Aging-related changes of neural mechanisms underlying visual-spatial working memory

Piefke M, Onur ÖA, Fink GR (2012)
Neurobiology of Aging 33(7): 1284-1297.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Piefke, MartinaUniBi; Onur, Özgür A.; Fink, Gereon R.
Abstract / Bemerkung
Capacities of the prefrontal cortex (PFC) such as working memory (WM) are known to decline with increasing age. However, it is unclear which neurofunctional mechanisms may underlie this aging-related cognitive decline. The finding that PFC activity tends to be less lateralized in older subjects has led to the assumption of a hemispheric asymmetry reduction in the PFC associated with aging (HAROLD). Using functional magnetic resonance imaging (fMRI), we here investigated aging-related neurofunctional alterations during the performance of a visual-spatial WM task with differential levels of difficulty. Older volunteers activated dorsolateral PFC regions bilaterally while young subjects recruited these areas only in the left hemisphere. These data corroborate the hemispheric asymmetry reduction in the PFC associated with aging (HAROLD) account. However, we also observed functional reorganizations in parieto-occipital areas, and with increasing WM demands, an aging-related reversed hemispheric asymmetry of prefrontal activations. Importantly, neither PFC nor parieto-occipital reorganizations prevented older participants from showing worse WM performance than young volunteers. We conclude that frontal-parietal functional reorganizations may reflect compensational mechanisms related to aging, but do not obviate diminished visual-spatial WM performance in older people.
Prefrontal cortex; Visual-spatial attention; Executive functions; Parietal cortex; Biological aging; fMRI
Neurobiology of Aging
Page URI


Piefke M, Onur ÖA, Fink GR. Aging-related changes of neural mechanisms underlying visual-spatial working memory. Neurobiology of Aging. 2012;33(7):1284-1297.
Piefke, M., Onur, Ö. A., & Fink, G. R. (2012). Aging-related changes of neural mechanisms underlying visual-spatial working memory. Neurobiology of Aging, 33(7), 1284-1297.
Piefke, Martina, Onur, Özgür A., and Fink, Gereon R. 2012. “Aging-related changes of neural mechanisms underlying visual-spatial working memory”. Neurobiology of Aging 33 (7): 1284-1297.
Piefke, M., Onur, Ö. A., and Fink, G. R. (2012). Aging-related changes of neural mechanisms underlying visual-spatial working memory. Neurobiology of Aging 33, 1284-1297.
Piefke, M., Onur, Ö.A., & Fink, G.R., 2012. Aging-related changes of neural mechanisms underlying visual-spatial working memory. Neurobiology of Aging, 33(7), p 1284-1297.
M. Piefke, Ö.A. Onur, and G.R. Fink, “Aging-related changes of neural mechanisms underlying visual-spatial working memory”, Neurobiology of Aging, vol. 33, 2012, pp. 1284-1297.
Piefke, M., Onur, Ö.A., Fink, G.R.: Aging-related changes of neural mechanisms underlying visual-spatial working memory. Neurobiology of Aging. 33, 1284-1297 (2012).
Piefke, Martina, Onur, Özgür A., and Fink, Gereon R. “Aging-related changes of neural mechanisms underlying visual-spatial working memory”. Neurobiology of Aging 33.7 (2012): 1284-1297.

