Inhibition of NF-kappa B potentiates amyloid beta-mediated neuronal apoptosis

Kaltschmidt B, Uherek M, Wellmann H, Volk B, Kaltschmidt C (1999)

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Kaltschmidt, BarbaraUniBi; Uherek, M.; Wellmann, H.; Volk, B.; Kaltschmidt, ChristianUniBi
Abstract / Bemerkung
One mechanism leading to neurodegeneration during Alzheimer's disease (AD) is amyloid beta peptide (A beta) neurotoxicity. A beta elicits in cultured central nervous system neurons a biphasic response: a low-dose neurotrophic response and a high-dose neurotoxic response. Previously me reported that NF-kappa B is activated by low doses of A beta only. Here we show that NF-kappa B activation leads to neuroprotection. In primary neurons me found that a pretreatment with 0.1 mu M A beta-(1-40) protects against neuronal death induced with 10 mu M A beta-(1-40). As a known neuroprotective agent we nest analyzed the effect of tumor necrosis factor alpha (TNF-alpha). Maximal activation of NF-kappa B was found with 2 ng/ml TNF-alpha. Pretreatment with TNF-alpha protected cerebellar granule cells from tell death induced by 10 mu M A beta-(1-40). This protection is described by an inverted U-shaped dose response and is maximal with a NF-kappa B-activating dose. The molecular specificity of this protective effect was analyzed by specific blockade of NF-kappa B activation. Overexpression of a transdominant negative I kappa B-alpha blocks NF-kappa B activation and potentiates A beta-mediated neuronal apoptosis. Our findings show that activation of NF-kappa B is the underlying mechanism of the neuroprotective effect of low-dose A beta and TNF-alpha. In accordance with these in vitro data we find that nuclear NF-kappa B immunoreactivity around various plaque stages of AD patients is reduced in comparison to age-matched controls, Taken together these data suggest that pharmacological NF-kappa B activation may be a useful approach in the treatment of AD and related neurodegenerative disorders.
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Kaltschmidt B, Uherek M, Wellmann H, Volk B, Kaltschmidt C. Inhibition of NF-kappa B potentiates amyloid beta-mediated neuronal apoptosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(16):9409-9414.
Kaltschmidt, B., Uherek, M., Wellmann, H., Volk, B., & Kaltschmidt, C. (1999). Inhibition of NF-kappa B potentiates amyloid beta-mediated neuronal apoptosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 96(16), 9409-9414. doi:10.1073/pnas.96.16.9409
Kaltschmidt, Barbara, Uherek, M., Wellmann, H., Volk, B., and Kaltschmidt, Christian. 1999. “Inhibition of NF-kappa B potentiates amyloid beta-mediated neuronal apoptosis”. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96 (16): 9409-9414.
Kaltschmidt, B., Uherek, M., Wellmann, H., Volk, B., and Kaltschmidt, C. (1999). Inhibition of NF-kappa B potentiates amyloid beta-mediated neuronal apoptosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96, 9409-9414.
Kaltschmidt, B., et al., 1999. Inhibition of NF-kappa B potentiates amyloid beta-mediated neuronal apoptosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 96(16), p 9409-9414.
B. Kaltschmidt, et al., “Inhibition of NF-kappa B potentiates amyloid beta-mediated neuronal apoptosis”, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 96, 1999, pp. 9409-9414.
Kaltschmidt, B., Uherek, M., Wellmann, H., Volk, B., Kaltschmidt, C.: Inhibition of NF-kappa B potentiates amyloid beta-mediated neuronal apoptosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 96, 9409-9414 (1999).
Kaltschmidt, Barbara, Uherek, M., Wellmann, H., Volk, B., and Kaltschmidt, Christian. “Inhibition of NF-kappa B potentiates amyloid beta-mediated neuronal apoptosis”. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 96.16 (1999): 9409-9414.

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Daten bereitgestellt von Europe PubMed Central.

Synaptically Localized Transcriptional Regulators in Memory Formation.
Uchida S, Shumyatsky GP., Neuroscience 370(), 2018
PMID: 28733211
Amyloid-β25-35 Upregulates Endogenous Neuroprotectant Neuroglobin via NFκB Activation in vitro.
Liu N, Yu Z, Xun Y, Shu P, Yue Y, Yuan S, Jiang Y, Huang Z, Yang X, Feng X, Xiang S, Wang X., J Alzheimers Dis 64(4), 2018
PMID: 30010125
Proteasomal Dysfunction Induced By Diclofenac Engenders Apoptosis Through Mitochondrial Pathway.
Amanullah A, Upadhyay A, Chhangani D, Joshi V, Mishra R, Yamanaka K, Mishra A., J Cell Biochem 118(5), 2017
PMID: 27487200
Transcriptional regulation of RACK1 and modulation of its expression: Role of steroid hormones and significance in health and aging.
Buoso E, Galasso M, Serafini MM, Ronfani M, Lanni C, Corsini E, Racchi M., Cell Signal 35(), 2017
PMID: 28192162
Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges.
Davinelli S, Maes M, Corbi G, Zarrelli A, Willcox DC, Scapagnini G., Immun Ageing 13(), 2016
PMID: 27081392
RAGE Expression and ROS Generation in Neurons: Differentiation versus Damage.
Piras S, Furfaro AL, Domenicotti C, Traverso N, Marinari UM, Pronzato MA, Nitti M., Oxid Med Cell Longev 2016(), 2016
PMID: 27313835
Virally delivered, constitutively active NFκB improves survival of injured retinal ganglion cells.
