Potential involvement of the transcription factor NF-kappa B in neurological disorders

Kaltschmidt B, Baeuerle PA, Kaltschmidt C (1993)
Mol Aspects Med 14(3): 171-190.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Abstract / Bemerkung
Reactive oxygen intermediates (ROIs) are involved in many neurological diseases. Despite the toxic nature of these compounds, low concentrations of ROIs can function as signaling molecules. One target for their signaling function is the inducible transcription factor NF-kappa B. Predominantly in lymphoid cells, induction of NF-kappa B in response to oxidative stress leads to transcriptional activation of many genes which are relevant for pathogen defense. These include the TNF, IL-6, IL-8, GM-CSF, beta-interferon, MHC class I and V-CAM genes. However, NF-kappa B is also abundant in various cell types of the nervous system, including neurons. We propose that NF-kappa B plays a role as a redox-controlled transcriptional activator also in cells of the nervous system and in that property may contribute to neurological disorders. Our finding that some neurons from healthy brain contain constitutively active NF-kappa B suggests a role of NF-kappa B in normal brain function as well.
Parkinson Disease/metabolism; Promoter Regions (Genetics); NF-kappa B/biosynthesis/*metabolism; Neurons/metabolism; Nervous System Diseases/genetics/*metabolism; Nervous System/*metabolism; Molecular Sequence Data; Humans; Gene Expression Regulation; Down Syndrome/genetics/metabolism; Enhancer Elements (Genetics); Free Radicals/metabolism; DNA/chemistry/metabolism; Cytokines/*biosynthesis; Signal Transduction; Binding Sites; Consensus Sequence; Base Sequence; Amyotrophic Lateral Sclerosis/metabolism; Animals; Alzheimer Disease/genetics/metabolism
Mol Aspects Med
Page URI


Kaltschmidt B, Baeuerle PA, Kaltschmidt C. Potential involvement of the transcription factor NF-kappa B in neurological disorders. Mol Aspects Med. 1993;14(3):171-190.
Kaltschmidt, B., Baeuerle, P. A., & Kaltschmidt, C. (1993). Potential involvement of the transcription factor NF-kappa B in neurological disorders. Mol Aspects Med, 14(3), 171-190. https://doi.org/10.1016/0098-2997(93)90004-W
Kaltschmidt, Barbara, Baeuerle, P. A., and Kaltschmidt, Christian. 1993. “Potential involvement of the transcription factor NF-kappa B in neurological disorders”. Mol Aspects Med 14 (3): 171-190.
Kaltschmidt, B., Baeuerle, P. A., and Kaltschmidt, C. (1993). Potential involvement of the transcription factor NF-kappa B in neurological disorders. Mol Aspects Med 14, 171-190.
Kaltschmidt, B., Baeuerle, P.A., & Kaltschmidt, C., 1993. Potential involvement of the transcription factor NF-kappa B in neurological disorders. Mol Aspects Med, 14(3), p 171-190.
B. Kaltschmidt, P.A. Baeuerle, and C. Kaltschmidt, “Potential involvement of the transcription factor NF-kappa B in neurological disorders”, Mol Aspects Med, vol. 14, 1993, pp. 171-190.
Kaltschmidt, B., Baeuerle, P.A., Kaltschmidt, C.: Potential involvement of the transcription factor NF-kappa B in neurological disorders. Mol Aspects Med. 14, 171-190 (1993).
Kaltschmidt, Barbara, Baeuerle, P. A., and Kaltschmidt, Christian. “Potential involvement of the transcription factor NF-kappa B in neurological disorders”. Mol Aspects Med 14.3 (1993): 171-190.

