MHC genotype and near-deterministic mortality in grey seals

de Assunção-Franco M, Hoffman J, Harwood J, Amos W (2012)
Scientific Reports 2(1): 659.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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de Assunção-Franco, M; Hoffman, JosephUniBi ; Harwood, J; Amos, W
Abstract / Bemerkung
The Major Histocompatability Complex (MHC) is one of the best known and best characterised components of the immune system, yet its functions remain somewhat enigmatic, including both anti-pathogen activity and kin recognition. To explore the importance of the MHC relative to literally hundreds of other components of the immune system, we compared MHC genotype frequencies between pups and adults in the grey seal (Halichoerus grypus), one of many marine mammals that exhibit low allelic diversity. We find that one allele is strongly associated with pup survival, pups being more likely to be found dead if they lack it, while total allele number is a remarkably strong predictor of survivorship to adulthood. We estimate that approximately 70% of mortality can be attributed to the MHC. Our study therefore shows that low MHC allele diversity belies its critical role in determining whether a weaned pup negotiates disease to become a breeding adult.
Erscheinungsjahr
2012
Zeitschriftentitel
Scientific Reports
Band
2
Ausgabe
1
Art.-Nr.
659
ISSN
2045-2322
eISSN
2045-2322
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Deutsche Forschungsgemeinschaft und die Universität Bielefeld gefördert.
Page URI
https://pub.uni-bielefeld.de/record/2541275

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de Assunção-Franco M, Hoffman J, Harwood J, Amos W. MHC genotype and near-deterministic mortality in grey seals. Scientific Reports. 2012;2(1): 659.
de Assunção-Franco, M., Hoffman, J., Harwood, J., & Amos, W. (2012). MHC genotype and near-deterministic mortality in grey seals. Scientific Reports, 2(1), 659. doi:10.1038/srep00659
de Assunção-Franco, M, Hoffman, Joseph, Harwood, J, and Amos, W. 2012. “MHC genotype and near-deterministic mortality in grey seals”. Scientific Reports 2 (1): 659.
de Assunção-Franco, M., Hoffman, J., Harwood, J., and Amos, W. (2012). MHC genotype and near-deterministic mortality in grey seals. Scientific Reports 2:659.
de Assunção-Franco, M., et al., 2012. MHC genotype and near-deterministic mortality in grey seals. Scientific Reports, 2(1): 659.
M. de Assunção-Franco, et al., “MHC genotype and near-deterministic mortality in grey seals”, Scientific Reports, vol. 2, 2012, : 659.
de Assunção-Franco, M., Hoffman, J., Harwood, J., Amos, W.: MHC genotype and near-deterministic mortality in grey seals. Scientific Reports. 2, : 659 (2012).
de Assunção-Franco, M, Hoffman, Joseph, Harwood, J, and Amos, W. “MHC genotype and near-deterministic mortality in grey seals”. Scientific Reports 2.1 (2012): 659.
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Daten bereitgestellt von Europe PubMed Central.

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14 References

Daten bereitgestellt von Europe PubMed Central.

MHC-dependent survival in a wild population: evidence for hidden genetic benefits gained through extra-pair fertilizations.
Brouwer L, Barr I, van de Pol M, Burke T, Komdeur J, Richardson DS., Mol. Ecol. 19(16), 2010
PMID: 20670363
The evolutionary ecology of the major histocompatibility complex.
Piertney SB, Oliver MK., Heredity (Edinb) 96(1), 2006
PMID: 16094301
Limited MHC polymorphism in the southern elephant seal: implications for MHC evolution and marine mammal population biology
AUTHOR UNKNOWN, 1992
Geographic variation of the major histocompatibility complex in Eastern Atlantic grey seals (Halichoerus grypus).
Cammen K, Hoffman JI, Knapp LA, Harwood J, Amos W., Mol. Ecol. 20(4), 2010
PMID: 21199032
Where have all the fathers gone? An extensive microsatellite analysis of paternity in the grey seal (Halichoerus grypus).
Worthington Wilmer J, Allen PJ, Pomeroy PP, Twiss SD, Amos W., Mol. Ecol. 8(9), 1999
PMID: 10564447
Low and delayed recruitment at two grey seal breeding colonies in the UK
AUTHOR UNKNOWN, 2010
Patterns of parental relatedness and pup survival in the grey seal (Halichoerus grypus).
Bean K, Amos W, Pomeroy PP, Twiss SD, Coulson TN, Boyd IL., Mol. Ecol. 13(8), 2004
PMID: 15245408
Behaviour of grey seals (Halichoerus grypus) during a breeding season at North Rona
AUTHOR UNKNOWN, 1975
Evidence for mate fidelity in the gray seal.
Amos B, Twiss S, Pomeroy P, Anderson S., Science 268(5219), 1995
PMID: 17797534
Do female grey seals select genetically diverse mates?
AUTHOR UNKNOWN, 2001
MHC-correlated odour preferences in humans and the use of oral contraceptives
AUTHOR UNKNOWN, 2008
Body odour preferences in men and women: Do they aim for specific MHC combinations or simply heterozygosity?
AUTHOR UNKNOWN, 1997
R: a language and environment for statistical computing. Vienna (Austria): R Foundation for Statistical Computing
AUTHOR UNKNOWN, 2005
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