Dvoriantchikova G, Pappas S, Luo X, Ribeiro M, Danek D, Pelaez D, Park KK, Ivanov D., Eur J Neurosci 44(11), 2016
PMID: 27564592
Neuronal Gene Targets of NF-κB and Their Dysregulation in Alzheimer's Disease.
Snow WM, Albensi BC., Front Mol Neurosci 9(), 2016
PMID: 27881951
Novel NF-κB inhibitors: a patent review (2011 - 2014).
Arepalli SK, Choi M, Jung JK, Lee H., Expert Opin Ther Pat 25(3), 2015
PMID: 25553724
PARP-1 involvement in neurodegeneration: A focus on Alzheimer's and Parkinson's diseases.
Martire S, Mosca L, d'Erme M., Mech Ageing Dev 146-148(), 2015
PMID: 25881554
NF-KappaB in Long-Term Memory and Structural Plasticity in the Adult Mammalian Brain.
Kaltschmidt B, Kaltschmidt C., Front Mol Neurosci 8(), 2015
PMID: 26635522
Complex regulation of acute and chronic neuroinflammatory responses in mouse models deficient for nuclear factor kappa B p50 subunit.
Rolova T, Puli L, Magga J, Dhungana H, Kanninen K, Wojciehowski S, Salminen A, Tanila H, Koistinaho J, Malm T., Neurobiol Dis 64(), 2014
PMID: 24345324
Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway.
Marwarha G, Raza S, Meiers C, Ghribi O., Biochim Biophys Acta 1842(9), 2014
PMID: 24874077
Inhibiting IκB kinase-β downregulates inflammatory cytokines in injured discs and neuropeptides in dorsal root ganglia innervating injured discs in rats.
Kobori S, Miyagi M, Orita S, Gemba T, Ishikawa T, Kamoda H, Suzuki M, Hishiya T, Yamada T, Eguchi Y, Arai G, Sakuma Y, Oikawa Y, Aoki Y, Toyone T, Takahashi K, Inoue G, Ohtori S., Spine (Phila Pa 1976) 39(15), 2014
PMID: 24825147
NF-κB signaling pathways: role in nervous system physiology and pathology.
Mincheva-Tasheva S, Soler RM., Neuroscientist 19(2), 2013
PMID: 22785105
Overexpression of the nuclear factor kappaB inhibitor A20 is neurotoxic after an excitotoxic injury to the immature rat brain.
Peluffo H, Gonzalez P, Acarin L, Arís A, Beyaert R, Villaverde A, Gonzalez B., Neurol Res 35(3), 2013
PMID: 23336395
Black rice anthocyanidins prevent retinal photochemical damage via involvement of the AP-1/NF-κB/Caspase-1 pathway in Sprague-Dawley rats.
Jia H, Chen W, Yu X, Wu X, Li S, Liu H, Liao J, Liu W, Mi M, Liu L, Cheng D., J Vet Sci 14(3), 2013
PMID: 23820171
Spinal TNF is necessary for inactivity-induced phrenic motor facilitation.
Broytman O, Baertsch NA, Baker-Herman TL., J Physiol 591(22), 2013
PMID: 23878370
Stimulation of central β2-adrenoceptors suppresses NFκB activity in rat brain: a role for IκB.
Ryan KJ, Griffin É, Yssel JD, Ryan KM, McNamee EN, Harkin A, Connor TJ., Neurochem Int 63(5), 2013
PMID: 23896303
Avermectin induced inflammation damage in king pigeon brain.
Chen LJ, Sun BH, Qu JP, Xu S, Li S., Chemosphere 93(10), 2013
PMID: 24134892
Neuronal NF-κB ablation does not influence neuro-axonal degeneration in experimental autoimmune demyelination.
Lee DH, Kubera K, Rosenthal B, Kaltschmidt B, Kaltschmidt C, Gold R, Linker RA., J Neuroimmunol 246(1-2), 2012
PMID: 22475633
Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain.
Pranski EL, Van Sanford CD, Dalal NV, Orr AL, Karmali D, Cooper DS, Costa N, Heilman CJ, Gearing M, Lah JJ, Levey AI, Betarbet RS., Neurosci Lett 520(1), 2012
PMID: 22634524
Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations.
Chami L, Buggia-Prévot V, Duplan E, Del Prete D, Chami M, Peyron JF, Checler F., J Biol Chem 287(29), 2012
PMID: 22654105
KSRP: a checkpoint for inflammatory cytokine production in astrocytes.
Li X, Lin WJ, Chen CY, Si Y, Zhang X, Lu L, Suswam E, Zheng L, King PH., Glia 60(11), 2012
PMID: 22847996
Pleiotropic neuroprotective and metabolic effects of Actovegin's mode of action.
Machicao F, Muresanu DF, Hundsberger H, Pflüger M, Guekht A., J Neurol Sci 322(1-2), 2012
PMID: 22910148
Transcriptional and post-transcriptional regulation of β-secretase.
Tamagno E, Guglielmotto M, Monteleone D, Vercelli A, Tabaton M., IUBMB Life 64(12), 2012
PMID: 23180460
Identification of novel small molecule activators of nuclear factor-κB with neuroprotective action via high-throughput screening.