Link(s) zu Volltext(en)
Access Level
Restricted Closed Access

66 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Role of TNF-TNF Receptor 2 Signal in Regulatory T Cells and Its Therapeutic Implications.
Yang S, Wang J, Brand DD, Zheng SG., Front Immunol 9(), 2018
PMID: 29725328
Low dose oral curcumin is not effective in induction of remission in mild to moderate ulcerative colitis: Results from a randomized double blind placebo controlled trial.
Kedia S, Bhatia V, Thareja S, Garg S, Mouli VP, Bopanna S, Tiwari V, Makharia G, Ahuja V., World J Gastrointest Pharmacol Ther 8(2), 2017
PMID: 28533925
Caspase-1 inhibition attenuates activation of BV2 microglia induced by LPS-treated RAW264.7 macrophages.
Pan Y, Shen B, Gao Q, Zhu J, Dong J, Zhang L, Zhang Y., J Biomed Res 30(3), 2016
PMID: 27533933
Impact of nuclear factor-κB on restoration of neuron growth and differentiation in hippocampus of degenerative brain.
Aloor R, Zhang C, Bandyopadhyay M, Dasgupta S., J Neurosci Res 93(10), 2015
PMID: 25586448
Genome-wide DNA methylome reveals the dysfunction of intronic microRNAs in major psychosis.
Zhao H, Xu J, Pang L, Zhang Y, Fan H, Liu L, Liu T, Yu F, Zhang G, Lan Y, Bai J, Li X, Xiao Y., BMC Med Genomics 8(), 2015
PMID: 26462620
Current hypotheses on the mechanisms of alcoholism.
Vetreno RP, Crews FT., Handb Clin Neurol 125(), 2014
PMID: 25307591
Neuroprotective effects of rosuvastatin against traumatic spinal cord injury in rats.
Kahveci R, Gökçe EC, Gürer B, Gökçe A, Kisa U, Cemil DB, Sargon MF, Kahveci FO, Aksoy N, Erdoğan B., Eur J Pharmacol 741(), 2014
PMID: 25084223
Molecular evidence for the involvement of PPAR-δ and PPAR-γ in anti-inflammatory and neuroprotective activities of palmitoylethanolamide after spinal cord trauma.
Paterniti I, Impellizzeri D, Crupi R, Morabito R, Campolo M, Esposito E, Cuzzocrea S., J Neuroinflammation 10(), 2013
PMID: 23374874
Aβ plaque-associated glial reaction as a determinant of apoptotic neuronal death and cortical gliogenesis: a study in APP mutant mice.
Luccarini I, Grossi C, Traini C, Fiorentini A, Ed Dami T, Casamenti F., Neurosci Lett 506(1), 2012
PMID: 22056484
Alzheimer's disease: pathological mechanisms and the beneficial role of melatonin.
Rosales-Corral SA, Acuña-Castroviejo D, Coto-Montes A, Boga JA, Manchester LC, Fuentes-Broto L, Korkmaz A, Ma S, Tan DX, Reiter RJ., J Pineal Res 52(2), 2012
PMID: 22107053
Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: involvement of PPAR-α.
Esposito E, Rinaldi B, Mazzon E, Donniacuo M, Impellizzeri D, Paterniti I, Capuano A, Bramanti P, Cuzzocrea S., J Neuroinflammation 9(), 2012
PMID: 22537532
Transcriptional regulation of UCP4 by NF-kappaB and its role in mediating protection against MPP+ toxicity.
Ho JW, Ho PW, Zhang WY, Liu HF, Kwok KH, Yiu DC, Chan KH, Kung MH, Ramsden DB, Ho SL., Free Radic Biol Med 49(2), 2010
PMID: 20385226
Absence of endogenous interleukin-10 enhances secondary inflammatory process after spinal cord compression injury in mice.
Genovese T, Esposito E, Mazzon E, Di Paola R, Caminiti R, Bramanti P, Cappelani A, Cuzzocrea S., J Neurochem 108(6), 2009
PMID: 19183262
Dual inhibition of proteasomal and lysosomal proteolysis ameliorates autoimmune central nervous system inflammation.
Fissolo N, Kraus M, Reich M, Ayturan M, Overkleeft H, Driessen C, Weissert R., Eur J Immunol 38(9), 2008
PMID: 18792018
NOD2 allele variants in patients with rheumatoid arthritis.
Pawlik A, Kurzawski M, Gawronska-Szklarz B, Drozdzik M, Herczynska M., Clin Rheumatol 26(6), 2007
PMID: 16977346
CARD15 variants in patients with sporadic Parkinson's disease.
Bialecka M, Kurzawski M, Klodowska-Duda G, Opala G, Juzwiak S, Kurzawski G, Tan EK, Drozdzik M., Neurosci Res 57(3), 2007
PMID: 17174426
p53 protein, interferon-gamma, and NF-kappaB levels are elevated in the parkinsonian brain.
Mogi M, Kondo T, Mizuno Y, Nagatsu T., Neurosci Lett 414(1), 2007
PMID: 17196747
The potential of melatonin in reducing morbidity-mortality after craniocerebral trauma.
Maldonado MD, Murillo-Cabezas F, Terron MP, Flores LJ, Tan DX, Manchester LC, Reiter RJ., J Pineal Res 42(1), 2007
PMID: 17198533
Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity.
Aschner M, Syversen T, Souza DO, Rocha JB, Farina M., Braz J Med Biol Res 40(3), 2007
PMID: 17334523
Nitric oxide in the injured spinal cord: synthases cross-talk, oxidative stress and inflammation.
Conti A, Miscusi M, Cardali S, Germanò A, Suzuki H, Cuzzocrea S, Tomasello F., Brain Res Rev 54(1), 2007
PMID: 17500094
Lovastatin improves histological and functional outcomes and reduces inflammation after experimental traumatic brain injury.
