miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling
Lüningschrör P, Stoecker B, Kaltschmidt B, Kaltschmidt C (2012)
Stem Cells 30(4): 655-664.
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Abstract / Bemerkung
Embryonic stem cell (ESC)-specific microRNAs (miRNAs) play a critical role in the maintenance of pluripotency and self-renewal but the complete network between these miRNAs and their broad range of target genes still remains elusive. Here we demonstrate that miR-290 cluster, the most abundant miRNA family in ESCs, targets the NF-?B subunit p65 (also known as RelA) by repressing its translation. Forced expression of p65 causes loss of pluripotency, promotes differentiation of ESCs, and leads to an epithelial to mesenchymal transition. These data define p65 as a novel target gene of miR-290 cluster and provide new insight into the function of ESC-specific miRNAs. STEM CELLS 2012; 30:655664
Stichworte
Pluripotency;
MicroRNA-290;
cluster;
NF-?B;
Embryonic stem cells;
Epithelial to mesenchymal transition
Erscheinungsjahr
2012
Zeitschriftentitel
Stem Cells
Band
30
Ausgabe
4
Seite(n)
655-664
ISSN
1066-5099
Page URI
https://pub.uni-bielefeld.de/record/2398758
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Lüningschrör P, Stoecker B, Kaltschmidt B, Kaltschmidt C. miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling. Stem Cells. 2012;30(4):655-664.
Lüningschrör, P., Stoecker, B., Kaltschmidt, B., & Kaltschmidt, C. (2012). miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling. Stem Cells, 30(4), 655-664. https://doi.org/10.1002/stem.1033
Lüningschrör, Patrick, Stoecker, B., Kaltschmidt, Barbara, and Kaltschmidt, Christian. 2012. “miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling”. Stem Cells 30 (4): 655-664.
Lüningschrör, P., Stoecker, B., Kaltschmidt, B., and Kaltschmidt, C. (2012). miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling. Stem Cells 30, 655-664.
Lüningschrör, P., et al., 2012. miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling. Stem Cells, 30(4), p 655-664.
P. Lüningschrör, et al., “miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling”, Stem Cells, vol. 30, 2012, pp. 655-664.
Lüningschrör, P., Stoecker, B., Kaltschmidt, B., Kaltschmidt, C.: miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling. Stem Cells. 30, 655-664 (2012).
Lüningschrör, Patrick, Stoecker, B., Kaltschmidt, Barbara, and Kaltschmidt, Christian. “miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling”. Stem Cells 30.4 (2012): 655-664.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
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