Cyclosporin A inhibits the degradation of signal sequences after processing of presecretory proteins by signal peptidase

Klappa P, Dierks T, Zimmermann R (1996)
EUROPEAN JOURNAL OF BIOCHEMISTRY 239(2): 509-518.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Klappa, P; Dierks, ThomasUniBi; Zimmermann, R
Abstract / Bemerkung
Targeting of presecretory proteins to, and insertion into, the microsomal membrane are mediated by signal sequences. These signal sequences are removed from presecretory proteins by signal peptidase. We demonstrate that the signal sequence of preprolactin, after translocation into microsomes and cleavage by signal peptidase, is converted to an intermediate form. This intermediate was found outside the microsomes, where it was degraded in the presence of cytosol. Degradation of the signal sequence of another presecretory protein, preprocecropinA, occurred even in the absence of cytosol. The immunosuppressant cyclosporin A inhibited trimming of the preprolactin signal sequence and degradation of the preprocecropinA signal sequence. We observed by cross-linking studies that cleaved signal sequences are bound to two microsomal proteins prior to degradation.
Erscheinungsjahr
1996
Zeitschriftentitel
EUROPEAN JOURNAL OF BIOCHEMISTRY
Band
239
Ausgabe
2
Seite(n)
509-518
ISSN
0014-2956
eISSN
1432-1033
Page URI
https://pub.uni-bielefeld.de/record/2350925

Zitieren

Klappa P, Dierks T, Zimmermann R. Cyclosporin A inhibits the degradation of signal sequences after processing of presecretory proteins by signal peptidase. EUROPEAN JOURNAL OF BIOCHEMISTRY. 1996;239(2):509-518.
Klappa, P., Dierks, T., & Zimmermann, R. (1996). Cyclosporin A inhibits the degradation of signal sequences after processing of presecretory proteins by signal peptidase. EUROPEAN JOURNAL OF BIOCHEMISTRY, 239(2), 509-518. https://doi.org/10.1111/j.1432-1033.1996.0509u.x
Klappa, P., Dierks, T., and Zimmermann, R. (1996). Cyclosporin A inhibits the degradation of signal sequences after processing of presecretory proteins by signal peptidase. EUROPEAN JOURNAL OF BIOCHEMISTRY 239, 509-518.
Klappa, P., Dierks, T., & Zimmermann, R., 1996. Cyclosporin A inhibits the degradation of signal sequences after processing of presecretory proteins by signal peptidase. EUROPEAN JOURNAL OF BIOCHEMISTRY, 239(2), p 509-518.
P. Klappa, T. Dierks, and R. Zimmermann, “Cyclosporin A inhibits the degradation of signal sequences after processing of presecretory proteins by signal peptidase”, EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 239, 1996, pp. 509-518.
Klappa, P., Dierks, T., Zimmermann, R.: Cyclosporin A inhibits the degradation of signal sequences after processing of presecretory proteins by signal peptidase. EUROPEAN JOURNAL OF BIOCHEMISTRY. 239, 509-518 (1996).
Klappa, P, Dierks, Thomas, and Zimmermann, R. “Cyclosporin A inhibits the degradation of signal sequences after processing of presecretory proteins by signal peptidase”. EUROPEAN JOURNAL OF BIOCHEMISTRY 239.2 (1996): 509-518.

9 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

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