Synthesis and conformational analysis of efrapeptins
Weigelt S, Huber T, Hofmann F, Jost M, Ritzefeld M, Luy B, Freudenberger C, Majer Z, Vass E, Greie J-C, Panella L, et al. (2012)
Chemistry - A European Journal 18(2): 478-487.
Zeitschriftenaufsatz
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Autor*in
Weigelt, Sven;
Huber, Thomas;
Hofmann, Frank;
Jost, Micha;
Ritzefeld, MarkusUniBi
;
Luy, Burkhard;
Freudenberger, Christoph;
Majer, Zsuzsanna;
Vass, Elemér;
Greie, Jörg-Christian;
Panella, Lavinia;
Kaptein, Bernard
Alle
![](https://pub.uni-bielefeld.de/images/icon_orcid.png)
Alle
Einrichtung
Abstract / Bemerkung
The efrapeptin family of peptide antibiotics produced by the fungus Tolypocladium niveum, and the neo-efrapeptins from the fungus Geotrichum candidumare inhibitors of F(1)-ATPase with promising antitumor, antimalaria, and insecticidal activity. They are rich in C(α)-dialkyl amino acids (Aib, Iva, Acc) and contain one β-alanine and several pipecolic acid residues. The C-terminus bears an unusual heterocyclic cationic cap. The efrapeptins C-G and three analogues of efrapeptin C were synthesized using α-azido carboxylic acids as masked amino acid derivatives. All compounds display inhibitory activity toward F(1)-ATPase. The conformation in solution of the peptides was investigated with electronic CD spectroscopy, FT-IR spectroscopy, and VCD spectroscopy. All efrapeptins and most efrapeptin analogues were shown to adopt helical conformations in solution. In the case of efrapeptin C, VCD spectra proved that a 3(10)-helix prevails. In addition, efrapeptin C was conformationally studied in detail with NMR and molecular modeling. Besides NOE distance restraints, residual dipolar couplings (RDC) observed upon partial alignment with stretched PDMS gels were used for the conformational analysis and confirmed the 3(10)-helical conformation.
Stichworte
Protein Structure;
Secondary;
Peptides/pharmacology;
Peptides/chemistry;
Peptides/chemical synthesis;
Biomolecular;
Nuclear Magnetic Resonance;
Amino Acid Sequence;
Adenosine Triphosphatases/antagonists & inhibitors;
Anti-Bacterial Agents/chemistry;
Anti-Bacterial Agents/chemical synthesis;
Anti-Bacterial Agents/pharmacology;
Circular Dichroism;
Escherichia coli/enzymology;
Hypocreales/chemistry;
Models;
Molecular Sequence Data;
Molecular
Erscheinungsjahr
2012
Zeitschriftentitel
Chemistry - A European Journal
Band
18
Ausgabe
2
Seite(n)
478-487
ISSN
0947-6539
Page URI
https://pub.uni-bielefeld.de/record/2499381
Zitieren
Weigelt S, Huber T, Hofmann F, et al. Synthesis and conformational analysis of efrapeptins. Chemistry - A European Journal. 2012;18(2):478-487.
Weigelt, S., Huber, T., Hofmann, F., Jost, M., Ritzefeld, M., Luy, B., Freudenberger, C., et al. (2012). Synthesis and conformational analysis of efrapeptins. Chemistry - A European Journal, 18(2), 478-487. doi:10.1002/chem.201102134
Weigelt, Sven, Huber, Thomas, Hofmann, Frank, Jost, Micha, Ritzefeld, Markus, Luy, Burkhard, Freudenberger, Christoph, et al. 2012. “Synthesis and conformational analysis of efrapeptins”. Chemistry - A European Journal 18 (2): 478-487.
Weigelt, S., Huber, T., Hofmann, F., Jost, M., Ritzefeld, M., Luy, B., Freudenberger, C., Majer, Z., Vass, E., Greie, J. - C., et al. (2012). Synthesis and conformational analysis of efrapeptins. Chemistry - A European Journal 18, 478-487.