Chen SF, Hung TH, Chen CC, Lin KH, Huang YN, Tsai HC, Wang JY., Life Sci 81(4), 2007
PMID: 17612572
Interleukin-10 gene polymorphism in Parkinson's disease patients.
Bialecka M, Klodowska-Duda G, Kurzawski M, Slawek J, Opala G, Bialecki P, Safranow K, Droździk M., Arch Med Res 38(8), 2007
PMID: 17923267
Attenuation in the evolution of experimental spinal cord trauma by treatment with melatonin.
Genovese T, Mazzon E, Muià C, Bramanti P, De Sarro A, Cuzzocrea S., J Pineal Res 38(3), 2005
PMID: 15725342
Methylmercury: recent advances in the understanding of its neurotoxicity.
Aschner M, Syversen T., Ther Drug Monit 27(3), 2005
PMID: 15905795
NF-kappaB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid beta-peptide toxicity.
Pizzi M, Sarnico I, Boroni F, Benarese M, Steimberg N, Mazzoleni G, Dietz GP, Bähr M, Liou HC, Spano PF., Cell Death Differ 12(7), 2005
PMID: 15818410
Inhibition of the nuclear factor-kappaB activation with pyrrolidine dithiocarbamate attenuating inflammation and oxidative stress after experimental spinal cord trauma in rats.
La Rosa G, Cardali S, Genovese T, Conti A, Di Paola R, La Torre D, Cacciola F, Cuzzocrea S., J Neurosurg Spine 1(3), 2004
PMID: 15478370
DNA damage in nasal and brain tissues of canines exposed to air pollutants is associated with evidence of chronic brain inflammation and neurodegeneration.
Calderón-Garcidueñas L, Maronpot RR, Torres-Jardon R, Henríquez-Roldán C, Schoonhoven R, Acuña-Ayala H, Villarreal-Calderón A, Nakamura J, Fernando R, Reed W, Azzarelli B, Swenberg JA., Toxicol Pathol 31(5), 2003
PMID: 14692621
Substance P induces TNF-alpha and IL-6 production through NF kappa B in peritoneal mast cells.
Azzolina A, Bongiovanni A, Lampiasi N., Biochim Biophys Acta 1643(1-3), 2003
PMID: 14654230
Pyrrolidine dithiocarbamate attenuates the development of acute and chronic inflammation.
Cuzzocrea S, Chatterjee PK, Mazzon E, Dugo L, Serraino I, Britti D, Mazzullo G, Caputi AP, Thiemermann C., Br J Pharmacol 135(2), 2002
PMID: 11815386
Methods of detection of the transcription factor NF-kappa B in rat hippocampal slices.
Butler MP, Moynagh PN, O'Connor JJ., J Neurosci Methods 119(2), 2002
PMID: 12323422
Delivery systems for antioxidant nutrients.
Takata J, Matsunaga K, Karube Y., Toxicology 180(2), 2002
PMID: 12324193
The pathogenic mechanisms of prion diseases.
Hur K, Kim JI, Choi SI, Choi EK, Carp RI, Kim YS., Mech Ageing Dev 123(12), 2002
PMID: 12470901
Model for aging in the basal forebrain cholinergic system.
Gu Z, Wortwein G, Yu J, Perez-Polo JR., Antioxid Redox Signal 2(3), 2000
PMID: 11229357
Neuroinflammatory signaling upregulation in Alzheimer's disease.
Lukiw WJ, Bazan NG., Neurochem Res 25(9-10), 2000
PMID: 11059791
Activation of NF-kappa B by reactive oxygen intermediates in the nervous system.
Kaltschmidt B, Sparna T, Kaltschmidt C., Antioxid Redox Signal 1(2), 1999
PMID: 11228742
Elevation of striatal interleukin-6 and serum corticosterone contents in MPTP-treated mice.
Kaku K, Shikimi T, Kamisaki Y, Shinozuka K, Ishino H, Okunishi H, Takaori S., Clin Exp Pharmacol Physiol 26(9), 1999
PMID: 10499156
Expression of cytokine genes and increased nuclear factor-kappa B activity in the brains of scrapie-infected mice.
Kim JI, Ju WK, Choi JH, Choi E, Carp RI, Wisniewski HM, Kim YS., Brain Res Mol Brain Res 73(1-2), 1999
PMID: 10581394
Prolonged activation of NF-kappaB following traumatic brain injury in rats.
Nonaka M, Chen XH, Pierce JE, Leoni MJ, McIntosh TK, Wolf JA, Smith DH., J Neurotrauma 16(11), 1999
PMID: 10595819
Excitotoxic spinal cord injury: behavioral and morphological characteristics of a central pain model.
Yezierski RP, Liu S, Ruenes GL, Kajander KJ, Brewer KL., Pain 75(1), 1998
PMID: 9539683
The NF-kappaB/Rel family of proteins mediates Abeta-induced neurotoxicity and glial activation.
Bales KR, Du Y, Dodel RC, Yan GM, Hamilton-Byrd E, Paul SM., Brain Res Mol Brain Res 57(1), 1998
PMID: 9630519
Oxidative damage and fibrogenesis.
Poli G, Parola M., Free Radic Biol Med 22(1-2), 1997
PMID: 8958154
Epithelial injury induced by exposure to residual oil fly-ash particles: role of reactive oxygen species?
Dye JA, Adler KB, Richards JH, Dreher KL., Am J Respir Cell Mol Biol 17(5), 1997
PMID: 9374114
Redox regulation of transcriptional activators.
Sun Y, Oberley LW., Free Radic Biol Med 21(3), 1996
PMID: 8855444
The dual effect of adenovirus type 5 E1A 13S protein on NF-kappaB activation is antagonized by E1B 19K.
Schmitz ML, Indorf A, Limbourg FP, Städtler H, Traenckner EB, Baeuerle PA., Mol Cell Biol 16(8), 1996
PMID: 8754803