14 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Functional Hemispheric (A)symmetries in the Aged Brain-Relevance for Working Memory.
Esteves M, Magalhães R, Marques P, Castanho TC, Portugal-Nunes C, Soares JM, Almeida A, Santos NC, Sousa N, Leite-Almeida H., Front Aging Neurosci 10(), 2018
PMID: 29593523
Beta Oscillatory Dynamics in the Prefrontal and Superior Temporal Cortices Predict Spatial Working Memory Performance.
Proskovec AL, Wiesman AI, Heinrichs-Graham E, Wilson TW., Sci Rep 8(1), 2018
PMID: 29855522
Neural Correlates of Working Memory Maintenance in Advanced Aging: Evidence From fMRI.
Suzuki M, Kawagoe T, Nishiguchi S, Abe N, Otsuka Y, Nakai R, Asano K, Yamada M, Yoshikawa S, Sekiyama K., Front Aging Neurosci 10(), 2018
PMID: 30459595
Age differences in the motor control of speech: An fMRI study of healthy aging.
Tremblay P, Sato M, Deschamps I., Hum Brain Mapp 38(5), 2017
PMID: 28263012
Language processing of auditory cortex revealed by functional magnetic resonance imaging in presbycusis patients.
Chen X, Wang M, Deng Y, Liang Y, Li J, Chen S., Acta Otolaryngol 136(2), 2016
PMID: 26503708
Aging and the Effects of Exploratory Behavior on Spatial Memory.
Varner KM, Dopkins S, Philbeck JW., Int J Aging Hum Dev 82(2-3), 2016
PMID: 26758675
The neural correlates of spatial and object working memory in elderly and Parkinson's disease subjects.
Caminiti SP, Siri C, Guidi L, Antonini A, Perani D., Behav Neurol 2015(), 2015
PMID: 25861157
Putting age-related task activation into large-scale brain networks: A meta-analysis of 114 fMRI studies on healthy aging.
Li HJ, Hou XH, Liu HH, Yue CL, Lu GM, Zuo XN., Neurosci Biobehav Rev 57(), 2015
PMID: 26318367
A systematic review of type 2 diabetes mellitus and hypertension in imaging studies of cognitive aging: time to establish new norms.
Meusel LA, Kansal N, Tchistiakova E, Yuen W, MacIntosh BJ, Greenwood CE, Anderson ND., Front Aging Neurosci 6(), 2014
PMID: 25071557
An exploratory study of the effects of spatial working-memory load on prefrontal activation in low- and high-performing elderly.
Vermeij A, van Beek AH, Reijs BL, Claassen JA, Kessels RP., Front Aging Neurosci 6(), 2014
PMID: 25414665
Learning real-life cognitive abilities in a novel 360°-virtual reality supermarket: a neuropsychological study of healthy participants and patients with epilepsy.
Grewe P, Kohsik A, Flentge D, Dyck E, Botsch M, Winter Y, Markowitsch HJ, Bien CG, Piefke M., J Neuroeng Rehabil 10(), 2013
PMID: 23618596

78 References

Daten bereitgestellt von Europe PubMed Central.

Aging and visual processing: declines in spatial not temporal integration
Andersen, Vis. Res 48(), 2008
Left inferior parietal cortex integrates time and space during collision judgments.
Assmus A, Marshall JC, Ritzl A, Noth J, Zilles K, Fink GR., Neuroimage 20 Suppl 1(), 2003
PMID: 14597300
Recent developments in working memory.
Baddeley A., Curr. Opin. Neurobiol. 8(2), 1998
PMID: 9635207
An inventory for measuring depression.
BECK AT, WARD CH, MENDELSON M, MOCK J, ERBAUGH J., Arch. Gen. Psychiatry 4(), 1961
PMID: 13688369

