A SMALL GTP-BINDING PROTEIN DISSOCIATES FROM SYNAPTIC VESICLES DURING EXOCYTOSIS

Fischer von Mollard G, SUDHOF TC, JAHN R (1991)
NATURE 349(6304): 79-81.

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Abstract / Bemerkung
LOW-molecular-weight GTP-binding proteins are strong candidates for regulators of membrane traffic1-3. In yeast, mutations in the sec4 or ypt1 genes encoding small GTP-binding proteins inhibit constitutive membrane flow at the plasma membrane or Golgi complex, respectively4-6. It has been suggested that membrane fusion-fission events are regulated by cycling of small GTP-binding proteins between a membrane-bound and free state7, but although most of these small proteins are found in both soluble and tightly membrane-bound forms, there is no direct evidence to support such cycling. In rat brain a small GTP-binding protein, rab3A, is exclusively associated with synaptic vesicles, the secretory organelles of nerve terminals8,9. Here we use isolated nerve terminals to study the fate of rab3A during synaptic vesicle exocytosis. We find that rab3A dissociates quantitatively from the vesicle membrane after Ca2+-dependent exocytosis and that this dissociation is partially reversible during recovery after stimulation. These results are direct evidence for an association-dissociation cycle of a small GTP-binding protein during traffic of its host membrane.
Erscheinungsjahr
1991
Zeitschriftentitel
NATURE
Band
349
Ausgabe
6304
Seite(n)
79-81
ISSN
0028-0836
Page URI
https://pub.uni-bielefeld.de/record/2374443

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Fischer von Mollard G, SUDHOF TC, JAHN R. A SMALL GTP-BINDING PROTEIN DISSOCIATES FROM SYNAPTIC VESICLES DURING EXOCYTOSIS. NATURE. 1991;349(6304):79-81.
Fischer von Mollard, G., SUDHOF, T. C., & JAHN, R. (1991). A SMALL GTP-BINDING PROTEIN DISSOCIATES FROM SYNAPTIC VESICLES DURING EXOCYTOSIS. NATURE, 349(6304), 79-81. doi:10.1038/349079a0
Fischer von Mollard, G., SUDHOF, T. C., and JAHN, R. (1991). A SMALL GTP-BINDING PROTEIN DISSOCIATES FROM SYNAPTIC VESICLES DURING EXOCYTOSIS. NATURE 349, 79-81.
Fischer von Mollard, G., SUDHOF, T.C., & JAHN, R., 1991. A SMALL GTP-BINDING PROTEIN DISSOCIATES FROM SYNAPTIC VESICLES DURING EXOCYTOSIS. NATURE, 349(6304), p 79-81.
G. Fischer von Mollard, T.C. SUDHOF, and R. JAHN, “A SMALL GTP-BINDING PROTEIN DISSOCIATES FROM SYNAPTIC VESICLES DURING EXOCYTOSIS”, NATURE, vol. 349, 1991, pp. 79-81.
Fischer von Mollard, G., SUDHOF, T.C., JAHN, R.: A SMALL GTP-BINDING PROTEIN DISSOCIATES FROM SYNAPTIC VESICLES DURING EXOCYTOSIS. NATURE. 349, 79-81 (1991).
Fischer von Mollard, Gabriele, SUDHOF, TC, and JAHN, R. “A SMALL GTP-BINDING PROTEIN DISSOCIATES FROM SYNAPTIC VESICLES DURING EXOCYTOSIS”. NATURE 349.6304 (1991): 79-81.

