Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin-integrin linked kinase signalling complex

Wiedemann T, Hofbaur S, Tegtmeyer N, Huber S, Sewald N, Wessler S, Backert S, Rieder G (2012)
Gut 61(7): 986-996.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Wiedemann, Tobias; Hofbaur, Stefan; Tegtmeyer, Nicole; Huber, Sylwia; Sewald, NorbertUniBi ; Wessler, Silja; Backert, Steffen; Rieder, Gabriele
Abstract / Bemerkung
Objective One of the most important hormones in the human stomach is the peptide gastrin. It is mainly required for the regulation of gastric pH but is also involved in growth and differentiation of gastric epithelial cells. In Helicobacter pylori infected patients, gastrin secretion can be upregulated by the pathogen, resulting in hypergastrinaemia. H pylori induced hypergastrinaemia is described as being a major risk factor for the development of gastric adenocarcinoma. Design In this study, the upstream receptor complex and bacterial factors involved in H pylori induced gastrin gene expression were investigated, utilising gastric epithelial cells which were stably transfected with a human gastrin promoter luciferase reporter construct. Results Integrin linked kinase (ILK) and integrin β5, but not integrin β1, played an important role in gastrin promoter activation. Interestingly, a novel CagL/integrin β5/ILK signalling complex was characterised as being important for H pylori induced gastrin expression. On interaction of H pylori with αvβ(5)-integrin and ILK, the epidermal growth factor receptor (EGFR) →Raf→mitogen activated protein kinase kinase (MEK)→extracellular signal regulated kinase (Erk) downstream signalling cascade was identified which plays a central role in H pylori gastrin induction. Conclusion The newly discovered recognition receptor complex could be a useful target in treating precancerous conditions triggered by H pylori induced hypergastrinaemia.
Erscheinungsjahr
2012
Zeitschriftentitel
Gut
Band
61
Ausgabe
7
Seite(n)
986-996
ISSN
0017-5749
Page URI
https://pub.uni-bielefeld.de/record/2499322

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Wiedemann T, Hofbaur S, Tegtmeyer N, et al. Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin-integrin linked kinase signalling complex. Gut. 2012;61(7):986-996.
Wiedemann, T., Hofbaur, S., Tegtmeyer, N., Huber, S., Sewald, N., Wessler, S., Backert, S., et al. (2012). Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin-integrin linked kinase signalling complex. Gut, 61(7), 986-996. doi:10.1136/gutjnl-2011-300525
Wiedemann, Tobias, Hofbaur, Stefan, Tegtmeyer, Nicole, Huber, Sylwia, Sewald, Norbert, Wessler, Silja, Backert, Steffen, and Rieder, Gabriele. 2012. “Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin-integrin linked kinase signalling complex”. Gut 61 (7): 986-996.
Wiedemann, T., Hofbaur, S., Tegtmeyer, N., Huber, S., Sewald, N., Wessler, S., Backert, S., and Rieder, G. (2012). Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin-integrin linked kinase signalling complex. Gut 61, 986-996.
Wiedemann, T., et al., 2012. Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin-integrin linked kinase signalling complex. Gut, 61(7), p 986-996.
T. Wiedemann, et al., “Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin-integrin linked kinase signalling complex”, Gut, vol. 61, 2012, pp. 986-996.
Wiedemann, T., Hofbaur, S., Tegtmeyer, N., Huber, S., Sewald, N., Wessler, S., Backert, S., Rieder, G.: Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin-integrin linked kinase signalling complex. Gut. 61, 986-996 (2012).
Wiedemann, Tobias, Hofbaur, Stefan, Tegtmeyer, Nicole, Huber, Sylwia, Sewald, Norbert, Wessler, Silja, Backert, Steffen, and Rieder, Gabriele. “Helicobacter pylori CagL dependent induction of gastrin expression via a novel αvβ5-integrin-integrin linked kinase signalling complex”. Gut 61.7 (2012): 986-996.

