The hybrid histidine kinase Slr1759 of the cyanobacterium Synechocystis sp. PCC 6803 contains FAD at its PAS domain
Michel K-P, Schröder A-K, Zimmermann M, Brandt S, Pistorius EK, Frankenberg-Dinkel N, Staiger D (2009)
Archives of Microbiology 191(6): 553-559.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
Autor*in
Michel, Klaus-Peter;
Schröder, Ann-Kristin;
Zimmermann, Maike;
Brandt, Sonja;
Pistorius, Elfriede K.;
Frankenberg-Dinkel, Nicole;
Staiger, DorotheeUniBi
Einrichtung
Abstract / Bemerkung
The cyanobacterium Synechocystis sp. PCC 6803 harbours 47 histidine kinases (Hiks). Among these are hybrid histidine kinases with one or two response regulator domains as well as numerous Hiks with several sensory domains. One example is the hybrid histidine kinase Slr1759 (Hik14) that has two PAS domains arranged in tandem linked to a predicted GAF domain. Here, we show that a Slr1759 derivative recombinantly expressed in Escherichia coli has a flavin cofactor. Using truncated Slr1759 variants, it is shown that the flavin associates with the first PAS domain. The cofactor reconstitutes the activity of d -amino acid oxidase apoprotein from pig kidney, indicating that the flavin derivative is FAD. Furthermore, the Slr1759 histidine kinase domain indeed undergoes autophosphorylation in vitro. The phosphorylated product of a recombinant Slr1759 derivative is sensitive to acids, pointing to a histidine residue as the phosphate-accepting group.
Stichworte
Synechocystis FAD Hybrid histidine kinase PAS domain
Erscheinungsjahr
2009
Zeitschriftentitel
Archives of Microbiology
Band
191
Ausgabe
6
Seite(n)
553-559
ISSN
0302-8933
eISSN
1432-072X
Page URI
https://pub.uni-bielefeld.de/record/2438873
Zitieren
Michel K-P, Schröder A-K, Zimmermann M, et al. The hybrid histidine kinase Slr1759 of the cyanobacterium Synechocystis sp. PCC 6803 contains FAD at its PAS domain. Archives of Microbiology. 2009;191(6):553-559.
Michel, K. - P., Schröder, A. - K., Zimmermann, M., Brandt, S., Pistorius, E. K., Frankenberg-Dinkel, N., & Staiger, D. (2009). The hybrid histidine kinase Slr1759 of the cyanobacterium Synechocystis sp. PCC 6803 contains FAD at its PAS domain. Archives of Microbiology, 191(6), 553-559. https://doi.org/10.1007/s00203-009-0483-x
Michel, Klaus-Peter, Schröder, Ann-Kristin, Zimmermann, Maike, Brandt, Sonja, Pistorius, Elfriede K., Frankenberg-Dinkel, Nicole, and Staiger, Dorothee. 2009. “The hybrid histidine kinase Slr1759 of the cyanobacterium Synechocystis sp. PCC 6803 contains FAD at its PAS domain”. Archives of Microbiology 191 (6): 553-559.
Michel, K. - P., Schröder, A. - K., Zimmermann, M., Brandt, S., Pistorius, E. K., Frankenberg-Dinkel, N., and Staiger, D. (2009). The hybrid histidine kinase Slr1759 of the cyanobacterium Synechocystis sp. PCC 6803 contains FAD at its PAS domain. Archives of Microbiology 191, 553-559.
Michel, K.-P., et al., 2009. The hybrid histidine kinase Slr1759 of the cyanobacterium Synechocystis sp. PCC 6803 contains FAD at its PAS domain. Archives of Microbiology, 191(6), p 553-559.
K.-P. Michel, et al., “The hybrid histidine kinase Slr1759 of the cyanobacterium Synechocystis sp. PCC 6803 contains FAD at its PAS domain”, Archives of Microbiology, vol. 191, 2009, pp. 553-559.
Michel, K.-P., Schröder, A.-K., Zimmermann, M., Brandt, S., Pistorius, E.K., Frankenberg-Dinkel, N., Staiger, D.: The hybrid histidine kinase Slr1759 of the cyanobacterium Synechocystis sp. PCC 6803 contains FAD at its PAS domain. Archives of Microbiology. 191, 553-559 (2009).
Michel, Klaus-Peter, Schröder, Ann-Kristin, Zimmermann, Maike, Brandt, Sonja, Pistorius, Elfriede K., Frankenberg-Dinkel, Nicole, and Staiger, Dorothee. “The hybrid histidine kinase Slr1759 of the cyanobacterium Synechocystis sp. PCC 6803 contains FAD at its PAS domain”. Archives of Microbiology 191.6 (2009): 553-559.
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