Structure function analysis of an ADP-ribosyltransferase type III effector and its RNA-binding target in plant immunity

Jeong B-ryool, Lin Y, Joe A, Guo M, Korneli C, Yang H, Wang P, Yu M, Cerny RL, Staiger D, Alfano JR, et al. (2011)
Journal of Biological Chemistry 286(50): 43272-43281.

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Autor*in
Jeong, Byeong-ryool; Lin, Yan; Joe, Anna; Guo, Ming; Korneli, ChristinUniBi; Yang, Huirong; Wang, Ping; Yu, Min; Cerny, Ronald L.; Staiger, DorotheeUniBi; Alfano, James R.; Xu, Yanhui
Einrichtung
Fakultät für Biologie > RNA Biologie und Molekulare Physiologie
Centrum für Biotechnologie > Arbeitsgruppe D. Staiger
Centrum für Biotechnologie > Institut für Genomforschung und Systembiologie
Abstract / Bemerkung
The Pseudomonas syringae type III effector HopU1 is a mono-ADP-ribosyltransferase (mADP-RT) that is injected into plant cells by the type III protein secretion system. Inside the plant cell it suppresses immunity by modifying RNA-binding proteins including the glycine-rich RNA-binding protein GRP7. The crystal structure of HopU1 at 2.7 angstrom resolution reveals two unique protruding loops, L1 and L4 not found in other mADP-RTs. Site-directed mutagenesis demonstrates these loops are essential for substrate recognition and enzymatic activity. HopU1 ADP-ribosylates the conserved arginine 49 (R49) of GRP7 and this reduces GRP7's ability to bind RNA in vitro. In vivo, expression of GRP7 with R49 replaced with lysine does not complement the reduced immune responses of the Arabidopsis thaliana grp7-1 mutant demonstrating the importance of this residue for GRP7 function. These data provide mechanistic details how HopU1 recognizes this novel type of substrate and highlights the role of GRP7 in plant immunity.
Erscheinungsjahr
2011
Zeitschriftentitel
Journal of Biological Chemistry
Band
286
Ausgabe
50
Seite(n)
43272-43281
ISSN
0021-9258
eISSN
1083-351X
Page URI
https://pub.uni-bielefeld.de/record/2438803

Zitieren

Jeong B-ryool, Lin Y, Joe A, et al. Structure function analysis of an ADP-ribosyltransferase type III effector and its RNA-binding target in plant immunity. Journal of Biological Chemistry. 2011;286(50):43272-43281.
Jeong, B. -ryool, Lin, Y., Joe, A., Guo, M., Korneli, C., Yang, H., Wang, P., et al. (2011). Structure function analysis of an ADP-ribosyltransferase type III effector and its RNA-binding target in plant immunity. Journal of Biological Chemistry, 286(50), 43272-43281. https://doi.org/10.1074/jbc.M111.290122
Jeong, Byeong-ryool, Lin, Yan, Joe, Anna, Guo, Ming, Korneli, Christin, Yang, Huirong, Wang, Ping, et al. 2011. “Structure function analysis of an ADP-ribosyltransferase type III effector and its RNA-binding target in plant immunity”. Journal of Biological Chemistry 286 (50): 43272-43281.
Jeong, B. -ryool, Lin, Y., Joe, A., Guo, M., Korneli, C., Yang, H., Wang, P., Yu, M., Cerny, R. L., Staiger, D., et al. (2011). Structure function analysis of an ADP-ribosyltransferase type III effector and its RNA-binding target in plant immunity. Journal of Biological Chemistry 286, 43272-43281.
Jeong, B.-ryool, et al., 2011. Structure function analysis of an ADP-ribosyltransferase type III effector and its RNA-binding target in plant immunity. Journal of Biological Chemistry, 286(50), p 43272-43281.
B.-ryool Jeong, et al., “Structure function analysis of an ADP-ribosyltransferase type III effector and its RNA-binding target in plant immunity”, Journal of Biological Chemistry, vol. 286, 2011, pp. 43272-43281.
Jeong, B.-ryool, Lin, Y., Joe, A., Guo, M., Korneli, C., Yang, H., Wang, P., Yu, M., Cerny, R.L., Staiger, D., Alfano, J.R., Xu, Y.: Structure function analysis of an ADP-ribosyltransferase type III effector and its RNA-binding target in plant immunity. Journal of Biological Chemistry. 286, 43272-43281 (2011).
Jeong, Byeong-ryool, Lin, Yan, Joe, Anna, Guo, Ming, Korneli, Christin, Yang, Huirong, Wang, Ping, Yu, Min, Cerny, Ronald L., Staiger, Dorothee, Alfano, James R., and Xu, Yanhui. “Structure function analysis of an ADP-ribosyltransferase type III effector and its RNA-binding target in plant immunity”. Journal of Biological Chemistry 286.50 (2011): 43272-43281.

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http://www.jbc.org/content/early/2011/10/19/jbc.M111.290122.abstract
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Restricted Closed Access

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Heintzen C, Nater M, Apel K, Staiger D., Proc. Natl. Acad. Sci. U.S.A. 94(16), 1997
PMID: 9238008
Global transcript profiling of transgenic plants constitutively overexpressing the RNA-binding protein AtGRP7.
Streitner C, Hennig L, Korneli C, Staiger D., BMC Plant Biol. 10(), 2010
PMID: 20946635
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