Weigelt, S., et al., 2012. Synthesis and conformational analysis of efrapeptins. Chemistry - A European Journal, 18(2), p 478-487.
S. Weigelt, et al., “Synthesis and conformational analysis of efrapeptins”, Chemistry - A European Journal, vol. 18, 2012, pp. 478-487.
Weigelt, S., Huber, T., Hofmann, F., Jost, M., Ritzefeld, M., Luy, B., Freudenberger, C., Majer, Z., Vass, E., Greie, J.-C., Panella, L., Kaptein, B., Broxterman, Q.B., Kessler, H., Altendorf, K., Hollósi, M., Sewald, N.: Synthesis and conformational analysis of efrapeptins. Chemistry - A European Journal. 18, 478-487 (2012).
Weigelt, Sven, Huber, Thomas, Hofmann, Frank, Jost, Micha, Ritzefeld, Markus, Luy, Burkhard, Freudenberger, Christoph, Majer, Zsuzsanna, Vass, Elemér, Greie, Jörg-Christian, Panella, Lavinia, Kaptein, Bernard, Broxterman, Quirinus B, Kessler, Horst, Altendorf, Karlheinz, Hollósi, Miklós, and Sewald, Norbert. “Synthesis and conformational analysis of efrapeptins”. Chemistry - A European Journal 18.2 (2012): 478-487.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
16 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
Expanding lysine industry: industrial biomanufacturing of lysine and its derivatives.
Cheng J, Chen P, Song A, Wang D, Wang Q., J Ind Microbiol Biotechnol 45(8), 2018
PMID: 29654382
Cheng J, Chen P, Song A, Wang D, Wang Q., J Ind Microbiol Biotechnol 45(8), 2018
PMID: 29654382
RDC-enhanced structure calculation of a β-heptapeptide in methanol.
Rigling C, Ebert MO., Magn Reson Chem 55(7), 2017
PMID: 27976817
Rigling C, Ebert MO., Magn Reson Chem 55(7), 2017
PMID: 27976817
Improvements, extensions, and practical aspects of rapid ASAP-HSQC and ALSOFAST-HSQC pulse sequences for studying small molecules at natural abundance.
Schulze-Sünninghausen D, Becker J, Koos MRM, Luy B., J Magn Reson 281(), 2017
PMID: 28603039
Schulze-Sünninghausen D, Becker J, Koos MRM, Luy B., J Magn Reson 281(), 2017
PMID: 28603039
Biphasic Liquid Crystal and the Simultaneous Measurement of Isotropic and Anisotropic Parameters by Spatially Resolved NMR Spectroscopy.
Reller M, Wesp S, Koos MRM, Reggelin M, Luy B., Chemistry 23(54), 2017
PMID: 28644550
Reller M, Wesp S, Koos MRM, Reggelin M, Luy B., Chemistry 23(54), 2017
PMID: 28644550
The influence of solvent on conformational properties of peptides with Aib residue-a DFT study.
Wałęsa R, Broda MA., J Mol Model 23(12), 2017
PMID: 29164349
Wałęsa R, Broda MA., J Mol Model 23(12), 2017
PMID: 29164349
Q.E.COSY: determining sign and size of small deuterium residual quadrupolar couplings using an extended E.COSY principle.
Tzvetkova P, Luy B., Magn Reson Chem 54(5), 2016
PMID: 26763050
Tzvetkova P, Luy B., Magn Reson Chem 54(5), 2016
PMID: 26763050
Functional expression of L-lysine α-oxidase from Scomber japonicus in Escherichia coli for one-pot synthesis of L-pipecolic acid from DL-lysine.
Tani Y, Miyake R, Yukami R, Dekishima Y, China H, Saito S, Kawabata H, Mihara H., Appl Microbiol Biotechnol 99(12), 2015
PMID: 25547835
Tani Y, Miyake R, Yukami R, Dekishima Y, China H, Saito S, Kawabata H, Mihara H., Appl Microbiol Biotechnol 99(12), 2015
PMID: 25547835
4-Cyano-α-methyl-l-phenylalanine as a spectroscopic marker for the investigation of peptaibiotic-membrane interactions.