Benton, 1976
Spatial reference and working memory across the lifespan of male Fischer 344 rats.
Bizon JL, LaSarge CL, Montgomery KS, McDermott AN, Setlow B, Griffith WH., Neurobiol. Aging 30(4), 2007
PMID: 17889407
What “works” in working memory?
Bledowski, J. Neurosci 29(), 2009
A theory of cognitive control, aging cognition, and neuromodulation.
Braver TS, Barch DM., Neurosci Biobehav Rev 26(7), 2002
PMID: 12470692
Protein kinase C activity is associated with prefrontal cortical decline in aging.
Brennan AR, Yuan P, Dickstein DL, Rocher AB, Hof PR, Manji H, Arnsten AF., Neurobiol. Aging 30(5), 2007
PMID: 17919783
Aging gracefully: compensatory brain activity in high-performing older adults.
Cabeza R, Anderson ND, Locantore JK, McIntosh AR., Neuroimage 17(3), 2002
PMID: 12414279
The relationship between white matter brain metabolites and cognition in normal aging: the GENIE study.
Charlton RA, McIntyre DJ, Howe FA, Morris RG, Markus HS., Brain Res. 1164(), 2007
PMID: 17632090
Zooming in and zooming out of the attentional focus: an FMRI study.
Chen Q, Marshall JC, Weidner R, Fink GR., Cereb. Cortex 19(4), 2008
PMID: 18689860
Aging and integrating spatial mental models.
Copeland DE, Radvansky GA., Psychol Aging 22(3), 2007
PMID: 17874955
Control of goal-directed and stimulus-driven attention in the brain.
Corbetta M, Shulman GL., Nat. Rev. Neurosci. 3(3), 2002
PMID: 11994752
Assessment of memory complaint in age-associated memory impairment: the MAC-Q.
Crook TH 3rd, Feher EP, Larrabee GJ., Int Psychogeriatr 4(2), 1992
PMID: 1477304
Molecular imaging of the dopaminergic system and its association with human cognitive function.
Cropley VL, Fujita M, Innis RB, Nathan PJ., Biol. Psychiatry 59(10), 2006
PMID: 16682268
From cognitive to neural models of working memory.
D'Esposito M., Philos. Trans. R. Soc. Lond., B, Biol. Sci. 362(1481), 2007
PMID: 17400538
Maintenance versus manipulation of information held in working memory: an event-related fMRI study.
D'Esposito M, Postle BR, Ballard D, Lease J., Brain Cogn 41(1), 1999
PMID: 10536086
Executive control during episodic retrieval: multiple prefrontal processes subserve source memory.
Dobbins IG, Foley H, Schacter DL, Wagner AD., Neuron 35(5), 2002
PMID: 12372291
Hemispheric asymmetry and aging: right hemisphere decline or asymmetry reduction.
Dolcos F, Rice HJ, Cabeza R., Neurosci Biobehav Rev 26(7), 2002
PMID: 12470693
Mental imagery and aging.
Dror IE, Kosslyn SM., Psychol Aging 9(1), 1994
PMID: 8185873
Age-related changes in neural activity during performance matched working memory manipulation.
Emery L, Heaven TJ, Paxton JL, Braver TS., Neuroimage 42(4), 2008
PMID: 18634891
The mind's eye--precuneus activation in memory-related imagery.
Fletcher PC, Frith CD, Baker SC, Shallice T, Frackowiak RS, Dolan RJ., Neuroimage 2(3), 1995
PMID: 9343602
Tracking the mind's image in the brain I: time-resolved fMRI during visuospatial mental imagery.
Formisano E, Linden DE, Di Salle F, Trojano L, Esposito F, Sack AT, Grossi D, Zanella FE, Goebel R., Neuron 35(1), 2002
PMID: 12123618
Spatial registration and normalization of images
Friston, Hum. Brain Mapp 3(), 1995
Statistical parametric maps in functional imaging: a general linear approach
Friston, Hum. Brain Mapp 2(), 1995
Conjunction revisited.
Friston KJ, Penny WD, Glaser DE., Neuroimage 25(3), 2005
PMID: 15808967
Functional interactions between prefrontal and visual association cortex contribute to top-down modulation of visual processing
Gazzaley, Cereb. Cortex 17 suppl 1(), 2007
Maintenance and manipulation in spatial working memory: dissociations in the prefrontal cortex.
Glahn DC, Kim J, Cohen MS, Poutanen VP, Therman S, Bava S, Van Erp TG, Manninen M, Huttunen M, Lonnqvist J, Standertskjold-Nordenstam CG, Cannon TD., Neuroimage 17(1), 2002
PMID: 12482077

Härting, 2000
Explaining age differences in temporal working memory.
Hartman M, Warren LH., Psychol Aging 20(4), 2005
PMID: 16420139
Neural activation during response competition.
Hazeltine E, Poldrack R, Gabrieli JD., J Cogn Neurosci 12 Suppl 2(), 2000
PMID: 11506652
Age differences in mental scanning of locomotor maps.
Iachini T, Poderico C, Ruggiero G, Iavarone A., Disabil Rehabil 27(13), 2005
PMID: 16096226
Age-related shifts in brain activity dynamics during task switching.
Jimura K, Braver TS., Cereb. Cortex 20(6), 2009
PMID: 19805420
Maintenance of real objects and their verbal designations in working memory.
Kaiser S, Kopka ML, Rentrop M, Walther S, Kronmuller K, Olbrich R, Weisbrod M, Stippich C., Neurosci. Lett. 469(1), 2009
PMID: 19932154

