Many transcription factors interact synergistically with steroid receptors

Schule R, Muller M, Kaltschmidt C, Renkawitz R (1988)
Science 242(4884): 1418-20.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor/in
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Abstract / Bemerkung
Progesterone (PRE) or glucocorticoid receptor (GRE) DNA binding sites are often found clustered with binding sites for other transcription factors. Individual protein binding sites were tested without the influence of adjacent factors by analyzing isolated combinations of several transcription factor binding sites with PREs or GREs. All show strong synergistic effects on steroid induction. The degree of synergism is inversely related to the strength of the GRE. Thus, a steroid responsive unit can be composed of several modules that, if positioned correctly, act synergistically.
Stichworte
Glucocorticoid/*genetics/metabolism; Receptors; Plasmids; Molecular Sequence Data; Humans; Hela Cells/metabolism; Genes; Molecular; Cloning; Base Sequence; Binding Sites; Receptors; Progesterone/*genetics/metabolism; Transcription Factors/*genetics/metabolism; Transfection
Erscheinungsjahr
1988
Zeitschriftentitel
Science
Band
242
Ausgabe
4884
Seite(n)
1418-20
ISSN
0036-8075 (Print) 0036-8075 (Linking)
Page URI
https://pub.uni-bielefeld.de/record/2398784

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Schule R, Muller M, Kaltschmidt C, Renkawitz R. Many transcription factors interact synergistically with steroid receptors. Science. 1988;242(4884):1418-20.
Schule, R., Muller, M., Kaltschmidt, C., & Renkawitz, R. (1988). Many transcription factors interact synergistically with steroid receptors. Science, 242(4884), 1418-20.
Schule, R., Muller, M., Kaltschmidt, C., and Renkawitz, R. (1988). Many transcription factors interact synergistically with steroid receptors. Science 242, 1418-20.
Schule, R., et al., 1988. Many transcription factors interact synergistically with steroid receptors. Science, 242(4884), p 1418-20.
R. Schule, et al., “Many transcription factors interact synergistically with steroid receptors”, Science, vol. 242, 1988, pp. 1418-20.
Schule, R., Muller, M., Kaltschmidt, C., Renkawitz, R.: Many transcription factors interact synergistically with steroid receptors. Science. 242, 1418-20 (1988).
Schule, R., Muller, M., Kaltschmidt, Christian, and Renkawitz, R. “Many transcription factors interact synergistically with steroid receptors”. Science 242.4884 (1988): 1418-20.

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