84 References

Daten bereitgestellt von Europe PubMed Central.

Stimulation of lipid peroxidation increases the intracellular calcium content of isolated hepatocytes.
Albano E, Bellomo G, Parola M, Carini R, Dianzani MU., Biochim. Biophys. Acta 1091(3), 1991
PMID: 2001414
I kappa B: a specific inhibitor of the NF-kappa B transcription factor.
Baeuerle PA, Baltimore D., Science 242(4878), 1988
PMID: 3140380
The physiology of the NF-κB transkription factor
Baeuerle, 1991
Function and activation of NF-κB in the immune system
Baeuerle, Ann. Rev. Immunol. (), 1993
Interleukin-6 and alpha-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices.
Bauer J, Strauss S, Schreiter-Gasser U, Ganter U, Schlegel P, Witt I, Yolk B, Berger M., FEBS Lett. 285(1), 1991
PMID: 1712317
Evidence that interleukin-1 and phorbol esters activate NF-kappa B by different pathways: role of protein kinase C.
Bomsztyk K, Rooney JW, Iwasaki T, Rachie NA, Dower SK, Sibley CH., Cell Regul. 2(4), 1991
PMID: 2059661
The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers.
Bours V, Franzoso G, Azarenko V, Park S, Kanno T, Brown K, Siebenlist U., Cell 72(5), 1993
PMID: 8453667
HIV-1 related neurological disease
Brew, J. Acquired Immune Deficiency Syndromes 5(), 1993
Mutual regulation of the transcriptional activator NF-κB and its inhibitor IκB-α
Brown, 1993
The molecular action of tumor necrosis factor-alpha.
Camussi G, Albano E, Tetta C, Bussolino F., Eur. J. Biochem. 202(1), 1991
PMID: 1657606
Expression directed from HIV long terminal repeats in the central nervous system of transgenic mice.
Corboy JR, Buzy JM, Zink MC, Clements JE., Science 258(5089), 1992
PMID: 1465618
Rel-associated pp40: an inhibitor of the rel family of transcription factors.
Davis N, Ghosh S, Simmons DL, Tempst P, Liou HC, Baltimore D, Bose HR Jr., Science 253(5025), 1991
PMID: 1891714
Nitric oxide mediates glutamate neurotoxicity in primary cortical culture
Dawson, 1991
Preferential localization of copper zinc superoxide dismutase in the vulnerable cortical neurons in Alzheimer's disease
Delacourte, Neurosci. Lett. 112(), 1988
Redox redux: the control of oxidative stress responses.
Demple B, Amabile-Cuevas CF., Cell 67(5), 1991
PMID: 1659949
Presenile dementia in Down's syndrome. Ultrastructural identity with Alzheimer's disease.
Ellis WG, McCulloch JR, Corley CL., Neurology 24(2), 1974
PMID: 4272520
On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases.
Frei K, Malipiero UV, Leist TP, Zinkernagel RM, Schwab ME, Fontana A., Eur. J. Immunol. 19(4), 1989
PMID: 2543584
NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices.
Garthwaite J, Garthwaite G, Palmer RM, Moncada S., Eur. J. Pharmacol. 172(4-5), 1989
PMID: 2555211
Spinal cord microglia in experimental allergic neuritis. Evidence for fast and remote activation.
Gehrmann J, Gold R, Linington C, Lannes-Vieira J, Wekerle H, Kreutzberg GW., Lab. Invest. 67(1), 1992
PMID: 1625441
Aluminium in Alzheimer's?
Good PF, Perl DP., Nature 362(6419), 1993
PMID: 8464473
Brain interleukin 1 and S-100 immunoreactivity are elevated in in Down syndrom and Alzheimer disease
Griffin, 1989
Free radicals in CNS injury
Hall, 1993