53 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

H. pylori isolates with amino acid sequence polymorphisms as presence of both HtrA-L171 & CagL-Y58/E59 increase the risk of gastric cancer.
Yeh YC, Kuo HY, Chang WL, Yang HB, Lu CC, Cheng HC, Wu MS, Sheu BS., J Biomed Sci 26(1), 2019
PMID: 30611258
CagL polymorphisms D58/K59 are predominant in Helicobacter pylori strains isolated from Mexican patients with chronic gastritis.
Román-Román A, Martínez-Santos VI, Castañón-Sánchez CA, Albañil-Muñoz AJ, González-Mendoza P, Soto-Flores DG, Martínez-Carrillo DN, Fernández-Tilapa G., Gut Pathog 11(), 2019
PMID: 30805032
Beyond the Matrix: The Many Non-ECM Ligands for Integrins.
LaFoya B, Munroe JA, Miyamoto A, Detweiler MA, Crow JJ, Gazdik T, Albig AR., Int J Mol Sci 19(2), 2018
PMID: 29393909
Amino-Terminal Processing of Helicobacter pylori Serine Protease HtrA: Role in Oligomerization and Activity Regulation.
Albrecht N, Tegtmeyer N, Sticht H, Skórko-Glonek J, Backert S., Front Microbiol 9(), 2018
PMID: 29713313
The type IV secretion system in Helicobacter pylori.
Yuan XY, Wang Y, Wang MY., Future Microbiol 13(), 2018
PMID: 29927340
Bacterial infections and cancer.
van Elsland D, Neefjes J., EMBO Rep 19(11), 2018
PMID: 30348892
Integrin but not CEACAM receptors are dispensable for Helicobacter pylori CagA translocation.
Zhao Q, Busch B, Jiménez-Soto LF, Ishikawa-Ankerhold H, Massberg S, Terradot L, Fischer W, Haas R., PLoS Pathog 14(10), 2018
PMID: 30365569
Lymphotoxin β receptor signalling executes Helicobacter pylori-driven gastric inflammation in a T4SS-dependent manner.
Mejías-Luque R, Zöller J, Anderl F, Loew-Gil E, Vieth M, Adler T, Engler DB, Urban S, Browning JL, Müller A, Gerhard M, Heikenwalder M., Gut 66(8), 2017
PMID: 27196595
The Helicobacter pylori Autotransporter ImaA Tempers the Bacterium's Interaction with α5β1 Integrin.
Sause WE, Keilberg D, Aboulhouda S, Ottemann KM., Infect Immun 85(1), 2017
PMID: 27795352
Helicobacter pylori-Induced HB-EGF Upregulates Gastrin Expression via the EGF Receptor, C-Raf, Mek1, and Erk2 in the MAPK Pathway.
Gunawardhana N, Jang S, Choi YH, Hong YA, Jeon YE, Kim A, Su H, Kim JH, Yoo YJ, Merrell DS, Kim J, Cha JH., Front Cell Infect Microbiol 7(), 2017
PMID: 29379775
Helicobacter pylori: A Paradigm Pathogen for Subverting Host Cell Signal Transmission.
Naumann M, Sokolova O, Tegtmeyer N, Backert S., Trends Microbiol 25(4), 2017
PMID: 28057411
Molecular dissection of protein-protein interactions between integrin α5β1 and the Helicobacter pylori Cag type IV secretion system.
Koelblen T, Bergé C, Cherrier MV, Brillet K, Jimenez-Soto L, Ballut L, Takagi J, Montserret R, Rousselle P, Fischer W, Haas R, Fronzes R, Terradot L., FEBS J 284(23), 2017
PMID: 29055076
Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA.
Tegtmeyer N, Moodley Y, Yamaoka Y, Pernitzsch SR, Schmidt V, Traverso FR, Schmidt TP, Rad R, Yeoh KG, Bow H, Torres J, Gerhard M, Schneider G, Wessler S, Backert S., Mol Microbiol 99(5), 2016
PMID: 26568477
Helicobacter pylori CagL Hypervariable Motif: A Global Analysis of Geographical Diversity and Association With Gastric Cancer.
Gorrell RJ, Zwickel N, Reynolds J, Bulach D, Kwok T., J Infect Dis 213(12), 2016
PMID: 26908724
Use of VacA as a Vaccine Antigen.
Moyat M, Velin D., Toxins (Basel) 8(6), 2016
PMID: 27338474
Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains.
Lind J, Backert S, Hoffmann R, Eichler J, Yamaoka Y, Perez-Perez GI, Torres J, Sticht H, Tegtmeyer N., BMC Microbiol 16(1), 2016
PMID: 27590005
The Role of H. pylori CagA in Regulating Hormones of Functional Dyspepsia Patients.
Meng WP, Wang ZQ, Deng JQ, Liu Y, Deng MM, Lü MH., Gastroenterol Res Pract 2016(), 2016
PMID: 27840636
Crystal structure of CagL from Helicobacter pylori K74 strain.
Choi JM, Choi YH, Sudhanva MS, Devakumar S, Lee KH, Cha JH, Lee SH., Biochem Biophys Res Commun 460(4), 2015
PMID: 25839651
Integrin engagement by the helical RGD motif of the Helicobacter pylori CagL protein is regulated by pH-induced displacement of a neighboring helix.
Bonsor DA, Pham KT, Beadenkopf R, Diederichs K, Haas R, Beckett D, Fischer W, Sundberg EJ., J Biol Chem 290(20), 2015
PMID: 25837254
Helicobacter pylori virulence factors affecting gastric proton pump expression and acid secretion.