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Moshiach S, Nelson TJ, Sanchez-Andres JV, Sakakibara M, Alkon DL., Brain Res 605(2), 1993
PMID: 8481780
Rabphilin-3A, a putative target protein for smg p25A/rab3A p25 small GTP-binding protein related to synaptotagmin.
Shirataki H, Kaibuchi K, Sakoda T, Kishida S, Yamaguchi T, Wada K, Miyazaki M, Takai Y., Mol Cell Biol 13(4), 1993
PMID: 8384302
Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization.
Lütcke A, Jansson S, Parton RG, Chavrier P, Valencia A, Huber LA, Lehtonen E, Zerial M., J Cell Biol 121(3), 1993
PMID: 8486736
cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein.
Andres DA, Seabra MC, Brown MS, Armstrong SA, Smeland TE, Cremers FP, Goldstein JL., Cell 73(6), 1993
PMID: 8513495
Synaptic vesicle traffic: rush hour in the nerve terminal.
Jahn R, Südhof TC., J Neurochem 61(1), 1993
PMID: 8515256
Inhibition of pituitary hormone exocytosis by a synthetic peptide related to the rab effector domain.
Davidson JS, Eales A, Roeske RW, Millar RP., FEBS Lett 326(1-3), 1993
PMID: 8391998
Structure of the murine rab3A gene: correlation of genomic organization with antibody epitopes.
Baumert M, Fischer von Mollard G, Jahn R, Südhof TC., Biochem J 293 ( Pt 1)(), 1993
PMID: 7687127
GTP gamma S stimulates exocytosis in patch-clamped rat melanotrophs.
Okano K, Monck JR, Fernandez JM., Neuron 11(1), 1993
PMID: 8338664
Regulated exocytosis.
Burgoyne RD, Morgan A., Biochem J 293 ( Pt 2)(), 1993
PMID: 8343109
Molecular cloning of a cDNA encoding a novel small GTP-binding protein.
Koda T, Kakinuma M., FEBS Lett 328(1-2), 1993
PMID: 7688322
A complex of rab3A, SNAP-25, VAMP/synaptobrevin-2 and syntaxins in brain presynaptic terminals.
Horikawa HP, Saisu H, Ishizuka T, Sekine Y, Tsugita A, Odani S, Abe T., FEBS Lett 330(2), 1993
PMID: 8365494
Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane.
Huber LA, Pimplikar S, Parton RG, Virta H, Zerial M, Simons K., J Cell Biol 123(1), 1993
PMID: 8408203
Comparison of the biochemical properties of unprocessed and processed forms of the small GTP-binding protein, rab6p.
Yang C, Mollat P, Chaffotte A, McCaffrey M, Cabanié L, Goud B., Eur J Biochem 217(3), 1993
PMID: 8223626
Botulinum neurotoxin C1 blocks neurotransmitter release by means of cleaving HPC-1/syntaxin.
Blasi J, Chapman ER, Yamasaki S, Binz T, Niemann H, Jahn R., EMBO J 12(12), 1993
PMID: 7901002
Synaptic vesicle membrane proteins interact to form a multimeric complex.
Bennett MK, Calakos N, Kreiner T, Scheller RH., J Cell Biol 116(3), 1992
PMID: 1730776
GTP-binding proteins in intracellular transport.
Pfeffer SR., Trends Cell Biol 2(2), 1992
PMID: 14731525
A synthetic peptide of the rab3a effector domain stimulates amylase release from permeabilized pancreatic acini.
Padfield PJ, Balch WE, Jamieson JD., Proc Natl Acad Sci U S A 89(5), 1992
PMID: 1371881
Amphiphysin, a novel protein associated with synaptic vesicles.
Lichte B, Veh RW, Meyer HE, Kilimann MW., EMBO J 11(7), 1992
PMID: 1628617
Polymyxin B inhibits insulin-induced glucose transporter and IGF II receptor translocation in isolated adipocytes.
Cormont M, Gremeaux T, Tanti JF, Van Obberghen E, Le Marchand-Brustel Y., Eur J Biochem 207(1), 1992
PMID: 1321040
Identification of rab2 as a tubulovesicle-membrane-associated protein in rabbit gastric parietal cells.
Tang LH, Stoch SA, Modlin IM, Goldenring JR., Biochem J 285 ( Pt 3)(), 1992
PMID: 1323270
Localization of smg p25A/rab3A p25, a small GTP-binding protein, at the active zone of the rat neuromuscular junction.
Mizoguchi A, Arakawa M, Masutani M, Tamekane A, Yamaguchi H, Minami N, Takai Y, Ide C., Biochem Biophys Res Commun 186(3), 1992
