miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling

Lüningschrör P, Stoecker B, Kaltschmidt B, Kaltschmidt C (2012)
Stem Cells 30(4): 655-664.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
Abstract / Bemerkung
Embryonic stem cell (ESC)-specific microRNAs (miRNAs) play a critical role in the maintenance of pluripotency and self-renewal but the complete network between these miRNAs and their broad range of target genes still remains elusive. Here we demonstrate that miR-290 cluster, the most abundant miRNA family in ESCs, targets the NF-?B subunit p65 (also known as RelA) by repressing its translation. Forced expression of p65 causes loss of pluripotency, promotes differentiation of ESCs, and leads to an epithelial to mesenchymal transition. These data define p65 as a novel target gene of miR-290 cluster and provide new insight into the function of ESC-specific miRNAs. STEM CELLS 2012; 30:655664
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Stem Cells
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655-664
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Lüningschrör P, Stoecker B, Kaltschmidt B, Kaltschmidt C. miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling. Stem Cells. 2012;30(4):655-664.
Lüningschrör, P., Stoecker, B., Kaltschmidt, B., & Kaltschmidt, C. (2012). miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling. Stem Cells, 30(4), 655-664. doi:10.1002/stem.1033
Lüningschrör, P., Stoecker, B., Kaltschmidt, B., and Kaltschmidt, C. (2012). miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling. Stem Cells 30, 655-664.
Lüningschrör, P., et al., 2012. miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling. Stem Cells, 30(4), p 655-664.
P. Lüningschrör, et al., “miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling”, Stem Cells, vol. 30, 2012, pp. 655-664.
Lüningschrör, P., Stoecker, B., Kaltschmidt, B., Kaltschmidt, C.: miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling. Stem Cells. 30, 655-664 (2012).
Lüningschrör, Patrick, Stoecker, B., Kaltschmidt, Barbara, and Kaltschmidt, Christian. “miR-290 cluster modulates pluripotency by repressing canonical NF-κB signaling”. Stem Cells 30.4 (2012): 655-664.

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