De Zotti M, Bobone S, Bortolotti A, Longo E, Biondi B, Peggion C, Formaggio F, Toniolo C, Dalla Bona A, Kaptein B, Stella L., Chem Biodivers 12(4), 2015
PMID: 25879497
De Zotti M, Bobone S, Bortolotti A, Longo E, Biondi B, Peggion C, Formaggio F, Toniolo C, Dalla Bona A, Kaptein B, Stella L., Chem Biodivers 12(4), 2015
PMID: 25879497
CLIP-ASAP-HSQC for fast and accurate extraction of one-bond couplings from isotropic and partially aligned molecules.
Becker J, Luy B., Magn Reson Chem 53(11), 2015
PMID: 26137959
Becker J, Luy B., Magn Reson Chem 53(11), 2015
PMID: 26137959
Cruentaren A binds F1F0 ATP synthase to modulate the Hsp90 protein folding machinery.
Hall JA, Kusuma BR, Brandt GE, Blagg BS., ACS Chem Biol 9(4), 2014
PMID: 24450340
Hall JA, Kusuma BR, Brandt GE, Blagg BS., ACS Chem Biol 9(4), 2014
PMID: 24450340
Solution synthesis, conformational analysis, and antimicrobial activity of three alamethicin F50/5 analogs bearing a trifluoroacetyl label.
De Zotti M, Ballano G, Jost M, Salnikov ES, Bechinger B, Oancea S, Crisma M, Toniolo C, Formaggio F., Chem Biodivers 11(8), 2014
PMID: 25146762
De Zotti M, Ballano G, Jost M, Salnikov ES, Bechinger B, Oancea S, Crisma M, Toniolo C, Formaggio F., Chem Biodivers 11(8), 2014
PMID: 25146762
Probing spatial distribution of alignment by deuterium NMR imaging.
Trigo-Mouriño P, Merle C, Koos MR, Luy B, Gil RR., Chemistry 19(22), 2013
PMID: 23559417
Trigo-Mouriño P, Merle C, Koos MR, Luy B, Gil RR., Chemistry 19(22), 2013
PMID: 23559417
Conformational properties of secondary amino acids: replacement of pipecolic acid by N-methyl-l-alanine in efrapeptin C.
Dutt Konar A, Vass E, Hollósi M, Majer Z, Grüber G, Frese K, Sewald N., Chem Biodivers 10(5), 2013
PMID: 23681735
Dutt Konar A, Vass E, Hollósi M, Majer Z, Grüber G, Frese K, Sewald N., Chem Biodivers 10(5), 2013
PMID: 23681735
(R)- α -Aminoadipic Acid: A Versatile Precursor for the Synthesis of D-Amino Acids.
Sadiq A, Sewald N., J Amino Acids 2013(), 2013
PMID: 24222844
Sadiq A, Sewald N., J Amino Acids 2013(), 2013
PMID: 24222844
Antimicrobial lipopeptaibol trichogin GA IV: role of the three Aib residues on conformation and bioactivity.
De Zotti M, Biondi B, Park Y, Hahm KS, Crisma M, Toniolo C, Formaggio F., Amino Acids 43(4), 2012
PMID: 22484376
De Zotti M, Biondi B, Park Y, Hahm KS, Crisma M, Toniolo C, Formaggio F., Amino Acids 43(4), 2012
PMID: 22484376
Configuration verification via RDCs on the example of a tetra-substituted pyrrolidine ring.
Tzvetkova P, Luy B, Simova S., Magn Reson Chem 50 Suppl 1(), 2012
PMID: 23280666
Tzvetkova P, Luy B, Simova S., Magn Reson Chem 50 Suppl 1(), 2012
PMID: 23280666
64 References
Daten bereitgestellt von Europe PubMed Central.