Manuvakhova MS, Johnson GG, White MC, Ananthan S, Sosa M, Maddox C, McKellip S, Rasmussen L, Wennerberg K, Hobrath JV, White EL, Maddry JA, Grimaldi M., J Neurosci Res 89(1), 2011
PMID: 21046675
Astrocytic P2Y(1) receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia.
Kuboyama K, Harada H, Tozaki-Saitoh H, Tsuda M, Ushijima K, Inoue K., J Cereb Blood Flow Metab 31(9), 2011
PMID: 21487414
Curcumin attenuates staurosporine-mediated death of retinal ganglion cells.
Burugula B, Ganesh BS, Chintala SK., Invest Ophthalmol Vis Sci 52(7), 2011
PMID: 21498608
Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination.
Brambilla R, Ashbaugh JJ, Magliozzi R, Dellarole A, Karmally S, Szymkowski DE, Bethea JR., Brain 134(pt 9), 2011
PMID: 21908877
Melatonin attenuates methamphetamine-induced overexpression of pro-inflammatory cytokines in microglial cell lines.
Tocharus J, Khonthun C, Chongthammakun S, Govitrapong P., J Pineal Res 48(4), 2010
PMID: 20374443
Neuroprotective herbs and foods from different traditional medicines and diets.
Iriti M, Vitalini S, Fico G, Faoro F., Molecules 15(5), 2010
PMID: 20657497
Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions.
Klaver DW, Wilce MC, Cui H, Hung AC, Gasperini R, Foa L, Small DH., Biol Chem 391(8), 2010
PMID: 20731541
Changes in TNFα, NFκB and MnSOD protein in the vestibular nuclei after unilateral vestibular deafferentation.
Liberge M, Manrique C, Bernard-Demanze L, Lacour M., J Neuroinflammation 7(), 2010
PMID: 21143912
Iron and mechanisms of neurotoxicity.
Salvador GA, Uranga RM, Giusto NM., Int J Alzheimers Dis 2011(), 2010
PMID: 21234369
Post-ischemic brain damage: NF-kappaB dimer heterogeneity as a molecular determinant of neuron vulnerability.
Pizzi M, Sarnico I, Lanzillotta A, Battistin L, Spano P., FEBS J 276(1), 2009
PMID: 19087197
NF-kappaB p50/RelA and c-Rel-containing dimers: opposite regulators of neuron vulnerability to ischaemia.
Sarnico I, Lanzillotta A, Boroni F, Benarese M, Alghisi M, Schwaninger M, Inta I, Battistin L, Spano P, Pizzi M., J Neurochem 108(2), 2009
PMID: 19094066
Cocaine induces cell death and activates the transcription nuclear factor kappa-B in PC12 cells.
Lepsch LB, Munhoz CD, Kawamoto EM, Yshii LM, Lima LS, Curi-Boaventura MF, Salgado TM, Curi R, Planeta CS, Scavone C., Mol Brain 2(), 2009
PMID: 19183502
NF-kappaB in the nervous system.
Kaltschmidt B, Kaltschmidt C., Cold Spring Harb Perspect Biol 1(3), 2009
PMID: 20066105
Prions: protein aggregation and infectious diseases.
Aguzzi A, Calella AM., Physiol Rev 89(4), 2009
PMID: 19789378
Transgenic expression of the human A20 gene in cloned pigs provides protection against apoptotic and inflammatory stimuli.
Oropeza M, Petersen B, Carnwath JW, Lucas-Hahn A, Lemme E, Hassel P, Herrmann D, Barg-Kues B, Holler S, Queisser AL, Schwinzer R, Hinkel R, Kupatt C, Niemann H., Xenotransplantation 16(6), 2009
PMID: 20042052
Amyloid beta serves as an NGF-like neurotrophic factor or acts as a NGF antagonist depending on its concentration.
Arevalo MA, Roldan PM, Chacón PJ, Rodríguez-Tebar A., J Neurochem 111(6), 2009
PMID: 20050289
NF-kB/NOS cross-talk induced by mitochondrial complex II inhibition: implications for Huntington's disease.
Napolitano M, Zei D, Centonze D, Palermo R, Bernardi G, Vacca A, Calabresi P, Gulino A., Neurosci Lett 434(3), 2008
PMID: 18329171
Accumulation of phosphorylated I kappaB alpha and activated IKK in nodes of Ranvier.
Politi C, Del Turco D, Sie JM, Golinski PA, Tegeder I, Deller T, Schultz C., Neuropathol Appl Neurobiol 34(3), 2008
PMID: 17986183
Pharmacological enhancement of neuronal survival.
Calabrese EJ., Crit Rev Toxicol 38(4), 2008
PMID: 18432420
Amyloid-beta E22Delta variant induces synaptic alteration in mouse hippocampal slices.
Takuma H, Teraoka R, Mori H, Tomiyama T., Neuroreport 19(6), 2008
PMID: 18382273
Flavanols, mild cognitive impairment, and Alzheimer's dementia.
Patel AK, Rogers JT, Huang X., Int J Clin Exp Med 1(2), 2008
PMID: 19079672
TNF-alpha receptor 1 deficiency enhances kainic acid-induced hippocampal injury in mice.
Lu MO, Zhang XM, Mix E, Quezada HC, Jin T, Zhu J, Adem A., J Neurosci Res 86(7), 2008
PMID: 18189316
Preconditioning induces prolonged expression of transcription factors pCREB and NF-kappa B in the neocortex of rats before and following severe hypobaric hypoxia.