Halliwell, 1989
Inhibition of entry of HIV-1 in neural cell lines by antibodies against galactosyl ceramide.
Harouse JM, Bhat S, Spitalnik SL, Laughlin M, Stefano K, Silberberg DH, Gonzalez-Scarano F., Science 253(5017), 1991
PMID: 1857969
Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity.
Haskill S, Beg AA, Tompkins SM, Morris JS, Yurochko AD, Sampson-Johannes A, Mondal K, Ralph P, Baldwin AS Jr., Cell 65(7), 1991
PMID: 1829648
Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B.
Henkel T, Machleidt T, Alkalay I, Kronke M, Ben-Neriah Y, Baeuerle PA., Nature 365(6442), 1993
PMID: 8371761
Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunit.
Henkel T, Zabel U, van Zee K, Muller JM, Fanning E, Baeuerle PA., Cell 68(6), 1992
PMID: 1547506
Biosynthesis and metabolism of endothelium-derived nitric oxide.
Ignarro LJ., Annu. Rev. Pharmacol. Toxicol. 30(), 1990
PMID: 2188578
Brain synapses contain inducible forms of the transcription factor NF-kappa B.
Kaltschmidt C, Kaltschmidt B, Baeuerle PA., Mech. Dev. 43(2-3), 1993
PMID: 8297787

Down's syndrome: a pathology involving the lack of balance of reactive oxygen species.
Kedziora J, Bartosz G., Free Radic. Biol. Med. 4(5), 1988
PMID: 2966094
Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase
Kinochi, 1991
Cerebral arteriolar damage by arachidonic acid and prostaglandin G2.
Kontos HA, Wei EP, Povlishock JT, Dietrich WD, Magiera CJ, Ellis EF., Science 209(4462), 1980
PMID: 7403881

