesis and biological evaluation of fluorinated cryptophycins”, Beilstein Journal Of Organic Chemistry, vol. 8, 2012, pp. 2060-2066.
Weiß, C., Bogner, T., Sammet, B., Sewald, N.: Total synthesis and biological evaluation of fluorinated cryptophycins. Beilstein Journal Of Organic Chemistry. 8, 2060-2066 (2012).
Weiß, Christine, Bogner, Tobias, Sammet, Benedikt, and Sewald, Norbert. “Total synthesis and biological evaluation of fluorinated cryptophycins”. Beilstein Journal Of Organic Chemistry 8 (2012): 2060-2066.
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8 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

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Figueras E, Borbély A, Ismail M, Frese M, Sewald N., Beilstein J Org Chem 14(), 2018
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Weiss C, Figueras E, Borbely AN, Sewald N., J Pept Sci 23(7-8), 2017
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Weiss C, Sammet B, Sewald N., Nat Prod Rep 30(7), 2013
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