Continuous and reversible mixing or demixing of nanoparticles by dielectrophoresis

Viefhues M, Eichhorn R, Fredrich E, Regtmeier J, Anselmetti D (2012)
Lab on a Chip 12(3): 485-494.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Abstract / Bemerkung
Mixing and demixing (separation) are essential tasks in microfluidic devices, which seem to be contrary in nature. Accordingly, completely different strategies and devices are usually employed for their realization. We here present a microfluidic device which is capable of performing both these tasks as it can be operated in either mixing or demixing mode. The mixing and demixing processes are reversible and are accomplished by continuous operation of the device. An asymmetric S-shaped ridge extends over the full width of a microfluidic channel (200 mu m) creating a constriction of 620 nm in height with an aspect ratio of 1 : 500. Appropriate AC and DC voltages generate electrodeless dielectrophoresis at the constriction as well as (linear) electrokinetic driving forces along the channel. These de/mixing parameters can be adapted in real time in such a way that continuous separation and mixing efficiencies of 85-100% can be achieved. As a proof of concept we demonstrate continuous mixing and demixing of polystyrene nanoparticles (20 and 100 nm). The experimental results are complemented by numerical simulations illustrating the particles' motion under the influence of the electrokinetic effects and thermal noise (diffusion). The monolithic one-step fabrication process by soft lithography (with PDMS in our case) will make integration and combination of several mixing and demixing functions into a more complex lab-on-a-chip device possible.
Erscheinungsjahr
2012
Zeitschriftentitel
Lab on a Chip
Band
12
Ausgabe
3
Seite(n)
485-494
ISSN
1473-0197
eISSN
1473-0189
Page URI
https://pub.uni-bielefeld.de/record/2474586

Zitieren

Viefhues M, Eichhorn R, Fredrich E, Regtmeier J, Anselmetti D. Continuous and reversible mixing or demixing of nanoparticles by dielectrophoresis. Lab on a Chip. 2012;12(3):485-494.
Viefhues, M., Eichhorn, R., Fredrich, E., Regtmeier, J., & Anselmetti, D. (2012). Continuous and reversible mixing or demixing of nanoparticles by dielectrophoresis. Lab on a Chip, 12(3), 485-494. doi:10.1039/c1lc20610a
Viefhues, Martina, Eichhorn, Ralf, Fredrich, Eugenie, Regtmeier, Jan, and Anselmetti, Dario. 2012. “Continuous and reversible mixing or demixing of nanoparticles by dielectrophoresis”. Lab on a Chip 12 (3): 485-494.
Viefhues, M., Eichhorn, R., Fredrich, E., Regtmeier, J., and Anselmetti, D. (2012). Continuous and reversible mixing or demixing of nanoparticles by dielectrophoresis. Lab on a Chip 12, 485-494.
Viefhues, M., et al., 2012. Continuous and reversible mixing or demixing of nanoparticles by dielectrophoresis. Lab on a Chip, 12(3), p 485-494.
M. Viefhues, et al., “Continuous and reversible mixing or demixing of nanoparticles by dielectrophoresis”, Lab on a Chip, vol. 12, 2012, pp. 485-494.
Viefhues, M., Eichhorn, R., Fredrich, E., Regtmeier, J., Anselmetti, D.: Continuous and reversible mixing or demixing of nanoparticles by dielectrophoresis. Lab on a Chip. 12, 485-494 (2012).
Viefhues, Martina, Eichhorn, Ralf, Fredrich, Eugenie, Regtmeier, Jan, and Anselmetti, Dario. “Continuous and reversible mixing or demixing of nanoparticles by dielectrophoresis”. Lab on a Chip 12.3 (2012): 485-494.