AUTHOR UNKNOWN, 0
Gupta, J. Am. Chem. Soc. 113(), 1991
Gupta, J. Org. Chem. 57(), 1992
Spermidine as a potential biosynthetic precursor to the 1,5-diazabicyclo[4:3:o]nonene residue in the efrapeptins.
Uma MV, Sudha R, Balaram P., J. Pept. Res. 58(5), 2001
PMID: 11892846
Uma MV, Sudha R, Balaram P., J. Pept. Res. 58(5), 2001
PMID: 11892846
Structure determination of neoefrapeptins A to N: peptides with insecticidal activity produced by the fungus Geotrichum candidum.
Fredenhagen A, Molleyres LP, Bohlendorf B, Laue G., J. Antibiot. 59(5), 2006
PMID: 16883776
Fredenhagen A, Molleyres LP, Bohlendorf B, Laue G., J. Antibiot. 59(5), 2006
PMID: 16883776
Structure at 2.8 A resolution of F1-ATPase from bovine heart mitochondria.
Abrahams JP, Leslie AG, Lutter R, Walker JE., Nature 370(6491), 1994
PMID: 8065448
Abrahams JP, Leslie AG, Lutter R, Walker JE., Nature 370(6491), 1994
PMID: 8065448
The structure of bovine F1-ATPase complexed with the peptide antibiotic efrapeptin.
Abrahams JP, Buchanan SK, Van Raaij MJ, Fearnley IM, Leslie AG, Walker JE., Proc. Natl. Acad. Sci. U.S.A. 93(18), 1996
PMID: 8790345
Abrahams JP, Buchanan SK, Van Raaij MJ, Fearnley IM, Leslie AG, Walker JE., Proc. Natl. Acad. Sci. U.S.A. 93(18), 1996
PMID: 8790345
Inhibition sites in F1-ATPase from bovine heart mitochondria.
Gledhill JR, Walker JE., Biochem. J. 386(Pt 3), 2005
PMID: 15537385
Gledhill JR, Walker JE., Biochem. J. 386(Pt 3), 2005
PMID: 15537385
Spectroscopic and crystallographic studies of the mutant R416W give insight into the nucleotide binding traits of subunit B of the A1Ao ATP synthase.
Kumar A, Manimekalai MS, Balakrishna AM, Hunke C, Weigelt S, Sewald N, Gruber G., Proteins 75(4), 2009
PMID: 19003877
Kumar A, Manimekalai MS, Balakrishna AM, Hunke C, Weigelt S, Sewald N, Gruber G., Proteins 75(4), 2009
PMID: 19003877
Antimalarial activities of peptide antibiotics isolated from fungi.
Nagaraj G, Uma MV, Shivayogi MS, Balaram H., Antimicrob. Agents Chemother. 45(1), 2001
PMID: 11120957
Nagaraj G, Uma MV, Shivayogi MS, Balaram H., Antimicrob. Agents Chemother. 45(1), 2001
PMID: 11120957
Inhibition of spinach chloroplasts photophosphorylation by the antibiotics leucinostatin and efrapeptin.
Lucero HA, Ravizzine RA, Vallejos RH., FEBS Lett. 68(1), 1976
PMID: 9316
Lucero HA, Ravizzine RA, Vallejos RH., FEBS Lett. 68(1), 1976
PMID: 9316
Inhibition of energy conservation reactions in chromatophores of Rhodospirillum rubrum by antibiotics.
Lucero H, Lescano WI, Vallejos RH., Arch. Biochem. Biophys. 186(1), 1978
PMID: 147053
Lucero H, Lescano WI, Vallejos RH., Arch. Biochem. Biophys. 186(1), 1978
PMID: 147053
Antibiotic inhibitors of mitochondrial ATP synthesis.
Lardy H, Reed P, Lin CH., Fed. Proc. 34(8), 1975
PMID: 124269
Lardy H, Reed P, Lin CH., Fed. Proc. 34(8), 1975
PMID: 124269
Inhibitors of the ATP synthethase system.
Linnett PE, Beechey RB., Meth. Enzymol. 55(), 1979
PMID: 156854
Linnett PE, Beechey RB., Meth. Enzymol. 55(), 1979
PMID: 156854
Properties of F1-ATPase from the uncD412 mutant of Escherichia coli.