Rybnikova E, Gluschenko T, Tulkova E, Churilova A, Jaroshevich O, Baranova K, Samoilov M., J Neurochem 106(3), 2008
PMID: 18547368
The IKK-NF-kappaB pathway: a source for novel molecular drug targets in pain therapy?
Niederberger E, Geisslinger G., FASEB J 22(10), 2008
PMID: 18559989
Histone deacetylase-related protein inhibits AES-mediated neuronal cell death by direct interaction.
Zhang X, Chen HM, Jaramillo E, Wang L, D'Mello SR., J Neurosci Res 86(11), 2008
PMID: 18438919
Raf inhibition protects cortical cells against beta-amyloid toxicity.
Echeverria V, Burgess S, Gamble-George J, Arendash GW, Citron BA., Neurosci Lett 444(1), 2008
PMID: 18706973
An inducer for glial cell line-derived neurotrophic factor and tumor necrosis factor-alpha protects against methamphetamine-induced rewarding effects and sensitization.
Niwa M, Nitta A, Yamada Y, Nakajima A, Saito K, Seishima M, Shen L, Noda Y, Furukawa S, Nabeshima T., Biol Psychiatry 61(7), 2007
PMID: 17046726
Neuroprotective effect of TNFalpha against the beta-amyloid neurotoxicity mediated by CDK5 kinase.
Orellana DI, Quintanilla RA, Maccioni RB., Biochim Biophys Acta 1773(2), 2007
PMID: 17150266
Impaired acute and inflammatory nociception in mice lacking the p50 subunit of NF-kappaB.
Niederberger E, Schmidtko A, Gao W, Kühlein H, Ehnert C, Geisslinger G., Eur J Pharmacol 559(1), 2007
PMID: 17217946
Divergent roles for tumor necrosis factor-alpha in the brain.
Sriram K, O'Callaghan JP., J Neuroimmune Pharmacol 2(2), 2007
PMID: 18040839
Nuclear factor kappa-B p50 and p65 subunits expression in dementia with Lewy bodies.
Saldaña M, Mullol J, Aguilar E, Bonastre M, Marin C., Neuropathol Appl Neurobiol 33(3), 2007
PMID: 17442064
Neuroprotective role of the innate immune system by microglia.
Glezer I, Simard AR, Rivest S., Neuroscience 147(4), 2007
PMID: 17459594
Hydrogen peroxide induces the death of astrocytes through the down-regulation of the constitutive nuclear factor-kappaB activity.
Choi JJ, Choi J, Kang CD, Chen X, Wu CF, Ko KH, Kim WK., Free Radic Res 41(5), 2007
PMID: 17454138
The nuclear factor kappaB-activator gene PLEKHG5 is mutated in a form of autosomal recessive lower motor neuron disease with childhood onset.
Maystadt I, Rezsöhazy R, Barkats M, Duque S, Vannuffel P, Remacle S, Lambert B, Najimi M, Sokal E, Munnich A, Viollet L, Verellen-Dumoulin C., Am J Hum Genet 81(1), 2007
PMID: 17564964
Alteration of NF-kappaB activity leads to mitochondrial apoptosis after infection with pathological prion protein.
Bourteele S, Oesterle K, Weinzierl AO, Paxian S, Riemann M, Schmid RM, Planz O., Cell Microbiol 9(9), 2007
PMID: 17573907
Over-expression of amyloid precursor protein in HEK cells alters p53 conformational state and protects against doxorubicin.
Uberti D, Cenini G, Olivari L, Ferrari-Toninelli G, Porrello E, Cecchi C, Pensalfini A, Liguri G, Govoni S, Racchi M, Maurizio M., J Neurochem 103(1), 2007
PMID: 17608641
Location, location, location: altered transcription factor trafficking in neurodegeneration.
Chu CT, Plowey ED, Wang Y, Patel V, Jordan-Sciutto KL., J Neuropathol Exp Neurol 66(10), 2007
PMID: 17917581
NF-kappaB-associated MnSOD induction protects against beta-amyloid-induced neuronal apoptosis.
Sompol P, Xu Y, Ittarat W, Daosukho C, St Clair D., J Mol Neurosci 29(3), 2006
PMID: 17085785
Potential role of NF-kappaB in adult neural stem cells: the underrated steersman?
Widera D, Mikenberg I, Kaltschmidt B, Kaltschmidt C., Int J Dev Neurosci 24(2-3), 2006
PMID: 16413989
Antioxidant pyrrolidine dithiocarbamate activates Akt-GSK signaling and is neuroprotective in neonatal hypoxia-ischemia.
Nurmi A, Goldsteins G, Närväinen J, Pihlaja R, Ahtoniemi T, Gröhn O, Koistinaho J., Free Radic Biol Med 40(10), 2006
PMID: 16678015
The various aggregation states of beta-amyloid 1-42 mediate different effects on oxidative stress, neurodegeneration, and BACE-1 expression.
Tamagno E, Bardini P, Guglielmotto M, Danni O, Tabaton M., Free Radic Biol Med 41(2), 2006
PMID: 16814100
NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling.
Kaltschmidt B, Ndiaye D, Korte M, Pothion S, Arbibe L, Prüllage M, Pfeiffer J, Lindecke A, Staiger V, Israël A, Kaltschmidt C, Mémet S., Mol Cell Biol 26(8), 2006
PMID: 16581769
NF-kappaB pathway: a target for preventing beta-amyloid (Abeta)-induced neuronal damage and Abeta42 production.