Kaplan, 1983

Kessler, 1990
Event-related potentials in young and elderly adults during a visual spatial working memory task.
Knott V, Millar A, Dulude L, Bradford L, Alwahhabi F, Lau T, Shea C, Wiens A., Clin EEG Neurosci 35(4), 2004
PMID: 15493533
The hemodynamics of cognitive control: the level of concentration of oxygenated hemoglobin in the superior prefrontal cortex varies as a function of performance in a modified Stroop task.
Leon-Carrion J, Damas-Lopez J, Martin-Rodriguez JF, Dominguez-Roldan JM, Murillo-Cabezas F, Barroso Y Martin JM, Dominguez-Morales MR., Behav. Brain Res. 193(2), 2008
PMID: 18606191
Under-recruitment and nonselective recruitment: dissociable neural mechanisms associated with aging.
Logan JM, Sanders AL, Snyder AZ, Morris JC, Buckner RL., Neuron 33(5), 2002
PMID: 11879658
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease.
Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L., Neurology 41(4), 1991
PMID: 2011243
Age-related changes in fronto-parietal networks during spatial memory: an ERP study.
Muller NG, Knight RT., Brain Res Cogn Brain Res 13(2), 2002
PMID: 11958965
White matter changes compromise prefrontal cortex function in healthy elderly individuals.
Nordahl CW, Ranganath C, Yonelinas AP, Decarli C, Fletcher E, Jagust WJ., J Cogn Neurosci 18(3), 2006
PMID: 16513006
The assessment and analysis of handedness: the Edinburgh inventory.
Oldfield RC., Neuropsychologia 9(1), 1971
PMID: 5146491
Cognitive control, goal maintenance, and prefrontal function in healthy aging.
Paxton JL, Barch DM, Racine CA, Braver TS., Cereb. Cortex 18(5), 2007
PMID: 17804479
Lateral prefrontal cortex: architectonic and functional organization.
Petrides M., Philos. Trans. R. Soc. Lond., B, Biol. Sci. 360(1456), 2005
PMID: 15937012
Differential remoteness and emotional tone modulate the neural correlates of autobiographical memory.
Piefke M, Weiss PH, Zilles K, Markowitsch HJ, Fink GR., Brain 126(Pt 3), 2003
PMID: 12566286
Neurofunctional modulation of brain regions by distinct forms of motor cognition and movement features.
Piefke M, Kramer K, Korte M, Schulte-Ruther M, Korte JM, Wohlschlager AM, Weber J, Shah NJ, Huber W, Fink GR., Hum Brain Mapp 30(2), 2009
PMID: 18064585
Activity in human frontal cortex associated with spatial working memory and saccadic behavior.
Postle BR, Berger JS, Taich AM, D'Esposito M., J Cogn Neurosci 12 Suppl 2(), 2000
PMID: 11506643
The where and how of attention-based rehearsal in spatial working memory.
Postle BR, Awh E, Jonides J, Smith EE, D'Esposito M., Brain Res Cogn Brain Res 20(2), 2004
PMID: 15183391
White matter lesions account for all age-related declines in speed but not in intelligence.
Rabbitt P, Scott M, Lunn M, Thacker N, Lowe C, Pendleton N, Horan M, Jackson A., Neuropsychology 21(3), 2007
PMID: 17484599
Validity of the trail making test as an indicator of organic brain damage
Reitan, Percept. Mot. Skills 73(), 1958
The effect of non-visual working memory load on top-down modulation of visual processing.
Rissman J, Gazzaley A, D'Esposito M., Neuropsychologia 47(7), 2009
PMID: 19397858
Isolating the neural mechanisms of age-related changes in human working memory.
Rypma B, D'Esposito M., Nat. Neurosci. 3(5), 2000
PMID: 10769393
Tracking the mind's image in the brain II: transcranial magnetic stimulation reveals parietal asymmetry in visuospatial imagery.
Sack AT, Sperling JM, Prvulovic D, Formisano E, Goebel R, Di Salle F, Dierks T, Linden DE., Neuron 35(1), 2002
PMID: 12123619
[Practical application of the CERAD test battery as a neuropsychological dementia screening test]
Satzger W, Hampel H, Padberg F, Burger K, Nolde T, Ingrassia G, Engel RR., Nervenarzt 72(3), 2001
PMID: 11268764
Disentangling the prefrontal network for rule selection by means of a non-verbal variant of the Wisconsin Card Sorting Test
Specht, Hum. Brain Mapp 30(), 2008
LPS-K—Eine LPS-Kurzform für hirngeschädigte Patienten; mit Anleitung zur psychometrischen Einzelfalldiagnostik
Sturm, Diagnostica 29(), 1983

Sturm, 1993
Neural correlates of visuospatial imagery.
Suchan B, Yaguez L, Wunderlich G, Canavan AG, Herzog H, Tellmann L, Homberg V, Seitz RJ., Behav. Brain Res. 131(1-2), 2002
PMID: 11844583

Tewes, 1991
Aging and visual short-term memory: effects of object type and information load.
Vaughan L, Hartman M., Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 17(1), 2009
PMID: 19626476
Dedifferentiation in the visual cortex: an fMRI investigation of individual differences in older adults.
Voss MW, Erickson KI, Chaddock L, Prakash RS, Colcombe SJ, Morris KS, Doerksen S, Hu L, McAuley E, Kramer AF., Brain Res. 1244(), 2008
PMID: 18848823
Color-word matching stroop task: separating interference and response conflict.
Zysset S, Muller K, Lohmann G, von Cramon DY., Neuroimage 13(1), 2001
PMID: 11133306

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

PMID: 21130531
PubMed | Europe PMC

Suchen in

Google Scholar