Wise JG, Duncan TM, Latchney LR, Cox DN, Senior AE., Biochem. J. 215(2), 1983
PMID: 6228224
Wise JG, Duncan TM, Latchney LR, Cox DN, Senior AE., Biochem. J. 215(2), 1983
PMID: 6228224
Resistance of thermophilic ATPase (TF1) to specific F1-atpase inhibitors including local anesthetics.
Saishu T, Kagawa Y, Shimizu R., Biochem. Biophys. Res. Commun. 112(3), 1983
PMID: 6221726
Saishu T, Kagawa Y, Shimizu R., Biochem. Biophys. Res. Commun. 112(3), 1983
PMID: 6221726
Influence of efrapeptin, aurovertin and citreoviridin on the mitochondrial adenosine triphosphatase from Trypanosoma cruzi.
Cataldi de Flombaum MA, Stoppani AO., Mol. Biochem. Parasitol. 3(3), 1981
PMID: 6454845
Cataldi de Flombaum MA, Stoppani AO., Mol. Biochem. Parasitol. 3(3), 1981
PMID: 6454845
AUTHOR UNKNOWN, 0
F1F0-ATP synthase functions as a co-chaperone of Hsp90-substrate protein complexes.
Papathanassiu AE, MacDonald NJ, Bencsura A, Vu HA., Biochem. Biophys. Res. Commun. 345(1), 2006
PMID: 16682002
Papathanassiu AE, MacDonald NJ, Bencsura A, Vu HA., Biochem. Biophys. Res. Commun. 345(1), 2006
PMID: 16682002
Mitochondrial inhibitors show preferential cytotoxicity to human pancreatic cancer PANC-1 cells under glucose-deprived conditions.
Momose I, Ohba S, Tatsuda D, Kawada M, Masuda T, Tsujiuchi G, Yamori T, Esumi H, Ikeda D., Biochem. Biophys. Res. Commun. 392(3), 2010
PMID: 20083087
Momose I, Ohba S, Tatsuda D, Kawada M, Masuda T, Tsujiuchi G, Yamori T, Esumi H, Ikeda D., Biochem. Biophys. Res. Commun. 392(3), 2010
PMID: 20083087
Efrapeptins block exocytic but not endocytic trafficking of proteins.
Muroi M, Kaneko N, Suzuki K, Nishio T, Oku T, Sato T, Takatsuki A., Biochem. Biophys. Res. Commun. 227(3), 1996
PMID: 8886013
Muroi M, Kaneko N, Suzuki K, Nishio T, Oku T, Sato T, Takatsuki A., Biochem. Biophys. Res. Commun. 227(3), 1996
PMID: 8886013
Highly N-methylated linear peptides produced by an atypical sponge-derived Acremonium sp.
Boot CM, Tenney K, Valeriote FA, Crews P., J. Nat. Prod. 69(1), 2006
PMID: 16441074
Boot CM, Tenney K, Valeriote FA, Crews P., J. Nat. Prod. 69(1), 2006
PMID: 16441074
Efrapeptin J, a new down-regulator of the molecular chaperone GRP78 from a marine Tolypocladium sp.
Hayakawa Y, Hattori Y, Kawasaki T, Kanoh K, Adachi K, Shizuri Y, Shin-ya K., J. Antibiot. 61(6), 2008
PMID: 18667784
Hayakawa Y, Hattori Y, Kawasaki T, Kanoh K, Adachi K, Shizuri Y, Shin-ya K., J. Antibiot. 61(6), 2008
PMID: 18667784
Krasnoff, J. Invertebr. Pathol. 58(), 1991
Effect of entomopathogenic fungus Tolypocladium species metabolite efrapeptin on Galleria mellonella agglutinin.
