PUB - Publikationen an der Universität Bielefeld

The leitmotif of this work is to exploit Brownian motion for bioanalysis in the context of migration and separation in microfluidic systems operating far from thermal equilibrium. The increasing importance of bioanalysis is based on the fast growing fields of biotechnology and pharmaceutics. They have a great demand of fast, cheap and robust bioanalytical systems. On the one hand, these systems have to provide pure samples, and on the other hand, have to assure the quality of the product. In order to contribute to these demands, fundamental physical phenomena are studied, such as Absolute Negative Mobility, ratchets and diffusion control and their relevance to bioanalytical applications is illustrated. Two possible approaches are pursued: either the phenomena are directly studied with biological samples or with microparticles as models for cells in order to provide a proof of principle.