Valerio A, Boroni F, Benarese M, Sarnico I, Ghisi V, Bresciani LG, Ferrario M, Borsani G, Spano P, Pizzi M., Eur J Neurosci 23(7), 2006
PMID: 16623827
Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease.
Rossner S, Sastre M, Bourne K, Lichtenthaler SF., Prog Neurobiol 79(2), 2006
PMID: 16904810
Emerging evidence for the neuroprotective role of alpha-synuclein.
Lee HG, Zhu X, Takeda A, Perry G, Smith MA., Exp Neurol 200(1), 2006
PMID: 16780837
Coincident enrichment of phosphorylated IkappaBalpha, activated IKK, and phosphorylated p65 in the axon initial segment of neurons.
Schultz C, König HG, Del Turco D, Politi C, Eckert GP, Ghebremedhin E, Prehn JH, Kögel D, Deller T., Mol Cell Neurosci 33(1), 2006
PMID: 16875840
Tumor necrosis factor alpha triggers proliferation of adult neural stem cells via IKK/NF-kappaB signaling.
Widera D, Mikenberg I, Elvers M, Kaltschmidt C, Kaltschmidt B., BMC Neurosci 7(), 2006
PMID: 16987412
Interaction of interleukin-1beta with muscarinic acetylcholine receptor-mediated signaling cascade in cholinergically differentiated SH-SY5Y cells.
Schliebs R, Heidel K, Apelt J, Gniezdzinska M, Kirazov L, Szutowicz A., Brain Res 1122(1), 2006
PMID: 17026971
Distinct destructive signal pathways of neuronal death in Alzheimer's disease.
Shen Y, He P, Zhong Z, McAllister C, Lindholm K., Trends Mol Med 12(12), 2006
PMID: 17055782
Mathematical model for NF-kappaB-driven proliferation of adult neural stem cells.
Piotrowska MJ, Widera D, Kaltschmidt B, an der Heiden U, Kaltschmidt C., Cell Prolif 39(6), 2006
PMID: 17109630
The inhibitor of I kappa B alpha phosphorylation BAY 11-7082 prevents NMDA neurotoxicity in mouse hippocampal slices.
Goffi F, Boroni F, Benarese M, Sarnico I, Benetti A, Spano PF, Pizzi M., Neurosci Lett 377(3), 2005
PMID: 15755516
Oxidative stress activates transcription factor NF-kB-mediated protective signaling in primary rat neuronal cultures.
Kratsovnik E, Bromberg Y, Sperling O, Zoref-Shani E., J Mol Neurosci 26(1), 2005
PMID: 15968083
Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways.
Tamagno E, Parola M, Bardini P, Piccini A, Borghi R, Guglielmotto M, Santoro G, Davit A, Danni O, Smith MA, Perry G, Tabaton M., J Neurochem 92(3), 2005
PMID: 15659232
Nuclear factor-kappaB inhibition by pyrrolidinedithiocarbamate attenuates gastric ischemia-reperfusion injury in rats.
El Eter E, Hagar HH, Al-Tuwaijiri A, Arafa M., Can J Physiol Pharmacol 83(6), 2005
PMID: 16049548
NF-kappaB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid beta-peptide toxicity.
Pizzi M, Sarnico I, Boroni F, Benarese M, Steimberg N, Mazzoleni G, Dietz GP, Bähr M, Liou HC, Spano PF., Cell Death Differ 12(7), 2005
PMID: 15818410
Signaling via NF-kappaB in the nervous system.
Kaltschmidt B, Widera D, Kaltschmidt C., Biochim Biophys Acta 1745(3), 2005
PMID: 15993497
Activation of NF-kappaB in bone marrow cells of BALB/cJ mice following exposure in vivo to low doses of (137)Cs gamma-rays.
Rithidech KN, Tungjai M, Arbab E, Simon SR., Radiat Environ Biophys 44(2), 2005
PMID: 16052312
Nuclear factor-kappaB contributes to infarction after permanent focal ischemia.
Nurmi A, Lindsberg PJ, Koistinaho M, Zhang W, Juettler E, Karjalainen-Lindsberg ML, Weih F, Frank N, Schwaninger M, Koistinaho J., Stroke 35(4), 2004
PMID: 14988572
Effect of cell density on intracellular levels of the Alzheimer's amyloid precursor protein.
Rebelo S, Henriques AG, da Cruz e Silva EF, da Cruz e Silva OA., J Neurosci Res 76(3), 2004
PMID: 15079870
N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-kappaB transcription factor.
Maruyama W, Nitta A, Shamoto-Nagai M, Hirata Y, Akao Y, Yodim M, Furukawa S, Nabeshima T, Naoi M., Neurochem Int 44(6), 2004
PMID: 14687604
Nuclear factor-kappaB: its role in health and disease.
Kumar A, Takada Y, Boriek AM, Aggarwal BB., J Mol Med (Berl) 82(7), 2004
PMID: 15175863
Mechanism of NF-kappaB inactivation induced by survival signal withdrawal in cerebellar granule neurons.
Kovács AD, Chakraborty-Sett S, Ramirez SH, Sniderhan LF, Williamson AL, Maggirwar SB., Eur J Neurosci 20(2), 2004
PMID: 15233744
Akt phosphorylation and NFkappaB activation are counterregulated under conditions of oxidative stress.