Bandani AR., Commun. Agric. Appl. Biol. Sci. 69(3), 2004
PMID: 15759408
Bandani AR., Commun. Agric. Appl. Biol. Sci. 69(3), 2004
PMID: 15759408
Morphological alterations accompanying the effect of peptaibiotics, alpha-aminoisobutyric acid-rich secondary metabolites of filamentous fungi, on Culex pipiens larvae.
Matha V, Jegorov A, Kiess M, Bruckner H., Tissue Cell 24(4), 1992
PMID: 1359675
Matha V, Jegorov A, Kiess M, Bruckner H., Tissue Cell 24(4), 1992
PMID: 1359675
Effects of efrapeptin and destruxin, metabolites of entomogenous fungi, on the hydrolytic activity of a vacuolar type ATPase identified on the brush border membrane vesicles of Galleria mellonella midgut and on plant membrane bound hydrolytic enzymes.
Bandani AR, Amiri B, Butt TM, Gordon-Weeks R., Biochim. Biophys. Acta 1510(1-2), 2001
PMID: 11342173
Bandani AR, Amiri B, Butt TM, Gordon-Weeks R., Biochim. Biophys. Acta 1510(1-2), 2001
PMID: 11342173
AUTHOR UNKNOWN, 0
Auvin-Guette, Tetrahedron Lett. 34(), 1993
Meldal, Tetrahedron Lett. 38(), 1997
Jost, Angew. Chem. 114(), 2002
The first total synthesis of efrapeptin C.
Jost M, Greie JC, Stemmer N, Wilking SD, Altendorf K, Sewald N., Angew. Chem. Int. Ed. Engl. 41(22), 2002
PMID: 12434358
Jost M, Greie JC, Stemmer N, Wilking SD, Altendorf K, Sewald N., Angew. Chem. Int. Ed. Engl. 41(22), 2002
PMID: 12434358
AUTHOR UNKNOWN, 0
Kruizinga, J. Org. Chem. 53(), 1988
Kaptein, Tetrahedron: Asymmetry 4(), 1993
Alpha-azido acids for direct use in solid-phase peptide synthesis.
Tornoe CW, Davis P, Porreca F, Meldal M., J. Pept. Sci. 6(12), 2000
PMID: 11192239
Tornoe CW, Davis P, Porreca F, Meldal M., J. Pept. Sci. 6(12), 2000
PMID: 11192239
Improved solid-phase peptide synthesis method utilizing alpha-azide-protected amino acids.
Lundquist JT 4th, Pelletier JC., Org. Lett. 3(5), 2001
PMID: 11259061
Lundquist JT 4th, Pelletier JC., Org. Lett. 3(5), 2001
PMID: 11259061
The chemistry of amine-azide interconversion: catalytic diazotransfer and regioselective azide reduction.
Nyffeler PT, Liang CH, Koeller KM, Wong CH., J. Am. Chem. Soc. 124(36), 2002
PMID: 12207533
Nyffeler PT, Liang CH, Koeller KM, Wong CH., J. Am. Chem. Soc. 124(36), 2002
PMID: 12207533
AUTHOR UNKNOWN, 0
Bartra, Tetrahedron Lett. 28(), 1987
Bartra, Tetrahedron 46(), 1990
Jost, Synthesis (), 2005
Synthesis, and structural and biological studies of efrapeptin C analogues.
Jost M, Weigelt S, Huber T, Majer Z, Greie JC, Altendorf K, Sewald N., Chem. Biodivers. 4(6), 2007
PMID: 17589859
Jost M, Weigelt S, Huber T, Majer Z, Greie JC, Altendorf K, Sewald N., Chem. Biodivers. 4(6), 2007
PMID: 17589859
Brückner, Angew. Chem. 91(), 1979
The sequences of the membrane-modifying peptide antibiotic trichotoxin A-40.
Bruckner H, Konig WA, Greiner M, Jung G., Angew. Chem. Int. Ed. Engl. 18(6), 1979
PMID: 111585
Bruckner H, Konig WA, Greiner M, Jung G., Angew. Chem. Int. Ed. Engl. 18(6), 1979
PMID: 111585
Caputo, Tetrahedron 51(), 1995
Weigelt, Synlett (), 2004
A microassay for ATPase.