PMID: 1324664
Regulation of intracellular membrane transport.
Gruenberg J, Clague MJ., Curr Opin Cell Biol 4(4), 1992
PMID: 1419040
Clathrin-coated vesicles in nervous tissue are involved primarily in synaptic vesicle recycling.
Maycox PR, Link E, Reetz A, Morris SA, Jahn R., J Cell Biol 118(6), 1992
PMID: 1325974
Characterization of small-molecular-mass guanine-nucleotide-binding regulatory proteins in insulin-secreting cells and PC12 cells.
Regazzi R, Vallar L, Ullrich S, Ravazzola M, Kikuchi A, Takai Y, Wollheim CB., Eur J Biochem 208(3), 1992
PMID: 1327767
Localization of the ras-like rab3A protein in the adult rat brain.
Moya KL, Tavitian B, Zahraoui A, Tavitian A., Brain Res 590(1-2), 1992
PMID: 1330210
Small GTP-binding proteins as compartmental markers.
Goud B., Semin Cell Biol 3(5), 1992
PMID: 1457774
Specific expression of the ras-related rab3A gene in human normal and malignant neuroendocrine cells.
Culine S, Rousseau-Merck MF, Honoré N, Nezelof C, Olofsson B., Cancer 70(10), 1992
PMID: 1384950
Expression of the ras-related rab3a gene in insulinoma-derived cell lines.
Lankat-Buttgereit B, Göke R, Fehmann HC, Niess C, Göke B., FEBS Lett 312(2-3), 1992
PMID: 1330692
Small GTP-binding proteins in parietal cells: candidate modulators of parietal cell membrane dynamics.
Goldenring JR, Tang LH, Modlin IM., Yale J Biol Med 65(6), 1992
PMID: 1341066
Expression of the small GTP-binding protein Rab3A in the adult rat brain.
Stettler O, Zahraoui A, Moya KL, Tavitian B., Mol Cell Neurosci 3(6), 1992
PMID: 19912893
Tetanus toxin action: inhibition of neurotransmitter release linked to synaptobrevin proteolysis.
Link E, Edelmann L, Chou JH, Binz T, Yamasaki S, Eisel U, Baumert M, Südhof TC, Niemann H, Jahn R., Biochem Biophys Res Commun 189(2), 1992
PMID: 1361727
Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1.
Rubinfeld B, Munemitsu S, Clark R, Conroy L, Watt K, Crosier WJ, McCormick F, Polakis P., Cell 65(6), 1991
PMID: 1904317
Differential expression of the p65 gene family.
Wendland B, Miller KG, Schilling J, Scheller RH., Neuron 6(6), 1991
PMID: 2054189
The small GTP-binding protein rab4 is associated with early endosomes.
Van Der Sluijs P, Hull M, Zahraoui A, Tavitian A, Goud B, Mellman I., Proc Natl Acad Sci U S A 88(14), 1991
PMID: 1906178
rab3A attachment to the synaptic vesicle membrane mediated by a conserved polyisoprenylated carboxy-terminal sequence.
Johnston PA, Archer BT, Robinson K, Mignery GA, Jahn R, Südhof TC., Neuron 7(1), 1991
PMID: 1648935
Small GTP-binding proteins and their role in transport.
Goud B, McCaffrey M., Curr Opin Cell Biol 3(4), 1991
PMID: 1663370
Secretory granule and synaptic vesicle formation.
Kelly RB., Curr Opin Cell Biol 3(4), 1991
PMID: 1663373
Association of a 24-kDa GTP-binding protein, Gn24, with human platelet alpha-granule membranes.
van der Meulen J, Bhullar RP, Chancellor-Maddison KA., FEBS Lett 291(1), 1991
PMID: 1936239
A synaptic vesicle specific GTP-binding protein from ray electric organ.
Volknandt W, Pevsner J, Elferink LA, Schilling J, Scheller RH., Brain Res Mol Brain Res 11(3-4), 1991
PMID: 1721993
Molecular architecture of the nerve terminal.
Linstedt AD, Kelly RB., Curr Opin Neurobiol 1(3), 1991
PMID: 1821681
Exocytotic and endocytotic membrane traffic in neurons.
Huttner WB, Dotti CG., Curr Opin Neurobiol 1(3), 1991
PMID: 1821682
Effect of botulinum D toxin on human neutrophilic leukocytes and localization of its substrates.
Andre P, Capo C, Fossat C, Bongrand P, Mege JL., Membr Biochem 9(3), 1990
PMID: 1966913

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