Taylor JM, Crack PJ, Gould JA, Ali U, Hertzog PJ, Iannello RC., Exp Cell Res 300(2), 2004
PMID: 15475010
Staying connected: synapses in Alzheimer disease.
Lee HG, Moreira PI, Zhu X, Smith MA, Perry G., Am J Pathol 165(5), 2004
PMID: 15509517
Peptides and hormesis.
Calabrese EJ, Baldwin LA., Crit Rev Toxicol 33(3-4), 2003
PMID: 12809429
Signal transduction and neurosurvival in experimental models of brain injury.
Butler TL, Kassed CA, Pennypacker KR., Brain Res Bull 59(5), 2003
PMID: 12507684
Hodgkin's lymphoma and CD30 signal transduction.
Horie R, Higashihara M, Watanabe T., Int J Hematol 77(1), 2003
PMID: 12568298
Caspase 3 activation is essential for neuroprotection in preconditioning.
McLaughlin B, Hartnett KA, Erhardt JA, Legos JJ, White RF, Barone FC, Aizenman E., Proc Natl Acad Sci U S A 100(2), 2003
PMID: 12522260
H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK.
Tamagno E, Robino G, Obbili A, Bardini P, Aragno M, Parola M, Danni O., Exp Neurol 180(2), 2003
PMID: 12684028
PEDF: a multifaceted neurotrophic factor.
Tombran-Tink J, Barnstable CJ., Nat Rev Neurosci 4(8), 2003
PMID: 12894238
Amyloid-beta: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-beta.
Atwood CS, Obrenovich ME, Liu T, Chan H, Perry G, Smith MA, Martins RN., Brain Res Brain Res Rev 43(1), 2003
PMID: 14499458
Microarray analysis of tumor necrosis factor alpha induced gene expression in U373 human glioblastoma cells.
Schwamborn J, Lindecke A, Elvers M, Horejschi V, Kerick M, Rafigh M, Pfeiffer J, Prüllage M, Kaltschmidt B, Kaltschmidt C., BMC Genomics 4(1), 2003
PMID: 14641910
Stimulus-dependent activation of NF-kappaB specifies apoptosis or neuroprotection in cerebellar granule cells.
Kaltschmidt B, Heinrich M, Kaltschmidt C., Neuromolecular Med 2(3), 2002
PMID: 12622408
NF-kappaB and IkappaBalpha expression following traumatic brain injury to the immature rat brain.
Sanz O, Acarin L, González B, Castellano B., J Neurosci Res 67(6), 2002
PMID: 11891791
Regulation of transcription factors by neuronal activity.
West AE, Griffith EC, Greenberg ME., Nat Rev Neurosci 3(12), 2002
PMID: 12461549
Cyclooxygenase-2 is a neuronal target gene of NF-kappaB.
Kaltschmidt B, Linker RA, Deng J, Kaltschmidt C., BMC Mol Biol 3(), 2002
PMID: 12466023
Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen.
Tegeder I, Niederberger E, Israr E, Gühring H, Brune K, Euchenhofer C, Grösch S, Geisslinger G., FASEB J 15(1), 2001
PMID: 11099482
Neuroprotection by estradiol.
Garcia-Segura LM, Azcoitia I, DonCarlos LL., Prog Neurobiol 63(1), 2001
PMID: 11040417
Dual role of the NF-kappaB transcription factor in the death of immature neurons.
Castagné V, Lefèvre K, Clarke PG., Neuroscience 108(3), 2001
PMID: 11738264
Cell death mechanisms in neurodegeneration.
Jellinger KA., J Cell Mol Med 5(1), 2001
PMID: 12067447
Neuroprotection from glutamate toxicity with ultra-low dose glutamate.
Jonas W, Lin Y, Tortella F., Neuroreport 12(2), 2001
PMID: 11209946
Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure.
Lucassen PJ, Müller MB, Holsboer F, Bauer J, Holtrop A, Wouda J, Hoogendijk WJ, De Kloet ER, Swaab DF., Am J Pathol 158(2), 2001
PMID: 11159183
Nuclear factor-kappaB activation is not involved in a MPTP model of Parkinson's disease.
Teismann P, Schwaninger M, Weih F, Ferger B., Neuroreport 12(5), 2001
PMID: 11303744
Developmental patterns of NF-kappaB activation during acute hypoxia in the caudal brainstem of the rat.
Simakajornboon N, Gozal E, Gozal D., Brain Res Dev Brain Res 127(2), 2001
PMID: 11335004
Amyloid beta-peptide: biphasic dose responses.
Calabrese EJ., Crit Rev Toxicol 31(4-5), 2001
PMID: 11504184
Enhanced expression of I-kappaB with neurofibrillary pathology in Alzheimer's disease.
Yoshiyama Y, Arai K, Hattori T., Neuroreport 12(12), 2001
PMID: 11522940
Specific deficiency in nuclear factor-kappaB activation in neurons of the central nervous system.
Jarosinski KW, Whitney LW, Massa PT., Lab Invest 81(9), 2001
PMID: 11555675
Tumor necrosis factor(alpha) and insulin-like growth factor-I in the brain: is the whole greater than the sum of its parts?
Venters HD, Broussard SR, Zhou JH, Bluthé RM, Freund GG, Johnson RW, Dantzer R, Kelley KW., J Neuroimmunol 119(2), 2001
PMID: 11585617
Preconditioning-induced neuroprotection is mediated by reactive oxygen species.