Henkel RD, VandeBerg JL, Walsh RA., Anal. Biochem. 169(2), 1988
PMID: 2968057
Henkel RD, VandeBerg JL, Walsh RA., Anal. Biochem. 169(2), 1988
PMID: 2968057
Altendorf, Acta Physiol. Scand. 163(), 1998
Properties of F1-ATPase from the uncD412 mutant of Escherichia coli.
Wise JG, Duncan TM, Latchney LR, Cox DN, Senior AE., Biochem. J. 215(2), 1983
PMID: 6228224
Wise JG, Duncan TM, Latchney LR, Cox DN, Senior AE., Biochem. J. 215(2), 1983
PMID: 6228224
The mode of inhibition of oxidative phosphorylation by efrapeptin (A23871). Evidence for an alternating site mechanism for ATP synthesis.
Cross RL, Kohlbrenner WE., J. Biol. Chem. 253(14), 1978
PMID: 149791
Cross RL, Kohlbrenner WE., J. Biol. Chem. 253(14), 1978
PMID: 149791
Perczel, 1996
Characterization of beta-bend ribbon spiral forming peptides using electronic and vibrational CD.
Yoder G, Keiderling TA, Formaggio F, Crisma M, Toniolo C., Biopolymers 35(1), 1995
PMID: 7696550
Yoder G, Keiderling TA, Formaggio F, Crisma M, Toniolo C., Biopolymers 35(1), 1995
PMID: 7696550
Toniolo, J. Am. Chem. Soc. 118(), 1996
Theoretical CD studies of polypeptide helices: examination of important electronic and geometric factors.
Manning MC, Woody RW., Biopolymers 31(5), 1991
PMID: 1868170
Manning MC, Woody RW., Biopolymers 31(5), 1991
PMID: 1868170
Studies of peptides forming 3(10)- and alpha-helices and beta-bend ribbon structures in organic solution and in model biomembranes by Fourier transform infrared spectroscopy.
Kennedy DF, Crisma M, Toniolo C, Chapman D., Biochemistry 30(26), 1991
PMID: 2054352
Kennedy DF, Crisma M, Toniolo C, Chapman D., Biochemistry 30(26), 1991
PMID: 2054352
Vibrational spectroscopy and conformation of peptides, polypeptides, and proteins.
Krimm S, Bandekar J., Adv. Protein Chem. 38(), 1986
PMID: 3541539
Krimm S, Bandekar J., Adv. Protein Chem. 38(), 1986
PMID: 3541539
Dwivedi, Biopolymers 23(), 1984
Discrimination between peptide 3(10)- and alpha-helices. Theoretical analysis of the impact of alpha-methyl substitution on experimental spectra.
Kubelka J, Silva RA, Keiderling TA., J. Am. Chem. Soc. 124(19), 2002
PMID: 11996573
Kubelka J, Silva RA, Keiderling TA., J. Am. Chem. Soc. 124(19), 2002
PMID: 11996573
Keiderling, 2000
Yoder, J. Am. Chem. Soc. 119(), 1997
Structure refinement of cyclosporin A in chloroform by using RDCs measured in a stretched PDMS-gel.
Klages J, Neubauer C, Coles M, Kessler H, Luy B., Chembiochem 6(9), 2005
PMID: 16138307
Klages J, Neubauer C, Coles M, Kessler H, Luy B., Chembiochem 6(9), 2005
PMID: 16138307
Kummerlöwe, TrAC Trends Anal. Chem. 28(), 2009
Stretched poly(dimethylsiloxane) gels as NMR alignment media for apolar and weakly polar organic solvents: an ideal tool for measuring RDCs at low molecular concentrations.
Freudenberger JC, Spiteller P, Bauer R, Kessler H, Luy B., J. Am. Chem. Soc. 126(45), 2004
PMID: 15535672
Freudenberger JC, Spiteller P, Bauer R, Kessler H, Luy B., J. Am. Chem. Soc. 126(45), 2004
PMID: 15535672
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