10 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

DNA dielectrophoresis: Theory and applications a review.
Viefhues M, Eichhorn R., Electrophoresis 38(11), 2017
PMID: 28306161
Reaching for the limits in continuous-flow dielectrophoretic DNA analysis.
Täuber S, Kunze L, Grauberger O, Grundmann A, Viefhues M., Analyst 142(24), 2017
PMID: 29119187
Droplet Merging on a Lab-on-a-Chip Platform by Uniform Magnetic Fields.
Varma VB, Ray A, Wang ZM, Wang ZP, Ramanujan RV., Sci Rep 6(), 2016
PMID: 27892475
Advancements in microfluidics for nanoparticle separation.
Salafi T, Zeming KK, Zhang Y., Lab Chip 17(1), 2016
PMID: 27830852
Rapid Prototyping of Nanofluidic Slits in a Silicone Bilayer.
Kole TP, Liao KT, Schiffels D, Ilic BR, Strychalski EA, Kralj JG, Liddle JA, Dritschilo A, Stavis SM., J Res Natl Inst Stand Technol 120(), 2015
PMID: 26958449
Dielectrophoresis for bioparticle manipulation.
Qian C, Huang H, Chen L, Li X, Ge Z, Chen T, Yang Z, Sun L., Int J Mol Sci 15(10), 2014
PMID: 25310652
Dielectrophoresis based continuous-flow nano sorter: fast quality control of gene vaccines.
Viefhues M, Wegener S, Rischmüller A, Schleef M, Anselmetti D., Lab Chip 13(15), 2013
PMID: 23760065

47 References

Daten bereitgestellt von Europe PubMed Central.

Chaotic mixer for microchannels.
Stroock AD, Dertinger SK, Ajdari A, Mezic I, Stone HA, Whitesides GM., Science 295(5555), 2002
PMID: 11809963

Hessel, Chem. Eng. Sci. 60(), 2005

Nguyen, J. Micromech. Microeng. 15(), 2005

Mansur, Chin. J. Chem. Eng. 16(), 2008
Micro total analysis systems. 1. Introduction, theory, and technology.
Reyes DR, Iossifidis D, Auroux PA, Manz A., Anal. Chem. 74(12), 2002
PMID: 12090653
Micro total analysis systems. 2. Analytical standard operations and applications.
Auroux PA, Iossifidis D, Reyes DR, Manz A., Anal. Chem. 74(12), 2002
PMID: 12090654
Micro total analysis systems. Recent developments.
Vilkner T, Janasek D, Manz A., Anal. Chem. 76(12), 2004
PMID: 15193114
Micro total analysis systems. Latest advancements and trends.
Dittrich PS, Tachikawa K, Manz A., Anal. Chem. 78(12), 2006
PMID: 16771530
Micro total analysis systems: latest achievements.
West J, Becker M, Tombrink S, Manz A., Anal. Chem. 80(12), 2008
PMID: 18498178
Latest developments in micro total analysis systems.
Arora A, Simone G, Salieb-Beugelaar GB, Kim JT, Manz A., Anal. Chem. 82(12), 2010
PMID: 20462185
Micro- and nanofluidics for DNA analysis.
Tegenfeldt JO, Prinz C, Cao H, Huang RL, Austin RH, Chou SY, Cox EC, Sturm JC., Anal Bioanal Chem 378(7), 2004
PMID: 15007591
Electrodeless dielectrophoresis for bioanalysis: theory, devices and applications.
Regtmeier J, Eichhorn R, Viefhues M, Bogunovic L, Anselmetti D., Electrophoresis 32(17), 2011
PMID: 23361920
Continuous separation of microparticles by size with direct current-dielectrophoresis.
Kang KH, Kang Y, Xuan X, Li D., Electrophoresis 27(3), 2006
PMID: 16385598
DC-Dielectrophoretic separation of biological cells by size.
Kang Y, Li D, Kalams SA, Eid JE., Biomed Microdevices 10(2), 2008
PMID: 17899384
DC-dielectrophoretic separation of microparticles using an oil droplet obstacle.
Barbulovic-Nad I, Xuan X, Lee JS, Li D., Lab Chip 6(2), 2005
PMID: 16450038
Dielectrophoretic manipulation of particles and cells using insulating ridges in faceted prism microchannels.
Barrett LM, Skulan AJ, Singh AK, Cummings EB, Fiechtner GJ., Anal. Chem. 77(21), 2005
PMID: 16255576