Ravati A, Ahlemeyer B, Becker A, Krieglstein J., Brain Res 866(1-2), 2000
PMID: 10825477
Microglia and neurodegeneration.
Rozemuller JM, van Muiswinkel FL., Eur J Clin Invest 30(6), 2000
PMID: 10849012
Silencing survival data.
Mattson MP, Barger SW, Dantzer R., Trends Neurosci 23(10), 2000
PMID: 11203139
Failure to activate NF-kappaB promotes apoptosis of retinal ganglion cells following optic nerve transection.
Choi JS, Kim JA, Kim DH, Chun MH, Gwag BJ, Yoon SK, Joo CK., Brain Res 883(1), 2000
PMID: 11063988
NF-kappaB transcription factors: critical regulators of hematopoiesis and neuronal survival.
Denk A, Wirth T, Baumann B., Cytokine Growth Factor Rev 11(4), 2000
PMID: 10959078
Tumor necrosis factor and reactive oxygen species cooperative cytotoxicity is mediated via inhibition of NF-kappaB.
Ginis I, Hallenbeck JM, Liu J, Spatz M, Jaiswal R, Shohami E., Mol Med 6(12), 2000
PMID: 11474119
Control of apoptosis by Rel/NF-kappaB transcription factors.
Barkett M, Gilmore TD., Oncogene 18(49), 1999
PMID: 10602466

62 References

Daten bereitgestellt von Europe PubMed Central.

Normal and abnormal biology of the beta-amyloid precursor protein.
Selkoe DJ., Annu. Rev. Neurosci. 17(), 1994
PMID: 8210185
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K., Proc. Natl. Acad. Sci. U.S.A. 82(12), 1985
PMID: 3159021
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.
Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K, Muller-Hill B., Nature 325(6106), 1987
PMID: 2881207
Frequency of stages of Alzheimer-related lesions in different age categories.
Braak H, Braak E., Neurobiol. Aging 18(4), 1997
PMID: 9330961
Receptors for advanced glycosylation endproducts in human brain: role in brain homeostasis.
Li JJ, Dickson D, Hof PR, Vlassara H., Mol. Med. 4(1), 1998
PMID: 9513189
Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide.
Yan SD, Yan SF, Chen X, Fu J, Chen M, Kuppusamy P, Smith MA, Perry G, Godman GC, Nawroth P., Nat. Med. 1(7), 1995
PMID: 7585153
Presenilins: genes for life and death.
Haass C., Neuron 18(5), 1997
PMID: 9182794
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.
Borchelt DR, Ratovitski T, van Lare J, Lee MK, Gonzales V, Jenkins NA, Copeland NG, Price DL, Sisodia SS., Neuron 19(4), 1997
PMID: 9354339
Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein.
Weidemann A, Paliga K, Durrwang U, Czech C, Evin G, Masters CL, Beyreuther K., Nat. Med. 3(3), 1997
PMID: 9055862
Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene.
Muller U, Cristina N, Li ZW, Wolfer DP, Lipp HP, Rulicke T, Brandner S, Aguzzi A, Weissmann C., Cell 79(5), 1994
PMID: 8001115
beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity.
Zheng H, Jiang M, Trumbauer ME, Sirinathsinghji DJ, Hopkins R, Smith DW, Heavens RP, Dawson GR, Boyce S, Conner MW, Stevens KA, Slunt HH, Sisoda SS, Chen HY, Van der Ploeg LH., Cell 81(4), 1995
PMID: 7758106
Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides.
Yankner BA, Duffy LK, Kirschner DA., Science 250(4978), 1990
PMID: 2218531
Hydrogen peroxide mediates amyloid beta protein toxicity.
Behl C, Davis JB, Lesley R, Schubert D., Cell 77(6), 1994
PMID: 8004671
High constitutive NF-kappaB activity mediates resistance to oxidative stress in neuronal cells.
Lezoualc'h F, Sagara Y, Holsboer F, Behl C., J. Neurosci. 18(9), 1998
PMID: 9547231
The NF-kappa B and I kappa B proteins: new discoveries and insights.
Baldwin AS Jr., Annu. Rev. Immunol. 14(), 1996
PMID: 8717528
I kappa B proteins: structure, function and regulation.
Whiteside ST, Israel A., Semin. Cancer Biol. 8(2), 1997
PMID: 9299585
I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.
Whiteside ST, Epinat JC, Rice NR, Israel A., EMBO J. 16(6), 1997
PMID: 9135156
NF-kappa B: a crucial transcription factor for glial and neuronal cell function.
O'Neill LA, Kaltschmidt C., Trends Neurosci. 20(6), 1997
PMID: 9185306
Synaptic activation of NF-kappa B by glutamate in cerebellar granule neurons in vitro.
Guerrini L, Blasi F, Denis-Donini S., Proc. Natl. Acad. Sci. U.S.A. 92(20), 1995
PMID: 7568076
Stimulation of ionotropic glutamate receptors activates transcription factor NF-kappa B in primary neurons.
Kaltschmidt C, Kaltschmidt B, Baeuerle PA., Proc. Natl. Acad. Sci. U.S.A. 92(21), 1995
PMID: 7568184
Constitutive NF-kappa B activity in neurons.
Kaltschmidt C, Kaltschmidt B, Neumann H, Wekerle H, Baeuerle PA., Mol. Cell. Biol. 14(6), 1994
PMID: 8196637
NF-kappaB activity in transgenic mice: developmental regulation and tissue specificity.
