MHC genotype and near-deterministic mortality in grey seals

de Assunção-Franco M, Hoffman J, Harwood J, Amos W (2012)
Scientific Reports 2(1): 659.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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de Assunção-Franco, M; Hoffman, JosephUniBi ; Harwood, J; Amos, W
Abstract / Bemerkung
The Major Histocompatability Complex (MHC) is one of the best known and best characterised components of the immune system, yet its functions remain somewhat enigmatic, including both anti-pathogen activity and kin recognition. To explore the importance of the MHC relative to literally hundreds of other components of the immune system, we compared MHC genotype frequencies between pups and adults in the grey seal (Halichoerus grypus), one of many marine mammals that exhibit low allelic diversity. We find that one allele is strongly associated with pup survival, pups being more likely to be found dead if they lack it, while total allele number is a remarkably strong predictor of survivorship to adulthood. We estimate that approximately 70% of mortality can be attributed to the MHC. Our study therefore shows that low MHC allele diversity belies its critical role in determining whether a weaned pup negotiates disease to become a breeding adult.
Erscheinungsjahr
2012
Zeitschriftentitel
Scientific Reports
Band
2
Ausgabe
1
Art.-Nr.
659
ISSN
2045-2322
eISSN
2045-2322
Page URI
https://pub.uni-bielefeld.de/record/2541275

Zitieren

de Assunção-Franco M, Hoffman J, Harwood J, Amos W. MHC genotype and near-deterministic mortality in grey seals. Scientific Reports. 2012;2(1): 659.
de Assunção-Franco, M., Hoffman, J., Harwood, J., & Amos, W. (2012). MHC genotype and near-deterministic mortality in grey seals. Scientific Reports, 2(1), 659. doi:10.1038/srep00659
de Assunção-Franco, M., Hoffman, J., Harwood, J., and Amos, W. (2012). MHC genotype and near-deterministic mortality in grey seals. Scientific Reports 2:659.
de Assunção-Franco, M., et al., 2012. MHC genotype and near-deterministic mortality in grey seals. Scientific Reports, 2(1): 659.
M. de Assunção-Franco, et al., “MHC genotype and near-deterministic mortality in grey seals”, Scientific Reports, vol. 2, 2012, : 659.
de Assunção-Franco, M., Hoffman, J., Harwood, J., Amos, W.: MHC genotype and near-deterministic mortality in grey seals. Scientific Reports. 2, : 659 (2012).
de Assunção-Franco, M, Hoffman, Joseph, Harwood, J, and Amos, W. “MHC genotype and near-deterministic mortality in grey seals”. Scientific Reports 2.1 (2012): 659.
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7 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

The Marine Mammal Class II Major Histocompatibility Complex Organization.
de Sá ALA, Breaux B, Burlamaqui TCT, Deiss TC, Sena L, Criscitiello MF, Schneider MPC., Front Immunol 10(), 2019
PMID: 31019512
Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals.
Litzke V, Ottensmann M, Forcada J, Heitzmann L, Ivan Hoffman J., Ecol Evol 9(14), 2019
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Spatial patterns of immunogenetic and neutral variation underscore the conservation value of small, isolated American badger populations.
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PMID: 27877205
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Serieys LE, Lea A, Pollinger JP, Riley SP, Wayne RK., Evol Appl 8(1), 2015
PMID: 25667604

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