Hammond CE, Beeson C, Suarez G, Peek RM, Backert S, Smolka AJ., Am J Physiol Gastrointest Liver Physiol 309(3), 2015
PMID: 26045613
Molecular Mechanisms of Helicobacter pylori Pathogenesis.
De Falco M, Lucariello A, Iaquinto S, Esposito V, Guerra G, De Luca A., J Cell Physiol 230(8), 2015
PMID: 25639461
Wnt/β-catenin, an oncogenic pathway targeted by H. pylori in gastric carcinogenesis.
Song X, Xin N, Wang W, Zhao C., Oncotarget 6(34), 2015
PMID: 26417932
Role of Helicobacter pylori infection in gastric carcinogenesis: Current knowledge and future directions.
Sokic-Milutinovic A, Alempijevic T, Milosavljevic T., World J Gastroenterol 21(41), 2015
PMID: 26556993
Structure of a three-dimensional domain-swapped dimer of the Helicobacter pylori type IV secretion system pilus protein CagL.
Barden S, Schomburg B, Conradi J, Backert S, Sewald N, Niemann HH., Acta Crystallogr D Biol Crystallogr 70(pt 5), 2014
PMID: 24816107
Immune responses to Helicobacter pylori infection.
Moyat M, Velin D., World J Gastroenterol 20(19), 2014
PMID: 24914318
Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of Western-type Helicobacter pylori strains.
Lind J, Backert S, Pfleiderer K, Berg DE, Yamaoka Y, Sticht H, Tegtmeyer N., PLoS One 9(5), 2014
PMID: 24800748
The impact of serine protease HtrA in apoptosis, intestinal immune responses and extra-intestinal histopathology during Campylobacter jejuni infection of infant mice.
Heimesaat MM, Fischer A, Alutis M, Grundmann U, Boehm M, Tegtmeyer N, Göbel UB, Kühl AA, Bereswill S, Backert S., Gut Pathog 6(), 2014
PMID: 24883112
The role of serine protease HtrA in acute ulcerative enterocolitis and extra-intestinal immune responses during Campylobacter jejuni infection of gnotobiotic IL-10 deficient mice.
Heimesaat MM, Alutis M, Grundmann U, Fischer A, Tegtmeyer N, Böhm M, Kühl AA, Göbel UB, Backert S, Bereswill S., Front Cell Infect Microbiol 4(), 2014
PMID: 24959425
Pharmacological and alimentary alteration of the gastric barrier.
Boltin D, Niv Y., Best Pract Res Clin Gastroenterol 28(6), 2014
PMID: 25439065
A novel NOD1- and CagA-independent pathway of interleukin-8 induction mediated by the Helicobacter pylori type IV secretion system.
Gorrell RJ, Guan J, Xin Y, Tafreshi MA, Hutton ML, McGuckin MA, Ferrero RL, Kwok T., Cell Microbiol 15(4), 2013
PMID: 23107019
Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori.
Salama NR, Hartung ML, Müller A., Nat Rev Microbiol 11(6), 2013
PMID: 23652324
The duration of gastrin treatment affects global gene expression and molecular responses involved in ER stress and anti-apoptosis.
Selvik LK, Fjeldbo CS, Flatberg A, Steigedal TS, Misund K, Anderssen E, Doseth B, Langaas M, Tripathi S, Beisvag V, Lægreid A, Thommesen L, Bruland T., BMC Genomics 14(), 2013
PMID: 23805861
Helicobacter pylori outer membrane protein HopQ identified as a novel T4SS-associated virulence factor.
Belogolova E, Bauer B, Pompaiah M, Asakura H, Brinkman V, Ertl C, Bartfeld S, Nechitaylo TY, Haas R, Machuy N, Salama N, Churin Y, Meyer TF., Cell Microbiol 15(11), 2013
PMID: 23782461
Pathogenesis of Helicobacter pylori infection.
Cid TP, Fernández MC, Benito Martínez S, Jones NL., Helicobacter 18 Suppl 1(), 2013
PMID: 24011239
Inflammation, immunity, vaccines for Helicobacter pylori infection.
Koch M, Meyer TF, Moss SF., Helicobacter 18 Suppl 1(), 2013
PMID: 24011240
A helical RGD motif promoting cell adhesion: crystal structures of the Helicobacter pylori type IV secretion system pilus protein CagL.
Barden S, Lange S, Tegtmeyer N, Conradi J, Sewald N, Backert S, Niemann HH., Structure 21(11), 2013
PMID: 24076404
Gastric secretion.
Chu S, Schubert ML., Curr Opin Gastroenterol 29(6), 2013
PMID: 24100729
How Helicobacter pylori infection controls gastric acid secretion.
Smolka AJ, Backert S., J Gastroenterol 47(6), 2012
PMID: 22565637
An RGD helper sequence in CagL of Helicobacter pylori assists in interactions with integrins and injection of CagA.
Conradi J, Tegtmeyer N, Woźna M, Wissbrock M, Michalek C, Gagell C, Cover TL, Frank R, Sewald N, Backert S., Front Cell Infect Microbiol 2(), 2012
PMID: 22919661
Pathogenesis of Helicobacter pylori infection.
Delahay RM, Rugge M., Helicobacter 17 Suppl 1(), 2012
PMID: 22958149
Gastric secretion.
Chu S, Schubert ML., Curr Opin Gastroenterol 28(6), 2012
PMID: 22954692

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