Korthuis, 1986
PGH synthase and lipoxygenase generate superoxide in the presence of NADH or NADPH.
Kukreja RC, Kontos HA, Hess ML, Ellis EF., Circ. Res. 59(6), 1986
PMID: 3028671
Activation of interleukin-6 gene expression through the NF-kappa B transcription factor.
Libermann TA, Baltimore D., Mol. Cell. Biol. 10(5), 1990
PMID: 2183031
Regulation of the NF-kappa B/rel transcription factor and I kappa B inhibitor system.
Liou HC, Baltimore D., Curr. Opin. Cell Biol. 5(3), 1993
PMID: 8352966
Inhibition of transcription factors belonging to the rel/NF-kappa B family by a transdominant negative mutant.
Logeat F, Israel N, Ten R, Blank V, Le Bail O, Kourilsky P, Israel A., EMBO J. 10(7), 1991
PMID: 1675604
Oxygen radicals and neuropsychiatric illness. Some speculations.
Lohr JB., Arch. Gen. Psychiatry 48(12), 1991
PMID: 1845228
Traumatic and ischemia/reperfusion injury to the CNS
McCall, Annual Reports In Medicinal Chemistry 27(), 1992
Protein kinase C-independent activation of nuclear factor kappa B by tumor necrosis factor.
Meichle A, Schutze S, Hensel G, Brunsing D, Kronke M., J. Biol. Chem. 265(14), 1990
PMID: 2186042
Redox control of gene expression by eukaryotic transcription factors NF-κB, AP-1 and SRF
Meyer, 1993
Molecular biology of Alzheimer's disease.
Muller-Hill B, Beyreuther K., Annu. Rev. Biochem. 58(), 1989
PMID: 2673012
Nuclear factor kappa B, a mediator of lipopolysaccharide effects.
Muller JM, Ziegler-Heitbrock HW, Baeuerle PA., Immunobiology 187(3-5), 1993
PMID: 8330898
Alteration in extracellular amino acids after traumatic spinal cord injury.
Panter SS, Yum SW, Faden AI., Ann. Neurol. 27(1), 1990
PMID: 2301932
Distinct combinations of NF-kappa B subunits determine the specificity of transcriptional activation
Perkins, 1992
The precursor of NF-kappa B p50 has I kappa B-like functions.
Rice NR, MacKichan ML, Israel A., Cell 71(2), 1992
PMID: 1423592
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis.
Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, Donaldson D, Goto J, O'Regan JP, Deng HX., Nature 362(6415), 1993
PMID: 8446170
Hemoglobin. A biologic fenton reagent.
Sadrzadeh SM, Graf E, Panter SS, Hallaway PE, Eaton JW., J. Biol. Chem. 259(23), 1984
PMID: 6094553
Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6.
Satoh T, Nakamura S, Taga T, Matsuda T, Hirano T, Kishimoto T, Kaziro Y., Mol. Cell. Biol. 8(8), 1988
PMID: 3264880
Proteins controlling the nuclear uptake of NF-kappa B, Rel and dorsal.
Schmitz ML, Henkel T, Baeuerle PA., Trends Cell Biol. 1(5), 1991
PMID: 14731544
A role for oxygen radicals as second messengers.
Schreck R, Baeuerle PA., Trends Cell Biol. 1(2-3), 1991
PMID: 14731549
Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells (a review).
Schreck R, Albermann K, Baeuerle PA., Free Radic. Res. Commun. 17(4), 1992
PMID: 1473734
Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.
Schreck R, Meier B, Mannel DN, Droge W, Baeuerle PA., J. Exp. Med. 175(5), 1992
PMID: 1314883
Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.
Schulze-Osthoff K, Bakker AC, Vanhaesebroeck B, Beyaert R, Jacob WA, Fiers W., J. Biol. Chem. 267(8), 1992
PMID: 1312087
Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.
Schulze-Osthoff K, Beyaert R, Vandevoorde V, Haegeman G, Fiers W., EMBO J. 12(8), 1993
PMID: 8344250
Proliferation of astrocytes in vitro in response to cytokines. A primary role for tumor necrosis factor.
Selmaj KW, Farooq M, Norton WT, Raine CS, Brosnan CF., J. Immunol. 144(1), 1990
PMID: 2104886
Involvement of a NF-kappa B-like transcription factor in the activation of the interleukin-6 gene by inflammatory lymphokines.
Shimizu H, Mitomo K, Watanabe T, Okamoto S, Yamamoto K., Mol. Cell. Biol. 10(2), 1990
PMID: 2405250
Nitric oxide: first in a new class of neurotransmitters.
Snyder SH., Science 257(5069), 1992
PMID: 1353273
Increased phospholipase C activity after experimental brain injury.
Wei EP, Lamb RG, Kontos HA., J. Neurosurg. 56(5), 1982
PMID: 7069482
Monosomie 21 syndrome: further delineation including clinical, neuropathological, cytogenetic and biochemical studies
Wisniewski, Clin. Gen. 23(), 1993
Nuclear uptake control of NF-kappa B by MAD-3, an I kappa B protein present in the nucleus.
Zabel U, Henkel T, Silva MS, Baeuerle PA., EMBO J. 12(1), 1993
PMID: 7679069

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

PMID: 8264332
PubMed | Europe PMC

Suchen in

Google Scholar