Church, J. Micromech. Microeng. 20(), 2010

Zhang, J. Phys. Conf. Ser. 34(), 2006
Separation of mixtures of particles in a multipart microdevice employing insulator-based dielectrophoresis.
Gallo-Villanueva RC, Perez-Gonzalez VH, Davalos RV, Lapizco-Encinas BH., Electrophoresis 32(18), 2011
PMID: 21874656
A patterned anisotropic nanofluidic sieving structure for continuous-flow separation of DNA and proteins.
Fu J, Schoch RB, Stevens AL, Tannenbaum SR, Han J., Nat Nanotechnol 2(2), 2007
PMID: 18654231
Continuous flow separations in microfluidic devices.
Pamme N., Lab Chip 7(12), 2007
PMID: 18030382

Pethig, Biomicrofluidics 4(), 2010
Particle separation by dielectrophoresis.
Gascoyne PR, Vykoukal J., Electrophoresis 23(13), 2002
PMID: 12210248
Dielectrophoresis for the manipulation of nanobioparticles.
Lapizco-Encinas BH, Rito-Palomares M., Electrophoresis 28(24), 2007
PMID: 18072220

Probstein, 2003

Schoch, Rev. Mod. Phys. 80(), 2008
Conditions for similitude between the fluid velocity and electric field in electroosmotic flow
Cummings EB, Griffiths SK, Nilson RH, Paul PH., Anal. Chem. 72(11), 2000
PMID: 10857630

Pohl, 1978
The Dielectrophoretic Behavior of Submicron Latex Spheres: Influence of Surface Conductance.
Hughes MP, Morgan H, Flynn MF., J Colloid Interface Sci 220(2), 1999
PMID: 10607465
Measurement and interpretation of electrokinetic phenomena.
Delgado AV, Gonzalez-Caballero F, Hunter RJ, Koopal LK, Lyklema J; International Union of Pure and Applied Chemistry, Physical and Biophysical Chemistry Division IUPAC Technical Report., J Colloid Interface Sci 309(2), 2007
PMID: 17368660

Hänggi, Rev. Mod. Phys. 62(), 1990

Odom, Langmuir 18(), 2002
Poly(oxyethylene) based surface coatings for poly(dimethylsiloxane) microchannels.
Hellmich W, Regtmeier J, Duong TT, Ros R, Anselmetti D, Ros A., Langmuir 21(16), 2005
PMID: 16042494
Joule heating in electrokinetic flow.
Xuan X., Electrophoresis 29(1), 2008
PMID: 18058768
Joule heating effects on electroosmotic flow in insulator-based dielectrophoresis.
Sridharan S, Zhu J, Hu G, Xuan X., Electrophoresis 32(17), 2011
PMID: 21792988
Hard-wall interactions in soft matter systems: exact numerical treatment.
Behringer H, Eichhorn R., Phys Rev E Stat Nonlin Soft Matter Phys 83(6 Pt 2), 2011
PMID: 21797434

Deval, Proc 15th IEEE workshop on MEMS (), 2002

Lee, Proc 14th IEEE workshop on MEMS (), 2001
Hybrid electrokinetics for separation, mixing, and concentration of colloidal particles.
Sin MLY, Shimabukuro Y, Wong PK., Nanotechnology 20(16), 2009
PMID: 19420574
Dielectrophoresis-based particle exchanger for the manipulation and surface functionalization of particles.
Tornay R, Braschler T, Demierre N, Steitz B, Finka A, Hofmann H, Hubbell JA, Renaud P., Lab Chip 8(2), 2007
PMID: 18231665
Dielectrophoretic manipulation of DNA: separation and polarizability.
Regtmeier J, Duong TT, Eichhorn R, Anselmetti D, Ros A., Anal. Chem. 79(10), 2007
PMID: 17444613
Dielectrophoretic trapping and polarizability of DNA: the role of spatial conformation.
Regtmeier J, Eichhorn R, Bogunovic L, Ros A, Anselmetti D., Anal. Chem. 82(17), 2010
PMID: 20690609
Trapping single molecules by dielectrophoresis.
Holzel R, Calander N, Chiragwandi Z, Willander M, Bier FF., Phys. Rev. Lett. 95(12), 2005
PMID: 16197115

Tay, Def. Sci. J. 59(), 2009
Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®
Quellen

PMID: 22193706
PubMed | Europe PMC

Suchen in

Google Scholar