Schmidt-Ullrich R, Memet S, Lilienbaum A, Feuillard J, Raphael M, Israel A., Development 122(7), 1996
PMID: 8681793
Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75.
Carter BD, Kaltschmidt C, Kaltschmidt B, Offenhauser N, Bohm-Matthaei R, Baeuerle PA, Barde YA., Science 272(5261), 1996
PMID: 8614802
NF-kappaB activation: the I kappaB kinase revealed?
Stancovski I, Baltimore D., Cell 91(3), 1997
PMID: 9363938
Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation.
Yamaoka S, Courtois G, Bessia C, Whiteside ST, Weil R, Agou F, Kirk HE, Kay RJ, Israel A., Cell 93(7), 1998
PMID: 9657155
IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex.
Rothwarf DM, Zandi E, Natoli G, Karin M., Nature 395(6699), 1998
PMID: 9751060
IKAP is a scaffold protein of the IkappaB kinase complex.
Cohen L, Henzel WJ, Baeuerle PA., Nature 395(6699), 1998
PMID: 9751059
Selective recognition of the activated form of transcription factor NF-kappa B by a monoclonal antibody.
Kaltschmidt C, Kaltschmidt B, Henkel T, Stockinger H, Baeuerle PA., Biol. Chem. Hoppe-Seyler 376(1), 1995
PMID: 7612189
The pathogenesis of senile plaques.
Dickson DW., J. Neuropathol. Exp. Neurol. 56(4), 1997
PMID: 9100663
Traumatic spinal cord injury induces nuclear factor-kappaB activation.
Bethea JR, Castro M, Keane RW, Lee TT, Dietrich WD, Yezierski RP., J. Neurosci. 18(9), 1998
PMID: 9547234
Ca2+ influx regulates BDNF transcription by a CREB family transcription factor-dependent mechanism.
Tao X, Finkbeiner S, Arnold DB, Shaywitz AJ, Greenberg ME., Neuron 20(4), 1998
PMID: 9581763
Identification and characterization of an IkappaB kinase.
Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M., Cell 90(2), 1997
PMID: 9244310
Enhancement of immunoreactivity for NF-kappa B in human cerebral infarctions.
Terai K, Matsuo A, McGeer EG, McGeer PL., Brain Res. 739(1-2), 1996
PMID: 8955958
Alteration of transcription factors NF-kappaB and STAT1 in Alzheimer's disease brains.
Kitamura Y, Shimohama S, Ota T, Matsuoka Y, Nomura Y, Taniguchi T., Neurosci. Lett. 237(1), 1997
PMID: 9406869
Nuclear translocation of NF-kappaB in cholinergic neurons of patients with Alzheimer's disease.
Boissiere F, Hunot S, Faucheux B, Duyckaerts C, Hauw JJ, Agid Y, Hirsch EC., Neuroreport 8(13), 1997
PMID: 9376517

Alteration of transcription factor binding activities in the ischemic rat brain.
Salminen A, Liu PK, Hsu CY., Biochem. Biophys. Res. Commun. 212(3), 1995
PMID: 7626134
Gene therapy. Intracellular immunization.
Baltimore D., Nature 335(6189), 1988
PMID: 3166513
The effects of 5-HT3 receptor antagonists on cognitive performance in aged monkeys.
Arnsten AF, Lin CH, Van Dyck CH, Stanhope KJ., Neurobiol. Aging 18(1), 1997
PMID: 8983029
Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ.
Lassmann H, Bancher C, Breitschopf H, Wegiel J, Bobinski M, Jellinger K, Wisniewski HM., Acta Neuropathol. 89(1), 1995
PMID: 7709729
Progressive neuronal injury associated with amyloid plaque formation in Alzheimer disease.
Sheng JG, Zhou XQ, Mrak RE, Griffin WS., J. Neuropathol. Exp. Neurol. 57(7), 1998
PMID: 9690675
Inhibition of TNF-induced apoptosis by NF-kappa B.
Van Antwerp DJ, Martin SJ, Verma IM, Green DR., Trends Cell Biol. 8(3), 1998
PMID: 9695819
Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques.
Dickson DW, Farlo J, Davies P, Crystal H, Fuld P, Yen SH., Am. J. Pathol. 132(1), 1988
PMID: 2456021
Ultrastructural studies of the cells forming amyloid fibers in classical plaques.
Wisniewski HM, Wegiel J, Wang KC, Kujawa M, Lach B., Can J Neurol Sci 16(4 Suppl), 1989
PMID: 2553231
Microglia in cerebellar plaques in Alzheimer's disease.
Mattiace LA, Davies P, Yen SH, Dickson DW., Acta Neuropathol. 80(5), 1990
PMID: 2251906
Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease.
Dickson DW, Lee SC, Mattiace LA, Yen SH, Brosnan C., Glia 7(1), 1993
PMID: 8423065
Activation of microglial cells by beta-amyloid protein and interferon-gamma.
Meda L, Cassatella MA, Szendrei GI, Otvos L Jr, Baron P, Villalba M, Ferrari D, Rossi F., Nature 374(6523), 1995
PMID: 7715705
Neuronal (type I) nitric oxide synthase regulates nuclear factor kappaB activity and immunologic (type II) nitric oxide synthase expression.
Togashi H, Sasaki M, Frohman E, Taira E, Ratan RR, Dawson TM, Dawson VL., Proc. Natl. Acad. Sci. U.S.A. 94(6), 1997
PMID: 9122255


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